CO6640284A2 - Miembros enlazadores para citomegalovirus humano - Google Patents
Miembros enlazadores para citomegalovirus humanoInfo
- Publication number
- CO6640284A2 CO6640284A2 CO12122672A CO12122672A CO6640284A2 CO 6640284 A2 CO6640284 A2 CO 6640284A2 CO 12122672 A CO12122672 A CO 12122672A CO 12122672 A CO12122672 A CO 12122672A CO 6640284 A2 CO6640284 A2 CO 6640284A2
- Authority
- CO
- Colombia
- Prior art keywords
- human cytomegalovirus
- binding members
- hcmv
- members
- linkers
- Prior art date
Links
- 241000701024 Human betaherpesvirus 5 Species 0.000 title abstract 5
- 230000004071 biological effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
- C07K16/089—Cytomegalovirus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- AIDS & HIV (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Radiology & Medical Imaging (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La invención se refiere a miembros enlazadores, en especial a moléculas de anticuerpos, que neutralizan los efectos biológicos del citomegalovirus humano (hCMV). Los miembros enlazadores son útiles para el tratamiento y la profilaxis de la infección por el citomegalovirus humano (hCMV).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28983509P | 2009-12-23 | 2009-12-23 | |
EP09015951 | 2009-12-23 | ||
EP10003669 | 2010-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6640284A2 true CO6640284A2 (es) | 2013-03-22 |
Family
ID=44246877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO12122672A CO6640284A2 (es) | 2009-12-23 | 2012-07-23 | Miembros enlazadores para citomegalovirus humano |
Country Status (17)
Country | Link |
---|---|
US (1) | US9346874B2 (es) |
EP (1) | EP2516463B1 (es) |
JP (1) | JP5833565B2 (es) |
KR (1) | KR20120105543A (es) |
CN (1) | CN102892782B (es) |
AU (1) | AU2010334809C1 (es) |
BR (1) | BR112012015523A2 (es) |
CA (1) | CA2785587A1 (es) |
CO (1) | CO6640284A2 (es) |
EA (1) | EA201270662A1 (es) |
HK (1) | HK1181398A1 (es) |
IL (1) | IL220617A0 (es) |
MX (1) | MX2012007489A (es) |
NZ (1) | NZ600974A (es) |
SG (1) | SG181901A1 (es) |
WO (1) | WO2011076883A1 (es) |
ZA (1) | ZA201204513B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2772265T (pt) | 2010-05-14 | 2018-04-20 | Univ Oregon Health & Science | Vectores de hcmv e rhcmv recombinantes e seus usos |
DK2691530T3 (en) | 2011-06-10 | 2018-05-22 | Univ Oregon Health & Science | CMV GLYCOPROTEIN AND RECOMBINANT VECTORS |
US9139659B2 (en) * | 2012-03-28 | 2015-09-22 | Genentech, Inc. | Idiotypic antibodies and uses thereof |
US20150110794A1 (en) * | 2012-04-30 | 2015-04-23 | Cell Signaling Technology, Inc. | Anti-Human Cytomegalovirus Antibodies And Use Thereof |
US9783823B2 (en) * | 2013-03-05 | 2017-10-10 | Oregon Health & Science University | Cytomegalovirus vectors enabling control of T cell targeting |
WO2014172623A1 (en) * | 2013-04-19 | 2014-10-23 | Ole Olsen | Compositions and methods for the therapy and diagnosis of cytomegalovirus |
WO2014200898A2 (en) * | 2013-06-10 | 2014-12-18 | Merck Sharp & Dohme Corp. | Cmv neutralizing antigen binding proteins |
AP2017009743A0 (en) | 2014-07-16 | 2017-02-28 | Univ Oregon Health & Science | Human cytomegalovirus comprising exogenous antigens |
MA41756A (fr) | 2015-02-10 | 2017-12-20 | Fruh Klaus | Procédés et compositions utiles dans la génération de réponses non canoniques de lymphocytes t cd8+ |
US10688164B2 (en) | 2015-11-20 | 2020-06-23 | Oregon Health & Science University | CMV vectors comprising microRNA recognition elements |
