DE69114935D1 - Mutanter Stamm von Clostridium histolyticum, Verfahren zu dessen Herstellung und Verwendung zur Herstellung von Clostripain-freier Kollagenase. - Google Patents

Mutanter Stamm von Clostridium histolyticum, Verfahren zu dessen Herstellung und Verwendung zur Herstellung von Clostripain-freier Kollagenase.

Info

Publication number
DE69114935D1
DE69114935D1 DE69114935T DE69114935T DE69114935D1 DE 69114935 D1 DE69114935 D1 DE 69114935D1 DE 69114935 T DE69114935 T DE 69114935T DE 69114935 T DE69114935 T DE 69114935T DE 69114935 D1 DE69114935 D1 DE 69114935D1
Authority
DE
Germany
Prior art keywords
clostripain
clostridium histolyticum
production
preparation
microbiology
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69114935T
Other languages
English (en)
Other versions
DE69114935T2 (de
Inventor
Milan Holjevac
Ivan Udovicic
Sonja Cizmek
Vlasta Sojak-Derkos
Stjepan Gamulin
Vladimir Delic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Farmaceutika dd
Original Assignee
Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd filed Critical Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Application granted granted Critical
Publication of DE69114935D1 publication Critical patent/DE69114935D1/de
Publication of DE69114935T2 publication Critical patent/DE69114935T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145—Clostridium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/842—Clostridium

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69114935T 1990-07-23 1991-07-22 Mutanter Stamm von Clostridium histolyticum, Verfahren zu dessen Herstellung und Verwendung zur Herstellung von Clostripain-freier Kollagenase. Expired - Fee Related DE69114935T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU144090 1990-07-23

Publications (2)

Publication Number Publication Date
DE69114935D1 true DE69114935D1 (de) 1996-01-11
DE69114935T2 DE69114935T2 (de) 1996-05-30

Family

ID=25554178

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69114935T Expired - Fee Related DE69114935T2 (de) 1990-07-23 1991-07-22 Mutanter Stamm von Clostridium histolyticum, Verfahren zu dessen Herstellung und Verwendung zur Herstellung von Clostripain-freier Kollagenase.

Country Status (10)

Country Link
US (1) US5252481A (de)
EP (1) EP0468411B1 (de)
JP (1) JPH05219942A (de)
AT (1) ATE130867T1 (de)
BG (1) BG94868A (de)
CA (1) CA2047306A1 (de)
CS (1) CS227791A3 (de)
DE (1) DE69114935T2 (de)
HU (1) HU912453D0 (de)
PL (1) PL291186A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332503A (en) * 1993-04-16 1994-07-26 Baxter International Inc. Process for purifying collagenase
DE19521829A1 (de) * 1995-06-16 1996-12-19 Knoll Ag Neue Verwendung von Collagenase
KR100246820B1 (ko) * 1997-12-30 2000-03-15 정수련 신균주 트리고높시스 배리아빌리스에 의한 에리쓰리톨의 제조방법
US6001616A (en) * 1998-09-16 1999-12-14 Dong Cheon Consulting Co., Ltd. Process for preparing erythritol using novel cell of pichia
US7811560B2 (en) * 2006-01-30 2010-10-12 Auxilium Us Holdings, Llc Compositions and methods for treating collagen-mediated diseases
US8323642B2 (en) * 2006-12-13 2012-12-04 Depuy Mitek, Inc. Tissue fusion method using collagenase for repair of soft tissue
EP2130551B1 (de) * 2008-06-02 2012-06-06 Roche Diagnostics GmbH Verbesserte Reinigung von Kollagenasen aus flüssiger Clostridium histolyticum-Kultur
US10119131B2 (en) 2011-03-16 2018-11-06 Biospecifics Technologies Corp. Compositions and methods for producing clostridial collagenases
ES2968836T3 (es) 2012-01-12 2024-05-14 Endo Global Ventures Enzima del clostridium histolyticum
US9744138B2 (en) 2013-03-15 2017-08-29 Biospecifics Technologies Corp. Treatment method and product for uterine fibroids using purified collagenase
CN103751102A (zh) 2014-01-15 2014-04-30 上海交通大学 一种胶原酶温敏水凝胶及其制备方法和应用
IL301796A (en) 2017-03-01 2023-05-01 Endo Ventures Ltd A method for evaluating and treating cellulite
WO2018183582A2 (en) 2017-03-28 2018-10-04 Endo Ventures Limited Improved method of producing collagenase
CZ308157B6 (cs) 2017-09-13 2020-01-29 MB PHARMA s.r.o. Kmen bakterie Clostridium histolyticum, kolagenáza připravená s použitím tohoto kmene a její použití
EP4045078A1 (de) 2019-10-15 2022-08-24 The Johns Hopkins University Behandlung von uterusfibroiden mittels gereinigter kollagenase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3201325A (en) * 1963-02-15 1965-08-17 Miles Lab Process for the recovery of collagenase
US3821364A (en) * 1966-07-08 1974-06-28 Advance Biofactures Corp Process of producing collagenase
US3705083A (en) * 1966-07-08 1972-12-05 Agricultural Biolog Corp Process for producing collagenase
US3677900A (en) * 1970-05-04 1972-07-18 Univ Lehigh Method of producing collagenase with a species of vibrio
FR2474052B1 (fr) * 1980-01-21 1984-04-20 Agronomique Inst Nat Rech Nouvelle collagenase, procede d'obtention et applications

