CS205026B2 - Method of producing glocosamine derivatives - Google Patents
Method of producing glocosamine derivatives Download PDFInfo
- Publication number
- CS205026B2 CS205026B2 CS768063A CS28379A CS205026B2 CS 205026 B2 CS205026 B2 CS 205026B2 CS 768063 A CS768063 A CS 768063A CS 28379 A CS28379 A CS 28379A CS 205026 B2 CS205026 B2 CS 205026B2
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- Czechoslovakia
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- acid
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- hydrogen
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- 238000000034 method Methods 0.000 title claims description 14
- 150000002301 glucosamine derivatives Chemical class 0.000 claims abstract description 5
- 150000001875 compounds Chemical class 0.000 claims description 50
- 150000003839 salts Chemical class 0.000 claims description 23
- 239000002253 acid Substances 0.000 claims description 22
- 239000001257 hydrogen Substances 0.000 claims description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims description 21
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
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- 150000002148 esters Chemical class 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
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- 238000002360 preparation method Methods 0.000 claims description 4
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- 239000000829 suppository Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 230000005951 type IV hypersensitivity Effects 0.000 description 1
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1604275A CH613709A5 (en) | 1975-12-10 | 1975-12-10 | Process for the preparation of glucosamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS205026B2 true CS205026B2 (en) | 1981-04-30 |
Family
ID=4414012
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS768063A CS205026B2 (en) | 1975-12-10 | 1976-12-09 | Method of producing glocosamine derivatives |
| CS768063A CS205027B2 (en) | 1975-12-10 | 1976-12-09 | Method of producing glucosamine derivatives |
| CS768063A CS205025B2 (en) | 1975-12-10 | 1976-12-09 | Process for preparing derivatives of glukosamine |
| CS768063A CS205028B2 (en) | 1975-12-10 | 1976-12-09 | Method of producing glucosamine derivatives |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS768063A CS205027B2 (en) | 1975-12-10 | 1976-12-09 | Method of producing glucosamine derivatives |
| CS768063A CS205025B2 (en) | 1975-12-10 | 1976-12-09 | Process for preparing derivatives of glukosamine |
| CS768063A CS205028B2 (en) | 1975-12-10 | 1976-12-09 | Method of producing glucosamine derivatives |
Country Status (30)
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4186194A (en) * | 1973-10-23 | 1980-01-29 | Agence Nationale De Valorisation De La Recherche (Anvar) | Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents |
| US4370265A (en) * | 1974-10-22 | 1983-01-25 | Agence Nationale De Valorisation | Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents |
| GB1571133A (en) * | 1976-04-26 | 1980-07-09 | Syntex Inc | Immuniological adjuvant peptidoglycans compounds and methods of preparation thereof |
| EP0002677B1 (en) | 1977-12-02 | 1982-10-13 | Takeda Chemical Industries, Ltd. | Glucosamine-peptide derivatives and their pharmaceutical compositions |
| CA1138436A (en) * | 1978-02-24 | 1982-12-28 | Gerhard Baschang | Process for the manufacture of novel antigens |
