CS236874B2 - Processing of ergoline derivatives - Google Patents

Processing of ergoline derivatives Download PDF

Info

Publication number
CS236874B2
CS236874B2 CS832921A CS292183A CS236874B2 CS 236874 B2 CS236874 B2 CS 236874B2 CS 832921 A CS832921 A CS 832921A CS 292183 A CS292183 A CS 292183A CS 236874 B2 CS236874 B2 CS 236874B2
Authority
CS
Czechoslovakia
Prior art keywords
group
methyl
hydrogen atom
formula
ergoline
Prior art date
Application number
CS832921A
Other languages
Czech (cs)
English (en)
Inventor
Luigi Bernardi
Aldemio Temperilli
Sergio Mantegani
Gabriella Traquandi
Patricia Salvati
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of CS236874B2 publication Critical patent/CS236874B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CS832921A 1982-04-30 1983-04-25 Processing of ergoline derivatives CS236874B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8212653 1982-04-30

Publications (1)

Publication Number Publication Date
CS236874B2 true CS236874B2 (en) 1985-05-15

Family

ID=10530108

Family Applications (1)

Application Number Title Priority Date Filing Date
CS832921A CS236874B2 (en) 1982-04-30 1983-04-25 Processing of ergoline derivatives

Country Status (21)

Country Link
US (1) US4657914A (hu)
JP (1) JPS58194884A (hu)
AT (1) AT385035B (hu)
AU (1) AU553851B2 (hu)
BE (1) BE896609A (hu)
CA (1) CA1210389A (hu)
CH (1) CH654305A5 (hu)
CS (1) CS236874B2 (hu)
DE (1) DE3314878A1 (hu)
DK (1) DK164058C (hu)
FI (1) FI73996C (hu)
FR (1) FR2526022B1 (hu)
GB (1) GB2120242A (hu)
GR (1) GR78842B (hu)
HU (1) HU193527B (hu)
IE (1) IE53950B1 (hu)
IL (1) IL68496A (hu)
IT (1) IT1215630B (hu)
NL (1) NL191709C (hu)
SE (1) SE460967B (hu)
ZA (1) ZA833008B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8714767D0 (en) * 1987-06-24 1987-07-29 Erba Farmitalia Egoline derivatives
HU190105B (en) * 1983-06-03 1986-08-28 Gyogyszerkutato Intezet Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
GB2173189B (en) * 1985-02-21 1988-04-27 Maruko Pharmaceutical Co Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
GB8702364D0 (en) * 1987-02-03 1987-03-11 Erba Farmitalia Ergolinyl heterocycles
US8877795B2 (en) 2010-05-07 2014-11-04 The Board Of Trustees Of The Leland Stanford Junior University Identification of stabilizers of multimeric proteins
EP3179857B1 (en) 2014-08-14 2021-09-08 Mamoun M. Alhamadsheh Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life
CA3051357A1 (en) 2017-02-17 2018-08-23 Eidos Therapeutics, Inc. Processes for preparing 3-(3-(3,5-dimethyl-1h-propoxy)-4-fluorobenzoic acid, its intermediates, and salts thereof
SG11202009073WA (en) 2018-03-23 2020-10-29 Eidos Therapeutics Inc Methods of treating ttr amyloidosis using ag10
US11260047B2 (en) 2018-08-17 2022-03-01 Eidos Therapeutics, Inc. Formulations of AG10

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238211A (en) * 1966-03-01 Derhvatives of g-methyl and i,g-dimethyl ergolhne
US3296071A (en) * 1963-05-31 1967-01-03 Upjohn Co Reducing blood sugar with 3-alkyl-5-alkoxymethylisoxazole
CH507248A (de) * 1967-03-16 1971-05-15 Spofa Vereinigte Pharma Werke Verfahren zur Herstellung von D-6-Methylergolin(I)ylessigsäure
US3957785A (en) * 1971-12-02 1976-05-18 Societa' Farmaceutici Italia S.P.A. Bβ-Pyrimidino-aminomethyl-10α-ergoline and 10α-methoxyergoline derivatives
CH563376A5 (hu) * 1972-06-29 1975-06-30 Lonza Ag
NL7416120A (nl) * 1973-12-21 1975-06-24 Farmaceutici Italia Werkwijze voor het bereiden van pyrimidinoami- nomethylergolinederivaten.
US3996228A (en) * 1973-12-21 1976-12-07 Societa' Farmaceutici Italia S.P.A. Pyrimidinoaminoethyl ergoline derivatives
IE41533B1 (en) * 1974-03-14 1980-01-30 Sandoz Ltd Thiomethyl ergolene derivatives
US4147789A (en) * 1974-03-14 1979-04-03 Sandoz Ltd. 6-Methyl-8-thiomethyl-ergolene derivatives
CS171480B1 (hu) * 1974-03-19 1976-10-29
CS177530B1 (en) * 1974-07-19 1977-07-29 Miroslav Semonsky New nbeta-substituted derivatives of b-beta-aminoethyl-ergoline-i their salts and methods for the production thereof
CH617452A5 (hu) * 1974-10-25 1980-05-30 Hoffmann La Roche
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
AU526764B2 (en) * 1978-09-08 1983-01-27 Farmitalia Carlo Erba S.P.A. Ergoline derivatives
GB2056437A (en) * 1979-08-07 1981-03-18 Erba Farmitalia Secoergoline derivatives
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity

Also Published As

Publication number Publication date
FI73996B (fi) 1987-08-31
DK164058C (da) 1992-10-12
DK189983D0 (da) 1983-04-28
IT1215630B (it) 1990-02-22
FI831406A0 (fi) 1983-04-25
AU1402983A (en) 1983-11-03
GB2120242A (en) 1983-11-30
IT8320807A0 (it) 1983-04-27
JPS58194884A (ja) 1983-11-12
FR2526022B1 (fr) 1985-06-14
JPH0354668B2 (hu) 1991-08-20
NL191709C (nl) 1996-04-02
FR2526022A1 (fr) 1983-11-04
FI831406L (fi) 1983-10-31
GR78842B (hu) 1984-10-02
SE460967B (sv) 1989-12-11
DE3314878C2 (hu) 1993-09-23
NL8301529A (nl) 1983-11-16
DK189983A (da) 1983-10-31
AU553851B2 (en) 1986-07-31
NL191709B (nl) 1995-12-01
US4657914A (en) 1987-04-14
CA1210389A (en) 1986-08-26
SE8302379D0 (sv) 1983-04-27
FI73996C (fi) 1987-12-10
ATA156783A (de) 1987-07-15
ZA833008B (en) 1984-01-25
HU193527B (en) 1987-10-28
DK164058B (da) 1992-05-04
BE896609A (fr) 1983-08-16
IE830932L (en) 1983-10-30
SE8302379L (sv) 1983-10-31
IL68496A (en) 1985-06-30
IE53950B1 (en) 1989-04-26
IL68496A0 (en) 1983-07-31
GB8310843D0 (en) 1983-05-25
DE3314878A1 (de) 1983-11-03
AT385035B (de) 1988-02-10
CH654305A5 (it) 1986-02-14

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