MX2017010027A - Métodos y composiciones útiles en la generación de respuestas de células t cd8+ no canónicas. - Google Patents

Métodos y composiciones útiles en la generación de respuestas de células t cd8+ no canónicas.

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Publication number
MX2017010027A
MX2017010027A MX2017010027A MX2017010027A MX2017010027A MX 2017010027 A MX2017010027 A MX 2017010027A MX 2017010027 A MX2017010027 A MX 2017010027A MX 2017010027 A MX2017010027 A MX 2017010027A MX 2017010027 A MX2017010027 A MX 2017010027A
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Mexico
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protein
methods
express
disclosed
cell responses
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MX2017010027A
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English (en)
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PICKER Louis
Frueh Klaus
Sacha Jonah
Malouli Daniel
Hansen Scott
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Univ Oregon Health & Science
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Publication of MX2017010027A publication Critical patent/MX2017010027A/es

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Abstract

Se describen métodos para inducir una respuesta de células T CD8+ a un antígeno heterólogo en donde al menos el 10% de las células T CD8+ están restringidas por CMH-E. El método implica inmunizar con un vector que contiene CMV que no expresa las proteínas UL128 y UL130. Se describen además vectores que contienen CMV recombinante que comprenden ácidos nucleicos que codifican un antígeno de proteína heterólogo, una proteína UL40 y una proteína US28 pero que no expresan proteínas UL128 y UL130 activas. También se describen vectores que contienen CMV recombinante que comprenden ácidos nucleicos que codifican un antígeno de proteína heteróloga, pero que no expresan una proteína UL40 activa, proteína UL128, proteína UL130, y opcionalmente una proteína US28. También se describen vectores que contienen CMV recombinante que comprenden ácidos nucleicos que codifican un antígeno de proteína heteróloga, pero que no expresan una proteína US28 activa, proteína UL128, proteína UL130, y opcionalmente una proteína UL40.
MX2017010027A 2015-02-10 2016-02-10 Métodos y composiciones útiles en la generación de respuestas de células t cd8+ no canónicas. MX2017010027A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562114203P 2015-02-10 2015-02-10
US201562196520P 2015-07-24 2015-07-24
US201562220703P 2015-09-18 2015-09-18
PCT/US2016/017373 WO2016130693A1 (en) 2015-02-10 2016-02-10 Methods and compositions useful in generating non canonical cd8+ t cell responses

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MX2017010027A true MX2017010027A (es) 2018-08-15

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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE037227T2 (hu) 2010-05-14 2018-08-28 Univ Oregon Health & Science Rekombináns HCMV és RHCMV vektorok és alkalmazásuk
HUE037408T2 (hu) 2011-06-10 2018-08-28 Univ Oregon Health & Science CMV glikoproteinek és rekombináns vektorok
AU2014225886B2 (en) * 2013-03-05 2020-04-16 Oregon Health & Science University Cytomegalovirus vectors enabling control of T cell targeting
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
US10428118B2 (en) 2014-07-16 2019-10-01 Oregon Health & Science University Human cytomegalovirus comprising exogenous antigens
MA41756A (fr) 2015-02-10 2017-12-20 Fruh Klaus Procédés et compositions utiles dans la génération de réponses non canoniques de lymphocytes t cd8+
AU2016342045A1 (en) 2015-10-22 2018-06-07 Modernatx, Inc. Human cytomegalovirus vaccine
CN116926128A (zh) 2015-11-20 2023-10-24 俄勒冈健康与科学大学 包含微小rna识别元件的cmv载体
EP3475446A1 (en) 2016-06-27 2019-05-01 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
CN110036112B (zh) 2016-10-18 2024-05-10 俄勒冈健康与科学大学 引发受主要组织相容性复合体e分子限制的t细胞的巨细胞病毒载体
JP6980780B2 (ja) 2016-10-21 2021-12-15 モデルナティーエックス， インコーポレイテッド ヒトサイトメガロウイルスワクチン
EP3539552A1 (en) * 2018-03-16 2019-09-18 Deutsches Rheuma-Forschungszentrum Berlin Activation and expansion of nkg2c+ nk cells
CN112969470A (zh) * 2018-09-10 2021-06-15 阿塔拉生物制药股份有限公司 用于扩增抗原特异性car-t细胞、组合物的方法及其相关用途
US11077185B2 (en) 2019-03-21 2021-08-03 21C Bio Vaccine to pathogenic immune activation cells during infections
JP2022526628A (ja) * 2019-03-21 2022-05-25 ２１シー バイオ 感染時の病原性免疫活性化細胞に対するワクチン
US10632186B1 (en) 2019-03-21 2020-04-28 21C Bio Vaccine to pathogenic immune activation cells during infections
CN110055228B (zh) * 2019-04-17 2023-04-28 华中科技大学同济医学院附属协和医院 用于乙肝病毒感染的重组巨细胞病毒与应用
WO2020247859A2 (en) * 2019-06-07 2020-12-10 Oregon Health & Science University Tumor-associated antigen-specific t cell responses
CN114402080A (zh) * 2019-08-20 2022-04-26 俄勒冈健康与科学大学 人巨细胞病毒的ul18对t细胞应答的调节
US11406703B2 (en) 2020-08-25 2022-08-09 Modernatx, Inc. Human cytomegalovirus vaccine
AU2022339765A1 (en) 2021-08-31 2024-01-25 Vir Biotechnology, Inc. Recombinant hcmv vectors and uses thereof
AU2022339918A1 (en) 2021-08-31 2024-02-08 Vir Biotechnology, Inc. Tuberculosis vaccines

