CO6541557A2 - Inhibidores del virus de hepatitis c - Google Patents
Inhibidores del virus de hepatitis cInfo
- Publication number
- CO6541557A2 CO6541557A2 CO12075545A CO12075545A CO6541557A2 CO 6541557 A2 CO6541557 A2 CO 6541557A2 CO 12075545 A CO12075545 A CO 12075545A CO 12075545 A CO12075545 A CO 12075545A CO 6541557 A2 CO6541557 A2 CO 6541557A2
- Authority
- CO
- Colombia
- Prior art keywords
- hepatitis
- virus inhibitors
- virus
- preparing
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere á procesos para elaborar compuestos útiles en el tratamiento de infección por virus de hepatitis C (VHC) En particular, a un proceso para preparar un compuesto de fórmula CX)y a un proceso para preparar un compuesto de fórmula (Z)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26011509P | 2009-11-11 | 2009-11-11 | |
US37880610P | 2010-08-31 | 2010-08-31 | |
US12/915,605 US20110269956A1 (en) | 2009-11-11 | 2010-10-29 | Hepatitis C Virus Inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6541557A2 true CO6541557A2 (es) | 2012-10-16 |
Family
ID=43466792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO12075545A CO6541557A2 (es) | 2009-11-11 | 2012-05-08 | Inhibidores del virus de hepatitis c |
Country Status (15)
Country | Link |
---|---|
US (2) | US20110269956A1 (es) |
EP (1) | EP2499115B1 (es) |
JP (2) | JP2013510850A (es) |
KR (1) | KR101730681B1 (es) |
CN (1) | CN102686565B (es) |
AR (1) | AR078968A1 (es) |
BR (1) | BR112012011134A2 (es) |
CA (3) | CA2780790C (es) |
CO (1) | CO6541557A2 (es) |
EA (1) | EA021194B1 (es) |
ES (1) | ES2589010T3 (es) |
IL (1) | IL219517A (es) |
MX (1) | MX2012005246A (es) |
TW (2) | TWI501957B (es) |
WO (1) | WO2011059850A1 (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104163816A (zh) * | 2008-12-03 | 2014-11-26 | 普雷西迪奥制药公司 | Hcv ns5a的抑制剂 |
RU2505539C2 (ru) | 2008-12-23 | 2014-01-27 | Эбботт Лэборетриз | Антивирусные соединения |
JP2012513409A (ja) | 2008-12-23 | 2012-06-14 | アボット・ラボラトリーズ | 抗ウイルス化合物 |
US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2010120935A1 (en) | 2009-04-15 | 2010-10-21 | Abbott Laboratories | Anti-viral compounds |
JP5582662B2 (ja) | 2009-05-13 | 2014-09-03 | ギリアード サイエンシーズ, インコーポレイテッド | 抗ウイルス化合物 |
US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
MY186633A (en) | 2009-06-11 | 2021-07-31 | Abbvie Bahamas Ltd | Heterocyclic compounds as inhibitors of hepatitis c virus (hcv) |
MX2012000695A (es) | 2009-07-16 | 2012-06-12 | Vertex Pharma | Análogos de bencimidazol para el tratamiento o la prevención de infecciones por flavivirus. |
US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
WO2011081918A1 (en) * | 2009-12-14 | 2011-07-07 | Enanta Pharmaceuticals, Inc | Hepatitis c virus inhibitors |
US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
KR20120130173A (ko) * | 2009-12-24 | 2012-11-29 | 버텍스 파마슈티칼스 인코포레이티드 | 플라비바이러스 감염을 치료 또는 예방하기 위한 유사체들 |
US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
CA2791630A1 (en) | 2010-03-04 | 2011-09-09 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as inhibitors of hcv replication |
JP2013522375A (ja) | 2010-03-24 | 2013-06-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | フラビウイルス感染を処置または予防するためのアナログ |
WO2011119858A1 (en) * | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
US8552047B2 (en) * | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
WO2013030750A1 (en) | 2011-09-01 | 2013-03-07 | Lupin Limited | Antiviral compounds |
