CS227791A3 - Mutant of clostridium histolyticum bacterium, process of its obtaining and its application for the production of collagenase without clostripain - Google Patents

Mutant of clostridium histolyticum bacterium, process of its obtaining and its application for the production of collagenase without clostripain Download PDF

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Publication number
CS227791A3
CS227791A3 CS912277A CS227791A CS227791A3 CS 227791 A3 CS227791 A3 CS 227791A3 CS 912277 A CS912277 A CS 912277A CS 227791 A CS227791 A CS 227791A CS 227791 A3 CS227791 A3 CS 227791A3
Authority
CS
Czechoslovakia
Prior art keywords
collagenase
clostripain
mutant
clostridium
clostridium histolyticum
Prior art date
Application number
CS912277A
Other languages
Czech (cs)
English (en)
Inventor
Milan Holjevac
C Ivan Udovici
Sonja Cizmek
Vlasta Sojak-Derkos
Stjepan Gamulin
C Vladimir Deli
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Publication of CS227791A3 publication Critical patent/CS227791A3/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145—Clostridium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/842—Clostridium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CS912277A 1990-07-23 1991-07-22 Mutant of clostridium histolyticum bacterium, process of its obtaining and its application for the production of collagenase without clostripain CS227791A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU144090 1990-07-23

Publications (1)

Publication Number Publication Date
CS227791A3 true CS227791A3 (en) 1992-03-18

Family

ID=25554178

Family Applications (1)

Application Number Title Priority Date Filing Date
CS912277A CS227791A3 (en) 1990-07-23 1991-07-22 Mutant of clostridium histolyticum bacterium, process of its obtaining and its application for the production of collagenase without clostripain

Country Status (10)

Country Link
US (1) US5252481A (hu)
EP (1) EP0468411B1 (hu)
JP (1) JPH05219942A (hu)
AT (1) ATE130867T1 (hu)
BG (1) BG94868A (hu)
CA (1) CA2047306A1 (hu)
CS (1) CS227791A3 (hu)
DE (1) DE69114935T2 (hu)
HU (1) HU912453D0 (hu)
PL (1) PL291186A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332503A (en) * 1993-04-16 1994-07-26 Baxter International Inc. Process for purifying collagenase
DE19521829A1 (de) * 1995-06-16 1996-12-19 Knoll Ag Neue Verwendung von Collagenase
KR100246820B1 (ko) * 1997-12-30 2000-03-15 정수련 신균주 트리고높시스 배리아빌리스에 의한 에리쓰리톨의 제조방법
US6001616A (en) * 1998-09-16 1999-12-14 Dong Cheon Consulting Co., Ltd. Process for preparing erythritol using novel cell of pichia
US7811560B2 (en) * 2006-01-30 2010-10-12 Auxilium Us Holdings, Llc Compositions and methods for treating collagen-mediated diseases
US8323642B2 (en) * 2006-12-13 2012-12-04 Depuy Mitek, Inc. Tissue fusion method using collagenase for repair of soft tissue
EP2130551B1 (en) 2008-06-02 2012-06-06 Roche Diagnostics GmbH Improved purification of collagenases from clostridium histolyticum liquid culture
WO2012125948A1 (en) * 2011-03-16 2012-09-20 Biospecifics Technologies Corp. Compositions and methods for producing clostridial collagenases
ES2904884T3 (es) 2012-01-12 2022-04-06 Endo Global Ventures Enzima del clostridium histolyticum
DK2968484T3 (da) 2013-03-15 2021-02-22 Biospecifics Tech Corporation Behandlingsfremgangsmåde og produkt til uterus fibromer, som anvender oprenset kollagenase
CN103751102A (zh) 2014-01-15 2014-04-30 上海交通大学 一种胶原酶温敏水凝胶及其制备方法和应用
KR102610801B1 (ko) 2017-03-01 2023-12-05 엔도 벤쳐즈 리미티드 셀룰라이트를 평가하고 치료하기 위한 장치 및 방법
CN110741085A (zh) 2017-03-28 2020-01-31 恩多风投有限公司 生产胶原酶的改进方法
CZ308157B6 (cs) * 2017-09-13 2020-01-29 MB PHARMA s.r.o. Kmen bakterie Clostridium histolyticum, kolagenáza připravená s použitím tohoto kmene a její použití
EP4045078A1 (en) 2019-10-15 2022-08-24 The Johns Hopkins University Treatment of uterine fibroids using purified collagenase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3201325A (en) * 1963-02-15 1965-08-17 Miles Lab Process for the recovery of collagenase
US3821364A (en) * 1966-07-08 1974-06-28 Advance Biofactures Corp Process of producing collagenase
US3705083A (en) * 1966-07-08 1972-12-05 Agricultural Biolog Corp Process for producing collagenase
US3677900A (en) * 1970-05-04 1972-07-18 Univ Lehigh Method of producing collagenase with a species of vibrio
FR2474052B1 (fr) * 1980-01-21 1984-04-20 Agronomique Inst Nat Rech Nouvelle collagenase, procede d'obtention et applications

Also Published As

Publication number Publication date
US5252481A (en) 1993-10-12
EP0468411A2 (en) 1992-01-29
CA2047306A1 (en) 1992-01-24
BG94868A (bg) 1993-12-24
EP0468411B1 (en) 1995-11-29
EP0468411A3 (en) 1992-09-23
HU912453D0 (en) 1991-12-30
ATE130867T1 (de) 1995-12-15
DE69114935T2 (de) 1996-05-30
DE69114935D1 (de) 1996-01-11
PL291186A1 (en) 1992-11-02
JPH05219942A (ja) 1993-08-31

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