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US5273876A (en) 1987-06-26 1993-12-28 Syntro Corporation Recombinant human cytomegalovirus containing foreign gene
CA1327171C (en) 1987-06-26 1994-02-22 Lisa J. Hock Recombinant human cytomegalovirus containing foreign gene and use thereof
SG49046A1 (en) 1991-07-05 1998-05-18 American Cyanamid Co Method for identifying non-essential genes of the human cytomegalovirus genome and for screening for inhibitors of human cytomegaloverirus
AU7192394A (en) 1993-07-19 1995-02-20 Cantab Pharmaceuticals Research Limited Production method for preparation of disabled viruses
AU2234995A (en) 1994-04-29 1995-11-29 Pharmacia & Upjohn Company Feline immunodeficiency virus vaccine
US5846806A (en) * 1994-07-29 1998-12-08 American Cyanamid Company Identification of a human cytomegalovirus gene region involved in down-regulation of MHC class I heavy chain expression
ES2264136T3 (es) 1995-02-21 2006-12-16 Cantab Pharmaceuticals Research Limited Preparaciones virales, vectores, inmunogenos y sus vacunas.
KR19980703665A (ko) 1995-04-04 1998-12-05 카렌 크루벤 세포 표면상 제 1 류 ｍｈｃ 단백질의 수준이 낮은 유전적으로변형된 세포의 이식
DE69732498T2 (de) 1996-07-31 2006-04-27 Ortho-Mcneil Pharmaceutical, Inc. Erkennung von menschlichen cytomegalovirus genes, welche die expression von mhc klasse i schweren ketten erniedrigen
US20030138454A1 (en) 1997-06-09 2003-07-24 Oxxon Pharmaccines, Ltd. Vaccination method
DE19733364A1 (de) 1997-08-01 1999-02-04 Koszinowski Ulrich H Prof Verfahren zur Klonierung eines großen Virusgenoms
WO1999007869A1 (en) 1997-08-05 1999-02-18 University Of Florida Live recombinant vaccine comprising inefficiently or non-replicating virus
US7204990B1 (en) 2000-11-28 2007-04-17 Medimmune Vaccines, Inc. Attenuation of cytomegalovirus virulence
WO2002062296A2 (en) * 2001-02-02 2002-08-15 Chemocentryx, Inc. Methods and compositions useful for stimulating an immune response
WO2002066629A2 (en) 2001-02-21 2002-08-29 Gabriele Hahn Recombinant vector containing infectious human cytomegalovirus genome with preserved wild-type characteristics of clinical isolates
GB0122232D0 (en) 2001-09-14 2001-11-07 Medical Res Council Gene expression
PL207168B1 (pl) 2001-09-20 2010-11-30 Glaxo Group Ltd Sekwencja nukleotydowa, wektor, białko, środek farmaceutyczny, urządzenie do podawania śródskórnego, zastosowanie sekwencji nukleotydowej i sposób wytwarzania nukleotydu
US20030118568A1 (en) 2001-12-18 2003-06-26 Board Of Trustees Of The University Of Arkansas Viral stealth technology to prevent T cell-mediated rejection of xenografts
CN100471957C (zh) 2002-04-30 2009-03-25 艾维亚医药/生物技术有限公司 用于免疫治疗的腺病毒载体
DE10232322A1 (de) 2002-07-16 2004-07-29 Hahn, Gabriele, Dr. Viral kodierte CxC determinieren den Gewebetropismus von HCMV
