HUE033332T2 - 4'-Azido-3'-fluoro-substituted nucleoside derivatives as inhibitors of HCV RNA replication - Google Patents

4'-Azido-3'-fluoro-substituted nucleoside derivatives as inhibitors of HCV RNA replication Download PDF

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Publication number
HUE033332T2
HUE033332T2 HUE12808791A HUE12808791A HUE033332T2 HU E033332 T2 HUE033332 T2 HU E033332T2 HU E12808791 A HUE12808791 A HU E12808791A HU E12808791 A HUE12808791 A HU E12808791A HU E033332 T2 HUE033332 T2 HU E033332T2
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HU
Hungary
Prior art keywords
compound
formula
azido
fluoro
furan
Prior art date
Application number
HUE12808791A
Other languages
English (en)
Hungarian (hu)
Inventor
Mark Smith
Francisco Xavier Talamas
Jing Zhang
Zhuming Zhang
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of HUE033332T2 publication Critical patent/HUE033332T2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HUE12808791A 2011-12-20 2012-12-17 4'-Azido-3'-fluoro-substituted nucleoside derivatives as inhibitors of HCV RNA replication HUE033332T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161577712P 2011-12-20 2011-12-20

Publications (1)

Publication Number Publication Date
HUE033332T2 true HUE033332T2 (en) 2017-11-28

Family

ID=47469968

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12808791A HUE033332T2 (en) 2011-12-20 2012-12-17 4'-Azido-3'-fluoro-substituted nucleoside derivatives as inhibitors of HCV RNA replication

Country Status (31)

Country Link
US (1) US9708357B2 (enExample)
EP (1) EP2794628B1 (enExample)
JP (1) JP6118336B2 (enExample)
KR (1) KR101687084B1 (enExample)
CN (2) CN108409820A (enExample)
AU (1) AU2012357986B2 (enExample)
BR (1) BR112014015066A2 (enExample)
CA (1) CA2869317C (enExample)
CL (1) CL2014001599A1 (enExample)
CO (1) CO6990719A2 (enExample)
CR (1) CR20140255A (enExample)
CY (1) CY1119015T1 (enExample)
DK (1) DK2794628T3 (enExample)
EA (1) EA024847B1 (enExample)
ES (1) ES2626484T3 (enExample)
HK (1) HK1200835A1 (enExample)
HU (1) HUE033332T2 (enExample)
IL (1) IL232843B (enExample)
IN (1) IN2014CN04530A (enExample)
LT (1) LT2794628T (enExample)
MA (1) MA35749B1 (enExample)
MX (1) MX350810B (enExample)
PE (1) PE20141599A1 (enExample)
PH (1) PH12014501283A1 (enExample)
PL (1) PL2794628T3 (enExample)
PT (1) PT2794628T (enExample)
SG (1) SG11201403086YA (enExample)
SI (1) SI2794628T1 (enExample)
UA (1) UA110428C2 (enExample)
WO (1) WO2013092447A1 (enExample)
ZA (1) ZA201404444B (enExample)

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PT2794628T (pt) 2011-12-20 2017-07-05 Riboscience Llc Derivados nucleosídicos 4¿-azido-3¿-fluoro substituídos como inibidores de replicação de arn de vhc
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CN104470939B (zh) 2012-05-22 2017-04-26 埃迪尼克斯医药有限责任公司 用于肝脏疾病的d型氨基酸化合物
PL2861611T3 (pl) 2012-05-25 2017-08-31 Janssen Sciences Ireland Uc Nukleozydy uracylowe spirooksetanu
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HK1207647A1 (en) 2012-10-08 2016-02-05 Idenix Pharmaceuticals Llc 2'-chloro nucleoside analogs for hcv infection
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WO2014165542A1 (en) 2013-04-01 2014-10-09 Idenix Pharmaceuticals, Inc. 2',4'-fluoro nucleosides for the treatment of hcv
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WO2015017713A1 (en) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
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Also Published As

Publication number Publication date
MX350810B (es) 2017-09-20
IL232843B (en) 2018-02-28
EP2794628B1 (en) 2017-03-29
WO2013092447A1 (en) 2013-06-27
PH12014501283A1 (en) 2014-09-08
HK1199037A1 (en) 2015-06-19
JP6118336B2 (ja) 2017-04-19
US20140369959A1 (en) 2014-12-18
MA35749B1 (fr) 2014-12-01
SG11201403086YA (en) 2014-07-30
KR20140108303A (ko) 2014-09-05
NZ625844A (en) 2016-08-26
AU2012357986A1 (en) 2014-06-19
SI2794628T1 (sl) 2017-07-31
KR101687084B1 (ko) 2016-12-15
CA2869317A1 (en) 2013-06-27
CL2014001599A1 (es) 2014-11-03
HK1200835A1 (en) 2015-08-14
CN108409820A (zh) 2018-08-17
AU2012357986B2 (en) 2017-02-02
CO6990719A2 (es) 2014-07-10
PT2794628T (pt) 2017-07-05
LT2794628T (lt) 2017-07-10
PE20141599A1 (es) 2014-10-30
US9708357B2 (en) 2017-07-18
IN2014CN04530A (enExample) 2015-09-11
PL2794628T3 (pl) 2017-09-29
UA110428C2 (uk) 2015-12-25
ZA201404444B (en) 2015-08-26
JP2015500851A (ja) 2015-01-08
BR112014015066A2 (pt) 2017-06-13
EA201491180A1 (ru) 2014-11-28
CR20140255A (es) 2014-08-20
CA2869317C (en) 2016-05-17
ES2626484T3 (es) 2017-07-25
EP2794628A1 (en) 2014-10-29
DK2794628T3 (en) 2017-07-10
CY1119015T1 (el) 2018-01-10
IL232843A0 (en) 2014-07-31
CN104011060A (zh) 2014-08-27
MX2014007028A (es) 2014-09-16
EA024847B1 (ru) 2016-10-31

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