CN1930277B - 在转基因植物中产生多不饱和脂肪酸的方法 - Google Patents
在转基因植物中产生多不饱和脂肪酸的方法 Download PDFInfo
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- CN1930277B CN1930277B CN2005800074288A CN200580007428A CN1930277B CN 1930277 B CN1930277 B CN 1930277B CN 2005800074288 A CN2005800074288 A CN 2005800074288A CN 200580007428 A CN200580007428 A CN 200580007428A CN 1930277 B CN1930277 B CN 1930277B
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- nucleic acid
- desaturase
- fatty acid
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- C—CHEMISTRY; METALLURGY
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/86—Products or compounds obtained by genetic engineering
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
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- Chemical & Material Sciences (AREA)
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- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Birds (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004009457.8 | 2004-02-27 | ||
| DE102004009457 | 2004-02-27 | ||
| DE102004012370 | 2004-03-13 | ||
| DE102004012370.5 | 2004-03-13 | ||
| DE102004017518.7 | 2004-04-08 | ||
| DE102004017518A DE102004017518A1 (de) | 2004-04-08 | 2004-04-08 | Verfahren zur Herstellung von mehrfach ungesättigten Fettsäuren |
| DE102004024014 | 2004-05-14 | ||
| DE102004024014.0 | 2004-05-14 | ||
| PCT/EP2004/007957 WO2005012316A2 (de) | 2003-08-01 | 2004-07-16 | Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen |
| EPPCT/EP04/07957 | 2004-07-16 | ||
| DE200410062543 DE102004062543A1 (de) | 2004-12-24 | 2004-12-24 | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Pflanzen |
| DE102004062543.3 | 2004-12-24 | ||
| PCT/EP2005/001863 WO2005083093A2 (de) | 2004-02-27 | 2005-02-23 | Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen pflanzen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1930277A CN1930277A (zh) | 2007-03-14 |
| CN1930277B true CN1930277B (zh) | 2011-02-02 |
Family
ID=38640115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005800074288A Expired - Fee Related CN1930277B (zh) | 2004-02-27 | 2005-02-23 | 在转基因植物中产生多不饱和脂肪酸的方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9458436B2 (https=) |
| EP (2) | EP2623584B1 (https=) |
| JP (1) | JP4567047B2 (https=) |
| CN (1) | CN1930277B (https=) |
| ES (1) | ES2421440T3 (https=) |
| IL (1) | IL177231A (https=) |
| MX (1) | MXPA06009572A (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8084074B2 (en) * | 2003-02-12 | 2011-12-27 | E. I. Du Pont De Nemours And Company | Production of very long chain polyunsaturated fatty acids in oil seed plants |
| DK1654344T3 (en) * | 2003-08-01 | 2019-02-04 | Basf Plant Science Gmbh | PROCEDURE FOR MANUFACTURING MULTI-Saturated FAT ACIDS IN TRANSGENES |
| US11952581B2 (en) * | 2003-08-01 | 2024-04-09 | Basf Plant Science Gmbh | Process for the production of polyunsaturated fatty acids in transgenic organisms |
| EP2623584B1 (de) | 2004-02-27 | 2019-04-10 | BASF Plant Science GmbH | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Pflanzen |
| CA2558726C (en) | 2004-02-27 | 2017-11-07 | Basf Plant Science Gmbh | Method for producing unsaturated .omega.-3-fatty acids in transgenic organisms |
| CN103451246B (zh) | 2004-04-22 | 2018-02-16 | 联邦科学技术研究组织 | 用重组细胞合成长链多不饱和脂肪酸 |
| EP2357244A3 (en) | 2004-04-22 | 2011-11-23 | Commonwealth Scientific and Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells. |
| AR059376A1 (es) * | 2006-02-21 | 2008-03-26 | Basf Plant Science Gmbh | Procedimiento para la produccion de acidos grasos poliinsaturados |
| RU2009111266A (ru) | 2006-08-29 | 2010-10-10 | Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) | Синтез жирных кислот |
| UA102063C2 (uk) * | 2007-02-12 | 2013-06-10 | Е. І. Дю Пон Де Немур Енд Компані | Трансгенна соєва рослина, що продукує арахідонову кислоту |
| DK2129777T3 (en) * | 2007-04-03 | 2016-01-25 | Du Pont | MULTIZYMER AND USE THEREOF FOR THE PRODUCTION OF polyunsaturated fatty acids |
| WO2009010825A2 (en) * | 2007-07-13 | 2009-01-22 | Ocean Nutrition Canada Ltd. | D4 desaturases and d5 elongases |
| WO2009130291A2 (de) * | 2008-04-25 | 2009-10-29 | Basf Plant Science Gmbh | Pflanzensamenöl |
| CA2734810C (en) * | 2008-08-26 | 2018-06-19 | Basf Plant Science Gmbh | Nucleic acids encoding desaturases and modified plant oil |
| BRPI0921467B1 (pt) | 2008-11-18 | 2021-12-14 | Commonwealth Scientific And Industrial Research Organisation | Processo para a produção de óleo compreendendo ácido eicosapentaenóico (epa), ácido docosapentaenóico (dpa) e ácido docosahexaenóico (dha) |
| US9493520B2 (en) | 2009-07-17 | 2016-11-15 | Basf Plant Science Company Gmbh | Fatty acid desaturases and elongases and uses thereof |
| WO2011037207A1 (ja) * | 2009-09-24 | 2011-03-31 | 国立大学法人九州大学 | ストラメノパイルの形質転換方法 |
| CA2779551C (en) * | 2009-11-03 | 2018-05-01 | Dsm Ip Assets B.V. | Composition comprising cells and a polyunsaturated fatty acid having at least 20 carbon atoms (lc-pufa) |
| WO2011054801A1 (en) | 2009-11-03 | 2011-05-12 | Dsm Ip Assets B.V. | Vegatable oil comprising a polyunsaturaded fatty acid having at least 20 carbon atoms |
| CN104982920A (zh) * | 2009-11-03 | 2015-10-21 | 帝斯曼知识产权资产管理有限公司 | 包含细胞和具有至少20个碳原子的多不饱和脂肪酸(lc-pufa)的组合物 |
| US20110159061A1 (en) * | 2009-12-30 | 2011-06-30 | Raphael Warren | Wipe article comprising lotion composition comprising omega-6 fatty acid and method of improving skin barrier function |
| US11236351B2 (en) | 2010-05-17 | 2022-02-01 | Dow Agrosciences Llc | Production of DHA and other LC PUFAs in plants |
| US9062315B2 (en) * | 2010-10-01 | 2015-06-23 | Kyushu University, National University Corporation | Method for transformation of stramenopile |
| TW201307553A (zh) | 2011-07-26 | 2013-02-16 | Dow Agrosciences Llc | 在植物中生產二十二碳六烯酸(dha)及其他長鏈多元不飽和脂肪酸(lc-pufa)之技術 |
| AU2012362825B2 (en) * | 2011-12-30 | 2016-07-21 | Corteva Agriscience Llc | DHA retention during canola processing |
| BR112014025265A2 (pt) * | 2012-04-12 | 2017-07-11 | Rothamsted Res Ltd | produção de ácidos graxos poli-insaturados ômega-3 de cadeia longa |
| WO2013185184A2 (en) | 2012-06-15 | 2013-12-19 | Commonwealth Scientific And Industrial Research Organisation | Production of long chain polyunsaturated fatty acids in plant cells |
| CN102786587B (zh) * | 2012-06-18 | 2014-01-01 | 中国农业大学 | 一种提高植物种子脂肪酸含量的转录因子及其应用 |
| EP3082405A4 (en) | 2013-12-18 | 2017-12-13 | Commonwealth Scientific and Industrial Research Organisation | Lipid comprising long chain polyunsaturated fatty acids |
