CO5150147A1 - Derivados de 6-azauracilo inhibidores de il-5 - Google Patents
Derivados de 6-azauracilo inhibidores de il-5Info
- Publication number
- CO5150147A1 CO5150147A1 CO99079022A CO99079022A CO5150147A1 CO 5150147 A1 CO5150147 A1 CO 5150147A1 CO 99079022 A CO99079022 A CO 99079022A CO 99079022 A CO99079022 A CO 99079022A CO 5150147 A1 CO5150147 A1 CO 5150147A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- mono
- aryl
- het3
- alkyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Un compuesto de la fórmula<EMI FILE="99079022_1" ID="1" IMF=JPEG >un N-óxido, una sal de adición farmacéuticamente aceptable, una amina cuaternaria o su forma estereoquímicamente isomérica, donde p representa un entero que es 0, 1, 2, 3 ó 4; q representa un entero que es 0, 1, 2, 3, 4 ó 5; X representa O, S, NR3 o un enlace directo; o -X-R2 tomados juntos pueden representar ciano; R1 representa hidrógeno, hidroxi, halo, amino, mono- o di(alquil C1-4)amino, alquilo C1-6, alquiloxi C1-6, cicloalquilo C3-7, arilo, arilalquilo C1-6, aminoalquilo C1-4, mono o di(alquil C1-4, mono o di(alquil C1-4)aminoalquilo C1-4 o mono- o di(alquil C1-4)amino-alquilamino C1-4;R2 representa arilo, Het1, cicloalquilo C3-7 opcionalmente sustituido, con -C(=0)-Z-R14, alquilo C1-6 o alquilo C-1-6 sustituido con uno o dos sustituyentes seleccionados de hidroxi, ciano, amino, mono- o di(alquil C1-4) amino, -C(=0)-Z-R14, alquiloxi C1-6, opcionalmente sustituido, con -C(=0)-Z-R14, alquilsulfoniloxi C1-6, cicloalquilo C3-7, opcionalmente sustituido con -C(=0)-Z-R14, arilo, ariloxi, ariltio, Het1, Het1oxi y Het1tio; y si X es O, S o NR3, entonces R2 también puede representar -C(=0)-Z-R14, aminotiocarbonilo, alquilcarbonilo C1-4 opcionalmente sustituido con -C(=O)-Z-R14, alquiltiocarbonilo C1-4 opcionalmente sustituido con -C(=O)-Z-R14, arilcarbonilo, ariltiocarbonilo, Het1carbonilo o Het1tiocarbonilo; R3 representa hidrógeno o alquilo C1-4; Cada R4 independientemente representa -C(=O)-Z-R14, alquilo C1-6, halo, polihaloalquilo C1-6, hidroxi, mercapto, alquiloxi C1-6, alquiltio C1-6, alquilcarboniloxi C1-6, arilo, ciano, nitro, Het3, R6, NR7R8 o alquilo C1-4 sustituido con -C(=O)-Z-R14, Het3, R6, NR7R8; Cada R5 independientemente representa -C(=O)-Z-R14, alquilo C1-6, halo, polihaloalquilo C1-6, hidroxi, mercapto, alquiloxi C1-6, alquiltio C1-6, alquilcarboniloxi C1-6 (arilo, ciano, nitro, Het3, R6, NR7R8 o alquilo C1-4 sustituido con -C(=0)-Z-R14, Het3, R6 o NR7R8; Cada R6 representa independientemente alquilsulfonilo de C1-6, aminosulfonilo, mono- o di(alquil C1-4)aminosulfonilo, mono- o di(bencil) aminosulfonilo, polihaloalquilo C1-6-sulfonilo, alquilsulfinilo C1-6, fenilalquilsulfonilo C1-4, piperazinilsulfonilo, piperidinil-sulfonilo, aminopiperidinilsulfonilo, piperidinilaminosulfonilo, N-alquil C1-4-N-piperidinilaminosulfonilo o mono- o di(alquil C1-4)aminoalquil C1-4sulfonilo; Cada R7 y cada R8 se selecciona independientemente de hidrógeno, alquilo C1-4, hidroxialquilo C1-4, dihidroxialquilo C1-4, arilo, arilalquilo C1-4, alquiloxi C1-4 alquilo C1-4, alquilo C1-4 carbonilo, arilcarbonilo, Het3 carbonilo, -C(=0)-Z-R14, mono- di (alquil C1-4)amino-alquilo C1-4, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98204336 | 1998-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5150147A1 true CO5150147A1 (es) | 2002-04-29 |
Family
