HRP20050945B1 - Sustav za primjenu lijeka - Google Patents

Sustav za primjenu lijeka

Info

Publication number
HRP20050945B1
HRP20050945B1 HRP20050945AA HRP20050945A HRP20050945B1 HR P20050945 B1 HRP20050945 B1 HR P20050945B1 HR P20050945A A HRP20050945A A HR P20050945AA HR P20050945 A HRP20050945 A HR P20050945A HR P20050945 B1 HRP20050945 B1 HR P20050945B1
Authority
HR
Croatia
Prior art keywords
drug
filled
delivery system
drug delivery
thermoplastic polymer
Prior art date
Application number
HRP20050945AA
Other languages
English (en)
Inventor
Rudolf Johannes Joseph Groenewegen
Wouter De Graaff
Henk Jan Out
Original Assignee
Merck Sharp & Dohme B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36701594&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20050945(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme B.V. filed Critical Merck Sharp & Dohme B.V.
Publication of HRP20050945A2 publication Critical patent/HRP20050945A2/hr
Publication of HRP20050945B1 publication Critical patent/HRP20050945B1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

Abstract

Predmetni izum pruža sustav za primjenu lijeka koji uključuje barem jedan odjeljak koji se sastoji od (i) termoplastične polimerne jezgre napunjene s lijekom, (ii) termoplastičnog polimernog međusloja napunjenog s lijekom i (iii) termoplastičnog polimernog ovoja koji ne sadrži lijek te prekriva međusloj, pri čemu je spomenuti međusloj napunjen s (a) kristalima prvog farmaceutski aktivnog spoja i s (b) drugim farmaceutski aktivnim spojem u otopljenom obliku, i gdje je spomenuta jezgra napunjena sa spomenutim drugim spojem u otopljenom obliku.
HRP20050945AA 2003-05-23 2005-11-04 Sustav za primjenu lijeka HRP20050945B1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47305503P 2003-05-23 2003-05-23
EP03101490 2003-05-23
PCT/EP2004/050850 WO2004103336A2 (en) 2003-05-23 2004-05-19 Drug delivery system

Publications (2)

Publication Number Publication Date
HRP20050945A2 HRP20050945A2 (en) 2006-02-28
HRP20050945B1 true HRP20050945B1 (hr) 2014-03-14

Family

ID=36701594

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20050945AA HRP20050945B1 (hr) 2003-05-23 2005-11-04 Sustav za primjenu lijeka

Country Status (30)

Country Link
US (3) US8333983B2 (hr)
EP (1) EP1631255B1 (hr)
JP (1) JP4685780B2 (hr)
KR (1) KR101116267B1 (hr)
CN (1) CN1794974B (hr)
AR (1) AR044547A1 (hr)
AU (1) AU2004241747B2 (hr)
BR (1) BRPI0410455B8 (hr)
CA (1) CA2524665C (hr)
CO (1) CO5630021A2 (hr)
CY (1) CY1113500T1 (hr)
DK (1) DK1631255T3 (hr)
EC (1) ECSP056250A (hr)
ES (1) ES2396100T3 (hr)
HK (1) HK1084337A1 (hr)
HR (1) HRP20050945B1 (hr)
IL (1) IL171622A (hr)
IS (1) IS2864B (hr)
MX (1) MXPA05012595A (hr)
NO (1) NO336456B1 (hr)
NZ (1) NZ543652A (hr)
PE (1) PE20050815A1 (hr)
PL (1) PL1631255T3 (hr)
PT (1) PT1631255E (hr)
RU (1) RU2340344C2 (hr)
SI (1) SI1631255T1 (hr)
TW (1) TWI336627B (hr)
UA (1) UA84287C2 (hr)
WO (1) WO2004103336A2 (hr)
ZA (1) ZA200509450B (hr)