US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
US10532099B2 (en) | 2016-10-18 | 2020-01-14 | Oregon Health & Science University | Cytomegalovirus vectors eliciting T cells restricted by major histocompatibility complex E molecules |
EP3823979A1 (en) * | 2018-07-20 | 2021-05-26 | AiCuris GmbH & Co. KG | Methods for screening and identifying agents that inhibit or modulate the nuclear egress complex of herpesviruses |
US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
CN112898414B (zh) * | 2019-12-04 | 2024-05-10 | 珠海泰诺麦博制药股份有限公司 | 抗人巨细胞病毒抗体及其用途 |
TWI810589B (zh) | 2020-06-21 | 2023-08-01 | 美商輝瑞股份有限公司 | 人巨細胞病毒糖蛋白B(gB)多肽 |
GB202020135D0 (en) * | 2020-12-18 | 2021-02-03 | Ucl Business Ltd | Immunogenic peptide |
Family Cites Families (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
US4424200A (en) | 1979-05-14 | 1984-01-03 | Nuc Med Inc. | Method for radiolabeling proteins with technetium-99m |
US4479930A (en) | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
FR2543570B1 (fr) | 1983-03-31 | 1985-08-09 | Pasteur Institut | Anticorps monoclonaux anticytomegalovirus humains, hybridomes secreteurs de ces anticorps et polypeptides porteurs d'un determinant antigenique sequentiel de cytomegalovirus humains |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
GB8404368D0 (en) | 1984-02-20 | 1984-03-28 | Cogent Ltd | Monoclonal antibodies to human cytomegalovirus |
US4618578A (en) | 1984-07-17 | 1986-10-21 | Chiron Corporation | Expression of glycoprotein D of herpes simplex virus |
US5244792A (en) | 1984-04-06 | 1993-09-14 | Chiron Corporation | Expression of recombinant glyoprotein B from herpes simplex virus |
US5171568A (en) | 1984-04-06 | 1992-12-15 | Chiron Corporation | Recombinant herpes simplex gb-gd vaccine |
US6100064A (en) | 1984-04-06 | 2000-08-08 | Chiron Corporation | Secreted viral proteins useful for vaccines and diagnostics |
FR2563630B1 (fr) | 1984-04-27 | 1988-02-19 | Pasteur Institut | Anticorps monoclonaux anticytomegalovirus et procedes pour le diagnostic in vitro des infections par les cytomegalovirus humains et d'une proteine-kinase inductible par les cytomegalovirus et susceptible d'etre reconnue par les susdits anticorps monoclonaux |
US5612041A (en) | 1984-07-17 | 1997-03-18 | Chiron Corporation | Recombinant herpes simplex gD vaccine |
US5194256A (en) | 1984-08-21 | 1993-03-16 | The Board Of Trustees Of The Leland Sanford Junior University | Purified human cytomegalovirus protein |
US4743562A (en) | 1984-08-21 | 1988-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Purified human cytomegalovirus protein |
WO1986002092A1 (en) | 1984-09-28 | 1986-04-10 | Teijin Limited | Mouse human hybridoma producing antivirus human antibody, process for its preparation, and antivirus human monoclonal antibody |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
EP0248909B1 (en) | 1985-12-06 | 1994-08-17 | Teijin Limited | Anticytomegaloviral human monoclonal antibody and process for its preparation |
US6162620A (en) | 1986-03-07 | 2000-12-19 | Cogent Limited | Processes for the production of HCMV glycoproteins, antibodies thereto and HCMV vaccines, and recombinant vectors therefor |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
DE3782867D1 (en) | 1986-06-12 | 1993-01-14 | Behringwerke Ag, 3550 Marburg, De | Human cytomegalovirus phospho-protein |
