CS207798B2 - Method of making the derivatives of the 1,2-dihydrochinoline-2-on - Google Patents

Method of making the derivatives of the 1,2-dihydrochinoline-2-on Download PDF

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Publication number
CS207798B2
CS207798B2 CS794286A CS428679A CS207798B2 CS 207798 B2 CS207798 B2 CS 207798B2 CS 794286 A CS794286 A CS 794286A CS 428679 A CS428679 A CS 428679A CS 207798 B2 CS207798 B2 CS 207798B2
Authority
CS
Czechoslovakia
Prior art keywords
dihydroquinoline
oxo
piperazin
methyl
hydrogen
Prior art date
Application number
CS794286A
Other languages
Czech (cs)
English (en)
Inventor
Werner Winter
Walter-Gunar Friebe
Wolfgang Kampe
Androniki Roosch
Otto-Henning Wilhelms
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of CS207798B2 publication Critical patent/CS207798B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
CS794286A 1978-06-23 1979-06-21 Method of making the derivatives of the 1,2-dihydrochinoline-2-on CS207798B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782827566 DE2827566A1 (de) 1978-06-23 1978-06-23 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
CS207798B2 true CS207798B2 (en) 1981-08-31

Family

ID=6042551

Family Applications (2)

Application Number Title Priority Date Filing Date
CS794286A CS207798B2 (en) 1978-06-23 1979-06-21 Method of making the derivatives of the 1,2-dihydrochinoline-2-on
CS798953A CS207799B2 (en) 1978-06-23 1979-06-21 Method of making the derivatives of the 1,2-dihydrochinoline-2-on

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS798953A CS207799B2 (en) 1978-06-23 1979-06-21 Method of making the derivatives of the 1,2-dihydrochinoline-2-on

Country Status (12)

Country Link
US (1) US4234585A (el)
EP (1) EP0006506B1 (el)
JP (1) JPS552693A (el)
AT (1) ATE224T1 (el)
CA (1) CA1122218A (el)
CS (2) CS207798B2 (el)
DE (2) DE2827566A1 (el)
ES (1) ES481729A1 (el)
HU (1) HU177959B (el)
IL (1) IL57577A (el)
PL (1) PL115260B1 (el)
SU (1) SU831077A3 (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS55162774A (en) * 1979-06-06 1980-12-18 Otsuka Pharmaceut Co Ltd Carbostyril derivative
DE3034237A1 (de) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
DE3033112A1 (de) * 1980-09-03 1982-04-01 Hochtemperatur-Reaktorbau GmbH, 5000 Köln Atomkernreaktor
JPS57130210A (en) * 1981-02-06 1982-08-12 Kinseishiya Kk Power switch noise remover for audio appliance
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
DE3225169A1 (de) * 1982-07-06 1984-01-12 Basf Ag, 6700 Ludwigshafen Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von pilzen
DE3434271A1 (de) * 1984-09-19 1986-03-20 Beiersdorf Ag, 2000 Hamburg Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
CN85108214A (zh) * 1984-11-22 1986-08-20 赫彻斯特股份公司 新的取代的苯基哌嗪衍生物及其药物的制造方法
GB8502267D0 (en) * 1985-01-30 1985-02-27 Pfizer Ltd Quinolone inotropic agents
JPS63119467A (ja) * 1987-10-21 1988-05-24 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JP2608788B2 (ja) * 1988-10-31 1997-05-14 大塚製薬 株式会社 精神分裂病治療剤
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US5457099A (en) * 1992-07-02 1995-10-10 Sawai Pharmaceutical Co., Ltd. Carbostyril derivatives and antiallergic agent
DE4410822A1 (de) * 1994-03-24 1995-09-28 Schering Ag Neue Piperidin-Derivate
CA2180190A1 (en) * 1995-07-10 1997-01-11 Kazumi Ogata Benzylpiperazine derivatives
GB0203778D0 (en) * 2002-02-18 2002-04-03 Glaxo Group Ltd Compounds
CN100497325C (zh) * 2004-04-21 2009-06-10 齐鲁制药有限公司 哌嗪衍生物及其在制备喹啉酮衍生物中的用途
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
CN101538252B (zh) * 2008-03-20 2011-04-20 成都康弘药业集团股份有限公司 阿立哌唑的制备方法及其中间体
US9511022B2 (en) * 2010-08-24 2016-12-06 Otsuka Pharmaceutical Co., Ltd. Suspension and cake composition containing carbostyryl derivative and silicone oil and/or silicone oil derivative
AU2013259551B2 (en) * 2012-05-09 2017-11-02 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
CN109180577B (zh) * 2018-10-15 2021-11-16 迪嘉药业集团有限公司 一种阿立哌唑的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH514611A (de) * 1968-07-05 1971-10-31 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Derivaten des 2-Oxo-1,2-dihydro-chinolins
JPS48103590A (el) * 1972-04-13 1973-12-25
DE2337461A1 (de) * 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
GB1501149A (en) * 1975-07-11 1978-02-15 Nisshin Flour Milling Co Isocarbostyril derivatives
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS55124766A (en) * 1979-03-20 1980-09-26 Otsuka Pharmaceut Co Ltd Antihistaminic

Also Published As

Publication number Publication date
CS207799B2 (en) 1981-08-31
SU831077A3 (ru) 1981-05-15
US4234585A (en) 1980-11-18
HU177959B (en) 1982-02-28
ES481729A1 (es) 1980-03-01
DE2827566A1 (de) 1980-01-10
PL115260B1 (en) 1981-03-31
IL57577A0 (en) 1979-10-31
PL216409A1 (el) 1980-03-24
EP0006506B1 (de) 1981-09-16
ATE224T1 (de) 1981-10-15
EP0006506A1 (de) 1980-01-09
DE2960820D1 (en) 1981-12-03
CA1122218A (en) 1982-04-20
IL57577A (en) 1982-03-31
JPS552693A (en) 1980-01-10
JPS6331465B2 (el) 1988-06-23

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