CR8168A - Espirobenzazepinas sustituidas - Google Patents
Espirobenzazepinas sustituidasInfo
- Publication number
- CR8168A CR8168A CR8168A CR8168A CR8168A CR 8168 A CR8168 A CR 8168A CR 8168 A CR8168 A CR 8168A CR 8168 A CR8168 A CR 8168A CR 8168 A CR8168 A CR 8168A
- Authority
- CR
- Costa Rica
- Prior art keywords
- heart failure
- hyponatremia
- hypertension
- formula
- treating conditions
- Prior art date
Links
- 206010019280 Heart failures Diseases 0.000 abstract 4
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 2
- 206010021036 Hyponatraemia Diseases 0.000 abstract 2
- 206010003225 Arteriospasm coronary Diseases 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010048962 Brain oedema Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010008132 Cerebral thrombosis Diseases 0.000 abstract 1
- 208000003890 Coronary Vasospasm Diseases 0.000 abstract 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 abstract 1
- 206010016807 Fluid retention Diseases 0.000 abstract 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 102000004136 Vasopressin Receptors Human genes 0.000 abstract 1
- 108090000643 Vasopressin Receptors Proteins 0.000 abstract 1
- 206010047163 Vasospasm Diseases 0.000 abstract 1
- 150000008038 benzoazepines Chemical class 0.000 abstract 1
- 208000006752 brain edema Diseases 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000011634 coronary artery vasospasm Diseases 0.000 abstract 1
- 208000033679 diabetic kidney disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
- 239000002536 vasopressin receptor antagonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47937803P | 2003-06-17 | 2003-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR8168A true CR8168A (es) | 2008-09-10 |
Family
ID=34465052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR8168A CR8168A (es) | 2003-06-17 | 2006-01-02 | Espirobenzazepinas sustituidas |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US20040266752A1 (enExample) |
| EP (1) | EP1633719B1 (enExample) |
| JP (1) | JP5252614B2 (enExample) |
| KR (1) | KR101086246B1 (enExample) |
| CN (1) | CN100467454C (enExample) |
| AR (1) | AR044782A1 (enExample) |
| AT (1) | ATE444953T1 (enExample) |
| AU (1) | AU2004281257C1 (enExample) |
| BR (1) | BRPI0411598A (enExample) |
| CA (1) | CA2529649C (enExample) |
| CL (1) | CL2004001507A1 (enExample) |
| CR (1) | CR8168A (enExample) |
| CY (1) | CY1109585T1 (enExample) |
| DE (1) | DE602004023501D1 (enExample) |
| DK (1) | DK1633719T3 (enExample) |
| EA (1) | EA011089B1 (enExample) |
| ES (1) | ES2332724T3 (enExample) |
| HR (2) | HRP20090606T1 (enExample) |
| IL (1) | IL172630A (enExample) |
| ME (1) | ME00320B (enExample) |
| NO (1) | NO20060247L (enExample) |
| NZ (1) | NZ544180A (enExample) |
| PL (1) | PL1633719T3 (enExample) |
| PT (1) | PT1633719E (enExample) |
| RS (1) | RS20050930A (enExample) |
| SI (1) | SI1633719T1 (enExample) |
| TW (1) | TWI354555B (enExample) |
| UA (1) | UA82236C2 (enExample) |
| WO (1) | WO2005037795A2 (enExample) |
| ZA (1) | ZA200600430B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20051005A2 (en) * | 2003-06-17 | 2006-09-30 | Janssen Pharmaceutica N.V. | Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives |
| CA2637838A1 (en) * | 2006-01-20 | 2007-07-26 | Janssen Pharmaceutica N.V. | Novel solid forms of (4r)-1-¬4-(2-chloro-5-fluorobenzoyl)amino-3-methoxybenzoyl|-1,2,3,5-tetrahydro-spiro¬4h-1-benzazepine-4,1'-¬2|cyclopentene|-3'-carboxylic acid |
| SI2078022T1 (sl) * | 2006-09-22 | 2012-01-31 | Janssen Pharmaceutica Nv | Spiro benzazepini, uporabljeni kot antagonisti vazopresina |
| EP2076517A1 (en) * | 2006-09-22 | 2009-07-08 | Janssen Pharmaceutica N.V. | Spiro benzazepines as vasopressin antagonists |
| AR066834A1 (es) * | 2007-06-06 | 2009-09-16 | Janssen Pharmaceutica Nv | Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central. |
| US20090118258A1 (en) * | 2007-11-07 | 2009-05-07 | Bruce Damiano | Combination therapy comprising angiotensin converting enzyme inhibitors and vasopressin receptor antagonists |
| WO2014062888A1 (en) | 2012-10-18 | 2014-04-24 | University Of South Florida | Compositions and methods for treating stroke |
| KR101983880B1 (ko) | 2012-12-26 | 2019-05-29 | 가부시키가이샤산와카가쿠켄큐쇼 | 신규 벤조아제핀 유도체 및 그 의약 용도 |
