FI875484A0 - Fosfinsyraderivat. - Google Patents

Fosfinsyraderivat.

Info

Publication number
FI875484A0
FI875484A0 FI875484A FI875484A FI875484A0 FI 875484 A0 FI875484 A0 FI 875484A0 FI 875484 A FI875484 A FI 875484A FI 875484 A FI875484 A FI 875484A FI 875484 A0 FI875484 A0 FI 875484A0
Authority
FI
Finland
Prior art keywords
fosfinsyraderivat
Prior art date
Application number
FI875484A
Other languages
English (en)
Other versions
FI875484A (fi
FI89059B (fi
FI89059C (fi
Inventor
Michael John Broadhurst
Balraj Krishan Handa
William Henry Johnson
Geoffrey Lawton
Peter James Machin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868629876A external-priority patent/GB8629876D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI875484A0 publication Critical patent/FI875484A0/fi
Publication of FI875484A publication Critical patent/FI875484A/fi
Publication of FI89059B publication Critical patent/FI89059B/fi
Application granted granted Critical
Publication of FI89059C publication Critical patent/FI89059C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI875484A 1986-12-15 1987-12-14 Foerfarande foer framstaellning av terapeutiskt anvaendbara dipeptidiska fosfinsyraderivat FI89059C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8629876 1986-12-15
GB868629876A GB8629876D0 (en) 1986-12-15 1986-12-15 Phosphinic acid derivatives
GB878722245A GB8722245D0 (en) 1986-12-15 1987-09-22 Phosphinic acid derivatives
GB8722245 1987-09-22

Publications (4)

Publication Number Publication Date
FI875484A0 true FI875484A0 (fi) 1987-12-14
FI875484A FI875484A (fi) 1988-06-16
FI89059B FI89059B (fi) 1993-04-30
FI89059C FI89059C (fi) 1993-08-10

Family

ID=26291694

Family Applications (1)

Application Number Title Priority Date Filing Date
FI875484A FI89059C (fi) 1986-12-15 1987-12-14 Foerfarande foer framstaellning av terapeutiskt anvaendbara dipeptidiska fosfinsyraderivat

Country Status (19)

