BR112015019754A2 - derivados de 2-((4-amino-3-(3-fluoro-5-hidroxifenil)-1h-pirazolo[3,4-d]pirimidin-1-il)metil)-3-(2-(trifluoro-metil)bezil)quinazolin-4(3h)-ona e seu uso como inibidores de fosfoinositídeo 3-quinase - Google Patents
derivados de 2-((4-amino-3-(3-fluoro-5-hidroxifenil)-1h-pirazolo[3,4-d]pirimidin-1-il)metil)-3-(2-(trifluoro-metil)bezil)quinazolin-4(3h)-ona e seu uso como inibidores de fosfoinositídeo 3-quinaseInfo
- Publication number
- BR112015019754A2 BR112015019754A2 BR112015019754A BR112015019754A BR112015019754A2 BR 112015019754 A2 BR112015019754 A2 BR 112015019754A2 BR 112015019754 A BR112015019754 A BR 112015019754A BR 112015019754 A BR112015019754 A BR 112015019754A BR 112015019754 A2 BR112015019754 A2 BR 112015019754A2
- Authority
- BR
- Brazil
- Prior art keywords
- methyl
- phosphoinositide
- quinazolin
- pyrazolo
- pyrimidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
resumo patente de invenção: "derivados de 2-((4-amino-3-(3-fluoro-5-hidroxifenil)-1h-pirazolo[3,4-d]pirimidin-1-il)metil)-3-(2-(trifluoro-metil)bezil)quinazolin-4(3h)-ona e seu uso como inibidores de fosfoinositídeo 3-quinase". a presente invenção refere-se inter alia a um composto de fórmula (i) e a composições que as contêm e ao uso dos compostos e das composições dos compostos no tratamento, por exemplo, de doenças inflamatórias, em particular doença respiratória inflamatória. a invenção também se refere a métodos de preparação dos referidos compostos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13275070 | 2013-03-15 | ||
EP13193372 | 2013-11-18 | ||
PCT/GB2014/050770 WO2014140597A1 (en) | 2013-03-15 | 2014-03-14 | 2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1 -yl)methyl)-3-(2-(trifluoromet hyl)benzyl)quinazolin-4(3h)-one derivatives and their use as phosphoinositide 3-kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015019754A2 true BR112015019754A2 (pt) | 2017-07-18 |
BR112015019754A8 BR112015019754A8 (pt) | 2019-11-12 |
Family
ID=50349644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015019754A BR112015019754A8 (pt) | 2013-03-15 | 2014-03-14 | derivados de 2-((4-amino-3-(3-fluoro-5-hidroxifenil)-1h-pirazolo[3,4-d]pirimidin-1-il)metil)-3-(2-(trifluoro-metil)bezil)quinazolin-4(3h)-ona e seu uso como inibidores de fosfoinositídeo 3-quinase |
Country Status (24)
Country | Link |
---|---|
US (2) | US9745306B2 (pt) |
EP (1) | EP2970293B1 (pt) |
JP (1) | JP6353856B2 (pt) |
KR (1) | KR20150127607A (pt) |
CN (1) | CN105229007B (pt) |
AU (1) | AU2014229768B2 (pt) |
BR (1) | BR112015019754A8 (pt) |
CA (1) | CA2899812A1 (pt) |
CL (1) | CL2015002606A1 (pt) |
EA (1) | EA029218B1 (pt) |
ES (1) | ES2640624T3 (pt) |
GT (1) | GT201500218A (pt) |
HK (1) | HK1214591A1 (pt) |
IL (1) | IL240061A0 (pt) |
JO (1) | JO3279B1 (pt) |
MX (1) | MX2015012091A (pt) |
NI (1) | NI201500134A (pt) |
PE (1) | PE20151653A1 (pt) |
PH (1) | PH12015501836A1 (pt) |
SG (1) | SG11201505928YA (pt) |
TW (1) | TW201522341A (pt) |
UA (1) | UA116002C2 (pt) |
UY (1) | UY35446A (pt) |
WO (1) | WO2014140597A1 (pt) |
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WO2009077766A1 (en) | 2007-12-19 | 2009-06-25 | Cancer Research Technology Limited | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
PL2531502T3 (pl) | 2010-02-01 | 2014-08-29 | Cancer Research Tech Ltd | 1-(5-tert-Butylo-2-fenylo-2H-pirazol-3-ilo)-3-[2-fluoro-4-(1-metylo-2-okso-2,3-dihydro-1H-imidazo[4,5-b]pirydyn-7-yloksy)-fenylo]-mocznik i związki pokrewne oraz ich zastosowanie w terapii |
WO2014110574A1 (en) | 2013-01-14 | 2014-07-17 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
WO2014113388A1 (en) | 2013-01-15 | 2014-07-24 | Incyte Corporation | Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors |
PE20160532A1 (es) | 2013-08-23 | 2016-05-21 | Incyte Corp | Compuesto de carboxamida de furo y tienopiridina utiles como inhibidores de cinasas pim |
GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
CR20160600A (es) | 2014-07-04 | 2017-03-07 | Lupin Ltd | Quinolizione derivados como inhibidores pi3k |
US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
WO2016010897A1 (en) | 2014-07-14 | 2016-01-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors |
US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
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US6383790B1 (en) | 1999-01-11 | 2002-05-07 | Princeton University | High affinity protein kinase inhibitors |
US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
IL152275A0 (en) | 2000-04-25 | 2003-05-29 | Icos Corp | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
KR100774855B1 (ko) | 2000-04-27 | 2007-11-08 | 아스텔라스세이야쿠 가부시키가이샤 | 축합 헤테로아릴 유도체 |
US6608053B2 (en) | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
EP1217000A1 (en) | 2000-12-23 | 2002-06-26 | Aventis Pharma Deutschland GmbH | Inhibitors of factor Xa and factor VIIa |
JP2005509594A (ja) | 2001-07-13 | 2005-04-14 | バーチャル ドラッグ ディヴェロップメント、インコーポレイティッド | Nadシンテターゼ阻害剤およびその使用 |
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DK2004654T3 (da) | 2006-04-04 | 2013-07-22 | Univ California | Pyrazolopyrimidin derivater til anvendelse som kinase antagonister |
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GB0918249D0 (en) * | 2009-10-19 | 2009-12-02 | Respivert Ltd | Compounds |
UY33337A (es) * | 2010-10-18 | 2011-10-31 | Respivert Ltd | DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS |
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-
2014
- 2014-03-13 JO JOP/2014/0103A patent/JO3279B1/ar active
- 2014-03-13 TW TW103108912A patent/TW201522341A/zh unknown
- 2014-03-14 BR BR112015019754A patent/BR112015019754A8/pt not_active IP Right Cessation
- 2014-03-14 UA UAA201507682A patent/UA116002C2/uk unknown
- 2014-03-14 PE PE2015001926A patent/PE20151653A1/es not_active Application Discontinuation
- 2014-03-14 ES ES14712334.3T patent/ES2640624T3/es active Active
- 2014-03-14 SG SG11201505928YA patent/SG11201505928YA/en unknown
- 2014-03-14 MX MX2015012091A patent/MX2015012091A/es unknown
- 2014-03-14 JP JP2015562319A patent/JP6353856B2/ja not_active Expired - Fee Related
- 2014-03-14 UY UY0001035446A patent/UY35446A/es unknown
- 2014-03-14 CA CA2899812A patent/CA2899812A1/en not_active Abandoned
- 2014-03-14 AU AU2014229768A patent/AU2014229768B2/en not_active Ceased
- 2014-03-14 WO PCT/GB2014/050770 patent/WO2014140597A1/en active Application Filing
- 2014-03-14 EP EP14712334.3A patent/EP2970293B1/en active Active
- 2014-03-14 KR KR1020157023823A patent/KR20150127607A/ko not_active Application Discontinuation
- 2014-03-14 CN CN201480015955.2A patent/CN105229007B/zh not_active Expired - Fee Related
- 2014-03-14 US US14/777,021 patent/US9745306B2/en not_active Expired - Fee Related
- 2014-03-14 EA EA201591804A patent/EA029218B1/ru not_active IP Right Cessation
-
2015
- 2015-07-21 IL IL240061A patent/IL240061A0/en unknown
- 2015-08-04 GT GT201500218A patent/GT201500218A/es unknown
- 2015-08-20 PH PH12015501836A patent/PH12015501836A1/en unknown
- 2015-09-11 CL CL2015002606A patent/CL2015002606A1/es unknown
- 2015-09-11 NI NI201500134A patent/NI201500134A/es unknown
-
2016
- 2016-03-03 HK HK16102451.0A patent/HK1214591A1/zh not_active IP Right Cessation
-
2017
- 2017-07-27 US US15/661,279 patent/US20170334919A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
SG11201505928YA (en) | 2015-09-29 |
UY35446A (es) | 2014-09-30 |
US9745306B2 (en) | 2017-08-29 |
CN105229007A (zh) | 2016-01-06 |
EP2970293A1 (en) | 2016-01-20 |
TW201522341A (zh) | 2015-06-16 |
HK1214591A1 (zh) | 2016-07-29 |
EP2970293B1 (en) | 2017-06-14 |
US20160039826A1 (en) | 2016-02-11 |
GT201500218A (es) | 2017-09-21 |
BR112015019754A8 (pt) | 2019-11-12 |
MX2015012091A (es) | 2016-04-15 |
WO2014140597A1 (en) | 2014-09-18 |
CN105229007B (zh) | 2017-08-25 |
JP6353856B2 (ja) | 2018-07-04 |
JO3279B1 (ar) | 2018-09-16 |
AU2014229768B2 (en) | 2018-01-04 |
CA2899812A1 (en) | 2014-09-18 |
KR20150127607A (ko) | 2015-11-17 |
PE20151653A1 (es) | 2015-11-12 |
NI201500134A (es) | 2016-01-06 |
PH12015501836A1 (en) | 2015-11-09 |
EA029218B1 (ru) | 2018-02-28 |
CL2015002606A1 (es) | 2016-03-04 |
AU2014229768A1 (en) | 2015-08-06 |
UA116002C2 (uk) | 2018-01-25 |
ES2640624T3 (es) | 2017-11-03 |
IL240061A0 (en) | 2015-09-24 |
JP2016510802A (ja) | 2016-04-11 |
US20170334919A1 (en) | 2017-11-23 |
EA201591804A1 (ru) | 2016-01-29 |
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