WO2013039878A1 (en) * | 2011-09-14 | 2013-03-21 | Merck Sharp & Dohme Corp. | Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases |
MD4589C1 (ro) | 2011-09-16 | 2019-03-31 | Gilead Pharmasset Llc | Compoziţie farmaceutică cu conţinut de sofosbuvir şi utilizarea acesteia în tratamentul hepatitei virale C |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
IN2014MN01547A (es) | 2012-02-10 | 2015-05-08 | Lupin Ltd | |
JP6006008B2 (ja) * | 2012-06-14 | 2016-10-12 | ユー・ディー・シー アイルランド リミテッド | 化合物、有機電界発光素子並びに該有機電界発光素子を用いた発光装置、表示装置及び照明装置 |
EA029081B9 (ru) | 2013-01-31 | 2018-09-28 | Джилид Фармассет Ллс | Комбинированный состав двух противовирусных соединений |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
US9775831B2 (en) | 2013-07-17 | 2017-10-03 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of HCV |
CA2921160C (en) | 2013-08-27 | 2021-04-13 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
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2010
- 2010-10-29 US US12/915,605 patent/US20110269956A1/en not_active Abandoned
- 2010-11-02 MX MX2012005246A patent/MX2012005246A/es active IP Right Grant
- 2010-11-02 CN CN201080061158.XA patent/CN102686565B/zh not_active Expired - Fee Related
- 2010-11-02 KR KR1020127014893A patent/KR101730681B1/ko active IP Right Grant
- 2010-11-02 JP JP2012538854A patent/JP2013510850A/ja active Pending
- 2010-11-02 CA CA2780790A patent/CA2780790C/en not_active Expired - Fee Related
- 2010-11-02 CA CA2920727A patent/CA2920727A1/en not_active Abandoned
- 2010-11-02 WO PCT/US2010/055045 patent/WO2011059850A1/en active Application Filing
- 2010-11-02 CA CA2967561A patent/CA2967561A1/en not_active Abandoned
- 2010-11-02 EA EA201270616A patent/EA021194B1/ru not_active IP Right Cessation
- 2010-11-02 BR BR112012011134-5A patent/BR112012011134A2/pt not_active IP Right Cessation
- 2010-11-02 ES ES10774103.5T patent/ES2589010T3/es active Active
- 2010-11-02 EP EP10774103.5A patent/EP2499115B1/en not_active Not-in-force
- 2010-11-10 TW TW099138750A patent/TWI501957B/zh not_active IP Right Cessation
- 2010-11-10 AR ARP100104176 patent/AR078968A1/es unknown
- 2010-11-10 TW TW104116886A patent/TWI547480B/zh not_active IP Right Cessation
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2012
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2013
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2014
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Publication number | Publication date |
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EP2499115B1 (en) | 2016-07-27 |
JP2013510850A (ja) | 2013-03-28 |
JP5847284B2 (ja) | 2016-01-20 |
BR112012011134A2 (pt) | 2021-09-21 |
CN102686565A (zh) | 2012-09-19 |
TWI501957B (zh) | 2015-10-01 |
CA2780790C (en) | 2017-10-17 |
KR20130143477A (ko) | 2013-12-31 |
CN102686565B (zh) | 2015-09-30 |
CA2780790A1 (en) | 2011-05-19 |
AU2010319764A1 (en) | 2012-06-28 |
IL219517A0 (en) | 2012-06-28 |
CA2920727A1 (en) | 2011-05-19 |
TW201533022A (zh) | 2015-09-01 |
TWI547480B (zh) | 2016-09-01 |
ES2589010T3 (es) | 2016-11-08 |
EP2499115A1 (en) | 2012-09-19 |
EA021194B1 (ru) | 2015-04-30 |
AR078968A1 (es) | 2011-12-14 |
IL219517A (en) | 2017-01-31 |
KR101730681B1 (ko) | 2017-04-26 |
US20130317213A1 (en) | 2013-11-28 |
MX2012005246A (es) | 2012-06-14 |
WO2011059850A1 (en) | 2011-05-19 |
US20110269956A1 (en) | 2011-11-03 |
EA201270616A1 (ru) | 2012-12-28 |
CA2967561A1 (en) | 2011-05-19 |
JP2015044866A (ja) | 2015-03-12 |
TW201120029A (en) | 2011-06-16 |
US9006455B2 (en) | 2015-04-14 |
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