CO4230241A1 - COMPUESTOS BICICLICOS UTILES COMO ANTAGONISTAS DE GLICOPROTEINA IIb/IIIa - Google Patents
COMPUESTOS BICICLICOS UTILES COMO ANTAGONISTAS DE GLICOPROTEINA IIb/IIIaInfo
- Publication number
- CO4230241A1 CO4230241A1 CO94031604A CO94031604A CO4230241A1 CO 4230241 A1 CO4230241 A1 CO 4230241A1 CO 94031604 A CO94031604 A CO 94031604A CO 94031604 A CO94031604 A CO 94031604A CO 4230241 A1 CO4230241 A1 CO 4230241A1
- Authority
- CO
- Colombia
- Prior art keywords
- compounds useful
- glycoprotein iib
- iiia antagonists
- bicycle compounds
- bicycle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
- C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrane Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
REIVINDICACION NUMERO COMPUESTO BICICLICO QUE TIENE UN NUCLEO FORMADO DE DOS ANILLOS DE SEIS MIEMBROS FUNDIDOS, A Y B, RE- PRESENTADOS POR LA FORMULA (I), O UNA DE SUS SALES SOLVATOS O DERIVADOS PROFARMACOS ACEPTABLES FARMA- CEUTICAMENTE: FIGURA 1 DONDE : B1, B2, B3, B4 SE SELECCIONAN INDEPENDIENTEMENTE DE CARBONO, OXIGENO, AZUFRE Y NITROGENO, CON LA SALVEDAD DE QUE AL MENOS DOS DE B1, B2, B3, B4 SEAN CARBONO; R3 ES UN GRUPO ACIDO; n ES UN NUMERO DE 2 A 6; Ro ES IGUAL O DIFERENTE Y SE SELECCIONA INDEPEN- DIENTEMENTE DE HIDROGENO, ALQUILO, ALQUILO SUBSTI- TUIDO CON HALOGENO, ALQUENILO, ALQUINILO, CICLOAL- QUILO, ARILO, ARILALQUILO, HIDROXI, ALCOXI, ARAL- COXI, AMINO, AMINO SUSBTITUIDO, CARBAMILO, CARBOXI ACILO, CIANO, HALO, NITRO, SULFO, =O, Y =S; CON LA SALVEDAD DE QUE SI Ro FUERA =O o =S, ENTONCES SOLO UNO DE B1,B2,B3 Y B4, PUEDE SER NITROGENO; A, A2, A3, Y A4 SE PUEDEN SELECCIONAR INDEPENDIEN- TEMENTE DE CARBONO, OXIGENO, AZUFRE Y NITROGENO, CON LA SALVEDAD DE QUE AL MENOS DOS DE A1, A2, A3, Y A4 SEAN CARBONO; m ES UN NUMERO DE 2 A 6; R10 ES IGUAL O DIFERENTE Y SE SELECCIONA INDEPEN- DIENTEMENTE DE HIDROGENO, ALQUILO, ALQUILO SUBSTI- TUIDO CON HALOGENO, ALQUENILO, ALQUINILO, CICLOAL- QUILO, ARILO, ARILALQUILO, HIDROXI, ALCOXI, ARAL- COXI, CARBOXI, ACILO, CIANO, HALO, NITRO, SULFO, =O, Y =S; CON LA SALVEDAD DE QUE SOLO UN R10 PUEDE SER =O o =S; EL GRUPO DE ENLACE -(L)- ES UN ENLACE O UNA CADENA DIVALENTE SUBSTITUIDA O NO SUBSTITUIDADE 1 A 10 ATOMOS DE CARBONO SELECCIONADO DEL GRUPO QUE CONS- TA DE CARBONO, NITROGENO, AZUFRE, Y OXIGENO; Y Q ES UN GRUPO ORGANICO QUE COMPRENDE UN RADICAL BASICO."