Country Link
US (2) US4885283A (fi)
EP (1) EP0276436B1 (fi)
CN (1) CN1017337B (fi)
AU (1) AU606901B2 (fi)
CA (1) CA1326737C (fi)
CS (1) CS272231B2 (fi)
DE (1) DE3786250T2 (fi)
DK (1) DK641687A (fi)
ES (1) ES2056810T3 (fi)
FI (1) FI89059C (fi)
HU (1) HU203109B (fi)
IE (1) IE62334B1 (fi)
IL (1) IL84766A (fi)
MC (1) MC1881A1 (fi)
NO (1) NO171788C (fi)
NZ (1) NZ222824A (fi)
PH (1) PH25030A (fi)
PT (1) PT86366B (fi)
ZW (1) ZW23187A1 (fi)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68925240T2 (de) * 1988-06-23 1996-06-13 Banyu Pharma Co Ltd Phosphinsäure-Derivate
US5268384A (en) * 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
US5239078A (en) * 1990-11-21 1993-08-24 Glycomed Incorporated Matrix metalloprotease inhibitors
US5183900A (en) * 1990-11-21 1993-02-02 Galardy Richard E Matrix metalloprotease inhibitors
US5189178A (en) * 1990-11-21 1993-02-23 Galardy Richard E Matrix metalloprotease inhibitors
US5114953A (en) * 1990-11-21 1992-05-19 University Of Florida Treatment for tissue ulceration
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
FR2676059B1 (fr) * 1991-05-02 1993-07-23 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes.
EP0520573A1 (en) * 1991-06-27 1992-12-30 Glaxo Inc. Cyclic imide derivatives
JPH07503016A (ja) * 1992-01-15 1995-03-30 メルク　エンド　カンパニー　インコーポレーテッド 変形防止剤としての置換されたホスフィン酸含有ペプチジル誘導体
US5326760A (en) * 1992-06-29 1994-07-05 Glaxo, Inc. Aminobutanoic acid compounds having metalloprotease inhibiting properties
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
WO1995014033A1 (en) * 1993-11-19 1995-05-26 Aktiebolaget Astra Novel dipeptide derivatives
GB9405076D0 (en) 1994-03-16 1994-04-27 Inst Of Ophtalmology A medical use of matrix metalloproteinase inhibitors
US5476847A (en) * 1994-06-29 1995-12-19 Schering Corporation Derivatives of phosphinic acid useful as endothelin converting enzyme inhibitors
US5831004A (en) 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US6011021A (en) * 1996-06-17 2000-01-04 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
FR2730235A1 (fr) * 1995-02-06 1996-08-09 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15
ES2195034T3 (es) * 1995-12-08 2003-12-01 Agouron Pharma Inhibidor de metaloproteinasas, composicion farmaceutica que contiene este inhibidor y su utilizacion farmaceutica, y procedimientos que sirven para su preparacion.
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
ATE225343T1 (de) * 1995-12-20 2002-10-15 Hoffmann La Roche Matrix-metalloprotease inhibitoren
US5795877A (en) * 1996-12-31 1998-08-18 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US5863536A (en) * 1996-12-31 1999-01-26 Guilford Pharmaceuticals Inc. Phosphoramidate derivatives
US6384022B1 (en) 1996-06-17 2002-05-07 Guilford Pharmaceuticals Inc. Prodrugs of NAALAdase inhibitors
US6025345A (en) * 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US5902817A (en) * 1997-04-09 1999-05-11 Guilford Pharmaceuticals Inc. Certain sulfoxide and sulfone derivatives
HUP9903421A3 (en) 1996-06-17 2001-08-28 Guilford Pharmaceuticals Inc B Use of phosphonic and phosphinic acid derivatives for producing pharmaceutical compositions having naaladase inhibitor activity
US5672592A (en) * 1996-06-17 1997-09-30 Guilford Pharmaceuticals Inc. Certain phosphonomethyl-pentanedioic acid derivatives thereof
US6046180A (en) * 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
US6071965A (en) * 1996-06-17 2000-06-06 Guilford Pharmaceuticals Inc. Phosphinic alkanoic acid derivatives
US5977090A (en) * 1996-09-27 1999-11-02 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors
US6025344A (en) 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
US6054444A (en) 1997-04-24 2000-04-25 Guilford Pharmaceuticals Inc. Phosphonic acid derivatives
DE69712496T2 (de) * 1996-07-18 2002-08-29 Pfizer Matrix metalloprotease-inhibitoren auf basis von phosphinsäuren
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US5962521A (en) 1997-04-04 1999-10-05 Guilford Pharmaceuticals Inc. Hydroxamic acid derivatives
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5981209A (en) * 1997-12-04 1999-11-09 Guilford Pharmaceuticals Inc. Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia
US6028216A (en) * 1997-12-31 2000-02-22 Guilford Pharmaceuticals Inc. Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives
US6121252A (en) * 1998-03-30 2000-09-19 Guilford Pharmaceuticals Inc. Phosphinic acid derivatives
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6265609B1 (en) 1998-07-06 2001-07-24 Guilford Pharmaceuticals Inc. Thio-substituted pentanedioic acid derivatives
US6395718B1 (en) * 1998-07-06 2002-05-28 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
AU770258B2 (en) 1998-07-06 2004-02-19 Eisai Inc. Naaladase inhibitors useful as pharmaceutical compounds and compositions
NZ509241A (en) 1998-08-07 2003-08-29 Du Pont Pharm Co Succinoylamino lactams as inhibitors of alpha-beta protein production
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
US6737038B1 (en) 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
US6331408B1 (en) * 1998-11-12 2001-12-18 Robert Zaczek Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production
US6313159B1 (en) 1999-08-20 2001-11-06 Guilford Pharmaceuticals Inc. Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
GB9922577D0 (en) * 1999-09-23 1999-11-24 Center For Clinical & Basic Re Substituted phosphinate based peptide derivatives
US6696456B1 (en) * 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
AU2001245862A1 (en) * 2000-03-21 2001-10-03 The Procter & Gamble Company Difluorobutyric acid metalloprotease inhibitors
BR0109354A (pt) * 2000-03-21 2003-04-15 Procter & Gamble Inibidores de metaloproteases os quais contêm cadeias laterais carbocìclicas
CN1425004A (zh) 2000-03-21 2003-06-18 宝洁公司 含杂环侧链的n－取代的金属蛋白酶抑制剂
CN1386118A (zh) 2000-06-01 2002-12-18 布里斯托尔-迈尔斯斯奎布药品公司 作为Aβ蛋白产生抑制剂的被环状琥珀酸酯取代的内酰胺类化合物
US8283135B2 (en) 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
AU2003233154A1 (en) 2002-06-10 2003-12-22 Pfizer Inc. Metabolites of prinomastat and their sythesis
CN106414465B (zh) 2014-02-28 2021-11-16 杭州多禧生物科技有限公司 带电荷链接体及其在共轭反应上的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226610A (en) * 1978-04-15 1980-10-07 Meiji Selka Kaisha, Ltd. Herbicidal compounds, preparation thereof and herbicides containing the same
JPS60163899A (ja) * 1984-02-03 1985-08-26 Sankyo Co Ltd レニン阻害ペプチド類
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
EP0210545A3 (en) * 1985-07-24 1988-07-20 Merck & Co. Inc. Phosphorous containing enzyme inhibitors
EP0209848A3 (en) * 1985-07-24 1988-07-27 Merck & Co. Inc. Enzyme inhibitors

