CO5510023A1 - Uso de antagonistas del canal de sodio neuronal para el control de ectoparasitos en animales homeotermicos - Google Patents
Uso de antagonistas del canal de sodio neuronal para el control de ectoparasitos en animales homeotermicosInfo
- Publication number
- CO5510023A1 CO5510023A1 CO03093177A CO03093177A CO5510023A1 CO 5510023 A1 CO5510023 A1 CO 5510023A1 CO 03093177 A CO03093177 A CO 03093177A CO 03093177 A CO03093177 A CO 03093177A CO 5510023 A1 CO5510023 A1 CO 5510023A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- alkoxy
- integer
- optionally substituted
- sodium channel
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Una composición farmacéutica la cual comprende un portador farmacéuticamente aceptable y una cantidad ectoparasiticidamente efectiva de un antagonista del canal de sodio neuronal. La composición de acuerdo con la reivindicación 1, en donde dicho antagonista del canal de sodio neuronal es un compuesto de fórmula I, II o III<EMI FILE="03093177_1" ID="1" IMF=JPEG >en donde A es CR4R5 o NR6;W es O o S;X. Y, Z, XAND#39, YAND#39 y ZAND#39 son cada uno independientemente H; halógeno; OH; CN; NO2, alquiloC1-C6 opcionalmente sustituido con uno o más grupos halógeno, alcoxiC1-C3, haloalcoxiC1-C3, cicloaquiloC3-C6, alqueniloxiC2-C6 o sulfoniloxi; alcoxiC1-C6 opcionalmente sustituido con uno o más grupos halógeno, alcoxiC1-C3 o cicloalquiloC3-C6;alcoxicarboniIC1-C6, cicloalquilcarboniloxiC3-C6, fenilo opcionalmente sustituido con uno o más grupos halógeno, alquiloC1-C4, o alcoxiC1-C4;aminocarboniloxi opcionalmente sustituido con uno o más grupos alquiloC1-C3;alcoxicarboniloxiC1-C6; alquilosulfoniloxiC1-C6; alqueniloC2-C6; o NR12R13;m, p y q son cada uno independientemente un entero de 1, 2, 3, 4, ó 5;n es un entero de 0, 1, ó 2;r es un entero de 1 ó 2;t es un entero de 1, 2, 3 ó 4;R, R1, R2, R3, R4 y R5 son cada uno independientemente H o alquiloC1-C4;R6 es H, alquiloC1-C6, haloalquiloC1-C6, alcoxialquiloC1-C6, alcoxiC1-C6, haloalcoxiC1-C6, alqueniloC2-C6, alquiniloC2-C6, alquilocarbonilo C1-C6, alcoxicarboniloC1-C6, alquiltioC1-C6, o haloalquiltioC1-C6; ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41988702P | 2002-10-21 | 2002-10-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5510023A1 true CO5510023A1 (es) | 2005-04-29 |
Family
ID=32069964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO03093177A CO5510023A1 (es) | 2002-10-21 | 2003-10-20 | Uso de antagonistas del canal de sodio neuronal para el control de ectoparasitos en animales homeotermicos |
Country Status (25)
Country | Link |
---|---|
US (1) | US7906128B2 (es) |
EP (2) | EP1967067A3 (es) |
JP (1) | JP2004143172A (es) |
KR (1) | KR101110579B1 (es) |
CN (1) | CN100531728C (es) |
AR (1) | AR041668A1 (es) |
AT (1) | ATE405161T1 (es) |
AU (2) | AU2003255177B2 (es) |
BR (1) | BR0304618A (es) |
CA (1) | CA2444692C (es) |
CO (1) | CO5510023A1 (es) |
CY (1) | CY1108430T1 (es) |
DE (1) | DE60323028D1 (es) |
DK (1) | DK1413201T3 (es) |
ES (1) | ES2311677T3 (es) |
HR (1) | HRP20030856A2 (es) |
ME (1) | ME00571A (es) |
MX (1) | MXPA03009595A (es) |
NZ (2) | NZ567277A (es) |
PL (1) | PL362962A1 (es) |
PT (1) | PT1413201E (es) |
RS (1) | RS51054B (es) |
SI (1) | SI1413201T1 (es) |
TW (1) | TWI311465B (es) |
ZA (1) | ZA200308147B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7906128B2 (en) | 2002-10-21 | 2011-03-15 | Wyeth Llc | Use of neuronal sodium channel antagonists for the control of ectoparasites in homeothermic animals |
US7531186B2 (en) * | 2003-12-17 | 2009-05-12 | Merial Limited | Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz |
KR100595446B1 (ko) * | 2004-01-19 | 2006-07-03 | 삼성전자주식회사 | 디스플레이장치 |
TWI350728B (en) * | 2004-10-08 | 2011-10-21 | Wyeth Corp | Amitraz compositions |
