MA41756A - Procédés et compositions utiles dans la génération de réponses non canoniques de lymphocytes t cd8+ - Google Patents
Procédés et compositions utiles dans la génération de réponses non canoniques de lymphocytes t cd8+Info
- Publication number
- MA41756A MA41756A MA041756A MA41756A MA41756A MA 41756 A MA41756 A MA 41756A MA 041756 A MA041756 A MA 041756A MA 41756 A MA41756 A MA 41756A MA 41756 A MA41756 A MA 41756A
- Authority
- MA
- Morocco
- Prior art keywords
- protein
- methods
- antigen
- canonic
- heterologous
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 12
- 108090000623 proteins and genes Proteins 0.000 abstract 12
- 102000036639 antigens Human genes 0.000 abstract 4
- 108091007433 antigens Proteins 0.000 abstract 4
- 239000013598 vector Substances 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 230000005867 T cell response Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
Classifications
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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Abstract
L'invention concerne des procédés d'induction d'une réponse de lymphocytes t cd8 + à un antigène hétérologue dans lequel au moins 10% des lymphocytes t cd8 + sont restreints par le cmh-e. La méthode consiste à immuniser avec un vecteur cmv qui n'exprime pas les protéines ul128 et ul130. L'invention concerne également des vecteurs cmv recombinants comprenant des acides nucléiques codant pour un antigène protéique hétérologue, une protéine ul40 et une protéine us28, mais n'exprimant pas une protéine active ul128 et ul130. L'invention concerne également des vecteurs cmv recombinants comprenant des acides nucléiques codant pour un antigène protéique hétérologue, mais n'exprimant pas une protéine ul40 active, une protéine ul128, une protéine ul130 et, facultativement, une protéine us28. L'invention concerne également des vecteurs cmv recombinants comprenant des acides nucléiques codant pour un antigène protéique hétérologue, mais n'exprimant pas une protéine us28 active, une protéine ul128, une protéine ul130 et éventuellement une protéine ul40.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562114203P | 2015-02-10 | 2015-02-10 | |
US201562196520P | 2015-07-24 | 2015-07-24 | |
US201562220703P | 2015-09-18 | 2015-09-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA41756A true MA41756A (fr) | 2017-12-20 |
Family
ID=56615684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA041756A MA41756A (fr) | 2015-02-10 | 2016-02-10 | Procédés et compositions utiles dans la génération de réponses non canoniques de lymphocytes t cd8+ |
Country Status (15)
Country | Link |
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US (2) | US20180298404A1 (fr) |
EP (2) | EP3256595A4 (fr) |
JP (3) | JP6816031B2 (fr) |
KR (1) | KR20170136512A (fr) |
CN (2) | CN108064304A (fr) |
AU (1) | AU2016219317A1 (fr) |
BR (1) | BR112017017092A2 (fr) |
CA (1) | CA2976245A1 (fr) |
EA (1) | EA201791806A1 (fr) |
HK (2) | HK1247638A1 (fr) |
IL (1) | IL253935B (fr) |
MA (1) | MA41756A (fr) |
MX (1) | MX2017010027A (fr) |
SG (1) | SG11201706454VA (fr) |
WO (1) | WO2016130693A1 (fr) |
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AU2014225886B2 (en) * | 2013-03-05 | 2020-04-16 | Oregon Health & Science University | Cytomegalovirus vectors enabling control of T cell targeting |
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MA41756A (fr) | 2015-02-10 | 2017-12-20 | Fruh Klaus | Procédés et compositions utiles dans la génération de réponses non canoniques de lymphocytes t cd8+ |
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CN116926128A (zh) | 2015-11-20 | 2023-10-24 | 俄勒冈健康与科学大学 | 包含微小rna识别元件的cmv载体 |
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CN110036112B (zh) | 2016-10-18 | 2024-05-10 | 俄勒冈健康与科学大学 | 引发受主要组织相容性复合体e分子限制的t细胞的巨细胞病毒载体 |