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9622093A | 1993-07-22 | 1993-07-22 | |
US08/255,821 US5618843A (en) | 1993-07-22 | 1994-07-08 | Glycoprotein IIb/IIIa antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4230241A1 true CO4230241A1 (es) | 1995-10-19 |
Family
ID=22256420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO94031604A CO4230241A1 (es) | 1993-07-22 | 1994-07-19 | COMPUESTOS BICICLICOS UTILES COMO ANTAGONISTAS DE GLICOPROTEINA IIb/IIIa |
Country Status (29)
Country | Link |
---|---|
US (1) | US5618843A (es) |
EP (1) | EP0635492B1 (es) |
JP (1) | JPH08188564A (es) |
KR (1) | KR100347278B1 (es) |
CN (2) | CN1057292C (es) |
AT (1) | ATE225337T1 (es) |
AU (1) | AU685807B2 (es) |
BR (1) | BR9402916A (es) |
CA (1) | CA2128348A1 (es) |
CO (1) | CO4230241A1 (es) |
CY (1) | CY2309B1 (es) |
CZ (1) | CZ174094A3 (es) |
DE (1) | DE69431462T2 (es) |
DK (1) | DK0635492T3 (es) |
ES (1) | ES2183830T3 (es) |
FI (2) | FI106854B (es) |
HU (1) | HUT70397A (es) |
IL (1) | IL110172A (es) |
MY (1) | MY115315A (es) |
NO (1) | NO302885B1 (es) |
NZ (1) | NZ264060A (es) |
PE (1) | PE10995A1 (es) |
PL (1) | PL181905B1 (es) |
PT (1) | PT635492E (es) |
RU (1) | RU2140907C1 (es) |
TW (1) | TW450953B (es) |
UA (1) | UA46692C2 (es) |
YU (1) | YU49070B (es) |
ZA (1) | ZA945251B (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994029273A1 (en) * | 1993-06-09 | 1994-12-22 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
US6137002A (en) | 1993-07-22 | 2000-10-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
US6448269B1 (en) | 1993-07-22 | 2002-09-10 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
CA2134192A1 (en) * | 1993-11-12 | 1995-05-13 | Michael L. Denney | 5, 6-bicyclic glycoprotein iib/iiia antagonists |
AU691677B2 (en) * | 1994-11-01 | 1998-05-21 | Terumo Kabushiki Kaisha | Tetrahydroisoquinoline derivative and medicinal preparation containing the same |
EP0799189A4 (en) * | 1994-12-13 | 1999-03-17 | Smithkline Beecham Corp | BICYCLIC FIBRINOGENIC ANTAGONISTS |
EP0832069B1 (en) * | 1995-06-07 | 2003-03-05 | Pfizer Inc. | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION |
US5919795A (en) * | 1995-06-07 | 1999-07-06 | Pfizer Inc. | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and their use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion |
TW363051B (en) * | 1995-08-31 | 1999-07-01 | Mitsui Toatsu Chemicals | Substituted amidine derivatives and platelet aggregation inhibitor containing the same |
US6291469B1 (en) | 1995-09-29 | 2001-09-18 | Eli Lilly And Company | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
HUP9902157A3 (en) * | 1996-04-30 | 2000-07-28 | Pfizer | Process and intermediates for preparing 4'trifluoromethylbiphenyl-2-carboxylic acid [2-(2h-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-amide |
AU3261097A (en) * | 1996-06-21 | 1998-01-14 | Glaxo Group Limited | Piperidine acetic acid derivatives and their use in the treatment of thrombotic disorders |
US6200967B1 (en) | 1996-06-25 | 2001-03-13 | Eli Lilly And Company | Anticoagulant agents |
