BG94868A - Мутант на бактерията сlоsтrifiuм нisтоlyтiсuм, метод за получаването му и използуването му за производство на свободна от клострипаин колагеназа - Google Patents

Мутант на бактерията сlоsтrifiuм нisтоlyтiсuм, метод за получаването му и използуването му за производство на свободна от клострипаин колагеназа

Info

Publication number
BG94868A
BG94868A BG094868A BG9486891A BG94868A BG 94868 A BG94868 A BG 94868A BG 094868 A BG094868 A BG 094868A BG 9486891 A BG9486891 A BG 9486891A BG 94868 A BG94868 A BG 94868A
Authority
BG
Bulgaria
Prior art keywords
nistolyticum
clostrifium
clostripain
mutant
bacteria
Prior art date
Application number
BG094868A
Other languages
English (en)
Inventor
Milan Holjevac
Ivan Udovicic
Sonja Cizmek
Vlasta Sojak-Derkos
Stjepan Gamulin
Vladimir Delic
Original Assignee
Pliva Farmaceutska, Kemijska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Farmaceutska, Kemijska filed Critical Pliva Farmaceutska, Kemijska
Publication of BG94868A publication Critical patent/BG94868A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145—Clostridium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/842—Clostridium

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BG094868A 1990-07-23 1991-07-22 Мутант на бактерията сlоsтrifiuм нisтоlyтiсuм, метод за получаването му и използуването му за производство на свободна от клострипаин колагеназа BG94868A (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU144090 1990-07-23

Publications (1)

Publication Number Publication Date
BG94868A true BG94868A (bg) 1993-12-24

Family

ID=25554178

Family Applications (1)

Application Number Title Priority Date Filing Date
BG094868A BG94868A (bg) 1990-07-23 1991-07-22 Мутант на бактерията сlоsтrifiuм нisтоlyтiсuм, метод за получаването му и използуването му за производство на свободна от клострипаин колагеназа

Country Status (10)

Country Link
US (1) US5252481A (bg)
EP (1) EP0468411B1 (bg)
JP (1) JPH05219942A (bg)
AT (1) ATE130867T1 (bg)
BG (1) BG94868A (bg)
CA (1) CA2047306A1 (bg)
CS (1) CS227791A3 (bg)
DE (1) DE69114935T2 (bg)
HU (1) HU912453D0 (bg)
PL (1) PL291186A1 (bg)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332503A (en) * 1993-04-16 1994-07-26 Baxter International Inc. Process for purifying collagenase
DE19521829A1 (de) * 1995-06-16 1996-12-19 Knoll Ag Neue Verwendung von Collagenase
KR100246820B1 (ko) * 1997-12-30 2000-03-15 정수련 신균주 트리고높시스 배리아빌리스에 의한 에리쓰리톨의 제조방법
US6001616A (en) * 1998-09-16 1999-12-14 Dong Cheon Consulting Co., Ltd. Process for preparing erythritol using novel cell of pichia
US7811560B2 (en) * 2006-01-30 2010-10-12 Auxilium Us Holdings, Llc Compositions and methods for treating collagen-mediated diseases
US8323642B2 (en) * 2006-12-13 2012-12-04 Depuy Mitek, Inc. Tissue fusion method using collagenase for repair of soft tissue
EP2130551B1 (en) * 2008-06-02 2012-06-06 Roche Diagnostics GmbH Improved purification of collagenases from clostridium histolyticum liquid culture
US10119131B2 (en) 2011-03-16 2018-11-06 Biospecifics Technologies Corp. Compositions and methods for producing clostridial collagenases
ES2968836T3 (es) 2012-01-12 2024-05-14 Endo Global Ventures Enzima del clostridium histolyticum
US9744138B2 (en) 2013-03-15 2017-08-29 Biospecifics Technologies Corp. Treatment method and product for uterine fibroids using purified collagenase
CN103751102A (zh) 2014-01-15 2014-04-30 上海交通大学 一种胶原酶温敏水凝胶及其制备方法和应用
IL301796A (en) 2017-03-01 2023-05-01 Endo Ventures Ltd A method for evaluating and treating cellulite
WO2018183582A2 (en) 2017-03-28 2018-10-04 Endo Ventures Limited Improved method of producing collagenase
CZ308157B6 (cs) 2017-09-13 2020-01-29 MB PHARMA s.r.o. Kmen bakterie Clostridium histolyticum, kolagenáza připravená s použitím tohoto kmene a její použití
EP4045078A1 (en) 2019-10-15 2022-08-24 The Johns Hopkins University Treatment of uterine fibroids using purified collagenase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3201325A (en) * 1963-02-15 1965-08-17 Miles Lab Process for the recovery of collagenase
US3821364A (en) * 1966-07-08 1974-06-28 Advance Biofactures Corp Process of producing collagenase
US3705083A (en) * 1966-07-08 1972-12-05 Agricultural Biolog Corp Process for producing collagenase
US3677900A (en) * 1970-05-04 1972-07-18 Univ Lehigh Method of producing collagenase with a species of vibrio
FR2474052B1 (fr) * 1980-01-21 1984-04-20 Agronomique Inst Nat Rech Nouvelle collagenase, procede d'obtention et applications

Also Published As

Publication number Publication date
EP0468411A2 (en) 1992-01-29
US5252481A (en) 1993-10-12
HU912453D0 (en) 1991-12-30
EP0468411B1 (en) 1995-11-29
PL291186A1 (en) 1992-11-02
DE69114935T2 (de) 1996-05-30
ATE130867T1 (de) 1995-12-15
EP0468411A3 (en) 1992-09-23
CS227791A3 (en) 1992-03-18
JPH05219942A (ja) 1993-08-31
DE69114935D1 (de) 1996-01-11
CA2047306A1 (en) 1992-01-24

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