| US4397844A (en) * | 1978-02-24 | 1983-08-09 | Ciba-Geigy Corporation | Antigen derivatives and processes for their preparation |
| FR2420545A1 (fr) * | 1978-03-20 | 1979-10-19 | Anvar | Nouveaux esters de l'acide n-acetyl-muramyl-aminoacyl-glutamique ou des derives de substitution de celui-ci a proprietes anti-infectieuses et/ou d'adjuvants immunologiques |
| FR2442241A2 (fr) * | 1978-03-20 | 1980-06-20 | Anvar | Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes |
| FR2428050A1 (fr) * | 1978-06-05 | 1980-01-04 | Anvar | Oligomeres de composes du type muramyl-peptide et medicaments les contenant |
| FR2428051A1 (fr) * | 1978-06-05 | 1980-01-04 | Anvar | Nouveaux composes du type muramyl-peptide et medicaments les contenant |
| FR2446292A1 (fr) * | 1979-01-12 | 1980-08-08 | Anvar | Muramyl-peptides fixes sur polymeres peptidiques et medicaments les contenant |
| US4256735A (en) | 1979-01-29 | 1981-03-17 | Merck & Co., Inc. | Immunologically active dipeptidyl saccharides and methods of preparation |
| FR2449697A1 (fr) | 1979-02-20 | 1980-09-19 | Anvar | Nouveaux muramyl-peptides substitues sur un azote peptidique et medicaments les contenant |
| JPS55111499A (en) * | 1979-02-21 | 1980-08-28 | Takeda Chem Ind Ltd | Glucosamine derivative and its preparation |
| JPS5618996A (en) * | 1979-06-21 | 1981-02-23 | Dai Ichi Seiyaku Co Ltd | Muramyldipeptide derivative |
| FI75578C (fi) | 1979-07-25 | 1988-07-11 | Ciba Geigy Ag | Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider. |
| JPS5649396A (en) * | 1979-09-28 | 1981-05-02 | Dai Ichi Seiyaku Co Ltd | Novel muramyldipeptide derivative |
| DE3070457D1 (en) * | 1979-10-02 | 1985-05-15 | Ciba Geigy Ag | Combinatory compositions for use in a method for enhancing the activity of antibiotics, antibiotic preparations having enhanced activity and process for their production |
| FI803077A7 (fi) | 1979-10-12 | 1981-04-13 | Ciba Geigy Ag | Foerfarande foer framstaellning av myramylpeptider |
| US4409209A (en) * | 1979-10-12 | 1983-10-11 | Ciba-Geigy Corporation | Novel phosphorylmuramyl peptides and processes for the manufacture thereof |
| US4406889A (en) * | 1980-02-15 | 1983-09-27 | Ciba-Geigy Corporation | Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use |
| US4368190A (en) * | 1980-04-17 | 1983-01-11 | Merck & Co., Inc. | Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation |
| US4310514A (en) | 1980-05-05 | 1982-01-12 | Merck & Co., Inc. | Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation |
| EP0056560A1 (de) * | 1981-01-19 | 1982-07-28 | Ciba-Geigy Ag | Antibiotische Präparate mit gesteigerter Wirksamkeit, Verfahren zu deren Herstellung und Verfahren zur Steigerung der antibiotischen Wirkung von Antibiotika |
| GR78246B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1981-01-23 | 1984-09-26 | Ciba Geigy Ag | |
| JPS6042398A (ja) * | 1983-08-18 | 1985-03-06 | Toshiyuki Hamaoka | ムラミルジペプチド活性エステル誘導体 |
| EP0541486A1 (de) * | 1991-11-07 | 1993-05-12 | Ciba-Geigy Ag | Polycyclische Konjugate |
| RU2181729C1 (ru) * | 2000-09-20 | 2002-04-27 | Калюжин Олег Витальевич | Производные мурамовой кислоты |
| US7838685B2 (en) | 2005-04-27 | 2010-11-23 | Shinji Takeoka | Cationic amino acid type lipid |
| WO2016138286A1 (en) | 2015-02-26 | 2016-09-01 | Stc.Unm | Irgm and precision autophagy controls for antimicrobial and inflammatory disease states and methods of detection of autophagy |