ID=8234494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99079022A CO5150147A1 (es) | 1998-12-18 | 1999-12-17 | Derivados de 6-azauracilo inhibidores de il-5 |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6803364B1 (es) |
| EP (1) | EP1140873B1 (es) |
| JP (1) | JP2002533331A (es) |
| KR (1) | KR100635721B1 (es) |
| CN (1) | CN100343239C (es) |
| AR (1) | AR021887A1 (es) |
| AT (1) | ATE365723T1 (es) |
| AU (1) | AU773780B2 (es) |
| BG (1) | BG105602A (es) |
| BR (1) | BR9916366A (es) |
| CA (1) | CA2354511A1 (es) |
| CO (1) | CO5150147A1 (es) |
| CZ (1) | CZ20012062A3 (es) |
| DE (1) | DE69936396T2 (es) |
| DK (1) | DK1140873T3 (es) |
| EA (1) | EA004806B1 (es) |
| EE (1) | EE200100320A (es) |
| ES (1) | ES2289835T3 (es) |
| HK (1) | HK1042491A1 (es) |
| HR (1) | HRP20010455A2 (es) |
| HU (1) | HUP0104641A3 (es) |
| ID (1) | ID28880A (es) |
| IL (1) | IL143766A (es) |
| MY (1) | MY125808A (es) |
| NO (1) | NO319814B1 (es) |
| NZ (1) | NZ512748A (es) |
| PL (1) | PL198205B1 (es) |
| PT (1) | PT1140873E (es) |
| SA (1) | SA00201030B1 (es) |
| SK (1) | SK8152001A3 (es) |
| TR (1) | TR200101729T2 (es) |
| TW (1) | TWI249530B (es) |
| UA (1) | UA73107C2 (es) |
| WO (1) | WO2000037451A1 (es) |
| ZA (1) | ZA200104942B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8466096B2 (en) * | 2007-04-26 | 2013-06-18 | Afton Chemical Corporation | 1,3,2-dioxaphosphorinane, 2-sulfide derivatives for use as anti-wear additives in lubricant compositions |
| RU2523651C2 (ru) * | 2012-05-22 | 2014-07-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Владивостокский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ВГМУ Минздравсоцразвития России) | Способ дифференцированного контроля базисного противовоспалительного лечения бронхиальной астмы у детей и подростков |
| RU2506045C1 (ru) * | 2012-09-05 | 2014-02-10 | Федеральное государственное бюджетное учреждение "Дальневосточный научный центр физиологии и патологии дыхания" Сибирского отделения РАМН | Способ прогнозирования достижения контроля бронхиальной астмы |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2149645A1 (de) | 1970-10-07 | 1972-09-14 | Pfizer | 2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose |
| US3912723A (en) | 1971-03-29 | 1975-10-14 | Pfizer | 2-Phenyl-as-triazine-3,5(2H,4H)diones |
| US3883528A (en) | 1974-04-19 | 1975-05-13 | Pfizer | Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats |
| US4631278A (en) | 1984-08-01 | 1986-12-23 | Janssen Pharmaceutica N.V. | Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor |
| CA1244024A (en) | 1984-08-01 | 1988-11-01 | Gustaaf M. Boeckx | .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES |
| GB8602342D0 (en) | 1986-01-30 | 1986-03-05 | Janssen Pharmaceutica Nv | 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones |
| CA1331757C (en) | 1988-02-29 | 1994-08-30 | Janssen Pharmaceutica Naamloze Vennootschap | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
| EP0476439A1 (de) | 1990-09-18 | 1992-03-25 | Bayer Ag | Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung |
| DE4120138A1 (de) | 1991-06-19 | 1992-12-24 | Bayer Ag | Substituierte hexahydro-1,2,4-triazindione, verfahren zu ihrer herstellung, zwischenprodukte dafuer und ihre verwendung |
| TW263495B (es) | 1992-12-23 | 1995-11-21 | Celltech Ltd | |