AU3496297A (en) * | 1996-06-25 | 1998-01-14 | Eli Lilly And Company | Anticoagulant agents |
US6686350B1 (en) | 1996-07-25 | 2004-02-03 | Biogen, Inc. | Cell adhesion inhibitors |
CZ298089B6 (cs) * | 1996-07-25 | 2007-06-20 | Biogen Idec Ma Inc. | Inhibitory bunecné adheze, zpusob jejich prípravya farmaceutické prostredky s jejich obsahem |
DE69736812T2 (de) * | 1996-11-27 | 2007-08-09 | Bristol-Myers Squibb Pharma Co. | Neue integrin rezeptor antagonisten |
US6034256A (en) | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
US6077850A (en) | 1997-04-21 | 2000-06-20 | G.D. Searle & Co. | Substituted benzopyran analogs for the treatment of inflammation |
JP2002502421A (ja) * | 1997-06-05 | 2002-01-22 | イーライ・リリー・アンド・カンパニー | 血栓障害の処置方法 |
US6089001A (en) * | 1998-03-17 | 2000-07-18 | Hurst; Richard F. | Inclined tray bottle traying machine |
CA2333927A1 (en) | 1998-04-01 | 1999-10-07 | Dupont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
AR019190A1 (es) * | 1998-07-08 | 2001-12-26 | Sod Conseils Rech Applic | Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos |
CA2347095A1 (en) * | 1998-10-16 | 2000-04-27 | Takeda Chemical Industries, Ltd. | Nitrogen-containing condensed heterocyclic derivatives, their production and agent |
US6204282B1 (en) | 1998-11-30 | 2001-03-20 | Schering Corporation | Benzimidazole compounds that are vitronectin receptor antagonists |
US6344484B1 (en) | 1999-02-12 | 2002-02-05 | 3-Dimensional Pharmaceuticals, Inc. | Tyrosine alkoxyguanidines as integrin inhibitors |
EP1198231A1 (en) | 1999-07-21 | 2002-04-24 | American Home Products Corporation | Bicyclic antagonists selective for the(alpha)v(beta)3 integrin |
AU2108601A (en) * | 1999-12-15 | 2001-06-25 | Axys Pharmaceuticals, Inc. | Salicylamides as serine protease inhibitors |
EP1268432A1 (en) | 2000-03-24 | 2003-01-02 | Millenium Pharmaceuticals, Inc. | ISOQUINOLONE INHIBITORS OF FACTOR Xa |
AU2001249398A1 (en) * | 2000-03-24 | 2001-10-08 | Cor Therapeutics, Inc. | Bicyclic sulfonyl amino inhibitors of factor xa |
US6486174B2 (en) | 2000-08-07 | 2002-11-26 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
AU2001288485A1 (en) * | 2000-08-29 | 2002-03-13 | Balekudru Devadas | Compounds containing a bicyclic ring system useful as alpha v beta 3 antagonists |
US6613930B2 (en) | 2000-12-13 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Methods for producing 3-cyano-and 4-cyano- benzoic acid derivative compounds |
JP2004517955A (ja) * | 2001-02-02 | 2004-06-17 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | カルボン酸アミド、その調製及びそれらの医薬組成物としての使用 |
PT1383756E (pt) * | 2001-04-24 | 2008-06-19 | Aryx Therapeutics | Derivados de cumarina a utilizar como anticoagulantes |
KR100681585B1 (ko) * | 2002-04-26 | 2007-02-09 | 에프. 호프만-라 로슈 아게 | 아이소퀴놀린 유도체 |
DE602004010791T2 (de) | 2003-03-03 | 2008-12-04 | F. Hoffmann-La Roche Ag | 2,5-substituiertetetrahydroisochinoline zur verwendung als 5-ht6 modulatoren |
CA2524027C (en) * | 2003-05-19 | 2013-03-19 | Irm Llc | Immunosuppressant compounds and compositions |
MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
