CO2018003863A2 - Anticuerpos anti-vegf - Google Patents

Anticuerpos anti-vegf

Info

Publication number
CO2018003863A2
CO2018003863A2 CONC2018/0003863A CO2018003863A CO2018003863A2 CO 2018003863 A2 CO2018003863 A2 CO 2018003863A2 CO 2018003863 A CO2018003863 A CO 2018003863A CO 2018003863 A2 CO2018003863 A2 CO 2018003863A2
Authority
CO
Colombia
Prior art keywords
vegf antibodies
present
pharmacokinetics
angiogenesis
pathological
Prior art date
Application number
CONC2018/0003863A
Other languages
English (en)
Inventor
Patrick Koenig
Chingwei Vivian Lee
Karthikan Rajagopal
Amin Famili
Germaine Fuh
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CO2018003863A2 publication Critical patent/CO2018003863A2/es

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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • C07K14/475—Growth factors; Growth regulators
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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Abstract

La presente invención proporciona anticuerpos anti-VEGF y composiciones que incluyen anticuerpos anti-VEGF (por ejemplo, conjugados de anticuerpos, proteínas de fusión, y formulaciones poliméricas), y usos de los mismos, por ejemplo para el tratamiento de trastornos asociados con la angiogénesis patológica. La presente invención también proporciona métodos para la identificación de variantes de anticuerpos con propiedades mejoradas, por ejemplo, afinidad de unión incrementada, estabilidad, farmacocinética, y/o expresión.
CONC2018/0003863A 2015-09-23 2018-04-11 Anticuerpos anti-vegf CO2018003863A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562222698P 2015-09-23 2015-09-23
US201562271913P 2015-12-28 2015-12-28
PCT/US2016/053454 WO2017053807A2 (en) 2015-09-23 2016-09-23 Optimized variants of anti-vegf antibodies

Publications (1)

Publication Number Publication Date
CO2018003863A2 true CO2018003863A2 (es) 2018-10-10

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Application Number Title Priority Date Filing Date
CONC2018/0003863A CO2018003863A2 (es) 2015-09-23 2018-04-11 Anticuerpos anti-vegf

Country Status (24)

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US (4) US10072075B2 (es)
EP (1) EP3353203A2 (es)
JP (2) JP6959912B2 (es)
KR (1) KR20180053315A (es)
CN (2) CN108137681A (es)
AU (1) AU2016326666B2 (es)
BR (1) BR112018005737A2 (es)
CA (1) CA2992602A1 (es)
CL (2) CL2018000732A1 (es)
CO (1) CO2018003863A2 (es)
CR (1) CR20180221A (es)
HK (1) HK1254198A1 (es)
IL (1) IL257565B1 (es)
MA (1) MA42924A (es)
MX (1) MX2018003537A (es)
MY (1) MY191756A (es)
PE (1) PE20181363A1 (es)
PH (1) PH12018500657A1 (es)
RU (1) RU2763916C2 (es)
SG (1) SG10201911226QA (es)
TW (1) TWI748962B (es)
UA (1) UA125432C2 (es)
WO (1) WO2017053807A2 (es)
ZA (1) ZA201800770B (es)

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US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
BR112018005737A2 (pt) 2015-09-23 2018-10-09 Genentech Inc anticorpos, polinucleotídeo, vetor, célula hospedeira, método para produzir o anticorpo, para reduzir ou inibir a angiogênese, para tratar um distúrbio associado à angiogênese, para inibir a permeabilidade vascular, composição, conjugado de anticorpo, proteína de fusão, para identificar uma alteração de resíduos, utilização do anticorpo, utilização do conjugado e utilização da proteína
US10975131B2 (en) * 2015-10-27 2021-04-13 University Of Massachusetts Factor H-Fc immunotheraphy
CN113546178A (zh) 2015-12-09 2021-10-26 加利福尼亚大学董事会 治疗眼部疾病或病症的方法
CA3010056A1 (en) 2015-12-30 2017-07-06 Kodiak Sciences Inc. Antibodies and conjugates thereof
AU2017299581B2 (en) 2016-07-20 2024-05-23 EyePoint Pharmaceuticals, Inc. Humanized monoclonal antibodies that target ve-ptp (hptp-β)
CR20190481A (es) * 2017-03-22 2020-01-06 Genentech Inc Composiciones de anticuerpo optimizados para el tratamiento de trastornos oculares
CA3055985A1 (en) 2017-03-22 2018-09-27 Genentech, Inc. Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
MX2019012985A (es) * 2017-05-06 2020-01-13 Regeneron Pharma Métodos para tratar trastornos oculares con antagonistas de aplnr e inhibidores de vegf.
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PH12018500657A1 (en) 2018-10-15
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