CS268654B2 - Method of 2-susbstituted 2-(omega-quanidino-alkamido,omega-quandino-alkenamido and omega-quanidino-hydroxyalkamiso-n-(4-(3-aminopropyl)aminobutyl(erganamides and teir salts production - Google Patents

Method of 2-susbstituted 2-(omega-quanidino-alkamido,omega-quandino-alkenamido and omega-quanidino-hydroxyalkamiso-n-(4-(3-aminopropyl)aminobutyl(erganamides and teir salts production Download PDF

Info

Publication number
CS268654B2
CS268654B2 CS827179A CS717982A CS268654B2 CS 268654 B2 CS268654 B2 CS 268654B2 CS 827179 A CS827179 A CS 827179A CS 717982 A CS717982 A CS 717982A CS 268654 B2 CS268654 B2 CS 268654B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
ncnh
aminobutyl
aminopropyl
carbon atoms
Prior art date
Application number
CS827179A
Other languages
Czech (cs)
English (en)
Other versions
CS717982A2 (en
Inventor
Hamao Umezawa
Original Assignee
Zaidan Hojin Biseibutsu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zaidan Hojin Biseibutsu filed Critical Zaidan Hojin Biseibutsu
Publication of CS717982A2 publication Critical patent/CS717982A2/cs
Publication of CS268654B2 publication Critical patent/CS268654B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CS827179A 1981-10-08 1982-10-07 Method of 2-susbstituted 2-(omega-quanidino-alkamido,omega-quandino-alkenamido and omega-quanidino-hydroxyalkamiso-n-(4-(3-aminopropyl)aminobutyl(erganamides and teir salts production CS268654B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56159503A JPS5862152A (ja) 1981-10-08 1981-10-08 Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法

Publications (2)

Publication Number Publication Date
CS717982A2 CS717982A2 (en) 1989-08-14
CS268654B2 true CS268654B2 (en) 1990-04-11

Family

ID=15695187

Family Applications (1)

Application Number Title Priority Date Filing Date
CS827179A CS268654B2 (en) 1981-10-08 1982-10-07 Method of 2-susbstituted 2-(omega-quanidino-alkamido,omega-quandino-alkenamido and omega-quanidino-hydroxyalkamiso-n-(4-(3-aminopropyl)aminobutyl(erganamides and teir salts production

Country Status (19)

