CS272231B2 - Method of phosphinic acid's derivatives production - Google Patents

Method of phosphinic acid's derivatives production Download PDF

Info

Publication number
CS272231B2
CS272231B2 CS879002A CS900287A CS272231B2 CS 272231 B2 CS272231 B2 CS 272231B2 CS 879002 A CS879002 A CS 879002A CS 900287 A CS900287 A CS 900287A CS 272231 B2 CS272231 B2 CS 272231B2
Authority
CS
Czechoslovakia
Prior art keywords
methyl
group
formula
acid
carbamoyl
Prior art date
Application number
CS879002A
Other languages
Czech (cs)
English (en)
Other versions
CS900287A2 (en
Inventor
Michael J Broadhurst
Balraj K Handa
William H Johnson
Geoffrey Lawton
Peter J Machin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868629876A external-priority patent/GB8629876D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CS900287A2 publication Critical patent/CS900287A2/cs
Publication of CS272231B2 publication Critical patent/CS272231B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS879002A 1986-12-15 1987-12-09 Method of phosphinic acid's derivatives production CS272231B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868629876A GB8629876D0 (en) 1986-12-15 1986-12-15 Phosphinic acid derivatives
GB878722245A GB8722245D0 (en) 1986-12-15 1987-09-22 Phosphinic acid derivatives

Publications (2)

Publication Number Publication Date
CS900287A2 CS900287A2 (en) 1990-03-14
CS272231B2 true CS272231B2 (en) 1991-01-15

Family

ID=26291694

Family Applications (1)

Application Number Title Priority Date Filing Date
CS879002A CS272231B2 (en) 1986-12-15 1987-12-09 Method of phosphinic acid's derivatives production

Country Status (19)