US5153311A (en) | 1986-11-24 | 1992-10-06 | The Children's Hospital, Incorporated | Immunogenic glycoproteins of human cytomegalovirus gCII |
US5124440A (en) | 1986-11-24 | 1992-06-23 | The Childrens Hospital, Inc. | Antibody and T cell recognition sites on glycoproteins comprising the GCI complex of human cytomegalovirus |
US5248768A (en) | 1986-11-24 | 1993-09-28 | The Children's Hospital, Incorporated | Immunogenic glycoproteins of human cytomegalovirus |
US5126130A (en) | 1986-11-24 | 1992-06-30 | The Childrens Hospital Incorporated | Monoclonal antibodies reactive with specific antigenic sites on human cytomegalovirus glycoprotein a |
LU86752A1 (fr) | 1987-01-30 | 1988-08-23 | Univ Bruxelles | Procede de production d'anticorps monoclonaux humains(igg)anticytomegalovirus et anticorps monoclonaux ainsi obtenus |
GB8729251D0 (en) | 1987-12-15 | 1988-01-27 | Cogent Ltd | Human cytomegalovirus protein |
US5547834A (en) | 1988-01-29 | 1996-08-20 | Chiron Corporation | Recombinant CMV neutralizing proteins |
EP0609580B1 (en) | 1988-01-29 | 2003-07-30 | Aventis Pasteur | Recombinant CMV neutralising proteins |
US6733989B1 (en) | 1988-02-24 | 2004-05-11 | Dade Behring Marburg Gmbh | Structural phosphoprotein (pp28) of human cytomegalovirus (HCMV), the preparation and use thereof |
EP0413738A1 (en) | 1988-05-09 | 1991-02-27 | The Children's Hospital, Incorporated | Vectors encoding hcmv glycoprotein and expression products |
US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
AU4664689A (en) | 1988-12-12 | 1990-07-10 | Children's Hospital Incorporated, The | Proteolytic fragments obtained from human cytomegalovirus glycoprotein complex i |
US5180813A (en) | 1989-03-24 | 1993-01-19 | University Of Iowa Research Foundation | Early envelope glycoprotein of human cytomegalovirus (hmcv) and monoclonal antibodies to the glycoproteins |
WO1991002004A1 (en) | 1989-08-07 | 1991-02-21 | Children's Biomedical Research Center | IMMUNOGENIC GLYCOPROTEINS OF HUMAN CYTOMEGALOVIRUS gCII |
WO1991004277A1 (en) | 1989-09-14 | 1991-04-04 | Children's Biomedical Research Institute | Monoclonal antibodies specific to cytomegalovirus glycoprotein |
WO1991005876A1 (en) | 1989-10-20 | 1991-05-02 | Children's Biomedical Research Institute | Human cytomegalovirus-specific monoclonal antibody cocktail |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
GB9008223D0 (en) | 1990-04-11 | 1990-06-13 | Royal Free Hosp School Med | Improvements relating to the detection of viruses |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
JP2535455B2 (ja) | 1991-02-07 | 1996-09-18 | 帝人株式会社 | サイトメガロウイルスに対するヒト・モノクロ―ナル抗体を産生するハイブリド―マ |
JPH053794A (ja) | 1991-06-26 | 1993-01-14 | Green Cross Corp:The | 抗サイトメガロウイルスヒトモノクローナル抗体およびその産生細胞 |
US5744298A (en) | 1991-08-29 | 1998-04-28 | Behringwerke Aktiengesellschaft | DNA sequences which encode immunoreactive HCMV-specific peptides |
DK1136556T3 (da) | 1991-11-25 | 2005-10-03 | Enzon Inc | Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner |
SE9201281L (sv) | 1992-04-23 | 1993-10-24 | Bioinvent Int Ab | Nya humana monoklonala antikroppar och förfarande för framställning därav |
JPH05260961A (ja) | 1992-05-21 | 1993-10-12 | Teijin Ltd | サイトメガロウイルスに対するヒト・モノクローナル抗体を産生するハイブリドーマ |
GB9221654D0 (en) | 1992-10-15 | 1992-11-25 | Scotgen Ltd | Recombinant human anti-cytomegalovirus antibodies |
JPH06157349A (ja) | 1992-11-13 | 1994-06-03 | Teijin Ltd | サイトメガロウイルス感染症治療剤 |
US5837242A (en) | 1992-12-04 | 1998-11-17 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