Country Link
US (3) US4518532A (ko)
JP (1) JPS5862152A (ko)
KR (1) KR870000656B1 (ko)
AT (1) AT393680B (ko)
AU (1) AU554489B2 (ko)
BE (1) BE894651A (ko)
CA (1) CA1187513A (ko)
CH (1) CH653015A5 (ko)
CS (1) CS268654B2 (ko)
DE (1) DE3236725A1 (ko)
DK (1) DK166080C (ko)
ES (2) ES8402558A1 (ko)
FR (1) FR2514350B1 (ko)
GB (1) GB2111480B (ko)
HU (1) HU187417B (ko)
IT (1) IT1189373B (ko)
NL (1) NL193107C (ko)
SE (1) SE452006B (ko)
YU (1) YU44678B (ko)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS60181056A (ja) * 1984-02-29 1985-09-14 Takara Shuzo Co Ltd Ν−〔４−（３−アミノプロピル）アミノブチル〕−２，２−ジヒドロキシエタンアミドの製造法
JPS60185758A (ja) * 1984-03-02 1985-09-21 Microbial Chem Res Found フエニレン基を有するスパガリン関連化合物およびその製造法
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
JPH0742268B2 (ja) * 1985-08-27 1995-05-10 財団法人微生物化学研究会 フエニレン基を有するスパガリン類縁化合物及びその製造法
ES2039213T3 (es) * 1986-04-04 1993-09-16 Microbial Chemistry Research Foundation Procedimiento para producir nuevos compuestos relacionados con espergualina.
JP2605762B2 (ja) * 1986-12-10 1997-04-30 武田薬品工業株式会社 δ−ハイドロキシ−β−リジン誘導体およびその製造法
US5061787A (en) * 1988-06-24 1991-10-29 Nippon Kayaku Kabushiki Kaisha Novel spergualin-related compounds and compositions
JPH0776204B2 (ja) * 1988-07-01 1995-08-16 寳酒造株式会社 スパガリン類の精製法
US4990536A (en) * 1989-04-03 1991-02-05 Nippon Kayaku Kabushiki Kaisha Immunopotentiator and spergualin-related compound therefor
US5162581A (en) * 1989-05-29 1992-11-10 Takaru Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same
RU2171811C2 (ru) * 1989-05-29 2001-08-10 Такара Сузо Ко., Лтд., (Jp), Ниппон Каяку Кабусики Кайся КРИСТАЛЛИЧЕСКИЙ ТРИГИДРОХЛОРИД ДЕОКСИСПЕРГУАЛИНА В β-ФОРМЕ, ОБЛАДАЮЩИЙ ПРОТИВООПУХОЛЕВОЙ АКТИВНОСТЬЮ И СПОСОБ ЕГО ПОЛУЧЕНИЯ
YU48230B (sh) * 1989-05-29 1997-08-22 Takara Shuzo Co.Ltd. Kristalni deoksispergvalin i postupak za njegovo pripremanje
US5196453A (en) * 1989-05-29 1993-03-23 Takara Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same
EP0467280B1 (en) * 1990-07-20 1994-09-28 Nippon Kayaku Kabushiki Kaisha Novel spergualin-related compound and use thereof
WO1994004140A1 (en) * 1992-08-19 1994-03-03 Nippon Kayaku Kabushiki Kaisha Antiprotozoan drug
CA2183917A1 (en) * 1995-09-26 1997-03-27 Xuebao Wang Preparation of optically active (s)-(-) and (r)-(+)- deoxyspergualin and novel intermediates thereof
CN1203846C (zh) 1998-03-19 2005-06-01 布里斯托尔-迈尔斯斯奎布公司 高溶解性药物的双相控释递送系统和方法
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
US6656917B1 (en) 1999-06-30 2003-12-02 Marker Gene Technologies, Inc. Compositions and methods for targeted enzymatic release of cell regulatory compounds
US8716558B2 (en) 1999-06-30 2014-05-06 Marker Gene Technologies, Inc. Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase
WO2004002367A1 (fr) * 2002-06-27 2004-01-08 Microport Medical (Shanghai) Co., Ltd. Stent eluant des medicaments
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
CA2804926C (en) 2010-07-09 2019-01-08 James Trinca Green Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin
CN104271605B (zh) 2012-02-15 2017-07-25 锡德克斯药物公司 环糊精衍生物的制造方法
JP2015508846A (ja) 2012-02-28 2015-03-23 サイデックス・ファーマシューティカルズ・インコーポレイテッド アルキル化シクロデキストリン組成物ならびにその調製方法および使用方法
BR112015008954B1 (pt) 2012-10-22 2021-03-02 Cydex Pharmaceuticals, Inc processos para preparar uma composição de ciclodextrina alquilatada compreendendo uma ciclodextrina alquilatada, para preparar pelo menos 9 lotes consecutivos da mesma e para preparar uma composição farmacêutica
FI3183295T3 (fi) 2014-08-22 2023-09-25 Cydex Pharmaceuticals Inc Fraktioidut alkyloidut syklodekstriinikoostumukset ja menetelmät niiden valmistamiseksi ja käyttämiseksi

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799988A (en) * 1969-04-02 1974-03-26 Taiho Pharmaceutical Co Ltd {107 -guanidino acid diamide derivatives and manufacturing the same
JPS5748957A (en) * 1980-09-08 1982-03-20 Microbial Chem Res Found Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient
JPS57192347A (en) * 1981-05-18 1982-11-26 Microbial Chem Res Found N-(4-(3-aminopropyl)aminobutyl)-2,2-dihydroxyethanamide and its synthesis
JPS57185254A (en) * 1981-05-11 1982-11-15 Microbial Chem Res Found Novel carcinostatic substances and their preparation
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
US4525299A (en) * 1983-05-10 1985-06-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same

