JPS5682099A - Production of glutathion - Google Patents

Production of glutathion

Info

Publication number
JPS5682099A
JPS5682099A JP15945279A JP15945279A JPS5682099A JP S5682099 A JPS5682099 A JP S5682099A JP 15945279 A JP15945279 A JP 15945279A JP 15945279 A JP15945279 A JP 15945279A JP S5682099 A JPS5682099 A JP S5682099A
Authority
JP
Japan
Prior art keywords
methylglyoxal
glutathion
resistant strain
cultured
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15945279A
Other languages
Japanese (ja)
Other versions
JPS6041599B2 (en
Inventor
Ichiro Senhata
Joji Kato
Kosaku Murata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP15945279A priority Critical patent/JPS6041599B2/en
Publication of JPS5682099A publication Critical patent/JPS5682099A/en
Publication of JPS6041599B2 publication Critical patent/JPS6041599B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: A methylglyoxal-resistant strain belonging to Escherichia coli and being capable of producing glutathion is cultured in a medium to accumulate glutathion, which is collected in high yield.
CONSTITUTION: An above-cited methylglyoxal-resistant strain, e.g., a methylglyoxal-resistant strain (FERM-5279) derived from Escherichia coli B wild strain (ATCC 23226), is cultured in a medium containing 0.2W10% of glucose as a carbon source and 0.5W1% of ammonium sulfate as a nitrogen source. Methylglyoxal is added to the medium by about 0.7W0.4mM and the methylglyoxal resistant strain is inoculated and cultured at 25W35°C and 6W7.5pH under aerobic conditions to accumulate glutathion. After cultivation, the bacterial cells are removed from the culture medium by filtration or the like and the filtrate is subjected to a well-known separation process such as treatment with ionexchange resin to collect glutathion.
COPYRIGHT: (C)1981,JPO&Japio
JP15945279A 1979-12-07 1979-12-07 How to make glutathione Expired JPS6041599B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15945279A JPS6041599B2 (en) 1979-12-07 1979-12-07 How to make glutathione

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15945279A JPS6041599B2 (en) 1979-12-07 1979-12-07 How to make glutathione

Publications (2)

Publication Number Publication Date
JPS5682099A true JPS5682099A (en) 1981-07-04
JPS6041599B2 JPS6041599B2 (en) 1985-09-18

Family

ID=15694061

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15945279A Expired JPS6041599B2 (en) 1979-12-07 1979-12-07 How to make glutathione

Country Status (1)

Country Link
JP (1) JPS6041599B2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071485A2 (en) * 1981-07-30 1983-02-09 Akira Kimura Novel microorganisms derived from microorganisms of the genus Escherichia by mutation and their use in the preparation of glutathione
EP0071486A2 (en) * 1981-07-30 1983-02-09 Akira Kimura Novel microorganisms of the genus Eschericia, hybrid DNA for use in their production and the use of the microorganisms in the preparation of glutathione
JPS60160894A (en) * 1984-01-30 1985-08-22 Ajinomoto Co Inc Preparation of gluthathione
KR20210105194A (en) * 2020-02-18 2021-08-26 주식회사 피코엔텍 Saccharomyces cerevisiae Kwon P-1,2,3 which produce Aldehyde dehydrogenase and Glutathione

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071485A2 (en) * 1981-07-30 1983-02-09 Akira Kimura Novel microorganisms derived from microorganisms of the genus Escherichia by mutation and their use in the preparation of glutathione
EP0071486A2 (en) * 1981-07-30 1983-02-09 Akira Kimura Novel microorganisms of the genus Eschericia, hybrid DNA for use in their production and the use of the microorganisms in the preparation of glutathione
US4596775A (en) * 1981-07-30 1986-06-24 Akira Kimura Microorganism and its use for the preparation of glutathione
US4598046A (en) * 1981-07-30 1986-07-01 Akira Kimura Mutant strain of Escherichia coli and its use for the preparation of glutathione
JPS60160894A (en) * 1984-01-30 1985-08-22 Ajinomoto Co Inc Preparation of gluthathione
JPH0424994B2 (en) * 1984-01-30 1992-04-28 Ajinomoto Kk
KR20210105194A (en) * 2020-02-18 2021-08-26 주식회사 피코엔텍 Saccharomyces cerevisiae Kwon P-1,2,3 which produce Aldehyde dehydrogenase and Glutathione
WO2021167279A1 (en) * 2020-02-18 2021-08-26 Pico Entech Co., Ltd. Saccharomyces cerevisiae kwon p-1, 2, 3 which produce aldehyde dehydrogenase and glutathione
KR20220150232A (en) * 2020-02-18 2022-11-10 주식회사 피코엔텍 Saccharomyces cerevisiae Kwon P-1,2,3 which produce Aldehyde dehydrogenase and Glutathione

Also Published As

Publication number Publication date
JPS6041599B2 (en) 1985-09-18

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