CO6990719A2 - Derivados de los nucleósidos sustituidos en 4´-azido, 3´-fluoro como inhibidores de la replicación del rna del vhc - Google Patents
Derivados de los nucleósidos sustituidos en 4´-azido, 3´-fluoro como inhibidores de la replicación del rna del vhcInfo
- Publication number
- CO6990719A2 CO6990719A2 CO14133951A CO14133951A CO6990719A2 CO 6990719 A2 CO6990719 A2 CO 6990719A2 CO 14133951 A CO14133951 A CO 14133951A CO 14133951 A CO14133951 A CO 14133951A CO 6990719 A2 CO6990719 A2 CO 6990719A2
- Authority
- CO
- Colombia
- Prior art keywords
- vna
- azido
- replication
- fluoro
- rna
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 125000003835 nucleoside group Chemical group 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161577712P | 2011-12-20 | 2011-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6990719A2 true CO6990719A2 (es) | 2014-07-10 |
Family
ID=47469968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO14133951A CO6990719A2 (es) | 2011-12-20 | 2014-06-20 | Derivados de los nucleósidos sustituidos en 4´-azido, 3´-fluoro como inhibidores de la replicación del rna del vhc |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US9708357B2 (enExample) |
| EP (1) | EP2794628B1 (enExample) |
| JP (1) | JP6118336B2 (enExample) |
| KR (1) | KR101687084B1 (enExample) |
| CN (2) | CN108409820A (enExample) |
| AU (1) | AU2012357986B2 (enExample) |
| BR (1) | BR112014015066A2 (enExample) |
| CA (1) | CA2869317C (enExample) |
| CL (1) | CL2014001599A1 (enExample) |
| CO (1) | CO6990719A2 (enExample) |
| CR (1) | CR20140255A (enExample) |
| CY (1) | CY1119015T1 (enExample) |
| DK (1) | DK2794628T3 (enExample) |
| EA (1) | EA024847B1 (enExample) |
| ES (1) | ES2626484T3 (enExample) |
| HK (1) | HK1200835A1 (enExample) |
| HU (1) | HUE033332T2 (enExample) |
| IL (1) | IL232843B (enExample) |
| IN (1) | IN2014CN04530A (enExample) |
| LT (1) | LT2794628T (enExample) |
| MA (1) | MA35749B1 (enExample) |
| MX (1) | MX350810B (enExample) |
| PE (1) | PE20141599A1 (enExample) |
| PH (1) | PH12014501283A1 (enExample) |
| PL (1) | PL2794628T3 (enExample) |
| PT (1) | PT2794628T (enExample) |
| SG (1) | SG11201403086YA (enExample) |
| SI (1) | SI2794628T1 (enExample) |
| UA (1) | UA110428C2 (enExample) |
| WO (1) | WO2013092447A1 (enExample) |
| ZA (1) | ZA201404444B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR088441A1 (es) | 2011-09-12 | 2014-06-11 | Idenix Pharmaceuticals Inc | Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales |
| SG11201403086YA (en) | 2011-12-20 | 2014-07-30 | Hoffmann La Roche | 4'-azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication |
| US9109001B2 (en) | 2012-05-22 | 2015-08-18 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphoramidate prodrugs for HCV infection |
| GEP20176800B (en) | 2012-05-22 | 2018-01-10 | Idenix Pharmaceuticals Llk | D-amino acid compounds for liver disease |
| WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
| WO2013174962A1 (en) | 2012-05-25 | 2013-11-28 | Janssen R&D Ireland | Uracyl spirooxetane nucleosides |
| EP2900682A1 (en) | 2012-09-27 | 2015-08-05 | IDENIX Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| CN111848711A (zh) | 2012-10-08 | 2020-10-30 | 埃迪尼克斯医药有限责任公司 | 用于hcv感染的2′-氯核苷类似物 |
| US10723754B2 (en) | 2012-10-22 | 2020-07-28 | Idenix Pharmaceuticals Llc | 2′,4′-bridged nucleosides for HCV infection |
| US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
| EP2970358B1 (en) | 2013-03-04 | 2021-06-30 | Idenix Pharmaceuticals LLC | 3'-deoxy nucleosides for the treatment of hcv |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| US20140271547A1 (en) | 2013-03-13 | 2014-09-18 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| US9187515B2 (en) | 2013-04-01 | 2015-11-17 | Idenix Pharmaceuticals Llc | 2′,4′-fluoro nucleosides for the treatment of HCV |
