CS214712B2 - Method of making the 6beta,7beta/+s/ 15, 16-dimethylen-1,4-androstadien-3-ons - Google Patents

Method of making the 6beta,7beta/+s/ 15, 16-dimethylen-1,4-androstadien-3-ons Download PDF

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Publication number
CS214712B2
CS214712B2 CS803714A CS371480A CS214712B2 CS 214712 B2 CS214712 B2 CS 214712B2 CS 803714 A CS803714 A CS 803714A CS 371480 A CS371480 A CS 371480A CS 214712 B2 CS214712 B2 CS 214712B2
Authority
CS
Czechoslovakia
Prior art keywords
dimethylen
androstadien
6beta
7beta
ons
Prior art date
Application number
CS803714A
Other languages
Czech (cs)
English (en)
Inventor
Rudolf Wiechert
Dieter Bittler
Ulrich Kerb
Klaus Prezewowsky
Jorge Casals-Stenzel
Wolfgang Losert
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CS214712B2 publication Critical patent/CS214712B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Control Of High-Frequency Heating Circuits (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
CS803714A 1979-05-31 1980-05-27 Method of making the 6beta,7beta/+s/ 15, 16-dimethylen-1,4-androstadien-3-ons CS214712B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792922500 DE2922500A1 (de) 1979-05-31 1979-05-31 6 beta .7 beta

Publications (1)

Publication Number Publication Date
CS214712B2 true CS214712B2 (en) 1982-05-28

Family

ID=6072347

Family Applications (1)

Application Number Title Priority Date Filing Date
CS803714A CS214712B2 (en) 1979-05-31 1980-05-27 Method of making the 6beta,7beta/+s/ 15, 16-dimethylen-1,4-androstadien-3-ons

Country Status (16)

Country Link
US (1) US4291029A (es)
EP (1) EP0019690B1 (es)
JP (1) JPS55162799A (es)
AT (1) ATE880T1 (es)
AU (1) AU531057B2 (es)
CA (1) CA1134814A (es)
CS (1) CS214712B2 (es)
DD (1) DD151172A5 (es)
DE (2) DE2922500A1 (es)
DK (1) DK145140C (es)
ES (1) ES8101082A1 (es)
HU (2) HU187419B (es)
IE (1) IE49899B1 (es)
IL (1) IL60185A (es)
SU (1) SU873890A3 (es)
YU (1) YU41926B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
DE3213962A1 (de) * 1982-04-13 1983-10-13 Schering AG, 1000 Berlin und 4709 Bergkamen 1(alpha).2(alpha);6(beta).7(beta).15(beta).16(beta)-trimethylen-3-oxo-17(alpha)-pregn-4-en-21.17-carbolacton, dessen herstellung und verwendung als arzneimittel
DE3222265A1 (de) * 1982-06-09 1983-12-15 Schering AG, 1000 Berlin und 4709 Bergkamen 6ss.7ss-methylen-17(alpha)-pregn-4-en-21.17-carbolactone, verfahren zu ihrer herstellung und verwendung als arzneimittel
JPS5921698A (ja) * 1982-07-22 1984-02-03 シエ−リング・アクチエンゲゼルシヤフト １７α−プレグネ−４−エン−３−オキソ−２１−カルボン酸エステル、その製法およびこれを含有する抗アンドロゲン作用を有する医薬
DE3227598A1 (de) * 1982-07-22 1984-01-26 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-acylthio-15.16-methylen-3-oxo-17(alpha)-pregna-1.4-dien-21,17-carbolactone, verfahren zu ihrer herstellung und verwendung als arzneimittel
DE3240510A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 7(alpha)-acylthio-1(alpha),2(alpha)-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, deren herstellung und diese enthaltende arzneimittel
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
DE3326013A1 (de) * 1983-07-15 1985-01-24 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-methylen-17(alpha)-pregna-4,6-dien-21-carbonsaeuresalze, diese enthaltende pharmazeutische praeparate sowie verfahren zu deren herstellung
EP0134529B1 (de) * 1983-08-17 1990-03-21 Schering Aktiengesellschaft 7-alpha-Substituierte 3-Oxo-17alpha-pregn-4-en-21.17-carbolactone, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE3410880A1 (de) * 1984-03-21 1985-10-03 Schering AG, Berlin und Bergkamen, 1000 Berlin 17-substituierte estradiene und estratriene
FR2697328A1 (fr) * 1992-10-23 1994-04-29 Giat Ind Sa Munition fumigène.
US6787531B1 (en) * 1999-08-31 2004-09-07 Schering Ag Pharmaceutical composition for use as a contraceptive
US20020132801A1 (en) * 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
DE102007027637A1 (de) 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17ß-Cyano-19-nor-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007027636A1 (de) * 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17ß-Cyano-18a-homo-19-nor-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007027635A1 (de) 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17ß-Cyano-19-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063501A1 (de) 2007-12-29 2009-07-02 Bayer Schering Pharma Aktiengesellschaft 15, 16-Methylen-17-hydroxy-19-nor-21-carbonsäure-Steroid y-Lacton-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063499A1 (de) 2007-12-29 2009-07-02 Bayer Schering Pharma Aktiengesellschaft Steroid-17,17-Lactol-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063503A1 (de) 2007-12-29 2009-07-02 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-19-nor-21-carbonsäure-Steroid y-Lacton-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063495A1 (de) 2007-12-29 2009-09-17 Bayer Schering Pharma Aktiengesellschaft 19-Nor-Steroidderivate mit einer 15α,16α-Methylengruppe und einem gesättigten 17,17-Spirolactonring, deren Verwendung sowie diese Derivate enthaltende Arzneimittel
DE102007063496A1 (de) 2007-12-29 2009-07-02 Bayer Schering Pharma Aktiengesellschaft 15,16-Methylen-17-(1'-propenyl)-17-3'-oxidoestra-4-en-3-on-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063500A1 (de) 2007-12-29 2009-07-02 Bayer Schering Pharma Aktiengesellschaft 17-(1'-Propenyl)-17-3'-oxidoestra-4-en-3-on-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007063498A1 (de) 2007-12-29 2009-07-02 Bayer Schering Pharma Aktiengesellschaft 15,16-Methylen-steroid-17,17-Lactol-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102008026793A1 (de) 2008-06-02 2009-12-03 Bayer Schering Pharma Aktiengesellschaft C-Ring-substituierte Pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate
IN2014CN03307A (es) 2011-11-04 2015-07-03 Bayer Pharma AG
WO2016063269A1 (en) 2014-10-20 2016-04-28 Prendergast Patrick T Use of antagonists to the nuclear steroid receptor alone or in combination as direct antiviral agents to inhibit alphavirus, togaviridae, arenaviridae, filoviridae, bunyaviridae, flaviviridae and rhabdoviridae

