CR20140255A - Derivados de los nucleósidos sustituidos en 4'-azido, 3'-fluoro como inhibidores de la replicación del rna del vhc - Google Patents
Derivados de los nucleósidos sustituidos en 4'-azido, 3'-fluoro como inhibidores de la replicación del rna del vhcInfo
- Publication number
- CR20140255A CR20140255A CR20140255A CR20140255A CR20140255A CR 20140255 A CR20140255 A CR 20140255A CR 20140255 A CR20140255 A CR 20140255A CR 20140255 A CR20140255 A CR 20140255A CR 20140255 A CR20140255 A CR 20140255A
- Authority
- CR
- Costa Rica
- Prior art keywords
- nucleosids
- azido
- fluoro
- inhibitors
- derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161577712P | 2011-12-20 | 2011-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20140255A true CR20140255A (es) | 2014-08-20 |
Family
ID=47469968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20140255A CR20140255A (es) | 2011-12-20 | 2014-05-28 | Derivados de los nucleósidos sustituidos en 4'-azido, 3'-fluoro como inhibidores de la replicación del rna del vhc |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US9708357B2 (enExample) |
| EP (1) | EP2794628B1 (enExample) |
| JP (1) | JP6118336B2 (enExample) |
| KR (1) | KR101687084B1 (enExample) |
| CN (2) | CN104011060A (enExample) |
| AU (1) | AU2012357986B2 (enExample) |
| BR (1) | BR112014015066A2 (enExample) |
| CA (1) | CA2869317C (enExample) |
| CL (1) | CL2014001599A1 (enExample) |
| CO (1) | CO6990719A2 (enExample) |
| CR (1) | CR20140255A (enExample) |
| CY (1) | CY1119015T1 (enExample) |
| DK (1) | DK2794628T3 (enExample) |
| EA (1) | EA024847B1 (enExample) |
| ES (1) | ES2626484T3 (enExample) |
| HK (1) | HK1200835A1 (enExample) |
| HU (1) | HUE033332T2 (enExample) |
| IL (1) | IL232843B (enExample) |
| IN (1) | IN2014CN04530A (enExample) |
| LT (1) | LT2794628T (enExample) |
| MA (1) | MA35749B1 (enExample) |
| MX (1) | MX350810B (enExample) |
| PE (1) | PE20141599A1 (enExample) |
| PH (1) | PH12014501283A1 (enExample) |
| PL (1) | PL2794628T3 (enExample) |
| PT (1) | PT2794628T (enExample) |
| SG (1) | SG11201403086YA (enExample) |
| SI (1) | SI2794628T1 (enExample) |
| UA (1) | UA110428C2 (enExample) |
| WO (1) | WO2013092447A1 (enExample) |
| ZA (1) | ZA201404444B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9676797B2 (en) * | 2015-09-02 | 2017-06-13 | Abbvie Inc. | Anti-viral compounds |
| AR088441A1 (es) | 2011-09-12 | 2014-06-11 | Idenix Pharmaceuticals Inc | Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales |
| DK2794628T3 (en) | 2011-12-20 | 2017-07-10 | Riboscience Llc | 4'-AZIDO-3'-FLUORO-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION |
| US9296778B2 (en) | 2012-05-22 | 2016-03-29 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphate prodrugs for HCV infection |
| US9109001B2 (en) | 2012-05-22 | 2015-08-18 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphoramidate prodrugs for HCV infection |
| CA2873315A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharamaceuticals, Inc. | D-amino acid compounds for liver disease |
| AR091156A1 (es) | 2012-05-25 | 2015-01-14 | Jansen R & D Ireland | Nucleosidos de espirooxetano de uracilo |
| EP2900682A1 (en) | 2012-09-27 | 2015-08-05 | IDENIX Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| MX353422B (es) | 2012-10-08 | 2018-01-12 | Idenix Pharmaceuticals Llc | Análogos de 2'-cloronucleósido para infección por vhc. |
| WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
| WO2014099941A1 (en) | 2012-12-19 | 2014-06-26 | Idenix Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| WO2014137926A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | 3'-deoxy nucleosides for the treatment of hcv |
| US20140271547A1 (en) | 2013-03-13 | 2014-09-18 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| EP2981542B1 (en) | 2013-04-01 | 2021-09-15 | Idenix Pharmaceuticals LLC | 2',4'-fluoro nucleosides for the treatment of hcv |
| JP2016519146A (ja) * | 2013-05-16 | 2016-06-30 | リボサイエンス・エルエルシー | ４’−アジド，３’−デオキシ−３’−フルオロ置換ヌクレオシド誘導体 |
| EP3004130B1 (en) | 2013-06-05 | 2019-08-07 | Idenix Pharmaceuticals LLC. | 1',4'-thio nucleosides for the treatment of hcv |
| EP3027636B1 (en) | 2013-08-01 | 2022-01-05 | Idenix Pharmaceuticals LLC | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| WO2020007070A1 (zh) * | 2018-07-02 | 2020-01-09 | 河南真实生物科技有限公司 | 4'-取代核苷的晶型、制备和应用 |
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| AU498131B2 (en) | 1974-02-26 | 1979-02-15 | Ciba-Geigy Ag | Production of cephems by cyclization |
| US4147864A (en) | 1975-02-20 | 1979-04-03 | Ciba-Geigy Corporation | Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds |
| US4322347A (en) | 1978-04-03 | 1982-03-30 | Bristol-Myers Company | 2-Carbamoyloxymethyl-penicillin derivatives |
| WO1986006380A1 (fr) | 1985-04-30 | 1986-11-06 | Takeda Chemical Industries, Ltd. | Composes antibacteriens, utilisation et preparation |
| JPS6422823A (en) * | 1987-07-17 | 1989-01-25 | Asahi Glass Co Ltd | Antiulcer agent |
| US5449664A (en) | 1988-11-21 | 1995-09-12 | Syntex (U.S.A.) Inc. | Antiviral agents |
| US6054472A (en) | 1996-04-23 | 2000-04-25 | Vertex Pharmaceuticals, Incorporated | Inhibitors of IMPDH enzyme |
| US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| EP0902782A1 (en) | 1996-04-23 | 1999-03-24 | Vertex Pharmaceuticals Incorporated | Urea derivatives as inhibitors of impdh enzyme |
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| GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
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| US6010848A (en) | 1997-07-02 | 2000-01-04 | Smithkline Beecham Corporation | Screening methods using an atpase protein from hepatitis C virus |
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| JP2002523371A (ja) | 1998-08-21 | 2002-07-30 | バイロファーマ・インコーポレイテッド | ウイルス感染および関連疾患を治療または予防するための化合物、組成物および方法 |
| CN1324250A (zh) | 1998-09-04 | 2001-11-28 | 维洛药品公司 | 治疗或预防病毒感染及其所致疾病的方法 |
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| EA004141B1 (ru) | 1999-03-19 | 2004-02-26 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы фермента impdh |
| US6566365B1 (en) | 1999-11-04 | 2003-05-20 | Biochem Pharma Inc. | Method for the treatment of Flaviviridea viral infection using nucleoside analogues |
| EP1292310A1 (en) | 2000-05-10 | 2003-03-19 | SmithKline Beecham Corporation | Novel anti-infectives |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
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| EA007484B1 (ru) | 2001-06-11 | 2006-10-27 | Вирокем Фарма Инк. | Соединения и способы лечения или предупреждения инфекций flavivirus |
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| GB0114286D0 (en) | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| AR035543A1 (es) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