US5750106A (en) | 1993-01-28 | 1998-05-12 | Novartis Ag | Human monoclonal antibodies to cytomegalovirus |
WO1994025490A1 (en) | 1993-04-30 | 1994-11-10 | The Scripps Research Institute | Human monoclonal antibodies to human cytomegalovirus, and methods therefor |
JP2538536B2 (ja) | 1994-07-06 | 1996-09-25 | 帝人株式会社 | サイトメガロウイルスに対するヒト・モノクロ―ナル抗体を産生するハイブリド―マ |
JP2538537B2 (ja) | 1994-07-06 | 1996-09-25 | 帝人株式会社 | サイトメガロウイルスに対するヒト・モノクロ―ナル抗体 |
JPH0859508A (ja) | 1994-08-16 | 1996-03-05 | Teijin Ltd | サイトメガロウイルス網膜炎予防または治療剤 |
JPH0859509A (ja) | 1994-08-16 | 1996-03-05 | Teijin Ltd | サイトメガロウイルス抗原血症治療剤およびサイトメガロウイルス感染症治療剤 |
US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
US5783383A (en) | 1995-05-23 | 1998-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Method of detecting cytomegalovirus (CMV) |
US20020102562A1 (en) | 1995-05-24 | 2002-08-01 | Pasteur Merieux Serums Et Vaccines S.A. | Recombinant CMV neutralizing proteins |
US5800981A (en) | 1996-02-22 | 1998-09-01 | University Of Limburg | Human cytomegalovirus antigen and its use |
US5814468A (en) | 1996-03-27 | 1998-09-29 | Coulter International Corp. | Methods of enumerating receptor molecules for specific binding partners on formed bodies and in solution |
AU728285C (en) | 1996-08-14 | 2002-02-21 | Wistar Institute Of Anatomy And Biology, The | Methods and compositions for preventing or retarding the development of atherosclerotic lesions |
US6183752B1 (en) | 1997-02-05 | 2001-02-06 | Pasteur Merieux Serums Et Vaccins | Restenosis/atherosclerosis diagnosis, prophylaxis and therapy |
DE19756214C1 (de) | 1997-12-17 | 1999-02-25 | Biotest Ag | Polypeptide mit Aminosäuresequenzen aus dem N-terminalen Bereich von gp116 und deren Verwendung bei der Diagnostik, Prophylaxe und Therapie |
PT1071700E (pt) | 1998-04-20 | 2010-04-23 | Glycart Biotechnology Ag | Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
EP2154535A1 (en) | 1998-12-10 | 2010-02-17 | Bristol-Myers Squibb Company | Protein scaffolds for antibody mimics and other binding proteins |
US6569616B1 (en) | 1999-07-29 | 2003-05-27 | Wisconsin Alumni Research Foundation | Human cytomegalovirus glycoprotein O as a new drug target and subunit vaccine candidate |
CA2420944A1 (en) | 2000-08-30 | 2002-03-07 | Chemocentryx, Inc. | Inhibition of cmv infection and dissemination |
CA2438322A1 (en) | 2001-02-21 | 2002-08-29 | Gabriele Hahn | Recombinant vector containing infectious human cytomegalovirus genome with preserved wild-type characteristics of clinical isolates |
EP1539233B1 (en) | 2001-07-12 | 2011-04-27 | FOOTE, Jefferson | Super humanized antibodies |
AU2002337935B2 (en) | 2001-10-25 | 2008-05-01 | Genentech, Inc. | Glycoprotein compositions |
NZ534205A (en) | 2001-12-22 | 2006-04-28 | Antibody A 4 | Method for the generation of genetically modified vertebrate precursor lymphocytes and use thereof for the production of heterologous binding proteins |
GB2398783A (en) | 2003-02-26 | 2004-09-01 | Antonio Lanzavecchia | A method for producing immortalised human B memory lymphocytes |
WO2004076677A2 (en) | 2003-02-26 | 2004-09-10 | Institute For Research In Biomedicine | Monoclonal antibody production by ebv transformation of b cells |
WO2004076645A2 (en) | 2003-02-27 | 2004-09-10 | University Of Massachusetts | Compositions and methods for cytomegalovirus treatment |
CA2527694C (en) | 2003-05-30 | 2015-07-14 | Hendricus Renerus Jacobus Mattheus Hoogenboom | Fab library for the preparation of anti vegf and anti rabies virus fabs |