WO2005012545A2 (en) 2003-07-25 2005-02-10 The Regents Of The University Of California Cytomegalovirus gene function and methods for developing antivirals, anti-cmv vaccines, and cmv-based vectors
US20080199493A1 (en) 2004-05-25 2008-08-21 Picker Louis J Siv and Hiv Vaccination Using Rhcmv- and Hcmv-Based Vaccine Vectors
EP1602676A1 (en) 2004-06-01 2005-12-07 SOLVAY (Société Anonyme) Catalytic compositions
WO2006004661A1 (en) 2004-06-25 2006-01-12 Medimmune Vaccines, Inc. Recombinant human cytomegalovirus and vaccines comprising heterologous antigens
EP1888622A1 (en) 2005-05-23 2008-02-20 Oxxon Therapeutics Ltd. Compositions for inducing an immune response against hepatitis b
WO2007027860A2 (en) 2005-08-31 2007-03-08 Genvec, Inc. Adenoviral vector-based malaria vaccines
US20100142823A1 (en) 2007-03-07 2010-06-10 Ze Wang 2d partially parallel imaging with k-space surrounding neighbors based data reconstruction
WO2010101663A2 (en) 2009-03-06 2010-09-10 Mount Sinai School Of Medicine Of New York University Live attenuated influenza virus vaccines comprising microrna response elements
WO2011076883A1 (en) 2009-12-23 2011-06-30 4-Antibody Ag Binding members for human cytomegalovirus
EP2529227B1 (en) 2010-01-27 2015-10-07 Oregon Health & Science University Cytomegalovirus-based immunogenic preparations
CA2793959C (en) 2010-03-25 2019-06-04 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
SG185121A1 (en) 2010-05-05 2012-11-29 Christian Thirion Vaccine against beta-herpesvirus infection and use thereof
HUE037227T2 (hu) 2010-05-14 2018-08-28 Univ Oregon Health & Science Rekombináns HCMV és RHCMV vektorok és alkalmazásuk
HUE037408T2 (hu) 2011-06-10 2018-08-28 Univ Oregon Health & Science CMV glikoproteinek és rekombináns vektorok
AU2014225886B2 (en) * 2013-03-05 2020-04-16 Oregon Health & Science University Cytomegalovirus vectors enabling control of T cell targeting
US10428118B2 (en) 2014-07-16 2019-10-01 Oregon Health & Science University Human cytomegalovirus comprising exogenous antigens
EP3048114A1 (en) 2015-01-22 2016-07-27 Novartis AG Cytomegalovirus antigens and uses thereof
MA41756A (fr) 2015-02-10 2017-12-20 Fruh Klaus Procédés et compositions utiles dans la génération de réponses non canoniques de lymphocytes t cd8+
CN116926128A (zh) 2015-11-20 2023-10-24 俄勒冈健康与科学大学 包含微小rna识别元件的cmv载体
US11091775B2 (en) 2016-06-22 2021-08-17 Oregon Health And Science University Recombinant cytomegalovirus vectors as vaccines for tuberculosis
EP3475446A1 (en) 2016-06-27 2019-05-01 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
CN110036112B (zh) 2016-10-18 2024-05-10 俄勒冈健康与科学大学 引发受主要组织相容性复合体e分子限制的t细胞的巨细胞病毒载体

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