CS196365B2 - Process for preparing di-n-propylacetonitrile - Google Patents
Process for preparing di-n-propylacetonitrile Download PDFInfo
- Publication number
- CS196365B2 CS196365B2 CS773335A CS333577A CS196365B2 CS 196365 B2 CS196365 B2 CS 196365B2 CS 773335 A CS773335 A CS 773335A CS 333577 A CS333577 A CS 333577A CS 196365 B2 CS196365 B2 CS 196365B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- propyl
- acid
- sodium
- temperature
- carried out
- Prior art date
Links
- YCBOPMITSGZJDX-UHFFFAOYSA-N 2-propylpentanenitrile Chemical compound CCCC(C#N)CCC YCBOPMITSGZJDX-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 238000004519 manufacturing process Methods 0.000 title description 7
- 238000000034 method Methods 0.000 claims abstract description 78
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims abstract description 46
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 42
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims abstract description 35
- UZRGQIZTJOPZGE-UHFFFAOYSA-N 2-cyano-2-propylpentanoic acid Chemical compound CCCC(C(O)=O)(C#N)CCC UZRGQIZTJOPZGE-UHFFFAOYSA-N 0.000 claims abstract description 32
- 150000002148 esters Chemical class 0.000 claims abstract description 21
- 238000010992 reflux Methods 0.000 claims abstract description 21
- RCOSUMRTSQULBK-UHFFFAOYSA-N sodium;propan-1-olate Chemical compound [Na+].CCC[O-] RCOSUMRTSQULBK-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000005804 alkylation reaction Methods 0.000 claims abstract description 17
- 238000010438 heat treatment Methods 0.000 claims abstract description 15
- 238000002360 preparation method Methods 0.000 claims abstract description 15
- CYNYIHKIEHGYOZ-UHFFFAOYSA-N 1-bromopropane Chemical compound CCCBr CYNYIHKIEHGYOZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000012429 reaction media Substances 0.000 claims abstract description 4
- 150000003839 salts Chemical class 0.000 claims abstract description 3
- 239000011541 reaction mixture Substances 0.000 claims description 22
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 18
- 238000006114 decarboxylation reaction Methods 0.000 claims description 16
- 238000007127 saponification reaction Methods 0.000 claims description 16
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 13
- 230000029936 alkylation Effects 0.000 claims description 13
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 8
- 239000007858 starting material Substances 0.000 claims description 8
- ANGDWNBGPBMQHW-UHFFFAOYSA-N methyl cyanoacetate Chemical compound COC(=O)CC#N ANGDWNBGPBMQHW-UHFFFAOYSA-N 0.000 claims description 6
- MLIREBYILWEBDM-UHFFFAOYSA-M 2-cyanoacetate Chemical compound [O-]C(=O)CC#N MLIREBYILWEBDM-UHFFFAOYSA-M 0.000 claims description 4
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 3
- PVWOIHVRPOBWPI-UHFFFAOYSA-N n-propyl iodide Chemical compound CCCI PVWOIHVRPOBWPI-UHFFFAOYSA-N 0.000 claims description 3
- 230000020477 pH reduction Effects 0.000 claims description 3
- KXHPPCXNWTUNSB-UHFFFAOYSA-M benzyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CC1=CC=CC=C1 KXHPPCXNWTUNSB-UHFFFAOYSA-M 0.000 claims description 2
- XJWSAJYUBXQQDR-UHFFFAOYSA-M dodecyltrimethylammonium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)C XJWSAJYUBXQQDR-UHFFFAOYSA-M 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract description 15
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 51
- 239000000203 mixture Substances 0.000 description 40
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 33
- -1 cyanoacetic acid ester Chemical class 0.000 description 26
- 239000012071 phase Substances 0.000 description 21
- 238000004821 distillation Methods 0.000 description 18
- 238000006243 chemical reaction Methods 0.000 description 16
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- 238000009835 boiling Methods 0.000 description 13
- 239000000047 product Substances 0.000 description 10
- 239000011734 sodium Substances 0.000 description 10
