CO4830459A1 - Procedimiento para la preapracion de (s,s)-bencil-2,8- diazabicilo[4,3,0]nonano - Google Patents
Procedimiento para la preapracion de (s,s)-bencil-2,8- diazabicilo[4,3,0]nonanoInfo
- Publication number
- CO4830459A1 CO4830459A1 CO99028729A CO99028729A CO4830459A1 CO 4830459 A1 CO4830459 A1 CO 4830459A1 CO 99028729 A CO99028729 A CO 99028729A CO 99028729 A CO99028729 A CO 99028729A CO 4830459 A1 CO4830459 A1 CO 4830459A1
- Authority
- CO
- Colombia
- Prior art keywords
- nonane
- diazabicyclo
- benzyl
- mixture
- alcohol
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- BKIMMITUMNQMOS-UHFFFAOYSA-N nonane Chemical compound CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 abstract 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 7
- 239000000203 mixture Substances 0.000 abstract 6
- 239000011877 solvent mixture Substances 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 235000011002 L(+)-tartaric acid Nutrition 0.000 abstract 1
- 239000001358 L(+)-tartaric acid Substances 0.000 abstract 1
- FEWJPZIEWOKRBE-LWMBPPNESA-N L-(+)-Tartaric acid Natural products OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19821039A DE19821039A1 (de) | 1998-05-11 | 1998-05-11 | Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4830459A1 true CO4830459A1 (es) | 1999-08-30 |
Family
ID=7867389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99028729A CO4830459A1 (es) | 1998-05-11 | 1999-05-10 | Procedimiento para la preapracion de (s,s)-bencil-2,8- diazabicilo[4,3,0]nonano |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6235908B1 (https=) |
| EP (1) | EP1077979B1 (https=) |
| JP (1) | JP4554076B2 (https=) |
| AR (1) | AR019123A1 (https=) |
| AU (1) | AU3824599A (https=) |
| CA (1) | CA2331526C (https=) |
| CO (1) | CO4830459A1 (https=) |
| DE (2) | DE19821039A1 (https=) |
| ES (1) | ES2245101T3 (https=) |
| PE (1) | PE20000477A1 (https=) |
| SV (1) | SV1999000060A (https=) |
| UY (1) | UY25501A1 (https=) |
| WO (1) | WO1999058532A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230030B1 (hu) * | 1999-10-08 | 2015-05-28 | Debiopharm International Sa | Fab I inhibitorok |
| US6476046B1 (en) | 2000-12-04 | 2002-11-05 | Sepracor, Inc. | Diazabicyclo[4.3.0]nonanes, and methods of use thereof |
| EP1560584B1 (en) * | 2001-04-06 | 2009-01-14 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| EP1575951B1 (en) * | 2002-12-06 | 2014-06-25 | Debiopharm International SA | Heterocyclic compounds, methods of making them and their use in therapy |
| WO2004082586A2 (en) | 2003-03-17 | 2004-09-30 | Affinium Pharmaceuticals, Inc. | Phamaceutical compositions comprising inhibitors of fab i and further antibiotics |
| DK1828167T3 (da) * | 2004-06-04 | 2014-10-20 | Debiopharm Int Sa | Acrylamidderivater som antibiotiske midler |
| KR20080075027A (ko) * | 2005-12-05 | 2008-08-13 | 아피늄 파마슈티컬스, 인크. | Ｆａｂｉ 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물 |
| JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ， インク． | Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 |
| JP2010509305A (ja) * | 2006-11-13 | 2010-03-25 | シプラ・リミテッド | モキシフロキサシン塩酸塩の合成方法 |
| US7692015B2 (en) * | 2007-01-05 | 2010-04-06 | Zheqing Wang | Economical process for preparing (S, S)-2, 8-diazabicyclo[4.3.0]nonane and its enantiomer |
| EP2125802A4 (en) | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS |
| WO2009125425A2 (en) * | 2008-02-08 | 2009-10-15 | Neuland Laboratories Ltd | Improved process for the preparation of (s.s)-2.8-diazabicyclo[4.3.0]nonane |
| IT1393337B1 (it) | 2009-03-06 | 2012-04-20 | Italiana Sint Spa | Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina |
| CN103044418B (zh) * | 2011-10-14 | 2015-02-04 | 上海朴颐化学科技有限公司 | (s,s)-2,8-二氮杂双环[4,3,0]壬烷的不对称合成方法、相关原料及制备方法 |
| AU2013279021C1 (en) | 2012-06-19 | 2017-03-16 | Debiopharm International Sa | Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
| RS61312B1 (sr) | 2016-02-26 | 2021-02-26 | Debiopharm Int Sa | Lek za lečenje infekcija dijabetskog stopala |
| TN2021000159A1 (en) | 2019-02-14 | 2023-04-04 | Debiopharm Int Sa | Afabicin formulation, method for making the same and uses thereof |
| SG11202113174SA (en) | 2019-06-14 | 2021-12-30 | Debiopharm Int Sa | Medicament and use thereof for treating bacterial infections involving biofilm |
| CN112574197B (zh) * | 2020-12-07 | 2021-12-31 | 泰安汉威集团有限公司 | 一种化合物c的手性纯化方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB354975A (en) * | 1929-07-19 | 1931-08-20 | Ig Farbenindustrie Ag | Manufacture of optically active phenylpropanol-methylamines |
| HU194221B (en) * | 1985-04-19 | 1988-01-28 | Richter Gedeon Vegyeszet | Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound |
| JPH0285235A (ja) * | 1988-09-22 | 1990-03-26 | Kohjin Co Ltd | 光学活性アミノアルコール類の製法 |
| JP2995704B2 (ja) * | 1989-02-17 | 1999-12-27 | 東京化成工業株式会社 | 光学活性な１ｈ−３−アミノピロリジン化合物の製造法 |
| IT1231158B (it) * | 1989-07-20 | 1991-11-19 | Dompe Farmaceutici Spa | Procedimento per la risoluzione ottica della dropropizina. |
| DE69108743T2 (de) * | 1991-01-31 | 1995-08-17 | Pfizer | Recematspaltung von trans-2-(2-pyrimidinyl)-7-(hydroxymethyl)octahydro-2h-pyrido[1,2-a]-pyrazin. |
| TW209865B (https=) * | 1992-01-10 | 1993-07-21 | Bayer Ag | |
| DE4234078A1 (de) * | 1992-10-09 | 1994-04-14 | Bayer Ag | Chinoloncarbonsäuren |
| DE4234330A1 (de) * | 1992-10-12 | 1994-04-14 | Bayer Ag | Chinoloncarbonsäuren |
| CA2112165C (en) * | 1992-12-25 | 2003-04-08 | Makoto Takemura | Bicyclic amine derivatives |
| US5686614A (en) * | 1995-04-11 | 1997-11-11 | Neurogen Corporation | Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution |
| DE19601745C1 (de) * | 1996-01-19 | 1997-10-09 | Gruenenthal Gmbh | Verfahren zur Racematspaltung von Tramadol |
-
1998
- 1998-05-11 DE DE19821039A patent/DE19821039A1/de not_active Ceased
-
1999
- 1999-04-28 DE DE59912242T patent/DE59912242D1/de not_active Expired - Lifetime
- 1999-04-28 AU AU38245/99A patent/AU3824599A/en not_active Abandoned
- 1999-04-28 CA CA2331526A patent/CA2331526C/en not_active Expired - Lifetime
- 1999-04-28 WO PCT/EP1999/002860 patent/WO1999058532A1/de not_active Ceased
- 1999-04-28 EP EP99920805A patent/EP1077979B1/de not_active Expired - Lifetime
- 1999-04-28 ES ES99920805T patent/ES2245101T3/es not_active Expired - Lifetime
- 1999-04-28 JP JP2000548336A patent/JP4554076B2/ja not_active Expired - Lifetime
- 1999-04-28 US US09/700,107 patent/US6235908B1/en not_active Expired - Lifetime
- 1999-04-30 AR ARP990102026A patent/AR019123A1/es unknown
- 1999-05-07 UY UY25501A patent/UY25501A1/es not_active Application Discontinuation
- 1999-05-10 PE PE1999000379A patent/PE20000477A1/es not_active Application Discontinuation
