IL68496A - 8-heteroarylalkyl-ergoline derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

8-heteroarylalkyl-ergoline derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL68496A
IL68496A IL68496A IL6849683A IL68496A IL 68496 A IL68496 A IL 68496A IL 68496 A IL68496 A IL 68496A IL 6849683 A IL6849683 A IL 6849683A IL 68496 A IL68496 A IL 68496A
Authority
IL
Israel
Prior art keywords
heteroarylalkyl
preparation
pharmaceutical compositions
compositions containing
ergoline derivatives
Prior art date
Application number
IL68496A
Other languages
English (en)
Other versions
IL68496A0 (en
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of IL68496A0 publication Critical patent/IL68496A0/xx
Publication of IL68496A publication Critical patent/IL68496A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL68496A 1982-04-30 1983-04-26 8-heteroarylalkyl-ergoline derivatives,their preparation and pharmaceutical compositions containing them IL68496A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8212653 1982-04-30

Publications (2)

Publication Number Publication Date
IL68496A0 IL68496A0 (en) 1983-07-31
IL68496A true IL68496A (en) 1985-06-30

Family

ID=10530108

Family Applications (1)

Application Number Title Priority Date Filing Date
IL68496A IL68496A (en) 1982-04-30 1983-04-26 8-heteroarylalkyl-ergoline derivatives,their preparation and pharmaceutical compositions containing them

Country Status (21)

Country Link
US (1) US4657914A (xx)
JP (1) JPS58194884A (xx)
AT (1) AT385035B (xx)
AU (1) AU553851B2 (xx)
BE (1) BE896609A (xx)
CA (1) CA1210389A (xx)
CH (1) CH654305A5 (xx)
CS (1) CS236874B2 (xx)
DE (1) DE3314878A1 (xx)
DK (1) DK164058C (xx)
FI (1) FI73996C (xx)
FR (1) FR2526022B1 (xx)
GB (1) GB2120242A (xx)
GR (1) GR78842B (xx)
HU (1) HU193527B (xx)
IE (1) IE53950B1 (xx)
IL (1) IL68496A (xx)
IT (1) IT1215630B (xx)
NL (1) NL191709C (xx)
SE (1) SE460967B (xx)
ZA (1) ZA833008B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8714767D0 (en) * 1987-06-24 1987-07-29 Erba Farmitalia Egoline derivatives
HU190105B (en) * 1983-06-03 1986-08-28 Gyogyszerkutato Intezet Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
GB2173189B (en) * 1985-02-21 1988-04-27 Maruko Pharmaceutical Co Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
GB8702364D0 (en) * 1987-02-03 1987-03-11 Erba Farmitalia Ergolinyl heterocycles
EP2566333A4 (en) 2010-05-07 2014-04-02 Univ Leland Stanford Junior IDENTIFICATION OF STABILIZERS OF MULTIMEDER PROTEINS
WO2016025129A1 (en) 2014-08-14 2016-02-18 Alhamadsheh Mamoun M Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life
MA47511A (fr) 2017-02-17 2019-12-25 Eidos Therapeutics Inc Procédés de préparation d'ag-10, de ses intermédiaires et de sels correspondants
KR20200135996A (ko) 2018-03-23 2020-12-04 에이도스 테라퓨틱스, 인코포레이티드 Ag10을 사용하여 ttr 아밀로이드증을 치료하는 방법
WO2020037189A1 (en) 2018-08-17 2020-02-20 Eidos Therapeutics, Inc. Formulations of ag10

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238211A (en) * 1966-03-01 Derhvatives of g-methyl and i,g-dimethyl ergolhne
US3296071A (en) * 1963-05-31 1967-01-03 Upjohn Co Reducing blood sugar with 3-alkyl-5-alkoxymethylisoxazole
BE712054A (xx) * 1967-03-16 1968-07-15
US3957785A (en) * 1971-12-02 1976-05-18 Societa' Farmaceutici Italia S.P.A. Bβ-Pyrimidino-aminomethyl-10α-ergoline and 10α-methoxyergoline derivatives
CH563376A5 (xx) * 1972-06-29 1975-06-30 Lonza Ag
US3996228A (en) * 1973-12-21 1976-12-07 Societa' Farmaceutici Italia S.P.A. Pyrimidinoaminoethyl ergoline derivatives
NL7416120A (nl) * 1973-12-21 1975-06-24 Farmaceutici Italia Werkwijze voor het bereiden van pyrimidinoami- nomethylergolinederivaten.
IE41533B1 (en) * 1974-03-14 1980-01-30 Sandoz Ltd Thiomethyl ergolene derivatives
US4147789A (en) * 1974-03-14 1979-04-03 Sandoz Ltd. 6-Methyl-8-thiomethyl-ergolene derivatives
CS171480B1 (xx) * 1974-03-19 1976-10-29
CS177530B1 (en) * 1974-07-19 1977-07-29 Miroslav Semonsky New nbeta-substituted derivatives of b-beta-aminoethyl-ergoline-i their salts and methods for the production thereof
CH617452A5 (xx) * 1974-10-25 1980-05-30 Hoffmann La Roche
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
AU526764B2 (en) * 1978-09-08 1983-01-27 Farmitalia Carlo Erba S.P.A. Ergoline derivatives
GB2056437A (en) * 1979-08-07 1981-03-18 Erba Farmitalia Secoergoline derivatives
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity

Also Published As

Publication number Publication date
HU193527B (en) 1987-10-28
FI831406L (fi) 1983-10-31
NL191709C (nl) 1996-04-02
SE8302379L (sv) 1983-10-31
ATA156783A (de) 1987-07-15
FI831406A0 (fi) 1983-04-25
AU1402983A (en) 1983-11-03
AU553851B2 (en) 1986-07-31
JPS58194884A (ja) 1983-11-12
CA1210389A (en) 1986-08-26
GB8310843D0 (en) 1983-05-25
SE460967B (sv) 1989-12-11
IL68496A0 (en) 1983-07-31
DK189983D0 (da) 1983-04-28
IT8320807A0 (it) 1983-04-27
IE53950B1 (en) 1989-04-26
CH654305A5 (it) 1986-02-14
DK164058C (da) 1992-10-12
GB2120242A (en) 1983-11-30
SE8302379D0 (sv) 1983-04-27
GR78842B (xx) 1984-10-02
FR2526022B1 (fr) 1985-06-14
BE896609A (fr) 1983-08-16
CS236874B2 (en) 1985-05-15
US4657914A (en) 1987-04-14
IT1215630B (it) 1990-02-22
FI73996B (fi) 1987-08-31
FI73996C (fi) 1987-12-10
DK164058B (da) 1992-05-04
DK189983A (da) 1983-10-31
ZA833008B (en) 1984-01-25
DE3314878C2 (xx) 1993-09-23
FR2526022A1 (fr) 1983-11-04
NL191709B (nl) 1995-12-01
JPH0354668B2 (xx) 1991-08-20
NL8301529A (nl) 1983-11-16
AT385035B (de) 1988-02-10
DE3314878A1 (de) 1983-11-03
IE830932L (en) 1983-10-30

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Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees