CN1931159A - 艾拉莫德微粉化及口服速释制剂 - Google Patents
艾拉莫德微粉化及口服速释制剂 Download PDFInfo
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- CN1931159A CN1931159A CN 200510015103 CN200510015103A CN1931159A CN 1931159 A CN1931159 A CN 1931159A CN 200510015103 CN200510015103 CN 200510015103 CN 200510015103 A CN200510015103 A CN 200510015103A CN 1931159 A CN1931159 A CN 1931159A
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- ailamode
- powder
- iguratimod
- crystalline powder
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Abstract
Description
2θ(°) | 面间距d(A) | 相对丰度(%) | 2θ(°) | 面间距d(A) | 相对丰度(%) |
5.9408.14010.48011.96012.44014.82015.92017.40018.32018.74020.06020.62021.12021.80022.98024.000 | 14.866510.85288.43427.39377.10945.97265.56235.09244.83874.73124.42274.30394.20314.07353.86693.7048 | 481010014161514885737373637406874 | 24.30025.16025.62027.20028.28029.02029.72031.78033.18034.48036.86038.22040.10041.90044.38047.180 | 3.65983.53663.47413.27583.15313.07443.00352.81342.69782.59902.43652.35282.24682.15432.03951.9248 | 63616161132815181112910161099 |
取样时间(分) | 释放量(%) | |||
样品1 | 样品2 | 样品3 | 常规片 | |
25101520304560 | 93.999.099.496.895.3 | 75.096.099.6100.9100.2 | /90.098.7/101.099.0 | /63.478.3/88.196.4100.3102.3 |
药动学参数 | 样品1 | 常规片 | P值 |
Tpeak(h)Cmax(μg/ml)Ke(1/h)T1/2Ke(h)AUC(0~∞)(μg*h/ml)AUC(0~t)(μg*h/ml) | 2.55±0.383.74±0.220.2039±0.07833.58±1.1035.53±4.9033.35±4.44 | 3.61±0.991.85±0.610.1472±0.02814.82±0.8623.24±5.5221.37±4.20 | >0.05<0.01**>0.05>0.05<0.05**<0.05** |
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN200510015103A CN1931159B (zh) | 2005-09-16 | 2005-09-16 | 艾拉莫德微粉化及口服速释制剂 |
Applications Claiming Priority (1)
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CN200510015103A CN1931159B (zh) | 2005-09-16 | 2005-09-16 | 艾拉莫德微粉化及口服速释制剂 |
Publications (2)
Publication Number | Publication Date |
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CN1931159A true CN1931159A (zh) | 2007-03-21 |
CN1931159B CN1931159B (zh) | 2010-05-12 |
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CN200510015103A Expired - Fee Related CN1931159B (zh) | 2005-09-16 | 2005-09-16 | 艾拉莫德微粉化及口服速释制剂 |
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CN (1) | CN1931159B (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102406939A (zh) * | 2010-09-26 | 2012-04-11 | 上海复星普适医药科技有限公司 | 提高难溶性药物溶解性能以提高生物利用度的方法 |
CN102429912A (zh) * | 2011-10-26 | 2012-05-02 | 庞飞 | 一种微粉化普拉睾酮或硫酸普拉睾酮钠制备的药物组合物及其用途 |
CN103565739A (zh) * | 2012-07-25 | 2014-02-12 | 天津金耀集团有限公司 | 瑞美松龙滴眼液 |
CN106008436A (zh) * | 2016-06-25 | 2016-10-12 | 江苏正大清江制药有限公司 | 一种艾拉莫德α晶型的制备方法 |
CN109512786A (zh) * | 2018-11-12 | 2019-03-26 | 北京化工大学 | 一种艾拉莫德纳米药物颗粒的制备方法 |
JP2021109849A (ja) * | 2020-01-10 | 2021-08-02 | 株式会社トクヤマ | 新規結晶構造を有するイグラチモド及びその製造方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100387231C (zh) * | 2003-03-24 | 2008-05-14 | 天津药物研究院 | 一种制备古拉替莫固体制剂的工艺及其固体制剂 |
SI1731138T1 (sl) * | 2004-03-31 | 2016-06-30 | Toyama Chemical Co., Ltd. | Fina disperzija slabo topljivega zdravila in postopek za njeno izdelavo |
-
2005
- 2005-09-16 CN CN200510015103A patent/CN1931159B/zh not_active Expired - Fee Related
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102406939A (zh) * | 2010-09-26 | 2012-04-11 | 上海复星普适医药科技有限公司 | 提高难溶性药物溶解性能以提高生物利用度的方法 |
CN102406939B (zh) * | 2010-09-26 | 2013-05-08 | 上海星泰医药科技有限公司 | 提高难溶性药物溶解性能以提高生物利用度的方法 |
CN102429912A (zh) * | 2011-10-26 | 2012-05-02 | 庞飞 | 一种微粉化普拉睾酮或硫酸普拉睾酮钠制备的药物组合物及其用途 |
CN103565739A (zh) * | 2012-07-25 | 2014-02-12 | 天津金耀集团有限公司 | 瑞美松龙滴眼液 |
CN106008436A (zh) * | 2016-06-25 | 2016-10-12 | 江苏正大清江制药有限公司 | 一种艾拉莫德α晶型的制备方法 |
CN109512786A (zh) * | 2018-11-12 | 2019-03-26 | 北京化工大学 | 一种艾拉莫德纳米药物颗粒的制备方法 |
JP2021109849A (ja) * | 2020-01-10 | 2021-08-02 | 株式会社トクヤマ | 新規結晶構造を有するイグラチモド及びその製造方法 |
JP7426832B2 (ja) | 2020-01-10 | 2024-02-02 | 株式会社トクヤマ | 新規結晶構造を有するイグラチモド及びその製造方法 |
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CN1931159B (zh) | 2010-05-12 |
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Effective date of registration: 20130130 Address after: 300193 Tianjin City, Nankai District Anshan West Road No. 308 Patentee after: Tianjin Taipu Pharmaceutical Intellectual Property Flow Reserve Center Co, Ltd. Address before: 300193 Tianjin City, Nankai District Anshan West Road No. 308 Patentee before: Tianjin Institute of Pharmaceutical Research |
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Owner name: TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH Free format text: FORMER OWNER: TIANJIN TAIPU PHARMACEUTICAL INTELLECTUAL PROPERTY TRANSFER RESERVE CENTER CO., LTD. Effective date: 20140505 |
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