EA201000037A1 - Производные n5-(2-этоксиэтил)-n3-(2-пиридинил)-3,5-пиперидиндикарбоксамида, предназначенные для применения в качестве ингибиторов ренина - Google Patents

Производные n5-(2-этоксиэтил)-n3-(2-пиридинил)-3,5-пиперидиндикарбоксамида, предназначенные для применения в качестве ингибиторов ренина

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Publication number
EA201000037A1
EA201000037A1 EA201000037A EA201000037A EA201000037A1 EA 201000037 A1 EA201000037 A1 EA 201000037A1 EA 201000037 A EA201000037 A EA 201000037A EA 201000037 A EA201000037 A EA 201000037A EA 201000037 A1 EA201000037 A1 EA 201000037A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
treatment
intended
class
piperidindikarboxamida
Prior art date
Application number
EA201000037A
Other languages
English (en)
Other versions
EA016446B1 (ru
Inventor
Фумиаки Йококава
Такеру Эхара
Шимпей Каваками
Осаму Ирие
Масаки Сузуки
Юко Хитоми
Атсуши Тояо
Original Assignee
Новартис Аг
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39926743&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201000037(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201000037A1 publication Critical patent/EA201000037A1/ru
Publication of EA016446B1 publication Critical patent/EA016446B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

В заявке описаны соединение формулы Iв которой Rl, R2, R3, R4 и R5 является таким, как определено в описании, предназначенные для применения для диагностики и лечения теплокровного животного, предпочтительно для лечения заболевания (нарушения), которое зависит от активности ренина; применение соединения этого класса для приготовления фармацевтической композиции, предназначенной для лечения заболевания, которое зависит от активности ренина; применение соединения этого класса для лечения заболевания, которое зависит от активности ренина; фармацевтические композиции соединения этого класса; способ лечения, включающий введение соединения этого класса, и способ его получения.
EA201000037A 2007-06-25 2008-06-23 Производные n5-(2-этоксиэтил)-n3-(2-пиридинил)-3,5-пиперидиндикарбоксамида, предназначенные для применения в качестве ингибиторов ренина EA016446B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07012412 2007-06-25
EP07111290 2007-06-28
PCT/EP2008/057964 WO2009000811A1 (en) 2007-06-25 2008-06-23 N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors

Publications (2)

Publication Number Publication Date
EA201000037A1 true EA201000037A1 (ru) 2010-06-30
EA016446B1 EA016446B1 (ru) 2012-05-30

Family

ID=39926743

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000037A EA016446B1 (ru) 2007-06-25 2008-06-23 Производные n5-(2-этоксиэтил)-n3-(2-пиридинил)-3,5-пиперидиндикарбоксамида, предназначенные для применения в качестве ингибиторов ренина

Country Status (26)

Country Link
US (2) US8383650B2 (ru)
EP (2) EP2527338B1 (ru)
JP (1) JP5086433B2 (ru)
KR (1) KR101238479B1 (ru)
CN (1) CN101687847B (ru)
AR (1) AR067132A1 (ru)
AU (1) AU2008267287B2 (ru)
BR (1) BRPI0813900A2 (ru)
CA (1) CA2689109A1 (ru)
CL (1) CL2008001872A1 (ru)
CO (1) CO6251267A2 (ru)
CR (1) CR11153A (ru)
CU (1) CU23842B1 (ru)
EA (1) EA016446B1 (ru)
EC (1) ECSP099825A (ru)
ES (2) ES2541107T3 (ru)
GT (1) GT200900324A (ru)
HN (1) HN2009003463A (ru)
IL (1) IL202494A0 (ru)
MA (1) MA31538B1 (ru)
NZ (1) NZ582098A (ru)
PE (1) PE20090425A1 (ru)
SG (1) SG182223A1 (ru)
TN (1) TN2009000530A1 (ru)
TW (1) TWI404714B (ru)
WO (1) WO2009000811A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ582098A (en) 2007-06-25 2012-03-30 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
US20180048921A1 (en) * 2016-08-12 2018-02-15 Microsoft Technology Licensing, Llc Real-time playback diagnostics

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Also Published As

Publication number Publication date
ECSP099825A (es) 2010-01-29
AR067132A1 (es) 2009-09-30
CU23842B1 (es) 2012-10-15
CL2008001872A1 (es) 2009-02-20
ES2543641T3 (es) 2015-08-20
CU20090226A7 (es) 2012-02-15
MA31538B1 (fr) 2010-07-01
KR101238479B1 (ko) 2013-03-04
EP2181105A1 (en) 2010-05-05
TWI404714B (zh) 2013-08-11
US8383650B2 (en) 2013-02-26
AU2008267287A1 (en) 2008-12-31
US20080319018A1 (en) 2008-12-25
SG182223A1 (en) 2012-07-30
KR20100023003A (ko) 2010-03-03
AU2008267287B2 (en) 2012-02-16
TW200911782A (en) 2009-03-16
ES2541107T3 (es) 2015-07-16
CA2689109A1 (en) 2008-12-31
EA016446B1 (ru) 2012-05-30
HN2009003463A (es) 2012-12-10
JP5086433B2 (ja) 2012-11-28
PE20090425A1 (es) 2009-05-12
BRPI0813900A2 (pt) 2014-12-30
CN101687847B (zh) 2013-11-06
US20130005770A1 (en) 2013-01-03
CR11153A (es) 2010-01-21
CO6251267A2 (es) 2011-02-21
US8497286B2 (en) 2013-07-30
GT200900324A (es) 2011-11-03
WO2009000811A1 (en) 2008-12-31
EP2181105B1 (en) 2015-04-29
EP2527338B1 (en) 2015-05-06
JP2010531328A (ja) 2010-09-24
TN2009000530A1 (en) 2011-03-31
EP2527338A1 (en) 2012-11-28
NZ582098A (en) 2012-03-30
CN101687847A (zh) 2010-03-31
IL202494A0 (en) 2010-06-30

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