US7976845B2 (en) | 2004-11-29 | 2011-07-12 | The Council Of The Queensland Institute Of Medical Research | Human cytomegalovirus immunotherapy |
EP1974020B1 (en) | 2005-12-16 | 2011-06-15 | Ribovax Biotechnologies SA | Methods for obtaining immortalized antibody secreting cells |
JPWO2007094423A1 (ja) | 2006-02-15 | 2009-07-09 | 株式会社イーベック | ヒトサイトメガロウイルスに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
US7704510B2 (en) | 2006-06-07 | 2010-04-27 | The Trustees Of Princeton University | Cytomegalovirus surface protein complex for use in vaccines and as a drug target |
GB0612944D0 (en) * | 2006-06-29 | 2006-08-09 | Bhr Group Ltd | Water jet cutting apparatus |
CA2672703C (en) | 2006-12-15 | 2016-11-22 | Ribovax Biotechnologies Sa | Antibodies against human cytomegalovirus (hcmv) |
GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
US7947274B2 (en) | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
CN101605808A (zh) | 2007-02-07 | 2009-12-16 | 希格马托制药工业公司 | 人巨细胞病毒(hcmv)的重组抗原 |
WO2008120202A2 (en) | 2007-03-29 | 2008-10-09 | Technion Research & Development Foundation Ltd. | Antibodies, methods and kits for diagnosing and treating melanoma |
US8361473B2 (en) | 2007-03-29 | 2013-01-29 | Technion Research & Development Foundation Ltd. | Antibodies and their uses for diagnosis and treatment of cytomegalovirus infection and associated diseases |
EP2173771A1 (en) | 2007-07-04 | 2010-04-14 | Ribovax Biotechnologies SA | Antibodies against human cytomegalovirus (hcmv) |
US20110171233A1 (en) | 2007-08-22 | 2011-07-14 | Ribovax Biotechnologies S.A. | Antibodies Against Human Cytomegalovirus (HCMV) |
WO2009085383A1 (en) | 2007-12-19 | 2009-07-09 | Dcb-Usa Llc | Anti-human cytomegalovirus antibodies |
US7982012B2 (en) | 2008-03-10 | 2011-07-19 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of cytomegalovirus |
CA2730620A1 (en) | 2008-07-16 | 2010-01-21 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
MX338067B (es) | 2008-07-16 | 2016-04-01 | Inst Research In Biomedicine | Anticuerpos neutralizantes de citomegalovirus humano y uso de los mismos. |
WO2010114105A1 (ja) | 2009-04-01 | 2010-10-07 | 株式会社イーベック | ヒトサイトメガロウイルスgB糖タンパク質のAD2領域に結合するモノクローナル抗体ならびにその抗原結合性断片 |
AU2011268277B2 (en) | 2010-06-16 | 2016-10-27 | Trellis Bioscience, Llc | High affinity human antibodies to human Cytomegalovirus (CMV) gB protein |
-
2010
- 2010-12-22 AU AU2010334809A patent/AU2010334809C1/en not_active Ceased
- 2010-12-22 CN CN201080064592.3A patent/CN102892782B/zh not_active Expired - Fee Related
- 2010-12-22 EA EA201270662A patent/EA201270662A1/ru unknown
- 2010-12-22 JP JP2012545334A patent/JP5833565B2/ja not_active Expired - Fee Related
- 2010-12-22 SG SG2012046686A patent/SG181901A1/en unknown
- 2010-12-22 NZ NZ60097410A patent/NZ600974A/en not_active IP Right Cessation
- 2010-12-22 WO PCT/EP2010/070568 patent/WO2011076883A1/en active Application Filing
- 2010-12-22 CA CA 2785587 patent/CA2785587A1/en not_active Abandoned
- 2010-12-22 MX MX2012007489A patent/MX2012007489A/es not_active Application Discontinuation
- 2010-12-22 BR BR112012015523A patent/BR112012015523A2/pt not_active IP Right Cessation
- 2010-12-22 KR KR20127019531A patent/KR20120105543A/ko not_active Application Discontinuation
- 2010-12-22 EP EP10796400.9A patent/EP2516463B1/en not_active Not-in-force
-
2012
- 2012-06-19 ZA ZA2012/04513A patent/ZA201204513B/en unknown
