CO5630021A2 - Sistema liberador en forma de anillo de dos esteroides y un antimicrobiano para administracion vaginal - Google Patents

Sistema liberador en forma de anillo de dos esteroides y un antimicrobiano para administracion vaginal

Info

Publication number
CO5630021A2
CO5630021A2 CO05117347A CO05117347A CO5630021A2 CO 5630021 A2 CO5630021 A2 CO 5630021A2 CO 05117347 A CO05117347 A CO 05117347A CO 05117347 A CO05117347 A CO 05117347A CO 5630021 A2 CO5630021 A2 CO 5630021A2
Authority
CO
Colombia
Prior art keywords
drug releasing
releasing system
steroid
intermediate layer
active
Prior art date
Application number
CO05117347A
Other languages
English (en)
Inventor
Rudolf Johannes Joseph Groenewegen
Graaff Wouter De
Henk Jan Out
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36701594&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5630021(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of CO5630021A2 publication Critical patent/CO5630021A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)

Abstract

1.- Un sistema liberador de droga que comprende al menos un compartimento que consiste de (i) un núcleo de polímero termoplástico cargado, (ii) una capa intermedia de polímero termoplástico cargada y (iii) una capa exterior de polímero termoplástico no- medicada que cubre la capa intermedia, donde la mencionada capa intermedia es cargada con (a) cristales de una primer sustancia activa y con (b) una segunda sustancia activa farmacéuticamente en forma disuelta y donde el núcleo mencionado es cargado con la mencionada segunda sustancia activa en forma disuelta.2.- Un sistema liberador de droga de acuerdo a la reivindicación 1 el cual es físicamente estable a cerca de 18 - 30°C.3.- Un sistema liberador de droga de acuerdo a la reivindicación 1 donde el mencionado segundo compuesto en el núcleo esta presente en la misma concentración que en la capa intermedia.4.- Un sistema liberador de droga de acuerdo a la reivindicación 1, caracterizado en que el sistema liberador tiene sustancialmente una forma de anillo y es pretendido para adminsitración vaginal.5.- Un sistema liberador de droga de acuerdo a la reivindicación 1, donde el mencionado primer compuesto activo es un esteroide y el mencionado segundo compuesto activo es un esteroide.6.- Un sistema liberador de droga de acuerdo a la reivindicación 5, donde el mencionado primer esteroide activo es un progestógeno.7.- Un sistema liberador de droga de acuerdo a la reivindicación 5 donde el mencionado segundo esteroide activo es un estrógeno.8.- Un sistema liberador de droga de acuerdo a la reivindicación 7, donde el estrógeno es etinil estradiol.9.- Un sistema liberador de droga de acuerdo a la reivindicación 6, donde el progestógeno es etonogestrel.
CO05117347A 2003-05-23 2005-11-18 Sistema liberador en forma de anillo de dos esteroides y un antimicrobiano para administracion vaginal CO5630021A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47305503P 2003-05-23 2003-05-23
EP03101490 2003-05-23

Publications (1)

Publication Number Publication Date
CO5630021A2 true CO5630021A2 (es) 2006-04-28

Family

ID=36701594

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05117347A CO5630021A2 (es) 2003-05-23 2005-11-18 Sistema liberador en forma de anillo de dos esteroides y un antimicrobiano para administracion vaginal

Country Status (30)

Country Link
US (3) US8333983B2 (es)
EP (1) EP1631255B1 (es)
JP (1) JP4685780B2 (es)
KR (1) KR101116267B1 (es)
CN (1) CN1794974B (es)
AR (1) AR044547A1 (es)
AU (1) AU2004241747B2 (es)
BR (1) BRPI0410455B8 (es)
CA (1) CA2524665C (es)
CO (1) CO5630021A2 (es)
CY (1) CY1113500T1 (es)
DK (1) DK1631255T3 (es)
EC (1) ECSP056250A (es)
ES (1) ES2396100T3 (es)
HK (1) HK1084337A1 (es)
HR (1) HRP20050945B1 (es)
IL (1) IL171622A (es)
IS (1) IS2864B (es)
MX (1) MXPA05012595A (es)
NO (1) NO336456B1 (es)
NZ (1) NZ543652A (es)
PE (1) PE20050815A1 (es)
PL (1) PL1631255T3 (es)
PT (1) PT1631255E (es)
RU (1) RU2340344C2 (es)
SI (1) SI1631255T1 (es)
TW (1) TWI336627B (es)
UA (1) UA84287C2 (es)
WO (1) WO2004103336A2 (es)
ZA (1) ZA200509450B (es)

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Also Published As

Publication number Publication date
HRP20050945B1 (hr) 2014-03-14
US20130078286A1 (en) 2013-03-28
EP1631255A2 (en) 2006-03-08
MXPA05012595A (es) 2006-02-22
NO20055171L (no) 2006-01-31
PE20050815A1 (es) 2005-10-04
WO2004103336A2 (en) 2004-12-02
RU2005140277A (ru) 2006-06-10
ECSP056250A (es) 2006-04-19
PL1631255T3 (pl) 2013-03-29
EP1631255B1 (en) 2012-10-17
BRPI0410455B8 (pt) 2021-05-25
PT1631255E (pt) 2013-01-07
RU2340344C2 (ru) 2008-12-10
US20130115265A1 (en) 2013-05-09
JP4685780B2 (ja) 2011-05-18
TW200505519A (en) 2005-02-16
HK1084337A1 (en) 2006-07-28
DK1631255T3 (da) 2013-02-04
NO336456B1 (no) 2015-08-31
AR044547A1 (es) 2005-09-21
KR101116267B1 (ko) 2012-03-14
TWI336627B (en) 2011-02-01
CY1113500T1 (el) 2016-06-22
HRP20050945A2 (en) 2006-02-28
CN1794974B (zh) 2010-09-29
UA84287C2 (uk) 2008-10-10
CA2524665C (en) 2011-12-20
WO2004103336A3 (en) 2005-01-06
JP2007502316A (ja) 2007-02-08
NO20055171D0 (no) 2005-11-03
NZ543652A (en) 2009-06-26
US20060280771A1 (en) 2006-12-14
IS8086A (is) 2005-10-24
BRPI0410455A (pt) 2006-06-13
AU2004241747B2 (en) 2010-03-11
CA2524665A1 (en) 2004-12-02
SI1631255T1 (sl) 2013-02-28
KR20060015617A (ko) 2006-02-17
ZA200509450B (en) 2007-03-28
US8900615B2 (en) 2014-12-02
BRPI0410455B1 (pt) 2018-05-15
AU2004241747A1 (en) 2004-12-02
US8858977B2 (en) 2014-10-14
IL171622A (en) 2012-01-31
IS2864B (is) 2014-01-15
US8333983B2 (en) 2012-12-18
CN1794974A (zh) 2006-06-28
ES2396100T3 (es) 2013-02-19

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