BRPI0413923A (pt) * | 2003-08-29 | 2006-11-07 | Ono Pharmaceutical Co | composto capaz de ligar o receptor de s1p e uso farmacêutico do mesmo |
CN1874991A (zh) | 2003-08-29 | 2006-12-06 | 小野药品工业株式会社 | 能够结合s1p受体的化合物及其药物用途 |
CA2543287A1 (en) | 2003-10-23 | 2005-05-06 | F.Hoffmann-La Roche Ag | Benzazepine derivatives as mao-b inhibitors |
ATE541830T1 (de) * | 2004-12-13 | 2012-02-15 | Ono Pharmaceutical Co | Aminocarbonsäurederivat und dessen medizinische verwendung |
AU2006218661A1 (en) | 2005-03-01 | 2006-09-08 | Wyeth | Cinnoline compounds and their use as liver X receptor modilators |
WO2007003010A1 (en) | 2005-07-05 | 2007-01-11 | Baker Medical Research Institute | Anticoagulation agent and uses thereof |
CA2662242C (en) | 2006-09-07 | 2012-06-12 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
TWI425945B (zh) * | 2007-05-28 | 2014-02-11 | Seldar Pharma Inc | 四氫異喹啉-1-酮衍生物或其鹽 |
US20100280594A1 (en) * | 2009-05-01 | 2010-11-04 | Medi-Solve, Llc | Antithrombotic Neurovascular Device Containing a Glycoprotein IIB/IIIA Receptor Inhibitor for The Treatment of Brain Aneurysms and/or Acute Ischemic Stroke, and Methods Related Thereto |
CN104276934B (zh) * | 2014-09-26 | 2016-03-02 | 浙江大学宁波理工学院 | 4,8-二羟基-1-四氢萘酮的化学合成方法 |
CN104276935B (zh) * | 2014-09-26 | 2016-05-04 | 浙江大学宁波理工学院 | 4-(3-羟基丙氧基)-8-羟基-1-四氢萘酮及合成方法 |
CN104355979B (zh) * | 2014-09-26 | 2016-05-04 | 浙江大学宁波理工学院 | 4-羟基-8-(2,3-二羟基丙氧基)-1-四氢萘酮及合成方法 |
CN114315651A (zh) * | 2021-12-29 | 2022-04-12 | 安徽昊帆生物有限公司 | 对胍基苯甲酸盐酸盐的制备方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2164643B (en) * | 1984-07-27 | 1988-11-02 | Boehringer Biochemia Srl | Tricyclic dihydropyridazinones and pharmaceutical compositions containing them |
US4920130A (en) * | 1987-11-02 | 1990-04-24 | Rorer Pharamceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4920133A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US5039805A (en) * | 1988-12-08 | 1991-08-13 | Hoffmann-La Roche Inc. | Novel benzoic and phenylacetic acid derivatives |
US5206428A (en) * | 1989-11-16 | 1993-04-27 | Tanabe Seiyaku Co., Ltd. | Tetrahydronaphthalene derivatives and preparation thereof |
JPH0747582B2 (ja) * | 1989-12-11 | 1995-05-24 | 杏林製薬株式会社 | キナゾリン―3―アルカン酸誘導体とその塩およびその製造法 |
ATE119523T1 (de) * | 1989-12-28 | 1995-03-15 | Snow Brand Milk Products Co Ltd | Isochinolinderivate und ihre salze als proteasehemmer. |
US5064814A (en) * | 1990-04-05 | 1991-11-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptide and pseudopeptide derivatives |
US5041453A (en) * | 1990-05-30 | 1991-08-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 |
IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
US5220050A (en) * | 1991-05-17 | 1993-06-15 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
ES2190428T3 (es) * | 1991-06-28 | 2003-08-01 | Smithkline Beecham Corp | Antagonistas biciclicos de fibrinogeno. |
US5250679A (en) * | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
US5389631A (en) * | 1991-10-29 | 1995-02-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
WO1994029273A1 (en) * | 1993-06-09 | 1994-12-22 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
-
1994
- 1994-06-30 IL IL11017294A patent/IL110172A/en not_active IP Right Cessation