| GB9304920D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| RU2146674C1 (ru) | 1993-10-15 | 2000-03-20 | Такеда Кемикал Индастриз, Лтд. | Производные триазина, способы их получения, антипротозойная композиция, добавка в пищу животных, способ ингибирования протозои у животных |
| TW332201B (en) | 1995-04-06 | 1998-05-21 | Janssen Pharmaceutica Nv | 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives |
| EP0737672B1 (en) | 1995-04-14 | 2001-10-04 | Takeda Schering-Plough Animal Health K.K. | Method of producing triazine derivatives |
| KR19980019182A (ko) * | 1996-08-30 | 1998-06-05 | 다께다 구니오 | 1,2,4-트리아진-3,5-디온 유도체, 그의 생성법 및 그의 용도(1,2,4-triazine-3,5-dione derivatives, their production a nd use thereof) |
| TR199903249T2 (xx) * | 1997-07-10 | 2000-09-21 | Janssen Pharmaceutica N.V. | �l-5 inhibit�rleri olarak 6-Azaurasil t�revleri. |
| SK183999A3 (en) * | 1997-07-10 | 2000-08-14 | Janssen Pharmaceutica Nv | Il-5 inhibiting 6-azauracil derivatives |
-
1999
- 1999-12-16 CA CA002354511A patent/CA2354511A1/en not_active Abandoned
- 1999-12-16 WO PCT/EP1999/010169 patent/WO2000037451A1/en active IP Right Grant
- 1999-12-16 NZ NZ512748A patent/NZ512748A/en unknown
- 1999-12-16 EA EA200100677A patent/EA004806B1/ru not_active IP Right Cessation
- 1999-12-16 HU HU0104641A patent/HUP0104641A3/hu unknown
- 1999-12-16 CN CNB998146110A patent/CN100343239C/zh not_active Expired - Fee Related
- 1999-12-16 SK SK815-2001A patent/SK8152001A3/sk unknown
- 1999-12-16 IL IL14376699A patent/IL143766A/xx not_active IP Right Cessation
- 1999-12-16 PT PT99965509T patent/PT1140873E/pt unknown
- 1999-12-16 CZ CZ20012062A patent/CZ20012062A3/cs unknown
- 1999-12-16 ID IDW00200101295A patent/ID28880A/id unknown
- 1999-12-16 JP JP2000589523A patent/JP2002533331A/ja not_active Withdrawn
- 1999-12-16 DE DE69936396T patent/DE69936396T2/de not_active Expired - Fee Related
- 1999-12-16 UA UA2001075132A patent/UA73107C2/uk unknown
- 1999-12-16 KR KR1020017006666A patent/KR100635721B1/ko not_active IP Right Cessation
- 1999-12-16 PL PL349526A patent/PL198205B1/pl not_active IP Right Cessation
- 1999-12-16 EE EEP200100320A patent/EE200100320A/xx unknown
- 1999-12-16 ES ES99965509T patent/ES2289835T3/es not_active Expired - Lifetime
- 1999-12-16 BR BR9916366-7A patent/BR9916366A/pt not_active Application Discontinuation
- 1999-12-16 US US09/868,384 patent/US6803364B1/en not_active Expired - Fee Related
- 1999-12-16 DK DK99965509T patent/DK1140873T3/da active
- 1999-12-16 TR TR2001/01729T patent/TR200101729T2/xx unknown
- 1999-12-16 AT AT99965509T patent/ATE365723T1/de not_active IP Right Cessation
- 1999-12-16 EP EP99965509A patent/EP1140873B1/en not_active Expired - Lifetime
- 1999-12-16 AU AU21001/00A patent/AU773780B2/en not_active Ceased
- 1999-12-17 TW TW088122197A patent/TWI249530B/zh not_active IP Right Cessation
- 1999-12-17 AR ARP990106512A patent/AR021887A1/es not_active Application Discontinuation
- 1999-12-17 MY MYPI99005536A patent/MY125808A/en unknown
- 1999-12-17 CO CO99079022A patent/CO5150147A1/es unknown
-
2000
- 2000-03-05 SA SA00201030A patent/SA00201030B1/ar unknown
-
2001
- 2001-06-14 BG BG105602A patent/BG105602A/xx unknown
- 2001-06-15 ZA ZA200104942A patent/ZA200104942B/en unknown
- 2001-06-15 NO NO20012987A patent/NO319814B1/no unknown
- 2001-06-15 HR HR20010455A patent/HRP20010455A2/hr not_active Application Discontinuation
-
2002
- 2002-06-03 HK HK02104206.0A patent/HK1042491A1/zh unknown
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