Also Published As

Publication number Publication date
CS900287A2 (en) 1990-03-14
CN1017337B (zh) 1992-07-08
CA1326737C (en) 1994-02-01
PT86366A (en) 1988-01-01
US5006651A (en) 1991-04-09
FI875484A (fi) 1988-06-16
IE62334B1 (en) 1995-01-25
PT86366B (pt) 1990-11-20
AU606901B2 (en) 1991-02-21
NO171788B (no) 1993-01-25
DK641687D0 (da) 1987-12-07
ZW23187A1 (en) 1988-06-29
PH25030A (en) 1991-01-28
CN87101164A (zh) 1988-06-29
HUT46699A (en) 1988-11-28
CS272231B2 (en) 1991-01-15
DE3786250T2 (de) 1993-10-07
US4885283A (en) 1989-12-05
AU8217687A (en) 1988-06-16
DE3786250D1 (en) 1993-07-22
FI89059B (fi) 1993-04-30
EP0276436B1 (en) 1993-06-16
NO875214D0 (no) 1987-12-14
DK641687A (da) 1988-06-16
NO875214L (no) 1988-06-16
IL84766A0 (en) 1988-05-31
NO171788C (no) 1993-05-05
FI89059C (fi) 1993-08-10
EP0276436A1 (en) 1988-08-03
IL84766A (en) 1994-02-27
HU203109B (en) 1991-05-28
NZ222824A (en) 1990-08-28
MC1881A1 (fr) 1989-01-24
IE873383L (en) 1988-06-15
ES2056810T3 (es) 1994-10-16

Similar Documents

Publication Publication Date Title
DE3774909D1 (de) Antitumormittel.
DE3775679D1 (de) Vernebler.
DE3767169D1 (de) Sportschuh.
ES2019949B3 (es) Propanaminas 3-ariloxi-3-sustituidas.
NO875214D0 (no) Fosfinsyrederivater.
DE3779761T2 (de) Abseilgeraet.
NO874182L (no) Kabelhaandteringsapparat.
DE3771918D1 (de) Chinolinamide.
DE3785294T2 (de) Neigungsmesser.
DE3786679D1 (de) Schmitt-triggerschaltung.
FI874993A0 (fi) Modulaert behaollarsystem.
DE3773636D1 (de) Saeurebeschleunigte hydrocarboxilierung.
DE3771271D1 (de) Fluorphthalimide.
FI860054A0 (fi) Motionsanordning.
FI873455A (fi) Rengoeringsolja foer kroppen.
DE3779382D1 (de) 3-6-diphenylpyridazine.
FI882959A0 (fi) Foerpackningsask.
FI860046A0 (fi) Foerlaengningsanordning foer traefaner.
FI880935A0 (fi) Kompostberedningsmaskin.
DE3770459D1 (de) 3-halogensuccinimide.
FI860072A (fi) Mataranordning foer en spannmaolstork.
FI874735A0 (fi) Elektronisk motorskyddsrelae.
DE3781179T2 (de) Acyl-coa-synthetase.
FI851776L (fi) Elkandelaber.
FI73944B (fi) Rullningsanordning foer pappersbana.

Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: F. HOFFMANN-LA ROCHE AG