Also Published As

Publication number Publication date
EP0468411A2 (de) 1992-01-29
US5252481A (en) 1993-10-12
HU912453D0 (en) 1991-12-30
BG94868A (bg) 1993-12-24
EP0468411B1 (de) 1995-11-29
PL291186A1 (en) 1992-11-02
DE69114935T2 (de) 1996-05-30
ATE130867T1 (de) 1995-12-15
EP0468411A3 (en) 1992-09-23
CS227791A3 (en) 1992-03-18
JPH05219942A (ja) 1993-08-31
CA2047306A1 (en) 1992-01-24

Similar Documents

Publication Publication Date Title
DE69114935D1 (de) Mutanter Stamm von Clostridium histolyticum, Verfahren zu dessen Herstellung und Verwendung zur Herstellung von Clostripain-freier Kollagenase.
MX9702389A (es) Cepa de streptococcus thermophilus, procedimiento de fermentacion usando dicha cepa y producto obtenido.
DE3777979D1 (de) Hochmolekulare homopolysaccharide, verfahren zu ihrer extrazellulaeren herstellung und zu ihrer anwendung, sowie die entsprechenden pilzstaemme.
BG60274B2 (en) Microbial process for the production of immunosuppressive antibiotics
AU654488B2 (en) Proteinaceous compositions from filamentous microorganisms, the branching of which is regulated by calcium ion concentration
Schloe et al. Polyphasic characterization of poly-3-hydroxybutyrate-co-3-hydroxyvalerate (P (HB-co-HV)) metabolizing and denitrifying Acidovorax sp. strains
EP0434393A2 (de) Verfahren zur Herstellung von R-(-)-3-Halogeno-1,2-propandiol durch Behandlung mit Mikroorganismen
DE3876737D1 (de) Enzymsystem, sein herstellungsverfahren und seine verwendung, insbesondere bei der herstellung von d-parahydroxyphenylglycin.
ES521943A0 (es) Un procedimiento de produccion de glucosa deshidrogenasa.
EP0320398A3 (de) Züchtung eines Mikroorganismus der Gattung Klebsiella, Verfahren zur Herstellung einer Mischung von Kohlehydraten mit einem hohen Gehalt an Rhamnose unter Verwendung dieser Züchtung
YU47646B (sh) Ekstracelularni egzopolimer i postupak za njegovu izradu
US4416987A (en) Method of synthesizing proteins from methanol
JPS5682099A (en) Production of glutathion
Duménil et al. Production of vitamin B12 by gram-variable methanol-utilizing bacteria
KR100205797B1 (ko) 글루탐산을 생산하는 미생물 및 이를 이용한 글루탐산의 제조방법
RU1806191C (ru) Штамм бактерий MIcRococcUS SpecIeS - продуцент рестриктазы MSp 20 I
RO114150B1 (ro) Procedeu de obţinere a unui complex proteazo-amilazic cu culturi selecţionate de bacillus sp
ES2094695A1 (es) Nueva cepa de haloferax gibbonsii, halocina h7 producida por ella y procedimiento de obtencion de ambas.
ATE389723T1 (de) Verfahren für die produktion von l-threonin mittels fermentation
RU2073717C1 (ru) Штамм бактерий bacillus schlegelii - продуцент эндонуклеазы рестрикции, узнающей и расщепляющей последовательность нуклеотидов 5' - ccnnnnnnn gg-3'
KR100262381B1 (ko) 감마-폴리글루타메이트 가수분해 효소(감마-polyglutamatehydrolase) 및 그 제조방법
KR880011324A (ko) 신규한 미생물 및 이를 사용하여 글루탐산을 제조하는 방법
JPS56148289A (en) Preparation of heat-resistant polynucleotide phosphorylase
JPS6485076A (en) Production of heat-resistant pullulanase
KR960023038A (ko) 코프로폴피린III(Coproporphyrin III)를 생산하는 미생물 및 이를 이용한 코프로폴피린 III의 제조방법

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee