CO5160287A1 - Formulacion de liberacion controlada de divalproex sodico - Google Patents

Formulacion de liberacion controlada de divalproex sodico

Info

Publication number
CO5160287A1
CO5160287A1 CO99078240A CO99078240A CO5160287A1 CO 5160287 A1 CO5160287 A1 CO 5160287A1 CO 99078240 A CO99078240 A CO 99078240A CO 99078240 A CO99078240 A CO 99078240A CO 5160287 A1 CO5160287 A1 CO 5160287A1
Authority
CO
Colombia
Prior art keywords
weight
percent
divalproex
sodico
formulation
Prior art date
Application number
CO99078240A
Other languages
English (en)
Inventor
Qui Yihong
Richard Paul Poska
Howard S Cheskin
J Daniel Bollinger
Kevin R Engh
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/216,650 external-priority patent/US6419953B1/en
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of CO5160287A1 publication Critical patent/CO5160287A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Una forma de dosificación en tabletas de liberación controlada que comprendea) desde 50 porciento en peso hasta 55 porciento en peso de ingrediente activo seleccionado de un grupo conformado por ácido valproico, una sal ó éster farmacéuticamente aceptables del ácido valproico, divalproex sódico, y valpromida;b) desde 20 porciento en peso hasta 40 porciento en peso de hidroxipropilmetilcelulosa;c) desde 5 porciento en peso hasta 15 porciento en peso de lactosa, desde 4 porciento en peso hasta 6 porciento en peso de celulosa microcristalina, y desde 1 hasta 5 porciento en peso de dióxido de silicio que tiene un tamaño de partícula promedio que oscila entre 1 micrón y 10 micrones;todos los porcentajes en peso con base en el peso total de la forma de dosificación en tabletas.
CO99078240A 1998-12-18 1999-12-15 Formulacion de liberacion controlada de divalproex sodico CO5160287A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/216,650 US6419953B1 (en) 1998-12-18 1998-12-18 Controlled release formulation of divalproex sodium
US12155799P 1999-02-25 1999-02-25

Publications (1)

Publication Number Publication Date
CO5160287A1 true CO5160287A1 (es) 2002-05-30

Family

ID=26819594

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99078240A CO5160287A1 (es) 1998-12-18 1999-12-15 Formulacion de liberacion controlada de divalproex sodico

Country Status (25)

Country Link
EP (1) EP1140034B1 (es)
JP (1) JP2003513882A (es)
KR (1) KR20010101295A (es)
CN (1) CN1335769A (es)
AR (1) AR021443A1 (es)
AT (1) ATE254907T1 (es)
AU (1) AU2478900A (es)
BG (1) BG105665A (es)
BR (1) BR9916361A (es)
CA (1) CA2330480C (es)
CO (1) CO5160287A1 (es)
CZ (1) CZ20012201A3 (es)
DE (1) DE69913197T2 (es)
DK (1) DK1140034T3 (es)
ES (1) ES2212667T3 (es)
HK (1) HK1043043B (es)
HU (1) HUP0105463A3 (es)
IL (1) IL143407A0 (es)
NO (1) NO20012986L (es)
PL (1) PL356899A1 (es)
PT (1) PT1140034E (es)
SI (1) SI20624A (es)
SK (1) SK8252001A3 (es)
TW (1) TW585788B (es)
WO (1) WO2000037055A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713086B2 (en) 1998-12-18 2004-03-30 Abbott Laboratories Controlled release formulation of divalproex sodium
US20020025341A1 (en) * 1998-12-18 2002-02-28 Yihong Qiu Controlled release formulation of divalproex sodium
US6419953B1 (en) 1998-12-18 2002-07-16 Abbott Laboratories Controlled release formulation of divalproex sodium
US6511678B2 (en) 1998-12-18 2003-01-28 Abbott Laboratories Controlled release formulation of divalproex sodium
US6528090B2 (en) 1998-12-18 2003-03-04 Abbott Laboratories Controlled release formulation of divalproex sodium
WO2002051402A1 (en) * 2000-12-22 2002-07-04 Abbott Laboratories Controlled release formulation of divalproex sodium
US7297346B2 (en) 2001-05-25 2007-11-20 Cephalon Inc. Pharmaceutical formulations of modafinil
US7229644B2 (en) * 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
US20040005357A1 (en) * 2002-07-03 2004-01-08 Sherman Bernard Charles Extended-release tablets comprising divalproex sodium
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
US20040116532A1 (en) 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
JP2006520390A (ja) * 2003-03-14 2006-09-07 ムルイェ、ニルマル 徐放性錠剤の製造方法
HUP0301537A3 (en) * 2003-06-03 2005-07-28 Egis Gyogyszergyar Nyilvanosan Deramcyclane fumarate tablets and process for producing them
US7713550B2 (en) 2004-06-15 2010-05-11 Andrx Corporation Controlled release sodium valproate formulation
WO2006025029A2 (en) * 2004-08-31 2006-03-09 Ranbaxy Laboratories Limited Extended release composition of divalproex
KR20070102563A (ko) * 2005-01-26 2007-10-18 엘란 파마 인터내셔널 리미티드 정신병치료제를 함유하는 조절방출형 조성물
US20070202164A1 (en) * 2006-02-28 2007-08-30 Hutchison Medipharma Enterprises Limited Andrographis Extract Formulations
AU2010248292B2 (en) * 2009-05-12 2014-06-12 Amorepacific Corporation Composition for preventing hair loss or for stimulating hair growth
WO2012121862A2 (en) * 2011-02-17 2012-09-13 University Of Florida Research Foundation Valproic acid derivative compounds
CN102138911B (zh) * 2011-03-28 2012-12-12 孙卫东 一种双丙戊酸钠缓释片及其制备方法
CN102895201B (zh) * 2011-07-26 2014-09-10 北大方正集团有限公司 丙戊酸半钠片剂及其制备方法
HUE051406T2 (hu) 2012-11-14 2021-03-01 Grace W R & Co Biológiailag aktív anyagot és rendezetlen szervetlen oxidot tartalmazó kompozíciók
CN105012264B (zh) * 2014-04-16 2019-11-29 四川科瑞德制药股份有限公司 丙戊酸钠缓释片及其制备工艺和用途
CN106389368B (zh) * 2015-07-29 2021-11-12 四川科瑞德制药股份有限公司 一种丙戊酸钠缓释制剂及其制备工艺和用途
CN105456218A (zh) * 2015-12-07 2016-04-06 黑龙江省智诚医药科技有限公司 一种丙戊酸镁缓释片及其制备方法
CN107028907B (zh) * 2016-02-04 2021-05-14 成都康弘药业集团股份有限公司 一种双丙戊酸钠缓释片
CN114681419A (zh) * 2020-12-28 2022-07-01 湖南省湘中制药有限公司 一种丙戊酰胺缓释片的组合物及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169642A (en) * 1988-06-24 1992-12-08 Abbott Laboratories Sustained-release drug dosage units
US5009897A (en) * 1988-06-24 1991-04-23 Abbott Laboratories Pharmaceutical granules and tablets made therefrom
FR2643556B1 (fr) * 1989-02-27 1993-03-05 Sanofi Sa Composition pharmaceutique a liberation prolongee d'acide valproique
IL96311A (en) * 1989-12-01 1995-05-26 Abbott Lab Medications with delayed release
US5075114A (en) * 1990-05-23 1991-12-24 Mcneil-Ppc, Inc. Taste masking and sustained release coatings for pharmaceuticals
TW224049B (es) * 1991-12-31 1994-05-21 Sunkyong Ind Ltd
TW222585B (es) * 1992-09-11 1994-04-21 Hoechst Ag
JP3552285B2 (ja) * 1993-08-03 2004-08-11 三菱化学株式会社 経口コレステロール低下剤
GB9501127D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Tablet
CA2216215A1 (en) * 1997-04-05 1998-10-05 Isa Odidi Controlled release formulations using intelligent polymers having opposing wettability characteristics of hydrophobicity and hydrophilicity

