AR067132A1 - Derivados de piperidina 3,5-sustituidos como inhibidores de renina - Google Patents
Derivados de piperidina 3,5-sustituidos como inhibidores de reninaInfo
- Publication number
- AR067132A1 AR067132A1 ARP080102691A ARP080102691A AR067132A1 AR 067132 A1 AR067132 A1 AR 067132A1 AR P080102691 A ARP080102691 A AR P080102691A AR P080102691 A ARP080102691 A AR P080102691A AR 067132 A1 AR067132 A1 AR 067132A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- alkyl
- compound
- treatment
- class
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Para utilizarse en el diagnostico y el tratamiento terapéutico de un animal de sangre caliente, en especial para el tratamiento de una enfermedad (= trastorno) que dependa de la actividad de la renina; al uso de un compuesto de esta clase para la preparacion de una formulacion farmacéutica para el tratamiento de una enfermedad que dependa de la actividad de la renina; al uso de un compuesto de esta clase en el tratamiento de una enfermedad que dependa de la actividad de la renina; a formulaciones farmacéuticas de un compuesto de esta clase; a un método de tratamiento, el cual comprende administrar un compuesto de esta clase, y a un método para su fabricacion. Reivindicacion 1: Un compuesto de la formula (1) en donde R1 es alquilo C1-7, el cual está opcionalmente sustituido por 1, 2 o 3 sustituyentes seleccionados a partir del grupo que consiste en hidroxilo, halogeno y alcoxilo C1-7, R2 es H, alquilo C1-7, alcoxilo C1-7, halo-alquilo C1-7, halo-alcoxilo C1-7, o alcoxilo C1-7-alcoxilo C1-7; R3 es alquilo C1-7 o cicloalquilo C3-8; R4 es H o hidroxilo; y R5 es alquilo C1-7 o cicloalquilo C3-8; o una sal del mismo, con la condicion de que se excluyan los compuestos de la formula (1), en donde R1 es metilo o isopropilo, R2 es 3-metoxi-propoxilo, R3 es ciclopropilo, R4 es H y R5 es 2-metil-propilo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07012412 | 2007-06-25 | ||
| EP07111290 | 2007-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR067132A1 true AR067132A1 (es) | 2009-09-30 |
Family
ID=39926743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080102691A AR067132A1 (es) | 2007-06-25 | 2008-06-23 | Derivados de piperidina 3,5-sustituidos como inhibidores de renina |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8383650B2 (es) |
| EP (2) | EP2527338B1 (es) |
| JP (1) | JP5086433B2 (es) |
| KR (1) | KR101238479B1 (es) |
| CN (1) | CN101687847B (es) |
| AR (1) | AR067132A1 (es) |
| AU (1) | AU2008267287B2 (es) |
| BR (1) | BRPI0813900A2 (es) |
| CA (1) | CA2689109A1 (es) |
| CL (1) | CL2008001872A1 (es) |
| CO (1) | CO6251267A2 (es) |
| CR (1) | CR11153A (es) |
| CU (1) | CU23842B1 (es) |
| EA (1) | EA016446B1 (es) |
| EC (1) | ECSP099825A (es) |
| ES (2) | ES2541107T3 (es) |
| GT (1) | GT200900324A (es) |
| HN (1) | HN2009003463A (es) |
| IL (1) | IL202494A0 (es) |
| MA (1) | MA31538B1 (es) |
| NZ (1) | NZ582098A (es) |
| PE (1) | PE20090425A1 (es) |
| SG (1) | SG182223A1 (es) |
| TN (1) | TN2009000530A1 (es) |
| TW (1) | TWI404714B (es) |
| WO (1) | WO2009000811A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ582098A (en) | 2007-06-25 | 2012-03-30 | Novartis Ag | N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
| US20180048921A1 (en) * | 2016-08-12 | 2018-02-15 | Microsoft Technology Licensing, Llc | Real-time playback diagnostics |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2090956T3 (es) | 1991-12-18 | 1996-10-16 | Schering Corp | Imidazolil o imidazolilalquil sustituido con un anillo heterociclico de cuatro o cinco miembros que contiene nitrogeno. |
