CS251752B2 - Method of simultaneous determination of several or all lactate hydrogenase's isoenzymes - Google Patents
Method of simultaneous determination of several or all lactate hydrogenase's isoenzymes Download PDFInfo
- Publication number
- CS251752B2 CS251752B2 CS756214A CS621475A CS251752B2 CS 251752 B2 CS251752 B2 CS 251752B2 CS 756214 A CS756214 A CS 756214A CS 621475 A CS621475 A CS 621475A CS 251752 B2 CS251752 B2 CS 251752B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- isoenzymes
- reagent
- lactate
- buffer
- tampon
- Prior art date
Links
- 108010044467 Isoenzymes Proteins 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 23
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 title claims abstract description 17
- 108010020056 Hydrogenase Proteins 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 claims abstract description 24
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 22
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 18
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims abstract description 17
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims abstract description 17
- 239000000872 buffer Substances 0.000 claims abstract description 13
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 10
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 6
- 210000001215 vagina Anatomy 0.000 claims description 6
- 238000003556 assay Methods 0.000 claims description 5
- 229960003966 nicotinamide Drugs 0.000 claims description 3
- 235000005152 nicotinamide Nutrition 0.000 claims description 3
- 239000011570 nicotinamide Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- 238000012360 testing method Methods 0.000 claims description 2
- 238000005462 in vivo assay Methods 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 239000000084 colloidal system Substances 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000009969 flowable effect Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 229960000448 lactic acid Drugs 0.000 claims 1
- QEHKBHWEUPXBCW-UHFFFAOYSA-N nitrogen trichloride Chemical compound ClN(Cl)Cl QEHKBHWEUPXBCW-UHFFFAOYSA-N 0.000 claims 1
- NGSFWBMYFKHRBD-UHFFFAOYSA-N sodium;2-hydroxypropanoic acid Chemical compound [Na+].CC(O)C(O)=O NGSFWBMYFKHRBD-UHFFFAOYSA-N 0.000 claims 1
- 229910052722 tritium Inorganic materials 0.000 claims 1
- -1 tritium amine Chemical class 0.000 claims 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 abstract description 8
- 229950006238 nadide Drugs 0.000 abstract description 6
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract description 6
- 229920002301 cellulose acetate Polymers 0.000 abstract description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 abstract description 2
- 150000003839 salts Chemical class 0.000 abstract description 2
- 229940101270 nicotinamide adenine dinucleotide (nad) Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 239000012530 fluid Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 6
- 239000010839 body fluid Substances 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 5
- 229960000583 acetic acid Drugs 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- BSABBBMNWQWLLU-UHFFFAOYSA-N lactaldehyde Chemical compound CC(O)C=O BSABBBMNWQWLLU-UHFFFAOYSA-N 0.000 description 4
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- 201000009030 Carcinoma Diseases 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000003139 buffering effect Effects 0.000 description 3
- 239000012362 glacial acetic acid Substances 0.000 description 3
- 231100000915 pathological change Toxicity 0.000 description 3
- 230000036285 pathological change Effects 0.000 description 3
- 210000005000 reproductive tract Anatomy 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 description 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000005515 coenzyme Substances 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 238000000099 in vitro assay Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- VEPOHXYIFQMVHW-XOZOLZJESA-N 2,3-dihydroxybutanedioic acid (2S,3S)-3,4-dimethyl-2-phenylmorpholine Chemical compound OC(C(O)C(O)=O)C(O)=O.C[C@H]1[C@@H](OCCN1C)c1ccccc1 VEPOHXYIFQMVHW-XOZOLZJESA-N 0.000 description 1