UY28617A1 (es) * | 2004-11-12 | 2006-06-30 | Popley Pharma Ltda | Nuevas composiciones |
US20060293260A1 (en) * | 2005-05-24 | 2006-12-28 | Wyeth | Useful high load concentrate compositions for control of ecto-and endo-parasites |
US7749527B2 (en) * | 2005-05-24 | 2010-07-06 | Wyeth Llc | Gel compositions for control of ecto-parasites |
TWI368505B (en) * | 2005-05-24 | 2012-07-21 | Wyeth Corp | Versatile high load concentrate compositions for control of ecto-parasites |
US20100095900A1 (en) * | 2005-05-24 | 2010-04-22 | Wyeth Llc | Device and method for controlling insects |
TW200846029A (en) * | 2007-02-09 | 2008-12-01 | Wyeth Corp | High dose, long-acting ectoparasiticide for extended control |
CL2008001614A1 (es) * | 2007-06-05 | 2008-08-08 | Wyeth Corp | Composicion parasiticida veterinaria que comprende un disolvente que no contiene hidroxilo, un estabilizador, amitraz y opcionalmente una lactona macrociclica y miristato de isopropilo; y su uso para tratar o controlar una infestacion o infeccion par |
JP5755143B2 (ja) | 2008-11-19 | 2015-07-29 | メリアル リミテッド | アリールピラゾールおよび/またはホルムアミジンを含む組成物、それらの方法ならびに使用 |
US9173728B2 (en) | 2008-11-19 | 2015-11-03 | Merial Inc. | Multi-cavity container having offset indentures for dispensing fluids |
AU2010224685A1 (en) | 2009-03-18 | 2011-11-03 | Fidopharm, Inc. | Parasiticidal formulation |
WO2012089622A2 (en) | 2010-12-27 | 2012-07-05 | Intervet International B.V. | Topical localized isoxazoline formulation |
WO2014060960A1 (en) | 2012-10-16 | 2014-04-24 | Solano Smart Products Ltd. | Topical formulations for treating parasitic infestations |
CN105168560A (zh) * | 2015-07-22 | 2015-12-23 | 贵州谷丰生态农业发展有限责任公司 | 一种从鹅耳孔驱赶虱子的方法 |
US10512628B2 (en) | 2016-04-24 | 2019-12-24 | Solano S.P. Ltd. | Dinotefuran liquid flea and tick treatment |
RU2020122841A (ru) | 2017-12-15 | 2022-01-18 | Тарсус Фармасьютикалс, Инк. | Изоксазолиновые паразитицидные составы и способы лечения блефарита |
Family Cites Families (28)
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CA1176167A (en) | 1980-03-06 | 1984-10-16 | John J. Windheuser | Use of n,n-diethyl-m-toluamide for enhancing skin permeation of bio-affecting agents |
US4560553A (en) * | 1981-07-07 | 1985-12-24 | Merck & Co., Inc. | Use of eucalyptol for enhancing skin permeation of bio-affecting agents |
GB8525447D0 (en) * | 1985-10-16 | 1985-11-20 | Fbc Ltd | Pesticidal compositions |
US5116850A (en) * | 1987-11-30 | 1992-05-26 | E. I. Du Pont De Nemours And Co. | Heterocyclic pyrazoline carboxanilides |
ES2089056T3 (es) * | 1990-06-16 | 1996-10-01 | Nihon Nohyaku Co Ltd | Derivados de hidrazincarboxamida, un procedimiento para la produccion de los mismos, y usos de los mismos. |
EP0553284A1 (en) | 1990-10-05 | 1993-08-04 | E.I. Du Pont De Nemours And Company | Semicarbazone arthropodicides |
EP0486937B1 (en) * | 1990-11-17 | 1995-03-22 | Nihon Nohyaku Co., Ltd. | Hydrazone derivatives, processes for production thereof, and uses thereof |
US5462938A (en) * | 1990-12-21 | 1995-10-31 | Annus; Gary D. | Arthropodicidal oxadiazinyl, thiadiazinyl and triazinyl carboxanilides |
US5250532A (en) * | 1991-04-11 | 1993-10-05 | Dowelanco | 3,4,N-trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides and their use as insecticides |
JPH07165697A (ja) | 1993-10-04 | 1995-06-27 | Nissan Chem Ind Ltd | セミカルバゾン化合物及び有害生物防除剤 |
JP3711581B2 (ja) | 1995-03-31 | 2005-11-02 | 日産化学工業株式会社 | セミカルバゾン誘導体及び有害生物防除剤 |
JPH09301947A (ja) | 1996-05-17 | 1997-11-25 | Nissan Chem Ind Ltd | セミカルバゾン誘導体及び有害生物防除剤 |
US5968990A (en) * | 1997-10-14 | 1999-10-19 | Isp Investments Inc. | Water-dilutable, microemulsion concentrate and pour-on formulations thereof |
JP4239298B2 (ja) * | 1998-07-27 | 2009-03-18 | 住友化学株式会社 | 動物の外部寄生虫防除剤 |