| AU2022230013B2 (en) * | 2021-03-05 | 2025-01-23 | Jiangxi Jemincare Group Co., Ltd | New-type benzazepine fused ring derivative |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617302A (en) | 1984-10-15 | 1986-10-14 | Eli Lilly And Company | Inotropic agents |
| WO1991005549A1 (en) | 1989-10-20 | 1991-05-02 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds |
| US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
| US5985869A (en) * | 1989-10-20 | 1999-11-16 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
| US5663431A (en) * | 1992-01-30 | 1997-09-02 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| US5686624A (en) * | 1992-01-30 | 1997-11-11 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| US5849780A (en) | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| CA2143117A1 (en) * | 1992-10-07 | 1994-04-14 | Ben E. Evans | Tocolytic oxytocin receptor antagonists |
| US5512563A (en) | 1993-07-29 | 1996-04-30 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| DE10199068I2 (de) * | 1994-04-22 | 2004-05-06 | Pentech Pharmaceuticals Inc | Sublinguale Dosierungsformen enthaltend apomorphinzur Verwendung bei der Behandlung von erektiler D ysfunktion. |
| US5753648A (en) | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| JP3282494B2 (ja) * | 1995-05-16 | 2002-05-13 | 富士ゼロックス株式会社 | 画像定着装置 |
| US5753715A (en) | 1995-06-02 | 1998-05-19 | Ortho Pharmaceutical Corporation | 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents |
| US5726723A (en) * | 1996-01-31 | 1998-03-10 | Technology Research International Corporation | Sub-twisted nematic liquid crystal display |
| AUPP150098A0 (en) | 1998-01-27 | 1998-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
| JP4916639B2 (ja) * | 2000-07-05 | 2012-04-18 | オーソーマクニール ファーマシューティカル， インコーポレイテッド | バソプレシン拮抗質としての非ペプチド系置換スピロベンゾアゼピン |
| HRP20051005A2 (en) * | 2003-06-17 | 2006-09-30 | Janssen Pharmaceutica N.V. | Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives |
-
2004
- 2004-06-16 DK DK04809449T patent/DK1633719T3/da active
- 2004-06-16 CN CNB2004800231176A patent/CN100467454C/zh not_active Expired - Fee Related
- 2004-06-16 WO PCT/US2004/019460 patent/WO2005037795A2/en not_active Ceased
- 2004-06-16 EA EA200501831A patent/EA011089B1/ru not_active IP Right Cessation
- 2004-06-16 JP JP2006517373A patent/JP5252614B2/ja not_active Expired - Fee Related
- 2004-06-16 RS YUP-2005/0930A patent/RS20050930A/sr unknown
- 2004-06-16 ES ES04809449T patent/ES2332724T3/es not_active Expired - Lifetime
- 2004-06-16 AT AT04809449T patent/ATE444953T1/de active
- 2004-06-16 EP EP04809449A patent/EP1633719B1/en not_active Expired - Lifetime
- 2004-06-16 US US10/869,746 patent/US20040266752A1/en not_active Abandoned
- 2004-06-16 ME MEP-2008-491A patent/ME00320B/me unknown
- 2004-06-16 UA UAA200512207A patent/UA82236C2/uk unknown
- 2004-06-16 SI SI200431304T patent/SI1633719T1/sl unknown
- 2004-06-16 AU AU2004281257A patent/AU2004281257C1/en not_active Ceased
- 2004-06-16 AR ARP040102087A patent/AR044782A1/es not_active Application Discontinuation
- 2004-06-16 BR BRPI0411598-8A patent/BRPI0411598A/pt not_active Application Discontinuation
- 2004-06-16 NZ NZ544180A patent/NZ544180A/en not_active IP Right Cessation
- 2004-06-16 PL PL04809449T patent/PL1633719T3/pl unknown
- 2004-06-16 DE DE602004023501T patent/DE602004023501D1/de not_active Expired - Lifetime
- 2004-06-16 KR KR1020057024157A patent/KR101086246B1/ko not_active Expired - Fee Related
- 2004-06-16 HR HR20090606T patent/HRP20090606T1/hr unknown
- 2004-06-16 CA CA2529649A patent/CA2529649C/en not_active Expired - Fee Related
- 2004-06-16 TW TW093117253A patent/TWI354555B/zh not_active IP Right Cessation
- 2004-06-16 HR HR20051006A patent/HRP20051006A2/hr not_active Application Discontinuation
- 2004-06-16 PT PT04809449T patent/PT1633719E/pt unknown
- 2004-06-17 CL CL200401507A patent/CL2004001507A1/es unknown
-
2005
- 2005-12-15 IL IL172630A patent/IL172630A/en active IP Right Grant
-
2006
- 2006-01-02 CR CR8168A patent/CR8168A/es not_active Application Discontinuation
- 2006-01-16 ZA ZA200600430A patent/ZA200600430B/xx unknown
- 2006-01-17 NO NO20060247A patent/NO20060247L/no not_active Application Discontinuation
-
2007
- 2007-04-13 US US11/735,149 patent/US7687494B2/en not_active Expired - Fee Related
-
2009
- 2009-12-11 CY CY20091101295T patent/CY1109585T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |