CS231199B2 - Processing method of derivative of 6alpha-methylhydrokortisone - Google Patents

Processing method of derivative of 6alpha-methylhydrokortisone Download PDF

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Publication number
CS231199B2
CS231199B2 CS819720A CS972081A CS231199B2 CS 231199 B2 CS231199 B2 CS 231199B2 CS 819720 A CS819720 A CS 819720A CS 972081 A CS972081 A CS 972081A CS 231199 B2 CS231199 B2 CS 231199B2
Authority
CS
Czechoslovakia
Prior art keywords
radical
derivative
alpha
6alpha
formula
Prior art date
Application number
CS819720A
Other languages
Czech (cs)
English (en)
Other versions
CS231188B2 (en
CS8109720A2 (en
CS231197B2 (en
CS231200B2 (en
CS231198B2 (en
Inventor
Klaus Annen
Karl Petzoldt
Henry Laurent
Rudolf Wiechert
Helmut Hofmeister
Hans Wendt
Manfred Albring
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CS8109720A2 publication Critical patent/CS8109720A2/cs
Publication of CS231188B2 publication Critical patent/CS231188B2/cs
Publication of CS231197B2 publication Critical patent/CS231197B2/cs
Publication of CS231200B2 publication Critical patent/CS231200B2/cs
Publication of CS231198B2 publication Critical patent/CS231198B2/cs
Publication of CS231199B2 publication Critical patent/CS231199B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Lubricants (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
CS819720A 1980-12-23 1981-12-23 Processing method of derivative of 6alpha-methylhydrokortisone CS231199B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3049400 1980-12-23

Publications (6)

Publication Number Publication Date
CS8109720A2 CS8109720A2 (en) 1984-02-13
CS231188B2 CS231188B2 (en) 1984-10-15
CS231197B2 CS231197B2 (en) 1984-10-15
CS231200B2 CS231200B2 (en) 1984-10-15
CS231198B2 CS231198B2 (en) 1984-10-15
CS231199B2 true CS231199B2 (en) 1984-10-15

Family

ID=6120491

Family Applications (5)

Application Number Title Priority Date Filing Date
CS832219A CS221981A2 (en) 1980-12-23 1981-12-23 Zpusob vyroby derivatu 6alfa methylhydrokortisonu
CS832217A CS221781A2 (en) 1980-12-23 1981-12-23 Zpusob vyroby derivatu 6alfa methylhydrokortisonu
CS819720A CS231199B2 (en) 1980-12-23 1981-12-23 Processing method of derivative of 6alpha-methylhydrokortisone
CS832220A CS222081A2 (en) 1980-12-23 1981-12-23 Zpusob vyroby derivatu 6alfa methylhydrokortisonu
CS832218A CS221883A2 (en) 1980-12-23 1981-12-23 Zpusob vyroby derivatu 6alfa methylhydrokortisonu

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CS832219A CS221981A2 (en) 1980-12-23 1981-12-23 Zpusob vyroby derivatu 6alfa methylhydrokortisonu
CS832217A CS221781A2 (en) 1980-12-23 1981-12-23 Zpusob vyroby derivatu 6alfa methylhydrokortisonu

Family Applications After (2)

Application Number Title Priority Date Filing Date
CS832220A CS222081A2 (en) 1980-12-23 1981-12-23 Zpusob vyroby derivatu 6alfa methylhydrokortisonu
CS832218A CS221883A2 (en) 1980-12-23 1981-12-23 Zpusob vyroby derivatu 6alfa methylhydrokortisonu

Country Status (26)