- 229910052708 sodium Inorganic materials 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- MLIREBYILWEBDM-UHFFFAOYSA-N anhydrous cyanoacetic acid Natural products OC(=O)CC#N MLIREBYILWEBDM-UHFFFAOYSA-N 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000007792 addition Methods 0.000 description 6
- 239000006227 byproduct Substances 0.000 description 6
- 238000001816 cooling Methods 0.000 description 6
- 239000000543 intermediate Substances 0.000 description 6
- FMKOJHQHASLBPH-UHFFFAOYSA-N isopropyl iodide Chemical compound CC(C)I FMKOJHQHASLBPH-UHFFFAOYSA-N 0.000 description 6
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 239000012485 toluene extract Substances 0.000 description 4
- NICLKHGIKDZZGV-UHFFFAOYSA-N 2-cyanopentanoic acid Chemical compound CCCC(C#N)C(O)=O NICLKHGIKDZZGV-UHFFFAOYSA-N 0.000 description 3
- FSCFMUWAEFAUJX-UHFFFAOYSA-N 3-methyl-2-propan-2-ylbutanenitrile Chemical compound CC(C)C(C#N)C(C)C FSCFMUWAEFAUJX-UHFFFAOYSA-N 0.000 description 3
- RFFFKMOABOFIDF-UHFFFAOYSA-N Pentanenitrile Chemical compound CCCCC#N RFFFKMOABOFIDF-UHFFFAOYSA-N 0.000 description 3
- 150000003863 ammonium salts Chemical class 0.000 description 3
- ZIUSEGSNTOUIPT-UHFFFAOYSA-N ethyl 2-cyanoacetate Chemical compound CCOC(=O)CC#N ZIUSEGSNTOUIPT-UHFFFAOYSA-N 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- OMOMUFTZPTXCHP-UHFFFAOYSA-N valpromide Chemical compound CCCC(C(N)=O)CCC OMOMUFTZPTXCHP-UHFFFAOYSA-N 0.000 description 3
- UGKAGYIWOQXPKP-UHFFFAOYSA-N 2-cyano-3-methyl-2-propan-2-ylbutanoic acid Chemical compound CC(C)C(C#N)(C(C)C)C(O)=O UGKAGYIWOQXPKP-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- GAORRGUPLLEASI-UHFFFAOYSA-N 2-cyano-n,n-dipropylacetamide Chemical compound CCCN(CCC)C(=O)CC#N GAORRGUPLLEASI-UHFFFAOYSA-N 0.000 description 1
- HCFAJYNVAYBARA-UHFFFAOYSA-N 4-heptanone Chemical compound CCCC(=O)CCC HCFAJYNVAYBARA-UHFFFAOYSA-N 0.000 description 1
- SJVGFKBLUYAEOK-SFHVURJKSA-N 6-[4-[(3S)-3-(3,5-difluorophenyl)-3,4-dihydropyrazole-2-carbonyl]piperidin-1-yl]pyrimidine-4-carbonitrile Chemical compound FC=1C=C(C=C(C=1)F)[C@@H]1CC=NN1C(=O)C1CCN(CC1)C1=CC(=NC=N1)C#N SJVGFKBLUYAEOK-SFHVURJKSA-N 0.000 description 1
- UCUJUFDOQOJLBE-UHFFFAOYSA-N [Cl].[Ca] Chemical compound [Cl].[Ca] UCUJUFDOQOJLBE-UHFFFAOYSA-N 0.000 description 1
- RZBSVYZMOJXQJU-UHFFFAOYSA-N [Na].CCCO Chemical compound [Na].CCCO RZBSVYZMOJXQJU-UHFFFAOYSA-N 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- DJACTCNGCHPGOI-UHFFFAOYSA-N butyl 2-cyanoacetate Chemical compound CCCCOC(=O)CC#N DJACTCNGCHPGOI-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 1
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 1
- XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical compound [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- MFPLOZTTYKIUQU-UHFFFAOYSA-N methyl 2-cyano-2-propylpentanoate Chemical compound CCCC(CCC)(C#N)C(=O)OC MFPLOZTTYKIUQU-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000004767 nitrides Chemical group 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NLFIMXLLXGTDME-UHFFFAOYSA-N propyl 2-cyanoacetate Chemical compound CCCOC(=O)CC#N NLFIMXLLXGTDME-UHFFFAOYSA-N 0.000 description 1
- NFQPKQCSKRLPHP-UHFFFAOYSA-N propyl cyanate Chemical compound CCCOC#N NFQPKQCSKRLPHP-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7707587A FR2383920A1 (fr) | 1977-03-15 | 1977-03-15 | Procede de preparation d'un derive d'acetonitrile et derive obtenu par ce procede |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS196365B2 true CS196365B2 (en) | 1980-03-31 |
Family
ID=9188072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS773335A CS196365B2 (en) | 1977-03-15 | 1977-05-20 | Process for preparing di-n-propylacetonitrile |
Country Status (34)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2470758A1 (fr) | 1979-12-07 | 1981-06-12 | Sanofi Sa | Procede pour la fixation de groupes alkyles sur une chaine carbonee portant un groupe fonctionnel |
| JP5036111B2 (ja) * | 2001-08-20 | 2012-09-26 | 旭化成イーマテリアルズ株式会社 | 置換シクロペンタジエンの製造方法 |