| CA2448737C (en) | 2001-07-20 | 2010-06-01 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
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| JP2005511572A (ja) | 2001-11-02 | 2005-04-28 | グラクソ グループ リミテッド | Ｈｃｖ阻害剤としてのアシルジヒドロピロール誘導体 |
| JP2005511573A (ja) | 2001-11-02 | 2005-04-28 | グラクソ グループ リミテッド | Ｈｃｖ阻害剤としての４−（５−員）−ヘテロアリールアシルピロリジン誘導体 |
| ATE370137T1 (de) | 2001-11-02 | 2007-09-15 | Glaxo Group Ltd | 4-(6-gliedriger)-heteroaryl-acyl-pyrrolidin derivate als hcv-inhibitoren |
| AU2003269890A1 (en) | 2002-06-21 | 2004-01-06 | Isis Pharmaceuticals, Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| WO2004014312A2 (en) | 2002-08-08 | 2004-02-19 | Sirna Therapeutics, Inc. | Small-mer compositions and methods of use |
| BRPI0409680A (pt) | 2003-04-25 | 2006-04-18 | Gilead Sciences Inc | análogos de fosfonato anti-cáncer |
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| DE602005017582D1 (en) | 2004-01-30 | 2009-12-24 | Medivir Ab | Hcv ns-3 serine protease inhibitoren |
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-
2012
- 2012-12-17 DK DK12808791.3T patent/DK2794628T3/en active
- 2012-12-17 MX MX2014007028A patent/MX350810B/es active IP Right Grant
- 2012-12-17 EP EP12808791.3A patent/EP2794628B1/en not_active Not-in-force
- 2012-12-17 ES ES12808791.3T patent/ES2626484T3/es active Active
- 2012-12-17 JP JP2014547882A patent/JP6118336B2/ja active Active
- 2012-12-17 SG SG11201403086YA patent/SG11201403086YA/en unknown
- 2012-12-17 BR BR112014015066A patent/BR112014015066A2/pt not_active IP Right Cessation
- 2012-12-17 CN CN201280064193.6A patent/CN104011060A/zh active Pending
- 2012-12-17 EA EA201491180A patent/EA024847B1/ru not_active IP Right Cessation
- 2012-12-17 PE PE2014000990A patent/PE20141599A1/es not_active Application Discontinuation
- 2012-12-17 HU HUE12808791A patent/HUE033332T2/en unknown
- 2012-12-17 CA CA2869317A patent/CA2869317C/en not_active Expired - Fee Related
- 2012-12-17 PT PT128087913T patent/PT2794628T/pt unknown
- 2012-12-17 KR KR1020147020094A patent/KR101687084B1/ko not_active Expired - Fee Related
- 2012-12-17 UA UAA201408090A patent/UA110428C2/uk unknown
- 2012-12-17 LT LTEP12808791.3T patent/LT2794628T/lt unknown
- 2012-12-17 IN IN4530CHN2014 patent/IN2014CN04530A/en unknown
- 2012-12-17 PL PL12808791T patent/PL2794628T3/pl unknown
- 2012-12-17 CN CN201810341927.XA patent/CN108409820A/zh not_active Withdrawn
- 2012-12-17 HK HK15101193.6A patent/HK1200835A1/xx unknown
- 2012-12-17 US US14/366,189 patent/US9708357B2/en not_active Expired - Fee Related
- 2012-12-17 WO PCT/EP2012/075688 patent/WO2013092447A1/en not_active Ceased
- 2012-12-17 AU AU2012357986A patent/AU2012357986B2/en not_active Ceased
- 2012-12-17 SI SI201230977A patent/SI2794628T1/sl unknown
-
2014
- 2014-05-28 CR CR20140255A patent/CR20140255A/es unknown
- 2014-05-28 IL IL232843A patent/IL232843B/en not_active IP Right Cessation
- 2014-06-06 PH PH12014501283A patent/PH12014501283A1/en unknown
- 2014-06-17 ZA ZA2014/04444A patent/ZA201404444B/en unknown
- 2014-06-18 CL CL2014001599A patent/CL2014001599A1/es unknown
- 2014-06-20 CO CO14133951A patent/CO6990719A2/es unknown
- 2014-06-25 MA MA37157A patent/MA35749B1/fr unknown
-
2017
- 2017-06-28 CY CY20171100679T patent/CY1119015T1/el unknown
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