Country Link
US (2) US4885283A (zh)
EP (1) EP0276436B1 (zh)
CN (1) CN1017337B (zh)
AU (1) AU606901B2 (zh)
CA (1) CA1326737C (zh)
CS (1) CS272231B2 (zh)
DE (1) DE3786250T2 (zh)
DK (1) DK641687A (zh)
ES (1) ES2056810T3 (zh)
FI (1) FI89059C (zh)
HU (1) HU203109B (zh)
IE (1) IE62334B1 (zh)
IL (1) IL84766A (zh)
MC (1) MC1881A1 (zh)
NO (1) NO171788C (zh)
NZ (1) NZ222824A (zh)
PH (1) PH25030A (zh)
PT (1) PT86366B (zh)
ZW (1) ZW23187A1 (zh)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68925240T2 (de) * 1988-06-23 1996-06-13 Banyu Pharma Co Ltd Phosphinsäure-Derivate
US5268384A (en) * 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
US5239078A (en) 1990-11-21 1993-08-24 Glycomed Incorporated Matrix metalloprotease inhibitors
US5183900A (en) * 1990-11-21 1993-02-02 Galardy Richard E Matrix metalloprotease inhibitors
US5189178A (en) * 1990-11-21 1993-02-23 Galardy Richard E Matrix metalloprotease inhibitors
US5114953A (en) * 1990-11-21 1992-05-19 University Of Florida Treatment for tissue ulceration
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
FR2676059B1 (fr) * 1991-05-02 1993-07-23 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes.
EP0520573A1 (en) * 1991-06-27 1992-12-30 Glaxo Inc. Cyclic imide derivatives
JPH07503016A (ja) * 1992-01-15 1995-03-30 メルク　エンド　カンパニー　インコーポレーテッド 変形防止剤としての置換されたホスフィン酸含有ペプチジル誘導体
US5326760A (en) * 1992-06-29 1994-07-05 Glaxo, Inc. Aminobutanoic acid compounds having metalloprotease inhibiting properties
US6037472A (en) 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
WO1995014033A1 (en) * 1993-11-19 1995-05-26 Aktiebolaget Astra Novel dipeptide derivatives
GB9405076D0 (en) * 1994-03-16 1994-04-27 Inst Of Ophtalmology A medical use of matrix metalloproteinase inhibitors
US5476847A (en) * 1994-06-29 1995-12-19 Schering Corporation Derivatives of phosphinic acid useful as endothelin converting enzyme inhibitors
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US6011021A (en) * 1996-06-17 2000-01-04 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
FR2730235A1 (fr) * 1995-02-06 1996-08-09 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
EP1095936B1 (en) * 1995-12-08 2004-11-24 Agouron Pharmaceuticals, Inc. Intermediates useful for the preparation of metallproteinase inhibitors
DK0780386T3 (da) * 1995-12-20 2003-02-03 Hoffmann La Roche Matrixmetalloproteaseinhibitorer
US5795877A (en) * 1996-12-31 1998-08-18 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US5977090A (en) * 1996-09-27 1999-11-02 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors
US5863536A (en) * 1996-12-31 1999-01-26 Guilford Pharmaceuticals Inc. Phosphoramidate derivatives
US5902817A (en) * 1997-04-09 1999-05-11 Guilford Pharmaceuticals Inc. Certain sulfoxide and sulfone derivatives
US6025345A (en) * 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US6025344A (en) * 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
US6071965A (en) * 1996-06-17 2000-06-06 Guilford Pharmaceuticals Inc. Phosphinic alkanoic acid derivatives
US6384022B1 (en) 1996-06-17 2002-05-07 Guilford Pharmaceuticals Inc. Prodrugs of NAALAdase inhibitors
US6046180A (en) * 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
RU2218179C2 (ru) 1996-06-17 2003-12-10 Гилфорд Фармасьютикалз Инк. СПОСОБЫ ЛЕЧЕНИЯ РАКА С ПРИМЕНЕНИЕМ ИНГИБИТОРОВ NAALADазы
US6054444A (en) 1997-04-24 2000-04-25 Guilford Pharmaceuticals Inc. Phosphonic acid derivatives
US5672592A (en) * 1996-06-17 1997-09-30 Guilford Pharmaceuticals Inc. Certain phosphonomethyl-pentanedioic acid derivatives thereof
TR199900066T2 (xx) * 1996-07-18 1999-04-21 Pfizer Inc. Matriks metalloproteazlar�n fosfinat bazl� inhibit�rleri
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US5962521A (en) * 1997-04-04 1999-10-05 Guilford Pharmaceuticals Inc. Hydroxamic acid derivatives
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5981209A (en) * 1997-12-04 1999-11-09 Guilford Pharmaceuticals Inc. Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia
US6028216A (en) * 1997-12-31 2000-02-22 Guilford Pharmaceuticals Inc. Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives
US6121252A (en) * 1998-03-30 2000-09-19 Guilford Pharmaceuticals Inc. Phosphinic acid derivatives
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
DE69927502T2 (de) 1998-07-06 2006-07-06 Mgi Gp, Inc. (N.D.Ges.D. Staates Delaware) Naaladase-hemmer anwendbar als pharmazeutische verbindungen und zusammensetzungen
US6395718B1 (en) 1998-07-06 2002-05-28 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
US6265609B1 (en) 1998-07-06 2001-07-24 Guilford Pharmaceuticals Inc. Thio-substituted pentanedioic acid derivatives
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
US6737038B1 (en) 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
AU1618000A (en) * 1998-11-12 2000-05-29 Du Pont Pharmaceuticals Company Use of radioligands to screen inhibitors of amyloid-beta peptide production
US6313159B1 (en) 1999-08-20 2001-11-06 Guilford Pharmaceuticals Inc. Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
GB9922577D0 (en) * 1999-09-23 1999-11-24 Center For Clinical & Basic Re Substituted phosphinate based peptide derivatives
US6696456B1 (en) * 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
MXPA02009310A (es) * 2000-03-21 2003-03-12 Procter & Gamble Inhibidores de las metaloproteasas que contienen cadenas laterales carbociclicas.
PL365444A1 (en) * 2000-03-21 2005-01-10 The Procter & Gamble Company Heterocyclic side chain containing, n-substituted metalloprotease inhibitors
AU2001245862A1 (en) * 2000-03-21 2001-10-03 The Procter & Gamble Company Difluorobutyric acid metalloprotease inhibitors
BR0106717A (pt) 2000-06-01 2002-04-16 Bristol Myers Squibb Pharma Co Compostos, composição farmacêutica e usos dos compostos de lactama inovadora
US8283135B2 (en) 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
WO2003104224A1 (en) 2002-06-10 2003-12-18 Pfizer Inc. Metabolites of prinomastat and their sythesis
ES2960619T3 (es) 2014-02-28 2024-03-05 Hangzhou Dac Biotech Co Ltd Enlazadores cargados y sus usos para la conjugación