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3254074A (en) * 1962-04-25 1966-05-31 Merck & Co Inc Spiroxenones
DE2264189C3 (de) * 1972-12-29 1979-05-31 Merck & Co., Inc., Rahway, N.J. (V.St.A.) 3'-(3-Oxo-17beta-hydroxy-6,7-methylen-androst-4en-bzw.-l,4-dien-17 a-yl) -propionsäureverbindungen, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
ES469510A1 (es) * 1977-05-16 1978-12-01 Schering Ag Procedimiento para la preparacion de 17beta hidroxi-4-an- drosten-3-onas.

Also Published As

Publication number Publication date
US4291029A (en) 1981-09-22
SU873890A3 (ru) 1981-10-15
IE49899B1 (en) 1986-01-08
DK145140C (da) 1983-02-21
CA1134814A (en) 1982-11-02
ES491916A0 (es) 1980-12-16
IE801127L (en) 1980-11-30
JPH0214360B2 (es) 1990-04-06
DE3060297D1 (en) 1982-06-03
AU531057B2 (en) 1983-08-11
YU41926B (en) 1988-02-29
DE2922500A1 (de) 1980-12-04
HU187419B (en) 1986-01-28
DK234780A (da) 1980-12-01
EP0019690B1 (de) 1982-04-21
IL60185A (en) 1983-06-15
ATE880T1 (de) 1982-05-15
JPS55162799A (en) 1980-12-18
DD151172A5 (de) 1981-10-08
HU181714B (en) 1983-11-28
ES8101082A1 (es) 1980-12-16
AU5874580A (en) 1980-12-04
IL60185A0 (en) 1980-07-31
YU132980A (en) 1983-02-28
EP0019690A1 (de) 1980-12-10
DK145140B (da) 1982-09-13

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