- 1994-07-08 US US08/255,821 patent/US5618843A/en not_active Expired - Lifetime
- 1994-07-13 TW TW083106357A patent/TW450953B/zh not_active IP Right Cessation
- 1994-07-15 AU AU67500/94A patent/AU685807B2/en not_active Ceased
- 1994-07-18 PT PT94305241T patent/PT635492E/pt unknown
- 1994-07-18 EP EP94305241A patent/EP0635492B1/en not_active Expired - Lifetime
- 1994-07-18 DK DK94305241T patent/DK0635492T3/da active
- 1994-07-18 DE DE69431462T patent/DE69431462T2/de not_active Expired - Fee Related
- 1994-07-18 ES ES94305241T patent/ES2183830T3/es not_active Expired - Lifetime
- 1994-07-18 ZA ZA945251A patent/ZA945251B/xx unknown
- 1994-07-18 AT AT94305241T patent/ATE225337T1/de not_active IP Right Cessation
- 1994-07-19 UA UA94075642A patent/UA46692C2/uk unknown
- 1994-07-19 CZ CZ941740A patent/CZ174094A3/cs unknown
- 1994-07-19 CA CA002128348A patent/CA2128348A1/en not_active Abandoned
- 1994-07-19 MY MYPI94001880A patent/MY115315A/en unknown
- 1994-07-19 PE PE1994246980A patent/PE10995A1/es not_active Application Discontinuation
- 1994-07-19 CO CO94031604A patent/CO4230241A1/es unknown
- 1994-07-21 PL PL94304388A patent/PL181905B1/pl unknown
- 1994-07-21 NO NO942734A patent/NO302885B1/no unknown
- 1994-07-21 NZ NZ264060A patent/NZ264060A/xx unknown
- 1994-07-21 RU RU94026092/04A patent/RU2140907C1/ru not_active IP Right Cessation
- 1994-07-21 KR KR1019940017557A patent/KR100347278B1/ko not_active IP Right Cessation
- 1994-07-21 HU HU9402156A patent/HUT70397A/hu unknown
- 1994-07-21 YU YU46694A patent/YU49070B/sh unknown
- 1994-07-22 JP JP6170747A patent/JPH08188564A/ja not_active Withdrawn
- 1994-07-22 BR BR9402916A patent/BR9402916A/pt not_active Application Discontinuation
- 1994-07-22 FI FI943478A patent/FI106854B/fi active
- 1994-07-22 CN CN94109191A patent/CN1057292C/zh not_active Expired - Fee Related
-
1999
- 1999-07-31 CN CN99111888A patent/CN1274723A/zh active Pending
-
2000
- 2000-03-20 FI FI20000648A patent/FI106858B/fi active
-
2003
- 2003-01-09 CY CY0300001A patent/CY2309B1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO4230241A1 (es) | COMPUESTOS BICICLICOS UTILES COMO ANTAGONISTAS DE GLICOPROTEINA IIb/IIIa | |
ATE220903T1 (de) | Glycoprotein iib/iiia-antagonisten | |
BR9405207A (pt) | Processo para a preparação de poliolefinas | |
DK0478328T3 (da) | Hidtil ukendte fibrinogenreceptorantagonister | |
HUT68094A (en) | Cyclic compounds for inhibiting trombocita glycoproteid iib/iiia complex, pharmaceutical compositions containing them, and process for producing them | |
FI954556A (fi) | Syklisiä yhdisteitä, jotka ovat käyttökelpoisia verihiutaleen glykoproteiinin IIb/IIIa inhibiittoreina | |
BR9815399A (pt) | Processo para formação de um composto, processo para preparação do composto e composto | |
ZA927515B (en) | Cyclic compounds useful as inhibitors of platelet glycoprotein IIb/IIIa | |
ITCE910001U1 (it) | Giubbini "alan martin segnaletici" con indicatori di direzione o di pr esenza adatti per conduttori di biciclette, di motocicli o per lavorat | |
TH41951A (th) | สารต่อต้านฤทธิ์ไกลโคโปรตีน IIb/IIIa |