CO5510023A1 - Uso de antagonistas del canal de sodio neuronal para el control de ectoparasitos en animales homeotermicos - Google Patents

Uso de antagonistas del canal de sodio neuronal para el control de ectoparasitos en animales homeotermicos

Info

Publication number
CO5510023A1
CO5510023A1 CO03093177A CO03093177A CO5510023A1 CO 5510023 A1 CO5510023 A1 CO 5510023A1 CO 03093177 A CO03093177 A CO 03093177A CO 03093177 A CO03093177 A CO 03093177A CO 5510023 A1 CO5510023 A1 CO 5510023A1
Authority
CO
Colombia
Prior art keywords
alkyl
alkoxy
integer
optionally substituted
sodium channel
Prior art date
Application number
CO03093177A
Other languages
English (en)
Inventor
Heaney Katheleen
Susan Joan Dunney
Douglas Rugg
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CO5510023A1 publication Critical patent/CO5510023A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una composición farmacéutica la cual comprende un portador farmacéuticamente aceptable y una cantidad ectoparasiticidamente efectiva de un antagonista del canal de sodio neuronal. La composición de acuerdo con la reivindicación 1, en donde dicho antagonista del canal de sodio neuronal es un compuesto de fórmula I, II o III<EMI FILE="03093177_1" ID="1" IMF=JPEG >en donde A es CR4R5 o NR6;W es O o S;X. Y, Z, XAND#39, YAND#39 y ZAND#39 son cada uno independientemente H; halógeno; OH; CN; NO2, alquiloC1-C6 opcionalmente sustituido con uno o más grupos halógeno, alcoxiC1-C3, haloalcoxiC1-C3, cicloaquiloC3-C6, alqueniloxiC2-C6 o sulfoniloxi; alcoxiC1-C6 opcionalmente sustituido con uno o más grupos halógeno, alcoxiC1-C3 o cicloalquiloC3-C6;alcoxicarboniIC1-C6, cicloalquilcarboniloxiC3-C6, fenilo opcionalmente sustituido con uno o más grupos halógeno, alquiloC1-C4, o alcoxiC1-C4;aminocarboniloxi opcionalmente sustituido con uno o más grupos alquiloC1-C3;alcoxicarboniloxiC1-C6; alquilosulfoniloxiC1-C6; alqueniloC2-C6; o NR12R13;m, p y q son cada uno independientemente un entero de 1, 2, 3, 4, ó 5;n es un entero de 0, 1, ó 2;r es un entero de 1 ó 2;t es un entero de 1, 2, 3 ó 4;R, R1, R2, R3, R4 y R5 son cada uno independientemente H o alquiloC1-C4;R6 es H, alquiloC1-C6, haloalquiloC1-C6, alcoxialquiloC1-C6, alcoxiC1-C6, haloalcoxiC1-C6, alqueniloC2-C6, alquiniloC2-C6, alquilocarbonilo C1-C6, alcoxicarboniloC1-C6, alquiltioC1-C6, o haloalquiltioC1-C6; ...
CO03093177A 2002-10-21 2003-10-20 Uso de antagonistas del canal de sodio neuronal para el control de ectoparasitos en animales homeotermicos CO5510023A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41988702P 2002-10-21 2002-10-21

Publications (1)

Publication Number Publication Date
CO5510023A1 true CO5510023A1 (es) 2005-04-29

Family

ID=32069964

Family Applications (1)

Application Number Title Priority Date Filing Date
CO03093177A CO5510023A1 (es) 2002-10-21 2003-10-20 Uso de antagonistas del canal de sodio neuronal para el control de ectoparasitos en animales homeotermicos

Country Status (25)

Country Link
US (1) US7906128B2 (es)
EP (2) EP1967067A3 (es)
JP (1) JP2004143172A (es)
KR (1) KR101110579B1 (es)
CN (1) CN100531728C (es)
AR (1) AR041668A1 (es)
AT (1) ATE405161T1 (es)
AU (2) AU2003255177B2 (es)
BR (1) BR0304618A (es)
CA (1) CA2444692C (es)
CO (1) CO5510023A1 (es)
CY (1) CY1108430T1 (es)
DE (1) DE60323028D1 (es)
DK (1) DK1413201T3 (es)
ES (1) ES2311677T3 (es)
HR (1) HRP20030856A2 (es)
ME (1) ME00571A (es)
MX (1) MXPA03009595A (es)
NZ (2) NZ567277A (es)
PL (1) PL362962A1 (es)
PT (1) PT1413201E (es)
RS (1) RS51054B (es)
SI (1) SI1413201T1 (es)
TW (1) TWI311465B (es)
ZA (1) ZA200308147B (es)

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UY28617A1 (es) * 2004-11-12 2006-06-30 Popley Pharma Ltda Nuevas composiciones
US20060293260A1 (en) * 2005-05-24 2006-12-28 Wyeth Useful high load concentrate compositions for control of ecto-and endo-parasites
US7749527B2 (en) * 2005-05-24 2010-07-06 Wyeth Llc Gel compositions for control of ecto-parasites
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US20100095900A1 (en) * 2005-05-24 2010-04-22 Wyeth Llc Device and method for controlling insects
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RU2020122841A (ru) 2017-12-15 2022-01-18 Тарсус Фармасьютикалс, Инк. Изоксазолиновые паразитицидные составы и способы лечения блефарита

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Also Published As

Publication number Publication date
CA2444692C (en) 2012-01-10
RS51054B (sr) 2010-10-31
TWI311465B (en) 2009-07-01
MXPA03009595A (es) 2004-10-15
TW200418388A (en) 2004-10-01
DK1413201T3 (da) 2008-11-10
YU82503A (sh) 2006-05-25
KR20040034542A (ko) 2004-04-28
AU2003255177A1 (en) 2004-05-06
EP1967067A3 (en) 2009-05-06
AR041668A1 (es) 2005-05-26
JP2004143172A (ja) 2004-05-20
US20040116419A1 (en) 2004-06-17
PT1413201E (pt) 2008-10-28
KR101110579B1 (ko) 2012-02-15
HRP20030856A2 (en) 2005-02-28
NZ567277A (en) 2009-12-24
US7906128B2 (en) 2011-03-15
PL362962A1 (en) 2004-05-04
CN100531728C (zh) 2009-08-26
AU2003255177B2 (en) 2009-10-08
EP1413201B1 (en) 2008-08-20
SI1413201T1 (sl) 2008-12-31
ZA200308147B (en) 2005-04-20
ATE405161T1 (de) 2008-09-15
ME00571A (en) 2011-12-20
BR0304618A (pt) 2004-08-31
CN1496736A (zh) 2004-05-19
EP1413201A2 (en) 2004-04-28
CA2444692A1 (en) 2004-04-21
EP1967067A2 (en) 2008-09-10
ES2311677T3 (es) 2009-02-16
DE60323028D1 (de) 2008-10-02
AU2009210409A1 (en) 2009-09-10
CY1108430T1 (el) 2014-04-09
NZ550771A (en) 2008-06-30
EP1413201A3 (en) 2004-06-23

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