AU1079000A (en) * | 1998-11-12 | 2000-06-05 | Mitsubishi Chemical Corporation | 2-anilino-4(3h)-pyrimidinone derivatives, intermediates in the production thereof, process for producing the same and pesticides containing the same as the active ingredient |
US5965137A (en) * | 1998-11-16 | 1999-10-12 | Advanced Medical Instruments | Insect repellent composition and method for inhibiting the transmission and treatment of symptoms of vector-borne diseases |
MXPA01009191A (es) * | 1999-03-12 | 2004-06-03 | Basf Ag | Composiciones insecticidas sinergicas. |
MY138864A (en) | 1999-07-05 | 2009-08-28 | Nihon Nohyaku Co Ltd | Ant controllers and method for application thereof |
AUPQ441699A0 (en) * | 1999-12-02 | 2000-01-06 | Eli Lilly And Company | Pour-on formulations |
JP2001240583A (ja) * | 1999-12-17 | 2001-09-04 | Mitsubishi Chemicals Corp | ジハロプロペニルオキシベンゼン誘導体及びこれを有効成分とする有害生物防除剤 |
JP2001240541A (ja) * | 2000-03-02 | 2001-09-04 | Kanto Kachiku Rinsho Center:Kk | 動物外部寄生虫の駆除方法及び駆除剤 |
AU781682B2 (en) * | 2000-03-20 | 2005-06-09 | Zoetis Services Llc | Sustained-release compositions for parenteral administration |
IL186223A0 (en) * | 2000-05-24 | 2008-01-20 | Pfizer | Treatment of rumen acidosis with ??-amylase inhibitors |
JP5093429B2 (ja) * | 2000-10-18 | 2012-12-12 | 日本農薬株式会社 | 動物用外部寄生性害虫防除剤及びその使用方法 |
US7906128B2 (en) | 2002-10-21 | 2011-03-15 | Wyeth Llc | Use of neuronal sodium channel antagonists for the control of ectoparasites in homeothermic animals |
US20040122075A1 (en) * | 2002-12-16 | 2004-06-24 | Wyeth | N-phenyl-3-cyclopropylpyrazole-4-carbonitriles as ectoparasiticidal agents |
MXPA06014862A (es) | 2004-07-06 | 2007-03-21 | Basf Ag | Composiciones plaguicidas liquidas |
TWI350728B (en) | 2004-10-08 | 2011-10-21 | Wyeth Corp | Amitraz compositions |
-
2003
- 2003-10-14 US US10/684,995 patent/US7906128B2/en not_active Expired - Fee Related
- 2003-10-15 CA CA2444692A patent/CA2444692C/en not_active Expired - Fee Related
- 2003-10-17 BR BR0304618-4A patent/BR0304618A/pt not_active IP Right Cessation
- 2003-10-17 NZ NZ567277A patent/NZ567277A/en active IP Right Revival
- 2003-10-17 NZ NZ550771A patent/NZ550771A/en not_active IP Right Cessation
- 2003-10-17 RS YUP-825/03A patent/RS51054B/sr unknown
- 2003-10-17 ME MEP-860/08A patent/ME00571A/xx unknown
- 2003-10-20 ES ES03256595T patent/ES2311677T3/es not_active Expired - Lifetime
- 2003-10-20 HR HR20030856A patent/HRP20030856A2/hr not_active Application Discontinuation
- 2003-10-20 SI SI200331381T patent/SI1413201T1/sl unknown
- 2003-10-20 CN CNB2003101156998A patent/CN100531728C/zh not_active Expired - Fee Related
- 2003-10-20 AT AT03256595T patent/ATE405161T1/de active
- 2003-10-20 MX MXPA03009595A patent/MXPA03009595A/es active IP Right Grant
- 2003-10-20 PT PT03256595T patent/PT1413201E/pt unknown
- 2003-10-20 TW TW092129004A patent/TWI311465B/zh not_active IP Right Cessation
- 2003-10-20 KR KR1020030072980A patent/KR101110579B1/ko not_active IP Right Cessation
- 2003-10-20 DE DE60323028T patent/DE60323028D1/de not_active Expired - Lifetime
- 2003-10-20 ZA ZA200308147A patent/ZA200308147B/xx unknown
- 2003-10-20 PL PL03362962A patent/PL362962A1/xx unknown
- 2003-10-20 EP EP08009618A patent/EP1967067A3/en not_active Withdrawn
- 2003-10-20 AR ARP030103810A patent/AR041668A1/es unknown
- 2003-10-20 CO CO03093177A patent/CO5510023A1/es not_active Application Discontinuation
- 2003-10-20 AU AU2003255177A patent/AU2003255177B2/en not_active Ceased
- 2003-10-20 EP EP03256595A patent/EP1413201B1/en not_active Expired - Lifetime
- 2003-10-20 DK DK03256595T patent/DK1413201T3/da active
- 2003-10-21 JP JP2003361009A patent/JP2004143172A/ja active Pending
-
2008
- 2008-10-21 CY CY20081101182T patent/CY1108430T1/el unknown
-
2009
- 2009-08-21 AU AU2009210409A patent/AU2009210409A1/en not_active Abandoned
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