| SG11201610596PA (en) | 2014-06-27 | 2017-01-27 | Commw Scient Ind Res Org | Lipid comprising docosapentaenoic acid |
| WO2016075313A1 (en) | 2014-11-14 | 2016-05-19 | Basf Plant Science Company Gmbh | Materials and methods for increasing the tocopherol content in seed oil |
| CN105177027A (zh) * | 2015-09-22 | 2015-12-23 | 浙江大学 | 一种桃脂肪酸去饱和酶基因PpFAD2及其应用 |
| CN105400805A (zh) * | 2015-12-24 | 2016-03-16 | 浙江大学 | 一个参与桃果实脂肪酸形成的基因及其应用 |
| US10499584B2 (en) | 2016-05-27 | 2019-12-10 | New West Genetics | Industrial hemp Cannabis cultivars and seeds with stable cannabinoid profiles |
| KR101883832B1 (ko) | 2016-09-19 | 2018-08-02 | 대한민국 | 파에오닥틸룸 트리코르누툼 유래 델타-7 불포화효소 유전자 및 이의 이용 |
| CN107760610B (zh) * | 2017-09-29 | 2021-01-19 | 中国科学院南京土壤研究所 | 一株长孢被孢霉及其应用 |
| CN109722455B (zh) * | 2017-10-31 | 2022-03-11 | 中国科学院天津工业生物技术研究所 | 微生物发酵生产谷内酯的方法、工程菌及应用 |
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| NZ228320A (en) | 1988-03-29 | 1991-06-25 | Du Pont | Nucleic acid promoter fragments of the promoter region homologous to the em gene of wheat, dna constructs therefrom and plants thereof |
| CA1341467C (en) | 1988-07-29 | 2004-12-07 | John C. Rogers | Producing commercially valuable polypeptides with genetically transformed endosperm tissue |
| DE3843628A1 (de) | 1988-12-21 | 1990-07-05 | Inst Genbiologische Forschung | Wundinduzierbare und kartoffelknollenspezifische transkriptionale regulation |
| EP0463056A1 (en) | 1989-03-17 | 1992-01-02 | E.I. Du Pont De Nemours And Company | External regulation of gene expression |
| EP0472722B1 (en) | 1990-03-16 | 2003-05-21 | Calgene LLC | Dnas encoding plant desaturases and their uses |
| EP0472712B1 (en) | 1990-03-16 | 2001-09-12 | Calgene LLC | Novel sequences preferentially expressed in early seed development and methods related thereto |
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-
2005
- 2005-02-23 EP EP13162907.3A patent/EP2623584B1/de not_active Revoked
- 2005-02-23 ES ES05715462T patent/ES2421440T3/es not_active Expired - Lifetime
- 2005-02-23 EP EP19155597.8A patent/EP3543324B1/de not_active Expired - Lifetime
- 2005-02-23 JP JP2007500134A patent/JP4567047B2/ja not_active Expired - Fee Related
- 2005-02-23 US US10/590,457 patent/US9458436B2/en active Active
- 2005-02-23 CN CN2005800074288A patent/CN1930277B/zh not_active Expired - Fee Related
- 2005-02-23 MX MXPA06009572A patent/MXPA06009572A/es active IP Right Grant
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- 2006-08-02 IL IL177231A patent/IL177231A/en not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| CN1930277A (zh) | 2007-03-14 |
| IL177231A0 (en) | 2006-12-10 |
| JP2007527716A (ja) | 2007-10-04 |
| EP2623584A1 (de) | 2013-08-07 |
| MXPA06009572A (es) | 2007-05-23 |
| US10035989B2 (en) | 2018-07-31 |
| US9458436B2 (en) | 2016-10-04 |
| EP3543324A1 (de) | 2019-09-25 |
| EP2623584B1 (de) | 2019-04-10 |
| ES2421440T3 (es) | 2013-09-02 |
| US20090222951A1 (en) | 2009-09-03 |
| JP4567047B2 (ja) | 2010-10-20 |
| EP3543324B1 (de) | 2022-11-30 |
| US20150361404A1 (en) | 2015-12-17 |
| IL177231A (en) | 2013-05-30 |
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