Also Published As

Publication number Publication date
KR840001952A (ko) 1984-06-07
DK166080B (da) 1993-03-08
AU554489B2 (en) 1986-08-21
DE3236725A1 (de) 1983-04-28
ES516258A0 (es) 1984-02-01
AT393680B (de) 1991-11-25
BE894651A (fr) 1983-01-31
US4658058A (en) 1987-04-14
CA1187513A (en) 1985-05-21
ES8504690A1 (es) 1985-04-16
JPS5862152A (ja) 1983-04-13
DK166080C (da) 1993-08-02
CH653015A5 (de) 1985-12-13
ES526501A0 (es) 1985-04-16
CS717982A2 (en) 1989-08-14
KR870000656B1 (ko) 1987-04-04
US4983328A (en) 1991-01-08
HU187417B (en) 1986-01-28
IT8249228A0 (it) 1982-10-07
SE8205698D0 (sv) 1982-10-06
NL193107C (nl) 1998-11-03
GB2111480B (en) 1985-03-13
NL193107B (nl) 1998-07-01
ATA369682A (de) 1991-05-15
AU8912182A (en) 1983-04-14
DK445182A (da) 1983-04-09
GB2111480A (en) 1983-07-06
YU227682A (en) 1985-06-30
FR2514350A1 (fr) 1983-04-15
YU44678B (en) 1990-12-31
IT1189373B (it) 1988-02-04
US4518532A (en) 1985-05-21
FR2514350B1 (fr) 1985-10-25
NL8203874A (nl) 1983-05-02
DE3236725C2 (ko) 1991-01-24
ES8402558A1 (es) 1984-02-01
SE452006B (sv) 1987-11-09
SE8205698L (sv) 1983-04-09
JPS6123183B2 (ko) 1986-06-04

Similar Documents

Publication Publication Date Title
CS268654B2 (en) Method of 2-susbstituted 2-(omega-quanidino-alkamido,omega-quandino-alkenamido and omega-quanidino-hydroxyalkamiso-n-(4-(3-aminopropyl)aminobutyl(erganamides and teir salts production
US4525299A (en) (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same
FI90243B (fi) Menetelmä amikasiinin valmistamiseksi
US4170642A (en) Derivatives of kanamycin A
US5545654A (en) Pleuromutilin derivatives
US4430346A (en) Novel carcinostatic substance and process for synthesis thereof
SK42497A3 (en) Colchicine derivatives, preparation method thereof, pharmauceutical composition containing the same and their use
US4337248A (en) Paromomycin containing compounds and method of use
KR900001076B1 (ko) N-[4-(3-아미노프로필)아미노부틸]-2,2-디히드록시에탄아미드의 제조방법
US5696244A (en) Method for preparing 1-N-ethylsisomicin
US4393052A (en) Antitumor anthracycline glycosides, their preparation, intermediates therefor, and compositions and use thereof
FR2465731A1 (fr) Derives de type desoxy-2 o-demethyl-3 des fortimicines a et b, utiles notamment comme medicaments antibiotiques
US4892939A (en) Oligopeptidyl-5-fluorouridine compounds and process for preparing the same
US5053395A (en) Pradimicin amide derivatives
US5374711A (en) Chemical modification of 2"-amino group in elsamicin a
US4497729A (en) Peptide, process for preparation thereof and use thereof
US4487924A (en) 2'-N-β-Lysyl) aminoglycosides
FR2566410A1 (fr) Nouveaux derives de l'acide diaminopimelique, leur procede de preparation et leur application en therapeutique
US4423210A (en) Intermediates for the preparation of 3-demethoxyfortimicins
US5237055A (en) Chemical modification of 2"-amino group in elsamicin A
CA1082697A (fr) Procede de preparation d'un nouveau derive de la desoxystreptamine et ses sels
EP0051812B1 (en) Peptide, process for preparation thereof and use thereof
EP0053388A1 (en) New peptide, process for preparation thereof and use thereof
CS237334B2 (en) Processing of aminopropylaminobleomycine derivative
KR900000871B1 (ko) 페닐렌기를 가지는 스페르구알린계 화합물의 제조방법