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226610A (en) * 1978-04-15 1980-10-07 Meiji Selka Kaisha, Ltd. Herbicidal compounds, preparation thereof and herbicides containing the same
JPS60163899A (ja) * 1984-02-03 1985-08-26 Sankyo Co Ltd レニン阻害ペプチド類
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
EP0209848A3 (en) * 1985-07-24 1988-07-27 Merck & Co. Inc. Enzyme inhibitors
EP0210545A3 (en) * 1985-07-24 1988-07-20 Merck & Co. Inc. Phosphorous containing enzyme inhibitors

Also Published As

Publication number Publication date
DE3786250T2 (de) 1993-10-07
EP0276436B1 (en) 1993-06-16
HUT46699A (en) 1988-11-28
FI89059C (fi) 1993-08-10
IE873383L (en) 1988-06-15
NO875214L (no) 1988-06-16
HU203109B (en) 1991-05-28
ZW23187A1 (en) 1988-06-29
IL84766A0 (en) 1988-05-31
CA1326737C (en) 1994-02-01
PH25030A (en) 1991-01-28
IE62334B1 (en) 1995-01-25
CN1017337B (zh) 1992-07-08
IL84766A (en) 1994-02-27
NZ222824A (en) 1990-08-28
US5006651A (en) 1991-04-09
PT86366B (pt) 1990-11-20
AU8217687A (en) 1988-06-16
NO171788B (no) 1993-01-25
FI875484A (fi) 1988-06-16
CN87101164A (zh) 1988-06-29
FI89059B (fi) 1993-04-30
MC1881A1 (fr) 1989-01-24
DK641687A (da) 1988-06-16
AU606901B2 (en) 1991-02-21
EP0276436A1 (en) 1988-08-03
DK641687D0 (da) 1987-12-07
ES2056810T3 (es) 1994-10-16
PT86366A (en) 1988-01-01
US4885283A (en) 1989-12-05
CS900287A2 (en) 1990-03-14
DE3786250D1 (en) 1993-07-22
NO875214D0 (no) 1987-12-14
FI875484A0 (fi) 1987-12-14
NO171788C (no) 1993-05-05

Similar Documents

Publication Publication Date Title
CS272231B2 (en) Method of phosphinic acid's derivatives production
DE69130408T2 (de) Endothelinantagonistische Peptidderivate
DE69533991T2 (de) Dipeptide, die die ausschüttung von wachstumshormonen stimulieren
BG60794B2 (bg) Производни на аминокиселина
HU199842B (en) Process for producing pyridazodiazepines and pharmaceutical compositions comprising same
US5162336A (en) Tetrahydro-pyrido-indoles as cholecystokinin and gastrin antagonists
CA2283704A1 (en) Thrombin inhibitors
HU185986B (en) Process for preparing substituted n-/carboxy-alkyl/-amino-acyl-proline dipeptide derivatives
EP0445467A1 (en) Renin inhibitors and antiviral agents
EP0428849A2 (de) Inhibitoren retroviraler Proteasen
AU2014392A (en) Anti-thrombotic peptides and pseudopeptides
US6143886A (en) Azepinone compounds useful in the inhibition of ACE and NEP
HU204285B (en) Process for producing renin-inhibiting polypeptides of small molecule mass and pharmaceutical compositions containing them
DE69610145T2 (de) Benzo-kondensierte Azepinon-und Piperidinonverbindungen, nützlich als ACE-und NEP-Inhibitoren
IE64509B1 (en) Novel derivatives of l-proline their preparation and their biological uses
FR2733995A1 (fr) Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments
CA1329680C (en) N-heterocyclic alcohol derivatives
US5932606A (en) Pyrazinone, pyridinone, piperidine and pyrrolidine thrombin inhibitors
KR890004365B1 (ko) 디플루오로사이클로스타틴 함유 폴리펩티드 유도체의 제조방법
HU198077B (en) Process for producing substituted aminoalkanoyl aminoalkylphosphonates
DE4030350A1 (de) Inhibitoren retroviraler proteasen
KR960003549B1 (ko) 글루타민산 유도체
JPS63156796A (ja) ホスフイン酸誘導体
CS250699B2 (en) Method of octahydro-6-azaindole's depetidic derivatives production
HU198720B (en) Process for producing pyridazodiazepines and pharmaceutical compositions containing them