- 1999-05-10 CO CO99028729A patent/CO4830459A1/es unknown
- 1999-05-11 SV SV1999000060A patent/SV1999000060A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SV1999000060A (es) | 1999-10-27 |
| US6235908B1 (en) | 2001-05-22 |
| WO1999058532A1 (de) | 1999-11-18 |
| JP4554076B2 (ja) | 2010-09-29 |
| DE59912242D1 (de) | 2005-08-11 |
| EP1077979B1 (de) | 2005-07-06 |
| ES2245101T3 (es) | 2005-12-16 |
| AU3824599A (en) | 1999-11-29 |
| CA2331526A1 (en) | 1999-11-18 |
| PE20000477A1 (es) | 2000-07-07 |
| JP2002514648A (ja) | 2002-05-21 |
| CA2331526C (en) | 2011-09-13 |
| UY25501A1 (es) | 1999-11-17 |
| AR019123A1 (es) | 2001-12-26 |
| DE19821039A1 (de) | 1999-11-18 |
| EP1077979A1 (de) | 2001-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO4830459A1 (es) | Procedimiento para la preapracion de (s,s)-bencil-2,8- diazabicilo[4,3,0]nonano | |
| BRPI0111639B8 (pt) | uso de uma molécula de ácido oligodeoxinucléico imunoestimulatório e composição farmacêutica. | |
| BRPI0009446B8 (pt) | composto derivado de pirimido [6,1-a] isoquinolin-4-ona, processo para preparar p mesmo, composição, e, uso de um composto | |
| ES8703846A1 (es) | Un procedimiento para preparar derivados de dihidropiridazi-nona | |
| BRPI0519106A2 (pt) | compostos, uso destes, processo para sua fabricaÇço, composiÇÕes farmacÊuticas, mÉtodo para o tratamento e/ou profilaxia de doenÇas que sço associadas com a dpp-iv | |
| CY1109329T1 (el) | Ξανθινες, αναστολεις της φωσφοδιεστερασης τυπου v | |
| ECSP034782A (es) | Derivados de mercaptoacetilamida, procedimiento para su preparacion y su uso | |
| ES2119837T3 (es) | Derivados de fenilimidazolidina, su preparacion y su utilizacion. | |
| NO20030495L (no) | Peptider som presenteres av celler | |
| BR0110430A (pt) | Processo para a preparação de um composto, composto, e, uso do mesmo | |
| TR200401436T4 (tr) | Monotiyogliserol, L-sistem veya tiyoglikolik asitle birlikte pemetrexed içeren farmasötik bileşim | |
| BR0008302A (pt) | Uso de um derivado de benzaldeìdo, derivado de benzaldeìdo, composição farmacêutica, e, processo para a fabricação da mesma | |
| EA200400708A1 (ru) | Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1 | |
| BR9003011A (pt) | Processo para purificacao de triptofano | |
| CO4940435A1 (es) | Sal de hemisulfato del (1s,4r)-cis-4-[2-amino-6- (ciclopropilamino)-9h-purin-9-il]-2-ciclopenten-1-metanol o un solvato del mismo | |
| ATE279414T1 (de) | Verfahren zur herstellung von reinem triethylendiamin (teda) | |
| Gloaguen et al. | Gas phase folding of an (Ala) 4 neutral peptide chain: spectroscopic evidence for the formation of a β-hairpin H-bonding pattern | |
| EA200101001A1 (ru) | Декурсинол или его производное в качестве аналгезирующего средства | |
| IT1307786B1 (it) | Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali. | |
| Nieddu et al. | Simultaneous determination of ten amphetamine designer drugs in human whole blood by capillary electrophoresis with diode array detection | |
| Stephenson et al. | Hydroiodic acid attachment kinetics as a chemical probe of gaseous protein ion structure: Bovine pancreatic trypsin inhibitor | |
| ID22843A (id) | Proses untuk n,n,n,n-tetra-(2-hidroksietil)-etilena diamina | |
| SE0201938D0 (sv) | New process | |
| TR200002293T2 (tr) | Farmasötik bileşimler. | |
| BR0112064A (pt) | Processo para a preparação de derivados da quinolina |