ES2119837T3 - Derivados de fenilimidazolidina, su preparacion y su utilizacion. - Google Patents
Derivados de fenilimidazolidina, su preparacion y su utilizacion.Info
- Publication number
- ES2119837T3 ES2119837T3 ES93110754T ES93110754T ES2119837T3 ES 2119837 T3 ES2119837 T3 ES 2119837T3 ES 93110754 T ES93110754 T ES 93110754T ES 93110754 T ES93110754 T ES 93110754T ES 2119837 T3 ES2119837 T3 ES 2119837T3
- Authority
- ES
- Spain
- Prior art keywords
- phenylimidazolidine
- derivatives
- preparation
- nhr
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/42—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/40—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
DERIVADO DE FENILOIMIDAZOLIDINA DE FORMULA (I) QUE PRESENTAN PROPIEDADES FARMACOLOGICAS TOTALES. SIENDO: R1 -NH-C(=NH)-NH2; R,R2,R3 HIDROGENO; R4 -CO-NHR5; -NH-R5 UN RESTO ALFA-AMINOACIDO; Y CH2-CH2-CO-; W HIDROXI; Z OXIGENO Y R 0 A 3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4224414A DE4224414A1 (de) | 1992-07-24 | 1992-07-24 | Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2119837T3 true ES2119837T3 (es) | 1998-10-16 |
Family
ID=6463969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93110754T Expired - Lifetime ES2119837T3 (es) | 1992-07-24 | 1993-07-06 | Derivados de fenilimidazolidina, su preparacion y su utilizacion. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5424293A (es) |
EP (1) | EP0580008B1 (es) |
JP (1) | JP3775808B2 (es) |
KR (1) | KR100418321B1 (es) |
AT (1) | ATE168116T1 (es) |
AU (1) | AU664630B2 (es) |
CA (1) | CA2101179C (es) |
CZ (1) | CZ289297B6 (es) |
DE (2) | DE4224414A1 (es) |
DK (1) | DK0580008T3 (es) |
ES (1) | ES2119837T3 (es) |
HU (1) | HU220767B1 (es) |
IL (1) | IL106462A (es) |
SK (1) | SK282517B6 (es) |
TW (1) | TW306918B (es) |
ZA (1) | ZA935341B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4308034A1 (de) * | 1993-03-13 | 1994-09-15 | Cassella Ag | Neue Heterocyclen, ihre Herstellung und ihre Verwendung |
DE4427979A1 (de) | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
US5563158A (en) * | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
ZA963391B (en) * | 1995-05-24 | 1997-10-29 | Du Pont Merck Pharma | Isoxazoline fibrinogen receptor antagonists. |
PT796855E (pt) | 1996-03-20 | 2002-07-31 | Hoechst Ag | Inibicao da reabsorcao nos ossos e antagonistas de vitronectina |
DE19622489A1 (de) | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
DE19647381A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
PL323130A1 (en) * | 1996-11-15 | 1998-05-25 | Hoechst Ag | Application of heterocyclic compounds in production of a pharmaceutic agent, novel heterocyclic compounds and pharmaceutic agent as such |
DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19751251A1 (de) | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
US6163155A (en) * | 1999-01-28 | 2000-12-19 | Dresser Industries, Inc. | Electromagnetic wave resistivity tool having a tilted antenna for determining the horizontal and vertical resistivities and relative dip angle in anisotropic earth formations |
DE19922462A1 (de) | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
EP1183274A1 (en) | 1999-06-17 | 2002-03-06 | Source Precision Medicine, Inc. | Method and compounds for inhibiting activity of serine elastases |
DE10111877A1 (de) | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE10137595A1 (de) * | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
US8222902B2 (en) * | 2006-07-11 | 2012-07-17 | Halliburton Energy Services, Inc. | Modular geosteering tool assembly |