| DE102008036495A1 (de) | 2008-08-04 | 2010-02-11 | Langhals, Heinz, Prof. Dr. | Persistente Pery-Imid-Radikalanionen als NIR-Farbstoffe |
| US9050302B2 (en) | 2013-03-01 | 2015-06-09 | Jazz Pharmaceuticals Ireland Limited | Method of administration of gamma hydroxybutyrate with monocarboxylate transporters |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE186739C (enrdf_load_stackoverflow) * |
-
1977
- 1977-03-15 FR FR7707587A patent/FR2383920A1/fr active Granted
- 1977-04-25 IN IN620/CAL/1977A patent/IN145220B/en unknown
- 1977-05-04 DK DK195877A patent/DK158038C/da not_active IP Right Cessation
- 1977-05-04 NO NO771576A patent/NO144067C/no unknown
- 1977-05-05 IL IL52021A patent/IL52021A/xx unknown
- 1977-05-05 SE SE7705257A patent/SE441596B/xx not_active IP Right Cessation
- 1977-05-06 GR GR53386A patent/GR60808B/el unknown
- 1977-05-09 LU LU77305A patent/LU77305A1/xx unknown
- 1977-05-10 HU HU77LA914A patent/HU175110B/hu not_active IP Right Cessation
- 1977-05-10 CA CA278,080A patent/CA1068302A/en not_active Expired
- 1977-05-11 DE DE2721265A patent/DE2721265C2/de not_active Expired
- 1977-05-11 BE BE177457A patent/BE854486A/xx not_active IP Right Cessation
- 1977-05-12 CH CH596277A patent/CH603563A5/xx not_active IP Right Cessation
- 1977-05-13 PT PT66542A patent/PT66542B/pt unknown
- 1977-05-18 JP JP5816577A patent/JPS53112813A/ja active Granted
- 1977-05-20 AR AR267718A patent/AR212999A1/es active
- 1977-05-20 CS CS773335A patent/CS196365B2/cs unknown
- 1977-05-20 NL NLAANVRAGE7705562,A patent/NL173747C/xx not_active IP Right Cessation
- 1977-05-26 DD DD7700199161A patent/DD129904A5/xx not_active IP Right Cessation
- 1977-05-31 PL PL1977198559A patent/PL108183B1/pl unknown
- 1977-06-03 GB GB23783/77A patent/GB1522450A/en not_active Expired
- 1977-06-03 FI FI771781A patent/FI65232C/fi not_active IP Right Cessation
- 1977-06-06 SU SU772490024A patent/SU715017A3/ru active
- 1977-06-08 NZ NZ184326A patent/NZ184326A/xx unknown
- 1977-06-14 MX MX775804U patent/MX4779E/es unknown
- 1977-06-15 AT AT423077A patent/AT351012B/de not_active IP Right Cessation
- 1977-06-15 YU YU1490/77A patent/YU40674B/xx unknown
- 1977-06-20 AU AU26263/77A patent/AU504487B2/en not_active Expired
- 1977-06-21 IE IE1270/77A patent/IE45345B1/en not_active IP Right Cessation
- 1977-06-23 ZA ZA00773779A patent/ZA773779B/xx unknown
- 1977-06-27 OA OA56208A patent/OA05696A/xx unknown
- 1977-07-11 IT IT25582/77A patent/IT1080764B/it active
-
1978
- 1978-02-20 ES ES467125A patent/ES467125A1/es not_active Expired
-
1980
- 1980-06-27 US US06/163,702 patent/USRE31260E/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2262756B1 (en) | Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates | |
| JP2009132676A (ja) | ストロンチウムラネレートおよびその水和物の新規な合成法 | |
| CN114763328A (zh) | 一种2-氰基-2-丙戊酸的制备方法与应用 | |
| CS196365B2 (en) | Process for preparing di-n-propylacetonitrile | |
| CN116621732B (zh) | 一种2-氰基-2-丙戊酸酯及其制备方法与应用 | |
| US2297921A (en) | Cyclic acetals | |
| JPS5949207B2 (ja) | ジエンの製造方法 | |
| KR900005681B1 (ko) | 2-티오펜 아세트산 유도체의 제조방법 | |
| JP3944876B2 (ja) | クエン酸エステル類の製造方法 | |
| SE431200B (sv) | Forfarande for framstellning av 1,5-dimetyl-bicyclo (3.2.1) oktanol-8 | |
| US4155929A (en) | Process for the preparation of an acetonitrile derivative | |
| WO1988010261A1 (en) | Novel thiophen compounds and their preparation | |
| JPS597136A (ja) | マロン酸エステルの製法 | |
| JPS6193834A (ja) | 随時置換されていてもよいケイ皮酸の製造方法 | |
| JPH0419216B2 (enrdf_load_stackoverflow) | ||
| US6730804B1 (en) | Process for preparing cyclopropanecarboxylates of lower alcohols | |
| US5066804A (en) | Preparation of alkyl morpholinones | |
| JPS58971A (ja) | テトロン酸の製造方法 | |
| JP3876933B2 (ja) | 硫酸水素エステルの製造方法 | |
| JP2003128658A (ja) | ４，５−ジヒドロ−１，３−チアゾール類の製造法 | |
| KR800001178B1 (ko) | 아세토 나이트릴유도체의 제조방법 | |
| US6388151B1 (en) | Synthesis of Tetraalkylcyclopentadienes | |
| JPS6252754B2 (enrdf_load_stackoverflow) | ||
| EP1948584B1 (en) | Process for the preparation of cyclopentanone derivatives | |
| JP2024509535A (ja) | ４－オキソテトラヒドロフラン－２－カルボン酸アルキルの調製方法 |