CS235072B2 - Method of l-tyrosyl-d-alanyl-glycyl-l-phenylalanylamide's new derivatives production - Google Patents

Method of l-tyrosyl-d-alanyl-glycyl-l-phenylalanylamide's new derivatives production Download PDF

Info

Publication number
CS235072B2
CS235072B2 CS786285A CS628578A CS235072B2 CS 235072 B2 CS235072 B2 CS 235072B2 CS 786285 A CS786285 A CS 786285A CS 628578 A CS628578 A CS 628578A CS 235072 B2 CS235072 B2 CS 235072B2
Authority
CS
Czechoslovakia
Prior art keywords
acid
acetic acid
tyrosyl
glycyl
alanyl
Prior art date
Application number
CS786285A
Other languages
Czech (cs)
English (en)
Inventor
Edward L Smithwick
Robert C A Frederickson
Robert Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS235072B2 publication Critical patent/CS235072B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS786285A 1977-10-03 1978-09-28 Method of l-tyrosyl-d-alanyl-glycyl-l-phenylalanylamide's new derivatives production CS235072B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/838,516 US4264491A (en) 1977-10-03 1977-10-03 Analgesic compounds

Publications (1)

Publication Number Publication Date
CS235072B2 true CS235072B2 (en) 1985-04-16

Family

ID=25277291

Family Applications (1)

Application Number Title Priority Date Filing Date
CS786285A CS235072B2 (en) 1977-10-03 1978-09-28 Method of l-tyrosyl-d-alanyl-glycyl-l-phenylalanylamide's new derivatives production

Country Status (33)

Country Link
US (1) US4264491A (fi)
EP (1) EP0001684B1 (fi)
JP (1) JPS5459247A (fi)
AR (1) AR224238A1 (fi)
AT (1) AT367028B (fi)
AU (1) AU520315B2 (fi)
BE (1) BE870819A (fi)
BG (1) BG31224A3 (fi)
CA (1) CA1156219A (fi)
CH (1) CH635571A5 (fi)
CS (1) CS235072B2 (fi)
DD (1) DD139710A5 (fi)
DE (1) DE2861019D1 (fi)
DK (1) DK149231C (fi)
EG (1) EG13636A (fi)
ES (1) ES473925A1 (fi)
FI (1) FI66842C (fi)
FR (1) FR2404629B1 (fi)
GB (1) GB2005688B (fi)
GR (1) GR71651B (fi)
HU (1) HU182866B (fi)
IE (1) IE47378B1 (fi)
IL (1) IL55650A (fi)
IT (1) IT1100839B (fi)
LU (1) LU80316A1 (fi)
NZ (1) NZ188521A (fi)
PH (1) PH14660A (fi)
PL (1) PL114271B1 (fi)
PT (1) PT68598A (fi)
RO (1) RO76176A (fi)
SU (1) SU908246A3 (fi)
YU (1) YU231578A (fi)
ZA (1) ZA785564B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2702711A1 (de) 1976-02-02 1977-08-04 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
US4331593A (en) * 1977-10-03 1982-05-25 Smithwick Jr Edward L Analgesic compounds
US4265808A (en) * 1979-12-17 1981-05-05 Eli Lilly And Company Pharmacologically active peptides
US4283330A (en) * 1979-12-17 1981-08-11 Eli Lilly And Company Pharmacologically active peptides
US4333873A (en) 1979-12-17 1982-06-08 Eli Lilly And Company Pharmacologically active peptides
JPS5692846A (en) * 1979-12-27 1981-07-27 Takeda Chem Ind Ltd Tetrapeptide derivative and its preparation
FR2488253A1 (fr) * 1980-08-08 1982-02-12 Roques Bernard Nouveaux peptides et leur application en therapeutique
JPS5738756A (en) * 1980-08-18 1982-03-03 Earth Chem Corp Ltd Tripeptide alkylamide derivative
JPS5785349A (en) * 1980-11-14 1982-05-28 Earth Chem Corp Ltd Tripeptide alkylamide derivative
US4322340A (en) * 1980-10-20 1982-03-30 Eli Lilly And Company Pharmacologically active peptides
JPS5772950A (en) * 1980-10-24 1982-05-07 Takeda Chem Ind Ltd Tetrapeptide derivative, its preparation and analgesic agent
EP0076557B1 (en) * 1981-06-22 1985-11-13 Imperial Chemical Industries Plc Peptides and pseudopeptides in which the n terminus bears two substituents
US4448717A (en) * 1982-11-12 1984-05-15 Eli Lilly And Company Pharmacologically active peptides
US4495178A (en) * 1983-10-06 1985-01-22 G. D. Searle & Co. Enkephalin analogs

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1042487A (en) * 1964-06-25 1966-09-14 Ici Ltd Polypeptide derivatives
IL51332A (en) * 1976-01-26 1980-09-16 Wellcome Found Peptides having a morphine-like effect, their preparation and pharmalceutical compositions containing them
GB1532181A (en) * 1976-02-02 1978-11-15 Beckman Instruments Inc Pentapetides and a method of preparing them
DE2702711A1 (de) * 1976-02-02 1977-08-04 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
US4028319A (en) * 1976-05-07 1977-06-07 G. D. Searle & Co. 2 and 3-substituted enkephalins
FR2359817A1 (fr) * 1976-07-27 1978-02-24 Reckitt & Colmann Prod Ltd Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant
DE2732451A1 (de) * 1976-07-27 1978-02-02 Reckitt & Colmann Prod Ltd Peptidverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate
US4259234A (en) * 1976-09-27 1981-03-31 Eli Lilly And Company Analgesic compounds

Also Published As

Publication number Publication date
HU182866B (en) 1984-03-28
AT367028B (de) 1982-05-25
SU908246A3 (ru) 1982-02-23
LU80316A1 (fr) 1979-03-16
EP0001684A3 (en) 1979-06-27
GB2005688A (en) 1979-04-25
DD139710A5 (de) 1980-01-16
IT7828359A0 (it) 1978-10-02
GB2005688B (en) 1982-02-24
RO76176A (ro) 1981-11-04
US4264491A (en) 1981-04-28
PH14660A (en) 1981-10-20
FI782971A (fi) 1979-04-04
DK149231B (da) 1986-03-24
CH635571A5 (fr) 1983-04-15
EG13636A (en) 1982-03-31
DK434778A (da) 1979-04-04
FR2404629A1 (fr) 1979-04-27
BG31224A3 (en) 1981-11-16
IL55650A (en) 1982-02-28
BE870819A (fr) 1979-03-28
EP0001684B1 (en) 1981-09-02
EP0001684A2 (en) 1979-05-02
YU231578A (en) 1982-10-31
FI66842C (fi) 1984-12-10
PL114271B1 (en) 1981-01-31
PT68598A (en) 1978-10-01
DE2861019D1 (en) 1981-11-26
ATA708778A (de) 1981-10-15
IT1100839B (it) 1985-09-28
IE47378B1 (en) 1984-03-07
ES473925A1 (es) 1980-01-16
DK149231C (da) 1986-08-18
FI66842B (fi) 1984-08-31
CA1156219A (en) 1983-11-01
IE781926L (en) 1979-04-03
NZ188521A (en) 1981-07-13
FR2404629B1 (fr) 1985-12-27
AR224238A1 (es) 1981-11-13
GR71651B (fi) 1983-06-20
ZA785564B (en) 1980-05-28
PL210045A1 (pl) 1979-06-18
AU520315B2 (en) 1982-01-28
AU4024778A (en) 1980-04-03
JPS5459247A (en) 1979-05-12

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