JP6980780B2 (ja) | 2016-10-21 | 2021-12-15 | モデルナティーエックス, インコーポレイテッド | ヒトサイトメガロウイルスワクチン |
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CN112969470A (zh) * | 2018-09-10 | 2021-06-15 | 阿塔拉生物制药股份有限公司 | 用于扩增抗原特异性car-t细胞、组合物的方法及其相关用途 |
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JP2022526628A (ja) * | 2019-03-21 | 2022-05-25 | 21シー バイオ | 感染時の病原性免疫活性化細胞に対するワクチン |
US10632186B1 (en) | 2019-03-21 | 2020-04-28 | 21C Bio | Vaccine to pathogenic immune activation cells during infections |
CN110055228B (zh) * | 2019-04-17 | 2023-04-28 | 华中科技大学同济医学院附属协和医院 | 用于乙肝病毒感染的重组巨细胞病毒与应用 |
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CN114402080A (zh) * | 2019-08-20 | 2022-04-26 | 俄勒冈健康与科学大学 | 人巨细胞病毒的ul18对t细胞应答的调节 |
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AU2022339918A1 (en) | 2021-08-31 | 2024-02-08 | Vir Biotechnology, Inc. | Tuberculosis vaccines |
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CN110036112B (zh) | 2016-10-18 | 2024-05-10 | 俄勒冈健康与科学大学 | 引发受主要组织相容性复合体e分子限制的t细胞的巨细胞病毒载体 |
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2016
- 2016-02-10 MA MA041756A patent/MA41756A/fr unknown
- 2016-02-10 CA CA2976245A patent/CA2976245A1/fr not_active Abandoned
- 2016-02-10 BR BR112017017092A patent/BR112017017092A2/pt not_active Application Discontinuation
- 2016-02-10 CN CN201680014682.9A patent/CN108064304A/zh active Pending
- 2016-02-10 WO PCT/US2016/017373 patent/WO2016130693A1/fr active Application Filing
- 2016-02-10 SG SG11201706454VA patent/SG11201706454VA/en unknown
- 2016-02-10 AU AU2016219317A patent/AU2016219317A1/en not_active Abandoned
- 2016-02-10 US US15/549,814 patent/US20180298404A1/en not_active Abandoned
- 2016-02-10 CN CN202111437865.0A patent/CN114317611A/zh active Pending
- 2016-02-10 JP JP2017560883A patent/JP6816031B2/ja active Active
- 2016-02-10 EP EP16749813.8A patent/EP3256595A4/fr not_active Withdrawn
- 2016-02-10 KR KR1020177025544A patent/KR20170136512A/ko not_active Application Discontinuation
- 2016-02-10 EA EA201791806A patent/EA201791806A1/ru unknown
- 2016-02-10 EP EP21205026.4A patent/EP4036239A1/fr active Pending
- 2016-02-10 MX MX2017010027A patent/MX2017010027A/es unknown
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2017
- 2017-08-09 IL IL253935A patent/IL253935B/en unknown
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2018
- 2018-05-28 HK HK18106974.7A patent/HK1247638A1/zh unknown
- 2018-10-11 HK HK18113013.6A patent/HK1254041A1/zh unknown
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2020
- 2020-01-09 US US16/738,178 patent/US11091779B2/en active Active
- 2020-12-23 JP JP2020213267A patent/JP2021121185A/ja active Pending
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2022
- 2022-08-08 JP JP2022126096A patent/JP2022166122A/ja active Pending
Also Published As
Publication number | Publication date |
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EP4036239A1 (fr) | 2022-08-03 |
JP2018510650A (ja) | 2018-04-19 |
CN114317611A (zh) | 2022-04-12 |
EP3256595A1 (fr) | 2017-12-20 |
AU2016219317A1 (en) | 2017-08-31 |
US20200392534A1 (en) | 2020-12-17 |
CA2976245A1 (fr) | 2016-08-18 |
JP2021121185A (ja) | 2021-08-26 |
WO2016130693A9 (fr) | 2016-09-15 |
HK1254041A1 (zh) | 2019-07-12 |
AU2016219317A8 (en) | 2017-09-14 |
US20180298404A1 (en) | 2018-10-18 |
WO2016130693A1 (fr) | 2016-08-18 |
SG11201706454VA (en) | 2017-09-28 |
JP2022166122A (ja) | 2022-11-01 |
MX2017010027A (es) | 2018-08-15 |
CN108064304A (zh) | 2018-05-22 |
IL253935B (en) | 2022-06-01 |
JP6816031B2 (ja) | 2021-01-20 |
EP3256595A4 (fr) | 2018-09-26 |
HK1247638A1 (zh) | 2018-09-28 |
BR112017017092A2 (pt) | 2018-06-26 |
KR20170136512A (ko) | 2017-12-11 |
IL253935A0 (en) | 2017-10-31 |
EA201791806A1 (ru) | 2017-12-29 |
US11091779B2 (en) | 2021-08-17 |
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