- 2012-06-22 US US13/530,891 patent/US9346874B2/en not_active Expired - Fee Related
- 2012-06-24 IL IL220617A patent/IL220617A0/en unknown
- 2012-07-23 CO CO12122672A patent/CO6640284A2/es not_active Application Discontinuation
-
2013
- 2013-07-22 HK HK13108568.0A patent/HK1181398A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR112012015523A2 (pt) | 2017-04-18 |
AU2010334809C1 (en) | 2015-02-26 |
IL220617A0 (en) | 2012-08-30 |
HK1181398A1 (en) | 2013-11-08 |
EP2516463B1 (en) | 2016-06-15 |
US9346874B2 (en) | 2016-05-24 |
ZA201204513B (en) | 2013-02-27 |
SG181901A1 (en) | 2012-08-30 |
JP2013515469A (ja) | 2013-05-09 |
CA2785587A1 (en) | 2011-06-30 |
MX2012007489A (es) | 2012-11-29 |
US20130089559A1 (en) | 2013-04-11 |
CN102892782A (zh) | 2013-01-23 |
AU2010334809A1 (en) | 2012-07-26 |
WO2011076883A1 (en) | 2011-06-30 |
CN102892782B (zh) | 2015-01-14 |
EA201270662A1 (ru) | 2013-01-30 |
NZ600974A (en) | 2014-08-29 |
KR20120105543A (ko) | 2012-09-25 |
AU2010334809B2 (en) | 2014-10-23 |
EP2516463A1 (en) | 2012-10-31 |
JP5833565B2 (ja) | 2015-12-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6640284A2 (es) | Miembros enlazadores para citomegalovirus humano | |
CY1118744T1 (el) | Υποκατεστημενες τρικυκλικες ενωσεις ως αναστολεις fgfr | |
CR20110066A (es) | Anticuerpos monoclonales contra el factor tisular inhibidor de la via | |
EA201171367A1 (ru) | Винилиндазолильные соединения | |
CY1121637T1 (el) | Αντι-dkk-1 αντισωματα | |
EA201491766A1 (ru) | Соединения для лечения спинальной мышечной атрофии | |
TR201813877T4 (tr) | Spi̇nal müsküler atrofi̇ni̇n tedavi̇ edi̇lmesi̇ne yöneli̇k bi̇leşi̇kler. | |
UY34101A (es) | Proteínas de unión a antígeno | |
CR20140161A (es) | Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas | |
GT201200258A (es) | Composiciones de anticuerpos anti-factor de crecimiento nervioso (ngf) | |
CO6551674A2 (es) | Anticuerpos anti-her3 y usos de los mismo | |
EA201270257A1 (ru) | Производные n1-сульфонил-5-фторпиримидинона | |
ECSP12011694A (es) | Anticuerpos humanos de alta afinidad para la angiopoyetina-2-humana | |
GT200900095A (es) | Dihidropirazolonas sustituidas para el tratamiento de enfermedades cardiovasculares y hermatologicas. | |
CL2012003283A1 (es) | Anticuerpo humano aislado o un fragmento de union al antigeno del mismo porque se une o bloquea la actividad biológica de gdf-8 humano maduro de tipo natural; composicion farmacéutica que comprende dicho anticuerpo o el fragmento de unión al antígeno; uso del anticuerpo para tratar una enfermedad o trastorno tratable mediante la inhibición de la actividad de gdf-8. | |
CL2012003385A1 (es) | Tratamiento para la incontinencia. | |
ECSP10010580A (es) | Inmunoglobulinas duales de dominio variable y sus aplicaciones | |
CY1120204T1 (el) | Αμορφη στερεα διασπορα για χρηση σε θεραπεια καρκινου του εγκεφαλο | |
PA8772101A1 (es) | Imidazol-triazolopirimidinas sustituidas | |
EA201100505A1 (ru) | Органические соединения для применения для лечения бактериальных инфекций | |
EA201390967A1 (ru) | Специфические для грамположительных бактерий связывающие соединения | |
CU20130066A7 (es) | Polipéptidos que se enlazan a cxcr2 | |
UY32061A (es) | Anticuerpos humanos para rankl humano | |
UY30572A1 (es) | N-(1-ftalazin-1-il-piperidin-4-il)-amidas como moduladores del receptor ep2 | |
CR20120453A (es) | Anticuerpos monoclonales optimizados contra el inhibidor de la vía del factor tisular (tfp) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn |