MA41756A - Procédés et compositions utiles dans la génération de réponses non canoniques de lymphocytes t cd8+ - Google Patents

Procédés et compositions utiles dans la génération de réponses non canoniques de lymphocytes t cd8+

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Publication number
MA41756A
MA41756A MA041756A MA41756A MA41756A MA 41756 A MA41756 A MA 41756A MA 041756 A MA041756 A MA 041756A MA 41756 A MA41756 A MA 41756A MA 41756 A MA41756 A MA 41756A
Authority
MA
Morocco
Prior art keywords
protein
methods
antigen
canonic
heterologous
Prior art date
Application number
MA041756A
Other languages
English (en)
Inventor
Daniel Malouli
Klaus Frueh
Louis Picker
Jonah Sacha
Original Assignee
Fruh Klaus
Hansen Scott
Univ Oregon Health & Science
Louis Picker
Jonah Sacha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fruh Klaus, Hansen Scott, Univ Oregon Health & Science, Louis Picker, Jonah Sacha filed Critical Fruh Klaus
Publication of MA41756A publication Critical patent/MA41756A/fr

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Abstract

L'invention concerne des procédés d'induction d'une réponse de lymphocytes t cd8 + à un antigène hétérologue dans lequel au moins 10% des lymphocytes t cd8 + sont restreints par le cmh-e. La méthode consiste à immuniser avec un vecteur cmv qui n'exprime pas les protéines ul128 et ul130. L'invention concerne également des vecteurs cmv recombinants comprenant des acides nucléiques codant pour un antigène protéique hétérologue, une protéine ul40 et une protéine us28, mais n'exprimant pas une protéine active ul128 et ul130. L'invention concerne également des vecteurs cmv recombinants comprenant des acides nucléiques codant pour un antigène protéique hétérologue, mais n'exprimant pas une protéine ul40 active, une protéine ul128, une protéine ul130 et, facultativement, une protéine us28. L'invention concerne également des vecteurs cmv recombinants comprenant des acides nucléiques codant pour un antigène protéique hétérologue, mais n'exprimant pas une protéine us28 active, une protéine ul128, une protéine ul130 et éventuellement une protéine ul40.
MA041756A 2015-02-10 2016-02-10 Procédés et compositions utiles dans la génération de réponses non canoniques de lymphocytes t cd8+ MA41756A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562114203P 2015-02-10 2015-02-10
US201562196520P 2015-07-24 2015-07-24
US201562220703P 2015-09-18 2015-09-18

Publications (1)

Publication Number Publication Date
MA41756A true MA41756A (fr) 2017-12-20

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MA041756A MA41756A (fr) 2015-02-10 2016-02-10 Procédés et compositions utiles dans la génération de réponses non canoniques de lymphocytes t cd8+

Country Status (15)

Country Link
US (2) US20180298404A1 (fr)
EP (2) EP4036239A1 (fr)
JP (3) JP6816031B2 (fr)
KR (1) KR20170136512A (fr)
CN (2) CN108064304A (fr)
AU (1) AU2016219317A1 (fr)
BR (1) BR112017017092A2 (fr)
CA (1) CA2976245A1 (fr)
EA (1) EA201791806A1 (fr)
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HK1247638A1 (zh) 2018-09-28
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EA201791806A1 (ru) 2017-12-29
CN108064304A (zh) 2018-05-22
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