CA2650481C (en) * | 2006-07-12 | 2013-09-03 | Halliburton Energy Services, Inc. | Method and apparatus for building a tilted antenna |
GB2459067B (en) * | 2007-03-16 | 2011-11-30 | Halliburton Energy Serv Inc | Robust inversion systems and methods for azimuthally sensitive resistivity logging tools |
BRPI0822137B1 (pt) | 2008-12-16 | 2018-10-09 | Halliburton Energy Serv Inc | conjunto de fundo de furo, e, método de perfilagem |
AU2010343292B2 (en) | 2010-01-22 | 2014-10-16 | Halliburton Energy Services Inc. | Method and apparatus for resistivity measurements |
EP2836860A4 (en) | 2012-06-25 | 2015-11-11 | Halliburton Energy Services Inc | TIP ANTENNA MEASURING SYSTEMS AND METHOD FOR GENERATING ROBUST MEASUREMENT SIGNALS |
US10526287B2 (en) | 2015-04-23 | 2020-01-07 | Constellation Pharmaceuticals, Inc. | LSD1 inhibitors and uses thereof |
LT3532459T (lt) | 2016-10-26 | 2023-11-10 | Constellation Pharmaceuticals, Inc. | Lsd1 inhibitoriai ir jų medicininis panaudojimas |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4126277A1 (de) * | 1991-08-08 | 1993-02-11 | Cassella Ag | Hydantoinderivate |
DE4213634A1 (de) * | 1992-04-24 | 1993-10-28 | Cassella Ag | 2,4-Dioxo-imidazolidin-Derivate |
-
1992
- 1992-07-24 DE DE4224414A patent/DE4224414A1/de not_active Withdrawn
-
1993
- 1993-07-01 JP JP16304293A patent/JP3775808B2/ja not_active Expired - Fee Related
- 1993-07-06 DK DK93110754T patent/DK0580008T3/da active
- 1993-07-06 EP EP93110754A patent/EP0580008B1/de not_active Expired - Lifetime
- 1993-07-06 AT AT93110754T patent/ATE168116T1/de not_active IP Right Cessation
- 1993-07-06 DE DE59308732T patent/DE59308732D1/de not_active Expired - Lifetime
- 1993-07-06 ES ES93110754T patent/ES2119837T3/es not_active Expired - Lifetime
- 1993-07-21 CZ CZ19931475A patent/CZ289297B6/cs not_active IP Right Cessation
- 1993-07-21 SK SK769-93A patent/SK282517B6/sk unknown
- 1993-07-22 US US08/095,905 patent/US5424293A/en not_active Expired - Lifetime
- 1993-07-23 HU HU9302138A patent/HU220767B1/hu not_active IP Right Cessation
- 1993-07-23 CA CA002101179A patent/CA2101179C/en not_active Expired - Fee Related
- 1993-07-23 IL IL10646293A patent/IL106462A/xx not_active IP Right Cessation
- 1993-07-23 AU AU42119/93A patent/AU664630B2/en not_active Ceased
- 1993-07-23 ZA ZA935341A patent/ZA935341B/xx unknown
- 1993-07-23 KR KR1019930013987A patent/KR100418321B1/ko not_active IP Right Cessation
- 1993-07-24 TW TW082105953A patent/TW306918B/zh active
Also Published As
Publication number | Publication date |
---|---|
JPH0725855A (ja) | 1995-01-27 |
IL106462A (en) | 1997-02-18 |
HU220767B1 (hu) | 2002-05-28 |
SK282517B6 (sk) | 2002-10-08 |
KR100418321B1 (ko) | 2004-05-07 |
CA2101179A1 (en) | 1994-01-25 |
JP3775808B2 (ja) | 2006-05-17 |
SK76993A3 (en) | 1994-04-06 |
ZA935341B (en) | 1994-02-14 |
EP0580008A3 (de) | 1995-03-15 |
AU664630B2 (en) | 1995-11-23 |
CZ147593A3 (en) | 1994-03-16 |
HUT65141A (en) | 1994-04-28 |
DE59308732D1 (de) | 1998-08-13 |
AU4211993A (en) | 1994-01-27 |
HU9302138D0 (en) | 1993-10-28 |
TW306918B (es) | 1997-06-01 |
US5424293A (en) | 1995-06-13 |
DE4224414A1 (de) | 1994-01-27 |
CA2101179C (en) | 2003-10-28 |
EP0580008B1 (de) | 1998-07-08 |
DK0580008T3 (da) | 1999-02-08 |
EP0580008A2 (de) | 1994-01-26 |
CZ289297B6 (cs) | 2001-12-12 |
IL106462A0 (en) | 1993-11-15 |
KR940005583A (ko) | 1994-03-21 |
ATE168116T1 (de) | 1998-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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