CS199696B2 - Method of producing derivatives of pyrimido/1,2-a/benzimidazole - Google Patents

Method of producing derivatives of pyrimido/1,2-a/benzimidazole Download PDF

Info

Publication number
CS199696B2
CS199696B2 CS778270A CS827077A CS199696B2 CS 199696 B2 CS199696 B2 CS 199696B2 CS 778270 A CS778270 A CS 778270A CS 827077 A CS827077 A CS 827077A CS 199696 B2 CS199696 B2 CS 199696B2
Authority
CS
Czechoslovakia
Prior art keywords
hydrogen
carbon atoms
formula
group
remaining
Prior art date
Application number
CS778270A
Other languages
Czech (cs)
English (en)
Inventor
Stuart D Mills
Original Assignee
Ici Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB51426/76A external-priority patent/GB1585965A/en
Application filed by Ici Ltd filed Critical Ici Ltd
Priority to CS791656A priority Critical patent/CS199697B2/cs
Publication of CS199696B2 publication Critical patent/CS199696B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CS778270A 1976-12-09 1977-12-09 Method of producing derivatives of pyrimido/1,2-a/benzimidazole CS199696B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS791656A CS199697B2 (cs) 1977-08-09 1979-03-13 Způsob výroby derivátů pyrimido[ 1,2-a ] benzimidazolu

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB51426/76A GB1585965A (en) 1976-12-09 1976-12-09 3,4-dihydropyrimido (1,2 - )benzimidazol - 2(1h) - ones
GB3334177 1977-08-09

Publications (1)

Publication Number Publication Date
CS199696B2 true CS199696B2 (en) 1980-07-31

Family

ID=26261828

Family Applications (1)

Application Number Title Priority Date Filing Date
CS778270A CS199696B2 (en) 1976-12-09 1977-12-09 Method of producing derivatives of pyrimido/1,2-a/benzimidazole

Country Status (23)

Country Link
US (1) US4167569A (de)
JP (1) JPS5390296A (de)
AT (1) AT359068B (de)
AU (1) AU514427B2 (de)
CA (1) CA1086727A (de)
CH (1) CH633291A5 (de)
CS (1) CS199696B2 (de)
DD (1) DD133330A5 (de)
DE (1) DE2754930A1 (de)
ES (1) ES464862A1 (de)
FI (1) FI63577C (de)
FR (1) FR2373543A1 (de)
GR (1) GR65298B (de)
HU (1) HU176540B (de)
IE (1) IE45924B1 (de)
IL (1) IL53507A (de)
IT (1) IT1143729B (de)
NL (1) NL7713658A (de)
NO (1) NO774216L (de)
NZ (1) NZ185823A (de)
PL (1) PL107142B1 (de)
SE (1) SE435385B (de)
SU (1) SU843751A3 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1157858A (en) 1979-12-03 1983-11-29 Ikuo Ueda Quinazoline derivatives
IE51802B1 (en) * 1979-12-03 1987-04-01 Fujisawa Pharmaceutical Co Quinazoline derivatives,processes for their preparation and pharmaceutical compositions containing them
DE3208218A1 (de) * 1982-03-06 1983-09-08 Basf Ag, 6700 Ludwigshafen Isoindolinfarbstoffe und deren verwendung
RU2453312C1 (ru) * 2010-11-10 2012-06-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" Средство, проявляющее антиагрегантную и антитромбогенную активности
AU2013283318B2 (en) 2012-06-27 2017-11-23 4Sc Ag Bifluorodioxalane-amino-benzimidazole kinase inhibitors for the treatment of cancer, autoimmuneinflammation and CNS disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468888A (en) * 1967-04-11 1969-09-23 Smithkline Corp 2-substituted pyrimido(1,2-a) benzimidazoles
US3988340A (en) * 1975-01-23 1976-10-26 Bristol-Myers Company 6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones
US4072679A (en) * 1976-06-15 1978-02-07 E. R. Squibb & Sons, Inc. 1,4- AND 4,10-DIHYDRO-4-OXO-PYRIMIDO (1,2-A)-benzimidazole-3-carboxylic acids, esters and amides