| IL111176A0 (en) | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them |
| TR199800409T1 (xx) | 1995-09-07 | 1998-05-21 | F.Hoffmann-La Roche Ag | Kalp ve b�brek yetersizli�inin tedavii�in yeni 4-(oksialkoksifenil)-3-oksi-piperidinler |
| EP0862435A4 (en) | 1995-11-22 | 1999-02-03 | Merck & Co Inc | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE |
| JP2001526178A (ja) | 1997-08-28 | 2001-12-18 | メルク エンド カムパニー インコーポレーテッド | ピロリジン系およびピペリジン系ケモカイン受容体活性調節剤 |
| JP2002518368A (ja) | 1998-06-17 | 2002-06-25 | デュポン ファーマシューティカルズ カンパニー | メタロプロテイナーゼ阻害剤としての環式ヒドロキサム酸類 |
| US6274735B1 (en) | 1998-08-10 | 2001-08-14 | Hoffmann-La Roche Inc. | Process and intermediates for preparation of substituted piperidines |
| CA2348734A1 (en) | 1998-10-30 | 2000-05-11 | Merck & Co., Inc. | Thrombin inhibitors |
| WO2000051607A1 (en) | 1999-03-02 | 2000-09-08 | Merck & Co., Inc. | 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity |
| US6372764B1 (en) | 1999-03-02 | 2002-04-16 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| AU3386700A (en) | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity |
| AU3818900A (en) | 1999-04-14 | 2000-11-02 | F. Hoffmann-La Roche Ag | Process for the preparation of substituted piperidines |
| US6197959B1 (en) | 1999-04-27 | 2001-03-06 | Hoffmann-La Roche Inc. | Piperidine derivatives |
| US6376672B1 (en) | 1999-04-27 | 2002-04-23 | Hoffmann-La Roche Inc. | Naphthalenylmethoxypiperidines as renin inhibitors |
| NZ521248A (en) | 2000-03-17 | 2004-04-30 | Bristol Myers Squibb Pharma Co | Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha |
| FR2811673B1 (fr) | 2000-07-17 | 2002-09-13 | Rhodia Chimie Sa | Utilisation de composes insatures comprenant un heterocycle comme stabilisants de polymeres halogenes |
| US7125887B2 (en) | 2000-10-11 | 2006-10-24 | Merck & Co., Inc. | Pyrrolidine modulators of CCR5 chemokine receptor activity |
| US20060079533A1 (en) | 2001-03-23 | 2006-04-13 | Nieman James A | Methods of treating alzheimer's disease |
| EP1389194A2 (en) | 2001-04-27 | 2004-02-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
| AU2002341715A1 (en) | 2001-09-17 | 2003-04-01 | Bristol-Myers Squibb Company | Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace) |
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| PL372141A1 (en) | 2002-04-29 | 2005-07-11 | Actelion Pharmaceuticals Ltd. | 7-aryl-3,9-diazabicyclo[3.3.1]non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases |
| PL213029B1 (pl) | 2002-05-20 | 2012-12-31 | Bristol Myers Squibb Co | Podstawiona pochodna cykloalkilowa, zawierajaca ja kompozycja oraz ich zastosowanie |
| PL374860A1 (en) | 2002-07-09 | 2005-11-14 | Bristol-Myers Squibb Company | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
| US20040204455A1 (en) | 2003-04-10 | 2004-10-14 | Cody Wayne Livingston | Piperidine derivative rennin inhibitors |
| US20040214832A1 (en) | 2003-04-10 | 2004-10-28 | Cuiman Cai | Piperazine derivative renin inhibitors |
| US20060217371A1 (en) | 2003-04-28 | 2006-09-28 | Olivier Bezencon | Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors |
| DE602004010385D1 (de) | 2003-04-29 | 2008-01-10 | Actelion Pharmaceuticals Ltd | 3,4-disubstituierte 1,2,3,4-tetrahydropyridinderivate |
| MXPA05011497A (es) | 2003-04-30 | 2005-12-15 | Actelion Pharmaceuticals Ltd | Derivados de tropano y su uso como inhibidores de la enzima de conversion de angiotensina (ace). |
| KR20060008937A (ko) | 2003-04-30 | 2006-01-27 | 액테리온 파마슈티칼 리미티드 | 레닌 억제제로서 3-위치에 헤테로원자를 갖는9-아자비사이클로[3.3.1]논-6-엔 유도체 |
| MXPA05011496A (es) | 2003-04-30 | 2005-12-15 | Actelion Pharmaceuticals Ltd | Derivados de azabiciclononeno. |
| CN1780838A (zh) | 2003-05-02 | 2006-05-31 | 埃科特莱茵药品有限公司 | 新型二氮杂双环壬烯衍生物 |
| US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| TW200900399A (en) | 2003-10-01 | 2009-01-01 | Speedel Experimenta Ag | Organic compounds |
| CA2540543A1 (en) | 2003-10-09 | 2005-05-06 | Actelion Pharmaceuticals Ltd | Tetrahydropyridine derivatives |
| CA2546264A1 (en) | 2003-11-26 | 2005-06-09 | Novartis Ag | 4-phenylpiperidine derivatives as renin inhibitors |
| CN1882528A (zh) | 2003-11-26 | 2006-12-20 | 诺瓦提斯公司 | 有机化合物 |
| CA2553840A1 (en) | 2004-01-23 | 2005-08-04 | Speedel Experimenta Ag | Amino alcohol derivatives and their activity as renin inhibitors |
| AR047447A1 (es) | 2004-01-23 | 2006-01-18 | Speedel Experimenta Ag | Compuestos derivados de amino alcohol con actividad inhibidora de la renina y su uso en composiciones farmaceuticas. |
| EP1711456A2 (en) | 2004-01-23 | 2006-10-18 | Speedel Experimenta AG | Amino alcohol derivatives and their use as renin inhibitors |
| ATE421501T1 (de) | 2004-03-19 | 2009-02-15 | Speedel Experimenta Ag | 2,7-substituierte 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octanamid derivate als renin inhibitoren zur behandlung von bluthochdruck |
| CN1934082A (zh) | 2004-03-19 | 2007-03-21 | 斯皮德尔实验股份公司 | 有机化合物 |
| AR053406A1 (es) | 2004-07-09 | 2007-05-09 | Speedel Experimenta Ag | Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas |
| TW200631929A (en) | 2004-12-10 | 2006-09-16 | Speedel Experimenta Ag | ω -phenyloctanamides |
| GB0428250D0 (en) | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
| GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
| GB0500784D0 (en) | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| GB0504850D0 (en) | 2005-03-09 | 2005-04-13 | Novartis Ag | Organic compounds |
| AR053826A1 (es) | 2005-03-11 | 2007-05-23 | Speedel Experimenta Ag | Compuestos organicos |
| GB0505969D0 (en) | 2005-03-23 | 2005-04-27 | Novartis Ag | Organic compounds |
| TW200722424A (en) | 2005-03-31 | 2007-06-16 | Speedel Experimenta Ag | Substituted piperidines |
| US20090270380A1 (en) | 2005-03-31 | 2009-10-29 | Peter Herold | 3,4,5-Substituted Piperidines as Renin Inhibitors |
| GB0508992D0 (en) * | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
| GB0510810D0 (en) | 2005-05-26 | 2005-06-29 | Novartis Ag | Organic compounds |
| GB0511063D0 (en) | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
| GB0514203D0 (en) * | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
| PT1948654E (pt) | 2005-09-17 | 2009-09-28 | Novartis Ag | Derivados da 5-amino-4-hidroxi-7-(imidazo[1,2-a] piridin-6-ilmetil)-8-metil-nonamida e compostos relacionados como inibidores da renina para o tratamento da hipertensão |
| BRPI0616219A2 (pt) | 2005-09-17 | 2011-06-14 | Speedel Experimenta Ag | amidas de Ácidos alcanàicos substituÍdas por o-heterociclos saturados |
| PE20071079A1 (es) * | 2005-11-15 | 2007-12-16 | Cytokinetics Inc | Compuestos de piperidina como inhibidores de la proliferacion celular |
| ES2476422T3 (es) * | 2005-12-30 | 2014-07-14 | Novartis Ag | Compuestos de piperidina 3,5-sustituida como inhibidores de renina |
