CS243485B2 - Method of benzothienylglycylcephaelosporines production - Google Patents

Method of benzothienylglycylcephaelosporines production Download PDF

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Publication number
CS243485B2
CS243485B2 CS842795A CS279584A CS243485B2 CS 243485 B2 CS243485 B2 CS 243485B2 CS 842795 A CS842795 A CS 842795A CS 279584 A CS279584 A CS 279584A CS 243485 B2 CS243485 B2 CS 243485B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
hydrogen
acid
methyl
benzothienyl
Prior art date
Application number
CS842795A
Other languages
Czech (cs)
English (en)
Other versions
CS279584A2 (en
Inventor
Larry Ch Blaszcak
Stjepjan Kukolja
Jan R Turner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS279584A2 publication Critical patent/CS279584A2/cs
Publication of CS243485B2 publication Critical patent/CS243485B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS842795A 1983-04-12 1984-04-12 Method of benzothienylglycylcephaelosporines production CS243485B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/484,129 US4492693A (en) 1983-04-12 1983-04-12 Benzothienylglycyl cephalosporin derivatives

Publications (2)

Publication Number Publication Date
CS279584A2 CS279584A2 (en) 1985-08-15
CS243485B2 true CS243485B2 (en) 1986-06-12

Family

ID=23922870

Family Applications (1)

Application Number Title Priority Date Filing Date
CS842795A CS243485B2 (en) 1983-04-12 1984-04-12 Method of benzothienylglycylcephaelosporines production

Country Status (23)

Country Link
US (1) US4492693A (da)
EP (1) EP0122154A3 (da)
JP (1) JPS59199692A (da)
KR (1) KR840008654A (da)
AU (1) AU2673684A (da)
CA (1) CA1212938A (da)
CS (1) CS243485B2 (da)
DD (1) DD213927A5 (da)
DK (1) DK187384A (da)
ES (1) ES531531A0 (da)
FI (1) FI841437A (da)
GB (1) GB2137995A (da)
GR (1) GR79908B (da)
GT (1) GT198400056A (da)
IL (1) IL71497A0 (da)
MA (1) MA20093A1 (da)
NO (1) NO841441L (da)
OA (1) OA07701A (da)
PL (1) PL247170A1 (da)
PT (1) PT78403A (da)
RO (1) RO88220B (da)
ZA (1) ZA842694B (da)
ZW (1) ZW4384A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581352A (en) * 1984-12-03 1986-04-08 Eli Lilly And Company Thienothienylglycyl cephalosporin derivatives
US4692587A (en) * 1986-02-19 1987-09-08 Spirk Jr John W Hand tool and support
EP1451147A4 (en) * 2001-07-24 2007-06-06 Pharmacore Inc AMINO ACID DERIVATIVES
CN103588790A (zh) * 2013-11-29 2014-02-19 中国科学院长春应用化学研究所 7-氨基-3-氯-3-头孢-4-羧酸-对硝基苄基酯的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1445685A1 (de) * 1961-09-11 1968-12-05 Lilly Co Eli Antibiotisch wirksame Cephalospransaeurederivate und Verfahren zu ihrer Herstellung
US3560489A (en) * 1966-08-12 1971-02-02 Lilly Co Eli 7-alpha-aminoacyl cephalosporins
US3575969A (en) * 1968-03-04 1971-04-20 Lilly Co Eli Desacetoxycephalosporin antibiotics
GB1445979A (en) * 1972-10-25 1976-08-11 Glaxo Lab Ltd Cephalosporin derivatives
US4024133A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-,furyl- or pyridylacetamido)]cephalosporins
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds

Also Published As

Publication number Publication date
GB2137995A (en) 1984-10-17
AU2673684A (en) 1984-10-18
ES8600308A1 (es) 1985-10-01
OA07701A (fr) 1985-08-30
KR840008654A (ko) 1984-12-17
JPS59199692A (ja) 1984-11-12
ES531531A0 (es) 1985-10-01
GR79908B (da) 1984-10-31
GT198400056A (es) 1985-10-03
CS279584A2 (en) 1985-08-15
RO88220B (ro) 1985-12-31
MA20093A1 (fr) 1984-12-31
NO841441L (no) 1984-10-15
IL71497A0 (en) 1984-07-31
CA1212938A (en) 1986-10-21
GB8409381D0 (en) 1984-05-23
EP0122154A3 (en) 1985-10-23
PL247170A1 (en) 1985-08-13
PT78403A (en) 1984-05-01
RO88220A (ro) 1985-12-30
ZA842694B (en) 1985-11-27
ZW4384A1 (en) 1984-10-03
FI841437A (fi) 1984-10-13
US4492693A (en) 1985-01-08
DK187384A (da) 1984-10-13
DK187384D0 (da) 1984-04-11
FI841437A0 (fi) 1984-04-11
DD213927A5 (de) 1984-09-26
EP0122154A2 (en) 1984-10-17

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