Country Link
US (1) US4912098A (pl)
EP (1) EP0054786B1 (pl)
JP (1) JPS57167999A (pl)
AT (1) ATE12237T1 (pl)
AU (1) AU548999B2 (pl)
BG (2) BG38337A3 (pl)
CA (1) CA1185234A (pl)
CS (5) CS221981A2 (pl)
DD (2) DD208812A5 (pl)
DE (1) DE3169460D1 (pl)
DK (1) DK159324C (pl)
ES (3) ES8307896A1 (pl)
FI (1) FI72729C (pl)
GB (1) GB2089809B (pl)
GR (1) GR76975B (pl)
HU (1) HU186460B (pl)
IE (1) IE52511B1 (pl)
IL (1) IL64614A (pl)
NO (1) NO156409C (pl)
PH (1) PH17637A (pl)
PL (5) PL130894B1 (pl)
PT (1) PT74183B (pl)
RO (1) RO83669B (pl)
SU (2) SU1255053A3 (pl)
YU (5) YU293181A (pl)
ZA (1) ZA818907B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3133081A1 (de) * 1981-08-18 1983-03-10 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue 6(alpha)-methylprednisolon-derivate, ihre herstellung und verwendung
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
DE3243482A1 (de) * 1982-11-22 1984-05-24 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6(alpha)-methylkortikoide, ihre herstellung und verwendung
DE3427486A1 (de) * 1984-07-23 1986-01-30 Schering AG, Berlin und Bergkamen, 1000 Berlin Verfahren zur herstellung von 6(alpha)-methylsteroiden
CN102401624B (zh) * 2010-09-10 2014-07-16 珠海格力电器股份有限公司 步进电机行程位置检测装置及检测控制方法
CN102964414A (zh) * 2012-12-14 2013-03-13 中国科学院上海有机化学研究所 17位甾体羧酸酯的合成方法
EP3006453A1 (en) * 2014-10-08 2016-04-13 Cosmo Technologies Ltd. 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3141876A (en) * 1956-08-02 1964-07-21 Upjohn Co 3-keto-6-methyl-4-pregnene-3, 20-diones and a method for the production thereof
US3176032A (en) * 1958-04-18 1965-03-30 Syntex Corp 17alpha, 21-diacyloxy derivatives of 6alpha-methyl-delta1, 4-pregnadien-3, 20-dione and of 6alpha-methyl-delta4-pregnen-3, 20-dione
JPS6040439B2 (ja) * 1978-03-29 1985-09-11 大正製薬株式会社 ヒドロコルチゾン誘導体
DE2848423A1 (de) * 1978-11-08 1980-05-29 Merck Patent Gmbh Hydrocortisonester, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0054786B1 (de) 1985-03-20
CS222081A2 (en) 1984-02-13
GR76975B (pl) 1984-09-04
GB2089809A (en) 1982-06-30
ES510339A0 (es) 1983-02-01
CS231188B2 (en) 1984-10-15
PL238738A1 (en) 1983-05-09
IE52511B1 (en) 1987-11-25
ES508325A0 (es) 1983-08-01
JPS57167999A (en) 1982-10-16
ES8302027A1 (es) 1983-02-01
PL130894B1 (en) 1984-09-29
AU7854981A (en) 1982-07-01
DD202580A5 (de) 1983-09-21
ES521498A0 (es) 1984-01-16
SU1255053A3 (ru) 1986-08-30
PL238741A1 (en) 1983-05-09
CS8109720A2 (en) 1984-02-13
US4912098A (en) 1990-03-27
ES8307896A1 (es) 1983-08-01
PL238739A1 (en) 1983-05-09
YU103183A (en) 1983-10-31
HU186460B (en) 1985-08-28
CS231197B2 (en) 1984-10-15
PH17637A (en) 1984-10-18
FI814126L (fi) 1982-06-24
GB2089809B (en) 1984-09-26
CS221883A2 (en) 1984-02-13
NO814394L (no) 1982-06-24
CS221781A2 (en) 1984-02-13
PT74183B (de) 1983-05-18
RO83669A (ro) 1984-06-21
BG38338A3 (en) 1985-11-15
YU103283A (en) 1983-10-31
PL130895B1 (en) 1984-09-29
NO156409B (no) 1987-06-09
RO83669B (ro) 1984-08-30
DE3169460D1 (en) 1985-04-25
FI72729C (fi) 1987-07-10
DK159324B (da) 1990-10-01
CS221981A2 (en) 1984-02-13
PL234367A1 (en) 1983-02-28
ES8401988A1 (es) 1984-01-16
DK159324C (da) 1991-02-25
IL64614A0 (en) 1982-03-31
AU548999B2 (en) 1986-01-09
CS231200B2 (en) 1984-10-15
IL64614A (en) 1985-06-30
CS231198B2 (en) 1984-10-15
FI72729B (fi) 1987-03-31
JPH0257559B2 (pl) 1990-12-05
BG38337A3 (en) 1985-11-15
CA1185234A (en) 1985-04-09
ZA818907B (en) 1982-11-24
DD208812A5 (de) 1984-04-11
YU102083A (en) 1983-10-31
ATE12237T1 (de) 1985-04-15
NO156409C (no) 1987-09-30
EP0054786A1 (de) 1982-06-30
PT74183A (de) 1982-01-01
SU1245264A3 (ru) 1986-07-15
DK571981A (da) 1982-06-24
PL238740A1 (en) 1983-05-09
YU293181A (en) 1983-10-31
YU103383A (en) 1983-12-31

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