CO2019011584A2 - Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos - Google Patents

Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos

Info

Publication number
CO2019011584A2
CO2019011584A2 CONC2019/0011584A CO2019011584A CO2019011584A2 CO 2019011584 A2 CO2019011584 A2 CO 2019011584A2 CO 2019011584 A CO2019011584 A CO 2019011584A CO 2019011584 A2 CO2019011584 A2 CO 2019011584A2
Authority
CO
Colombia
Prior art keywords
ahr
inhibitors
aryl hydrocarbon
hydrocarbon receptor
indole aryl
Prior art date
Application number
CONC2019/0011584A
Other languages
English (en)
Inventor
Alfredo C Castro
Catherine Anne Evans
Original Assignee
Kyn Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyn Therapeutics filed Critical Kyn Therapeutics
Publication of CO2019011584A2 publication Critical patent/CO2019011584A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La presente invención proporciona compuestos útiles como inhibidores de AHR, composiciones de los mismos y métodos para usar los mismos.
CONC2019/0011584A 2017-04-21 2019-10-18 Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos CO2019011584A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762488476P 2017-04-21 2017-04-21
US201762592542P 2017-11-30 2017-11-30
US201862658454P 2018-04-16 2018-04-16
PCT/US2018/028532 WO2018195397A2 (en) 2017-04-21 2018-04-20 Indole ahr inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
CO2019011584A2 true CO2019011584A2 (es) 2020-02-18

Family

ID=63856153

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0011584A CO2019011584A2 (es) 2017-04-21 2019-10-18 Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos

Country Status (15)

Country Link
US (4) US10570138B2 (es)
EP (1) EP3612030A4 (es)
JP (2) JP7232244B2 (es)
KR (1) KR20190141722A (es)
CN (1) CN110831600B (es)
AU (1) AU2018256459B2 (es)
BR (1) BR112019021992A2 (es)
CA (1) CA3059939A1 (es)
CL (1) CL2019003015A1 (es)
CO (1) CO2019011584A2 (es)
IL (1) IL270025B2 (es)
MX (1) MX2019012431A (es)
SG (1) SG11201909710XA (es)
TW (1) TWI778050B (es)
WO (1) WO2018195397A2 (es)

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AU2018256459A1 (en) 2019-11-07
CN110831600A (zh) 2020-02-21
US20230028336A1 (en) 2023-01-26
IL270025B2 (en) 2023-05-01
BR112019021992A2 (pt) 2020-06-09
EP3612030A2 (en) 2020-02-26
US11358969B2 (en) 2022-06-14
JP2020517734A (ja) 2020-06-18
KR20190141722A (ko) 2019-12-24
US10689388B1 (en) 2020-06-23
JP2022116319A (ja) 2022-08-09
TW201841917A (zh) 2018-12-01
US20200331917A1 (en) 2020-10-22
WO2018195397A2 (en) 2018-10-25
CL2019003015A1 (es) 2020-03-27
SG11201909710XA (en) 2019-11-28
IL270025B1 (en) 2023-01-01
IL270025A (es) 2019-12-31
JP7232244B2 (ja) 2023-03-08
TWI778050B (zh) 2022-09-21
CN110831600B (zh) 2023-10-17
MX2019012431A (es) 2020-08-03
WO2018195397A3 (en) 2018-12-13
CA3059939A1 (en) 2018-10-25
AU2018256459B2 (en) 2023-12-07
US20180327411A1 (en) 2018-11-15
EP3612030A4 (en) 2021-04-28
US10570138B2 (en) 2020-02-25

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