Also Published As

Publication number Publication date
IE45924B1 (en) 1982-12-29
SE7713958L (sv) 1978-06-10
JPS5390296A (en) 1978-08-08
SU843751A3 (ru) 1981-06-30
FI63577C (fi) 1983-07-11
AT359068B (de) 1980-10-27
AU3112177A (en) 1979-06-07
NO774216L (no) 1978-06-12
NZ185823A (en) 1980-08-26
GR65298B (en) 1980-08-01
PL202753A1 (pl) 1978-10-09
CA1086727A (en) 1980-09-30
DE2754930A1 (de) 1978-06-15
FI63577B (fi) 1983-03-31
FR2373543B1 (de) 1980-05-16
PL107142B1 (pl) 1980-01-31
ES464862A1 (es) 1979-01-01
ATA883677A (de) 1980-03-15
IL53507A (en) 1981-07-31
IT1143729B (it) 1986-10-22
IE45924L (en) 1978-06-09
IL53507A0 (en) 1978-03-10
HU176540B (en) 1981-03-28
CH633291A5 (de) 1982-11-30
FI773724A (fi) 1978-06-10
NL7713658A (nl) 1978-06-13
DD133330A5 (de) 1978-12-27
AU514427B2 (en) 1981-02-12
SE435385B (sv) 1984-09-24
US4167569A (en) 1979-09-11
FR2373543A1 (fr) 1978-07-07

Similar Documents

Publication Publication Date Title
US10676483B2 (en) Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
Mathew et al. Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors
CN1807413B (zh) 咔唑磺酰胺衍生物及其制备方法
AU2005227954B2 (en) Heterocyclic compound and anti-malignant-tumor agent comprising the same as effective component
EA000897B1 (ru) ПРОИЗВОДНЫЕ ПИРИДО[2,3-d]ПИРИМИДИНА И ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ОБЛАДАЮЩАЯ ИНГИБИРУЮЩЕЙ ПРОТЕИН-ТИРОЗИН-КИНАЗУ АКТИВНОСТЬЮ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, ОПОСРЕДОВАННЫХ КЛЕТОЧНОЙ ПРОЛИФЕРАЦИЕЙ, И СПОСОБ ЛЕЧЕНИЯ РАКА, АТЕРОСКЛЕРОЗА, ПСОРИАЗА ИЛИ РЕСТЕНОЗА
CN109134463B (zh) β-咔啉类5型磷酸二酯酶抑制剂及其制备方法和用途
CA2837268C (en) Compositions and methods for modulating a kinase
EP0369145B1 (de) Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidinderivate und diese enthaltende Arzneimittel
CS199696B2 (en) Method of producing derivatives of pyrimido/1,2-a/benzimidazole
CA2354852C (en) 4,5-azolo-oxindoles
US20110160226A1 (en) Substituted Triazolo-Pyrimidine Compounds
CA3135449A1 (en) Triazolopyrimidines based on thymine nucleobase and methods for producing them
RU2631100C1 (ru) Новые производные гетероаренантрацен-2-карбоксамидов, ингибирующие опухолевый рост
GB1585965A (en) 3,4-dihydropyrimido (1,2 - )benzimidazol - 2(1h) - ones
CS199697B2 (cs) Způsob výroby derivátů pyrimido[ 1,2-a ] benzimidazolu
CN117777135A (zh) 氘代芳胺基嘌呤衍生物及其制备方法和用途
CN117924279A (zh) 一种melk抑制剂及其应用
PL106798B1 (pl) Sposob wytwarzania pochodnych pirymido/1,2-a/benzimidazolu
MXPA01005933A (en) 4,5-azolo-oxindoles