CU20170004A7 - 8-cloro-n-quinoleínas y 8-cloro-o-quinoleínas y sus derivados como reguladores de citocinas proinflamatorias - Google Patents

8-cloro-n-quinoleínas y 8-cloro-o-quinoleínas y sus derivados como reguladores de citocinas proinflamatorias

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Publication number
CU20170004A7
CU20170004A7 CUP2017000004A CU20170004A CU20170004A7 CU 20170004 A7 CU20170004 A7 CU 20170004A7 CU P2017000004 A CUP2017000004 A CU P2017000004A CU 20170004 A CU20170004 A CU 20170004A CU 20170004 A7 CU20170004 A7 CU 20170004A7
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CU
Cuba
Prior art keywords
group
formula
quinoleins
chlorine
regulators
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CUP2017000004A
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English (en)
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CU24459B1 (es
Inventor
Karim Chebli
Michael Hahne
Florence Mahuteau
Romain Najman
Didier Scherrer
Jamal Tazi
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Abivax
Centre Nat Rech Scient
Inst Curie
Univ Montpellier
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Application filed by Abivax, Centre Nat Rech Scient, Inst Curie, Univ Montpellier filed Critical Abivax
Publication of CU20170004A7 publication Critical patent/CU20170004A7/es
Publication of CU24459B1 publication Critical patent/CU24459B1/es

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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente invención se refiere a un compuesto de Ia fórmula (I) ESPACIO PARA FÓRMULA en donde:Ia formula (II) ESPACIO PARA FÓRMULA significa un anillo aromático en donde V es C o N y cuando V es N; Q es N u O, con Ia condición de que R" no existe cuando Q es O; R' representa independientemente un átomo de hidrógeno o un grupo elegido entre un grupo alquilo (C1-C3), un átomo de halógeno, un grupo hidroxilo, un grupo -COOR1, un grupo -NO2, un grupo -NR1R2, un grupo morfolinilo o un grupo morfolino, un grupo N-metilpiperazinilo, un grupo fluoroalquilo (C1-C3), un grupo -O-P(=O)-(OR3XOR4), un grupo alcoxi (C1-C4), y un grupo -CN, y ademas puede ser un grupo seleccionado entre: (IIa), (IIIa): ESPACIO PARA FÓRMULA La presente invencion se refiere también a derivados del compuesto de fórmula (I) o cualquiera de sus sales farmacéuticamente aceptables, como reguladores de citocinas proinflamatorias, para su uso en el tratamiento y/o prevención de enfermedades inflamatorias, donde la enfermedad inflamatoria del intestino, la artritis reumatoide y la esclerosis múltiple son de particular interés.
CU2017000004A 2014-07-17 2015-07-17 8-cloro-n-quinoleínas y sus derivados como activos antiinflamatorios CU24459B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14306164.6A EP2974729A1 (en) 2014-07-17 2014-07-17 Quinoline derivatives for use in the treatment of inflammatory diseases
PCT/EP2015/066458 WO2016009065A2 (en) 2014-07-17 2015-07-17 Quinoline derivatives for the treatment of inflammatory diseases

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CU20170004A7 true CU20170004A7 (es) 2017-06-05
CU24459B1 CU24459B1 (es) 2019-12-03

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CU2017000004A CU24459B1 (es) 2014-07-17 2015-07-17 8-cloro-n-quinoleínas y sus derivados como activos antiinflamatorios

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EP (3) EP2974729A1 (es)
JP (3) JP6884690B2 (es)
KR (2) KR102537958B1 (es)
CN (5) CN117568459A (es)
AU (4) AU2015289033A1 (es)
CA (2) CA2954951C (es)
CU (2) CU24565B1 (es)
DK (1) DK3169328T3 (es)
ES (1) ES2914066T3 (es)
HR (1) HRP20220598T1 (es)
HU (1) HUE058713T2 (es)
LT (1) LT3169328T (es)
MX (2) MX2017000533A (es)
PL (1) PL3169328T3 (es)
PT (1) PT3169328T (es)
RS (1) RS63231B1 (es)
RU (2) RU2760686C2 (es)
SI (1) SI3169328T1 (es)
WO (1) WO2016009065A2 (es)

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US10253020B2 (en) * 2009-06-12 2019-04-09 Abivax Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging
EP2757161A1 (en) 2013-01-17 2014-07-23 Splicos miRNA-124 as a biomarker of viral infection
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