- 241000234282 Allium Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- 208000009458 Carcinoma in Situ Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 201000004933 in situ carcinoma Diseases 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 150000004685 tetrahydrates Chemical class 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S604/00—Surgery
- Y10S604/904—Tampons
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742443741 DE2443741C3 (de) | 1974-09-12 | Verfahren zur gemeinsamen Bestimmung der Isoenzyme 4 und 5 der LDH |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS621475A2 CS621475A2 (en) | 1986-12-18 |
| CS251752B2 true CS251752B2 (en) | 1987-08-13 |
Family
ID=5925603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS756214A CS251752B2 (en) | 1974-09-12 | 1975-09-12 | Method of simultaneous determination of several or all lactate hydrogenase's isoenzymes |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US4003795A (ru) |
| JP (2) | JPS5512239B2 (ru) |
| AR (1) | AR211523A1 (ru) |
| AT (1) | AT351173B (ru) |
| AU (1) | AU503460B2 (ru) |
| BE (1) | BE833348A (ru) |
| BR (1) | BR7505850A (ru) |
| CA (1) | CA1076010A (ru) |
| CH (1) | CH631209A5 (ru) |
| CS (1) | CS251752B2 (ru) |
| DD (1) | DD120296A1 (ru) |
| DK (1) | DK144659C (ru) |
| ES (1) | ES440870A1 (ru) |
| FI (1) | FI58943C (ru) |
| FR (1) | FR2284882A1 (ru) |
| GB (1) | GB1527243A (ru) |
| HK (1) | HK79879A (ru) |
| HU (1) | HU171962B (ru) |
| IE (1) | IE41901B1 (ru) |
| IL (1) | IL48071A (ru) |
| IN (1) | IN142896B (ru) |
| IT (1) | IT1155451B (ru) |
| NL (1) | NL178086C (ru) |
| NO (1) | NO144929C (ru) |
| PL (1) | PL98619B1 (ru) |
| RO (1) | RO68447A (ru) |
| SE (1) | SE417109B (ru) |
| SU (2) | SU663329A3 (ru) |
| TR (1) | TR19139A (ru) |
| YU (1) | YU218175A (ru) |
| ZA (1) | ZA755704B (ru) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4311791A (en) * | 1978-06-05 | 1982-01-19 | Bernstein Larry H | Automated kinetic determination of lactate dehydrogenase isoenzymes in serum |
| US4309184A (en) * | 1980-05-08 | 1982-01-05 | Majid Ali | Method of determining food or chemical allergy and intolerance |
| US4543327A (en) * | 1980-06-10 | 1985-09-24 | Bernstein Larry H | Malate dehydrogenase method |
| DE3231288C2 (de) * | 1982-08-23 | 1984-06-28 | MEDI-PHARMA Vertriebsgesellschaft mbH, 5000 Köln | Diagnostische Vorrichtung und ihre Verwendung |
| DE3231287C2 (de) * | 1982-08-23 | 1984-09-06 | MEDI-PHARMA Vertriebsgesellschaft mbH, 5000 Köln | Verfahren zum Herstellen einer diagnostischen Vorrichtung |
| GB2147415B (en) * | 1983-08-05 | 1987-02-11 | Powell & Scholefield Limited | Device and method for antibiotic sensitivity testing |
| DK427784A (da) * | 1984-09-06 | 1986-03-07 | Forenede Bryggerier As | Fremgangsmaade og apparat til bestemmelse af vitalitet i froe |
| US4849347A (en) * | 1984-11-29 | 1989-07-18 | Hoffmann-La Roche Inc. | Colorimetric biological assay |
| US5141853A (en) * | 1988-07-22 | 1992-08-25 | Abbott Laboratories | Determination of ammonia levels in a sample |
| EP0401641B1 (en) * | 1989-06-09 | 1995-01-25 | Abbott Laboratories | Method for assaying isoenzymes |
| US5468236A (en) * | 1993-06-09 | 1995-11-21 | Kimberly-Clark Corporation | Disposable absorbent product incorporating chemically reactive substance |
| US7947467B2 (en) * | 2001-07-19 | 2011-05-24 | Common Sense Ltd. | Methods for monitoring pathological conditions in a female subject |
| US20070134740A1 (en) * | 2005-12-12 | 2007-06-14 | David Brusilovsky | Compositions and articles for detection of analytes exceeding a pre-set threshold |
| US7083569B2 (en) * | 2001-08-03 | 2006-08-01 | Zassi Medical Evolutions, Inc. | Ostomy cartridge |
| US20070031914A1 (en) * | 2005-08-05 | 2007-02-08 | Wei Zhu | Devices for analyte assays and methods of use |
| US8053625B2 (en) * | 2006-12-14 | 2011-11-08 | Kimberly-Clark Worldwide, Inc. | Absorbent articles including a body fluid signaling device |
| CN109613177B (zh) | 2014-07-01 | 2021-08-20 | 科蒙森斯公司 | 用于鉴定羊水的诊断组合物 |