| US12134664B2 (en) | 2015-12-10 | 2024-11-05 | Bharat Biotech International Ltd. | Muramyl peptide derivatives |
| CN108884132B (zh) * | 2015-12-10 | 2022-10-04 | 巴拉特生物技术国际有限公司 | 胞壁酰肽衍生物化合物、其合成及其用途 |
| EP3389643B1 (en) * | 2015-12-15 | 2023-05-03 | Bharat Biotech International Limited | Novel muramyl peptide derivative compound, synthesis and uses thereof |
| EP3672939A1 (en) | 2017-08-21 | 2020-07-01 | Celgene Corporation | Processes for preparation of (s)-tert-butyl 4,5-diamino-5-oxopentanoate |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4186194A (en) * | 1973-10-23 | 1980-01-29 | Agence Nationale De Valorisation De La Recherche (Anvar) | Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents |
-
1975
- 1975-12-10 CH CH1604275A patent/CH613709A5/xx not_active IP Right Cessation
-
1976
- 1976-12-08 GR GR52361A patent/GR61647B/el unknown
- 1976-12-08 SU SU762428152A patent/SU660589A3/ru active
- 1976-12-08 CA CA000267474A patent/CA1262400A/en not_active Expired
- 1976-12-08 GB GB51228/76A patent/GB1570625A/en not_active Expired
- 1976-12-08 NL NL7613666A patent/NL7613666A/xx not_active Application Discontinuation
- 1976-12-08 DE DE19762655500 patent/DE2655500A1/de active Granted
- 1976-12-09 CS CS768063A patent/CS205026B2/cs unknown
- 1976-12-09 CS CS768063A patent/CS205027B2/cs unknown
- 1976-12-09 DK DK552476A patent/DK154654C/da not_active IP Right Cessation
- 1976-12-09 CS CS768063A patent/CS205025B2/cs unknown
- 1976-12-09 IL IL51076A patent/IL51076A/xx unknown
- 1976-12-09 AT AT0909276A patent/AT365607B/de not_active IP Right Cessation
- 1976-12-09 PT PT65946A patent/PT65946B/pt unknown
- 1976-12-09 AU AU20422/76A patent/AU508764B2/en not_active Expired
- 1976-12-09 FR FR7637091A patent/FR2361902A1/fr active Granted
- 1976-12-09 HU HU76CI1702A patent/HU177970B/hu unknown
- 1976-12-09 IE IE2689/76A patent/IE44190B1/en not_active IP Right Cessation
- 1976-12-09 NO NO764191A patent/NO144850C/no unknown
- 1976-12-09 FI FI763541A patent/FI64164C/fi not_active IP Right Cessation
- 1976-12-09 DD DD7600196215A patent/DD129781A5/xx unknown
- 1976-12-09 BE BE173091A patent/BE849214A/xx not_active IP Right Cessation
- 1976-12-09 CS CS768063A patent/CS205028B2/cs unknown
- 1976-12-09 ZA ZA767333A patent/ZA767333B/xx unknown
- 1976-12-09 SE SE7613851A patent/SE445923B/xx not_active IP Right Cessation
- 1976-12-09 NZ NZ182837A patent/NZ182837A/xx unknown
- 1976-12-10 PL PL1976210828A patent/PL110794B1/pl unknown
- 1976-12-10 AR AR265799A patent/AR224091A1/es active
- 1976-12-10 ES ES454118A patent/ES454118A1/es not_active Expired
- 1976-12-10 PL PL1976210826A patent/PL112672B1/pl unknown
- 1976-12-10 PL PL1976194291A patent/PL110353B1/pl not_active IP Right Cessation
- 1976-12-10 PL PL1976210827A patent/PL110787B1/pl unknown
- 1976-12-10 JP JP51147903A patent/JPS5273820A/ja active Granted
-
1977
- 1977-09-08 SU SU772518658A patent/SU1060118A3/ru active
- 1977-09-08 SU SU772521659A patent/SU747430A3/ru active
- 1977-09-30 AR AR269405A patent/AR220686A1/es active
- 1977-12-28 ES ES465514A patent/ES465514A1/es not_active Expired
-
1978
- 1978-08-24 CH CH898378A patent/CH614718A5/xx not_active IP Right Cessation
-
1983
- 1983-03-14 SG SG110/83A patent/SG11083G/en unknown
- 1983-08-25 HK HK328/83A patent/HK32883A/xx unknown
-
1984
- 1984-12-30 MY MY123/84A patent/MY8400123A/xx unknown
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