Also Published As

Publication number Publication date
IL143407A0 (en) 2002-04-21
PT1140034E (pt) 2004-03-31
PL356899A1 (en) 2004-07-12
NO20012986D0 (no) 2001-06-15
WO2000037055A1 (en) 2000-06-29
SK8252001A3 (en) 2001-12-03
EP1140034A1 (en) 2001-10-10
ATE254907T1 (de) 2003-12-15
DE69913197D1 (de) 2004-01-08
NO20012986L (no) 2001-08-15
CA2330480A1 (en) 2000-06-29
EP1140034B1 (en) 2003-11-26
JP2003513882A (ja) 2003-04-15
HUP0105463A3 (en) 2003-03-28
HUP0105463A2 (hu) 2002-05-29
BR9916361A (pt) 2002-11-05
TW585788B (en) 2004-05-01
HK1043043B (zh) 2004-09-10
SI20624A (sl) 2002-02-28
ES2212667T3 (es) 2004-07-16
CZ20012201A3 (cs) 2001-09-12
BG105665A (bg) 2002-03-29
KR20010101295A (ko) 2001-11-14
DK1140034T3 (da) 2004-03-08
AU2478900A (en) 2000-07-12
HK1043043A1 (en) 2002-09-06
CA2330480C (en) 2002-05-21
AR021443A1 (es) 2002-07-17
CN1335769A (zh) 2002-02-13
DE69913197T2 (de) 2004-09-02

Similar Documents

Publication Publication Date Title
CO5160287A1 (es) Formulacion de liberacion controlada de divalproex sodico
HUP0101237A1 (hu) Elnyújtott kioldódású gyógyszerkészítmények
ATE333265T1 (de) Oral anzuwendende schnell zerfallende feste darreichungsformen
IT1276689B1 (it) Forma farmaceutica solida ad uso orale
BRPI0015567B8 (pt) composto, composição farmacêutica, forma de unidade de dosagem, uso da composição farmacêutica e método para preparar uma composição farmacêutica
AR035195A1 (es) Formulaciones de liberacion sostenida para secretagogos de hormona del crecimiento
AR084101A2 (es) Comprimido de carga de droga alta y proceso para su preparacion
AR028299A1 (es) Una composicion farmaceutica que comprende nateglinida, un proceso para su preparacion y el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con diabetes.
ES2162517T3 (es) Composicion farmaceutica que comprende una combinacion de metformin y fibrato y su uso en la preparacion de medicamentos destinados a reducir la hiperglicemia.
ITMI931631A1 (it) Composizioni farmaceutiche a rilascio controllato a base di uno o piu' sali farmaceuticamente accettabili dell'acido gamma-idrossi-butirrico.
ES2530719T3 (es) Formulaciones de oxicodona para ser administradas una vez al día
EA200700049A1 (ru) Препаративные формы оральных лекарственных форм мемантина с модифицированным высвобождением
MY100721A (en) Therapeutic agent.
AR018829A1 (es) Formulaciones farmaceuticas solidas de rapida desintegracion, administrables via oral y procedimiento para prepararlos
AR017512A1 (es) Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas
CL2009001682A1 (es) Composición farmacéutica espontáneamente dispersable para administración oral que comprende n-benzoil-estaurosporina; método para incrementar los niveles de biodisponibilidad. (divisional de la solocitud 333-00).
PT1131050E (pt) Formulacoes galenicas que se desintegram rapidamente na boca e metodo para as preparar
MY122124A (en) Solid pharmaceutical composition containing benzofurane derivatives
CO5280073A1 (es) Composiciones
DE69940557D1 (de) Ein hydrokolloid und einen celluloseether enthaltende tablette mit verzögerter freisetzung
PE20001414A1 (es) Procedimiento de preparacion de globulos que contienen 50% en peso o mas de una sustancia farmaceutica de hidrosolubilidad
EA200001201A3 (ru) Таблетка с основой, позволяющая осуществлять пролонгированное высвобождение триметазидина после введения оральным путем
ES2130081B1 (es) Comprimido de maleato de trimebutina con recubrimiento laminar.
CO4940406A1 (es) Composiciones de paracetamol de accion rapida
IT1270239B (it) Composizione farmaceutica solida contenente acido (s)-2-(4- isobutilfenil) propionico come principio attivo