| CN113329697A (zh) * | 2019-01-23 | 2021-08-31 | 吉娜-生命诊断有限公司 | 癌症诊断和监测设备、其系统和方法 |
| EP3928977A4 (en) | 2019-02-19 | 2022-11-09 | Nitto Denko Corporation | PROCESS FOR MAKING A LAMINATE FROM A TWO-DIMENSIONAL MATERIAL AND LAMINATE |
| US20230054322A1 (en) * | 2021-08-23 | 2023-02-23 | Leslie P. Taylor | Urine indication pad with inbuilt diagnostics for training and indication of potential disease |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2905169A (en) * | 1955-03-10 | 1959-09-22 | Herbert E Nieburgs | Device for cancer detection |
| US2999052A (en) | 1959-03-16 | 1961-09-05 | Miles Lab | Composition for colorimetric test for serum enzymes |
| US3326777A (en) * | 1964-12-10 | 1967-06-20 | Warner Lambert Pharmaceutical | Process for differentiating the isoenzymes of lactic dehydrogenase |
| US3388044A (en) * | 1965-12-07 | 1968-06-11 | Warner Lambert Pharmaceutical | Process for differentiating the isoenzymes of lactic dehydrogenase |
| DE1959410C3 (de) * | 1969-11-26 | 1974-02-28 | Boehringer Mannheim Gmbh, 6800 Mannheim | Indikator zur Bestimmung der reduzierten Pyridincöenzyme |
| US3663374A (en) * | 1970-08-14 | 1972-05-16 | Geomet | Method and apparatus for quantitating enzyme activity |
| DE2061984C3 (de) | 1970-12-16 | 1974-04-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Reagens zur Bestimmung der Lactat-Dehydrogenase im Farbtest |
| US3862010A (en) * | 1972-06-09 | 1975-01-21 | Technicon Instr | Method of heat fractionating ldh into isoenzyme components |
| US3867258A (en) * | 1973-11-08 | 1975-02-18 | American Cyanamid Co | Lactate dehydrogenase test material |
| US4046634A (en) * | 1974-05-28 | 1977-09-06 | Mercer Donald W | Assay of isoenzymes by ion exchange chromatography |
| US4080263A (en) * | 1976-08-11 | 1978-03-21 | Boehringer Mannheim Gmbh | Process and reagent for the rapid quantitative determination of lactate or alanine |
-
1975
- 1975-08-27 YU YU02181/75A patent/YU218175A/xx unknown
- 1975-08-29 AT AT667075A patent/AT351173B/de not_active IP Right Cessation
- 1975-09-01 NL NLAANVRAGE7510277,A patent/NL178086C/xx not_active IP Right Cessation
- 1975-09-03 GB GB36351/75A patent/GB1527243A/en not_active Expired
- 1975-09-05 ZA ZA00755704A patent/ZA755704B/xx unknown
- 1975-09-09 IT IT69244/75A patent/IT1155451B/it active
- 1975-09-10 IL IL48071A patent/IL48071A/xx unknown
- 1975-09-10 RO RO7583353A patent/RO68447A/ro unknown
- 1975-09-10 DD DD188274A patent/DD120296A1/xx unknown
- 1975-09-11 ES ES440870A patent/ES440870A1/es not_active Expired
- 1975-09-11 SE SE7510130A patent/SE417109B/xx not_active IP Right Cessation
- 1975-09-11 CH CH1178775A patent/CH631209A5/de not_active IP Right Cessation
- 1975-09-11 DK DK406475A patent/DK144659C/da not_active IP Right Cessation
- 1975-09-11 AU AU84720/75A patent/AU503460B2/en not_active Expired
- 1975-09-11 BR BR7505850*A patent/BR7505850A/pt unknown
- 1975-09-11 FI FI752550A patent/FI58943C/fi not_active IP Right Cessation
- 1975-09-11 CA CA235,284A patent/CA1076010A/en not_active Expired
- 1975-09-12 CS CS756214A patent/CS251752B2/cs unknown
- 1975-09-12 JP JP11079975A patent/JPS5512239B2/ja not_active Expired
- 1975-09-12 BE BE159982A patent/BE833348A/xx not_active IP Right Cessation
- 1975-09-12 IE IE2000/75A patent/IE41901B1/en unknown
- 1975-09-12 AR AR260373A patent/AR211523A1/es active
- 1975-09-12 TR TR19139A patent/TR19139A/xx unknown
- 1975-09-12 NO NO753119A patent/NO144929C/no unknown
- 1975-09-12 SU SU752171403A patent/SU663329A3/ru active
- 1975-09-12 HU HU75SCHA170A patent/HU171962B/hu unknown
- 1975-09-12 PL PL1975183289A patent/PL98619B1/pl unknown
- 1975-09-12 FR FR7528099A patent/FR2284882A1/fr active Granted
- 1975-09-12 US US05/612,633 patent/US4003795A/en not_active Expired - Lifetime
- 1975-10-09 IN IN1960/CAL/1975A patent/IN142896B/en unknown
-
1976
- 1976-09-09 SU SU762405873A patent/SU657732A3/ru active
-
1978
- 1978-07-10 US US05/923,641 patent/US4266022A/en not_active Expired - Lifetime
-
1979
- 1979-11-15 HK HK798/79A patent/HK79879A/xx unknown
- 1979-11-22 JP JP54150822A patent/JPS5850720B2/ja not_active Expired
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