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US8703167B2 (en) * 2006-06-05 2014-04-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug
UA94118C2 (ru) 2006-11-20 2011-04-11 Н.В. Органон Спиральная система введения лекарства
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TW200930343A (en) * 2007-09-21 2009-07-16 Organon Nv Drug delivery system
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WO2009141309A1 (en) * 2008-05-20 2009-11-26 N.V. Organon Delivery system for paliperidone
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FI121000B (fi) * 2008-11-19 2010-06-15 Bayer Schering Pharma Oy Intravaginaalinen antojärjestelmä ja menetelmä sen valmistamiseksi
WO2010077096A2 (ko) * 2008-12-31 2010-07-08 한올바이오파마주식회사 약물전달기구
WO2010105995A2 (en) 2009-03-17 2010-09-23 Intervet International B.V. Zoo-technical drug delivery device
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CA2798034A1 (en) * 2010-03-28 2011-10-13 Evestra, Inc. Intravaginal drug delivery device
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AU2012283837B2 (en) * 2011-07-20 2017-04-27 Patrick F. Kiser Intravaginal devices for drug delivery
HRP20211377T1 (hr) 2011-11-23 2022-01-07 Therapeuticsmd, Inc. Prirodne kombinirane hormonske supstitucijske formulacije i terapije
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
WO2015086489A1 (en) 2013-12-11 2015-06-18 Merck Sharp & Dohme B.V. Drug delivery system for delivery of anti-virals
US10413504B2 (en) * 2013-12-11 2019-09-17 Merck Sharp & Dohme Corp. Intravaginal ring drug delivery system
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
AU2017239645A1 (en) 2016-04-01 2018-10-18 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
CN109069526A (zh) * 2016-05-12 2018-12-21 默沙东公司 用于递送抗病毒剂的药物递送系统
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CA3080325A1 (en) 2017-10-27 2019-05-02 Renovia Inc. Devices, systems, and methods for training pelvic floor muscles
US11690806B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
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US20200179274A1 (en) * 2018-12-11 2020-06-11 Lupin Inc. Drug delivery system for ultra-low dose estrogen combinations and methods and uses thereof
KR102159904B1 (ko) 2020-04-24 2020-09-24 강경원 약물 방출 고리를 구비한 월경컵
EP4215181A1 (en) * 2022-01-21 2023-07-26 Sever Pharma Solutions An intravaginal ring
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EP0303306A1 (en) * 1987-08-08 1989-02-15 Akzo N.V. Contraceptive implant
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EP0303306A1 (en) * 1987-08-08 1989-02-15 Akzo N.V. Contraceptive implant
WO1997002015A1 (en) * 1995-07-04 1997-01-23 Akzo Nobel N.V. Ring-shaped devices
EP0876815A1 (en) * 1997-04-11 1998-11-11 Akzo Nobel N.V. "Drug delivery system for two or more active substances"

Also Published As

Publication number Publication date
IS2864B (is) 2014-01-15
NO20055171D0 (no) 2005-11-03
CN1794974B (zh) 2010-09-29
NZ543652A (en) 2009-06-26
WO2004103336A2 (en) 2004-12-02
AU2004241747B2 (en) 2010-03-11
CA2524665C (en) 2011-12-20
IS8086A (is) 2005-10-24
SI1631255T1 (sl) 2013-02-28
TWI336627B (en) 2011-02-01
AR044547A1 (es) 2005-09-21
US20060280771A1 (en) 2006-12-14
BRPI0410455B8 (pt) 2021-05-25
EP1631255A2 (en) 2006-03-08
BRPI0410455A (pt) 2006-06-13
US8858977B2 (en) 2014-10-14
PL1631255T3 (pl) 2013-03-29
MXPA05012595A (es) 2006-02-22
HRP20050945A2 (en) 2006-02-28
NO336456B1 (no) 2015-08-31
JP2007502316A (ja) 2007-02-08
UA84287C2 (uk) 2008-10-10
CN1794974A (zh) 2006-06-28
CY1113500T1 (el) 2016-06-22
IL171622A (en) 2012-01-31
US8900615B2 (en) 2014-12-02
DK1631255T3 (da) 2013-02-04
CO5630021A2 (es) 2006-04-28
JP4685780B2 (ja) 2011-05-18
AU2004241747A1 (en) 2004-12-02
BRPI0410455B1 (pt) 2018-05-15
ZA200509450B (en) 2007-03-28
KR101116267B1 (ko) 2012-03-14
EP1631255B1 (en) 2012-10-17
CA2524665A1 (en) 2004-12-02
ES2396100T3 (es) 2013-02-19
ECSP056250A (es) 2006-04-19
HK1084337A1 (en) 2006-07-28
PT1631255E (pt) 2013-01-07
US20130078286A1 (en) 2013-03-28
US8333983B2 (en) 2012-12-18
KR20060015617A (ko) 2006-02-17
US20130115265A1 (en) 2013-05-09
RU2005140277A (ru) 2006-06-10
PE20050815A1 (es) 2005-10-04
WO2004103336A3 (en) 2005-01-06
RU2340344C2 (ru) 2008-12-10
NO20055171L (no) 2006-01-31
TW200505519A (en) 2005-02-16

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