| EA201592185A1 (ru) * | 2013-05-16 | 2016-05-31 | Рибосайенс Ллк | 4'-азидо, 3'-дезокси-3'-фторзамещенные нуклеозидные производные |
| WO2014197578A1 (en) | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
| EP3027636B1 (en) | 2013-08-01 | 2022-01-05 | Idenix Pharmaceuticals LLC | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| EP3344642A1 (en) * | 2015-09-02 | 2018-07-11 | AbbVie Inc. | Anti-viral tetrahydrofurane derivatives |
| CN109893536B (zh) * | 2018-07-02 | 2021-04-27 | 河南真实生物科技有限公司 | 4’-取代核苷的晶型、制备和应用 |
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| US4147864A (en) | 1975-02-20 | 1979-04-03 | Ciba-Geigy Corporation | Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds |
| US4322347A (en) | 1978-04-03 | 1982-03-30 | Bristol-Myers Company | 2-Carbamoyloxymethyl-penicillin derivatives |
| WO1986006380A1 (fr) | 1985-04-30 | 1986-11-06 | Takeda Chemical Industries, Ltd. | Composes antibacteriens, utilisation et preparation |
| JPS6422823A (en) * | 1987-07-17 | 1989-01-25 | Asahi Glass Co Ltd | Antiulcer agent |
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| ES2289161T3 (es) | 2001-11-02 | 2008-02-01 | Glaxo Group Limited | Derivados de 4-(heteroaril de 6 miembros)-acil pirrolidina como inhibidores de hcv. |
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-
2012
- 2012-12-17 SG SG11201403086YA patent/SG11201403086YA/en unknown
- 2012-12-17 SI SI201230977A patent/SI2794628T1/sl unknown
- 2012-12-17 JP JP2014547882A patent/JP6118336B2/ja active Active
- 2012-12-17 WO PCT/EP2012/075688 patent/WO2013092447A1/en not_active Ceased
- 2012-12-17 MX MX2014007028A patent/MX350810B/es active IP Right Grant
- 2012-12-17 DK DK12808791.3T patent/DK2794628T3/en active
- 2012-12-17 EA EA201491180A patent/EA024847B1/ru not_active IP Right Cessation
- 2012-12-17 IN IN4530CHN2014 patent/IN2014CN04530A/en unknown
- 2012-12-17 KR KR1020147020094A patent/KR101687084B1/ko not_active Expired - Fee Related
- 2012-12-17 US US14/366,189 patent/US9708357B2/en not_active Expired - Fee Related
- 2012-12-17 PT PT128087913T patent/PT2794628T/pt unknown
- 2012-12-17 CA CA2869317A patent/CA2869317C/en not_active Expired - Fee Related
- 2012-12-17 AU AU2012357986A patent/AU2012357986B2/en not_active Ceased
- 2012-12-17 EP EP12808791.3A patent/EP2794628B1/en not_active Not-in-force
- 2012-12-17 LT LTEP12808791.3T patent/LT2794628T/lt unknown
- 2012-12-17 HU HUE12808791A patent/HUE033332T2/en unknown
- 2012-12-17 BR BR112014015066A patent/BR112014015066A2/pt not_active IP Right Cessation
- 2012-12-17 CN CN201810341927.XA patent/CN108409820A/zh not_active Withdrawn
- 2012-12-17 PE PE2014000990A patent/PE20141599A1/es not_active Application Discontinuation
- 2012-12-17 PL PL12808791T patent/PL2794628T3/pl unknown
- 2012-12-17 ES ES12808791.3T patent/ES2626484T3/es active Active
- 2012-12-17 CN CN201280064193.6A patent/CN104011060A/zh active Pending
- 2012-12-17 UA UAA201408090A patent/UA110428C2/uk unknown
- 2012-12-17 HK HK15101193.6A patent/HK1200835A1/xx unknown
-
2014
- 2014-05-28 IL IL232843A patent/IL232843B/en not_active IP Right Cessation
- 2014-05-28 CR CR20140255A patent/CR20140255A/es unknown
- 2014-06-06 PH PH12014501283A patent/PH12014501283A1/en unknown
- 2014-06-17 ZA ZA2014/04444A patent/ZA201404444B/en unknown
- 2014-06-18 CL CL2014001599A patent/CL2014001599A1/es unknown
- 2014-06-20 CO CO14133951A patent/CO6990719A2/es unknown
- 2014-06-25 MA MA37157A patent/MA35749B1/fr unknown
-
2017
- 2017-06-28 CY CY20171100679T patent/CY1119015T1/el unknown
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