| EP1816122A3 (en) * | 2006-01-19 | 2007-09-19 | Speedel Experimenta AG | 3,4,5-substituted piperidines as therapeutic compounds |
| EP1979323A1 (en) | 2006-01-30 | 2008-10-15 | Speedel Experimenta AG | Process for the stereoselective preparation of alcohols from alpha, beta-insaturated compounds |
| WO2007141318A1 (en) | 2006-06-08 | 2007-12-13 | Speedel Experimenta Ag | 2,5-disubstituted piperidines |
| GB0611697D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
| GB0611696D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
| TW200831463A (en) | 2006-09-12 | 2008-08-01 | Speedel Experimenta Ag | Nitrate esters of aminoalcohols |
| EP1908471A1 (en) | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Tetrahydropyridines as renin inhibitors |
| EP1921069A1 (de) | 2006-11-08 | 2008-05-14 | Speedel Experimenta AG | Verfahren zur Herstellung von 2-Alkyl-3-heterocyclyl-prop-2-en-1-olen |
| AR065792A1 (es) | 2007-03-21 | 2009-07-01 | Speedel Experimenta Ag | Proceso para preparar (r o s) -5- (1 -azido-3-(6-metoxi-5-(3-metoxi-propoxi) -piridin-3-ilmetil) -4-metil- pentil) -3-alquil-dihidro-furan-2-ona |
| NZ582098A (en) | 2007-06-25 | 2012-03-30 | Novartis Ag | N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
-
2008
- 2008-06-23 NZ NZ582098A patent/NZ582098A/en not_active IP Right Cessation
- 2008-06-23 EA EA201000037A patent/EA016446B1/ru not_active IP Right Cessation
- 2008-06-23 AR ARP080102691A patent/AR067132A1/es not_active Application Discontinuation
- 2008-06-23 CN CN2008800218979A patent/CN101687847B/zh not_active Expired - Fee Related
- 2008-06-23 ES ES08761309.7T patent/ES2541107T3/es active Active
- 2008-06-23 KR KR1020097027047A patent/KR101238479B1/ko not_active IP Right Cessation
- 2008-06-23 EP EP20120176689 patent/EP2527338B1/en active Active
- 2008-06-23 EP EP08761309.7A patent/EP2181105B1/en active Active
- 2008-06-23 SG SG2012046132A patent/SG182223A1/en unknown
- 2008-06-23 BR BRPI0813900-8A2A patent/BRPI0813900A2/pt not_active IP Right Cessation
- 2008-06-23 JP JP2010513876A patent/JP5086433B2/ja not_active Expired - Fee Related
- 2008-06-23 WO PCT/EP2008/057964 patent/WO2009000811A1/en active Application Filing
- 2008-06-23 CA CA002689109A patent/CA2689109A1/en not_active Abandoned
- 2008-06-23 AU AU2008267287A patent/AU2008267287B2/en not_active Ceased
- 2008-06-23 ES ES12176689.3T patent/ES2543641T3/es active Active
- 2008-06-24 CL CL2008001872A patent/CL2008001872A1/es unknown
- 2008-06-24 PE PE2008001078A patent/PE20090425A1/es not_active Application Discontinuation
- 2008-06-24 TW TW097123556A patent/TWI404714B/zh not_active IP Right Cessation
- 2008-06-25 US US12/146,073 patent/US8383650B2/en not_active Expired - Fee Related
-
2009
- 2009-12-03 IL IL202494A patent/IL202494A0/en unknown
- 2009-12-09 CR CR11153A patent/CR11153A/es unknown
- 2009-12-17 TN TNP2009000530A patent/TN2009000530A1/fr unknown
- 2009-12-18 GT GT200900324A patent/GT200900324A/es unknown
- 2009-12-22 CO CO09146659A patent/CO6251267A2/es active IP Right Grant
- 2009-12-22 HN HN2009003463A patent/HN2009003463A/es unknown
- 2009-12-22 CU CU2009000226A patent/CU23842B1/es not_active IP Right Cessation
- 2009-12-23 EC EC2009009825A patent/ECSP099825A/es unknown
-
2010
- 2010-01-22 MA MA32543A patent/MA31538B1/fr unknown
-
2012
- 2012-09-14 US US13/616,081 patent/US8497286B2/en not_active Expired - Fee Related
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