CN1906187A - 作为代谢型谷氨酸受体－5配体的5－氟－,氯－和氰基－吡啶－2－基－四唑类化合物 - Google Patents

作为代谢型谷氨酸受体－5配体的5－氟－,氯－和氰基－吡啶－2－基－四唑类化合物 Download PDF

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Publication number
CN1906187A
CN1906187A CNA2004800406448A CN200480040644A CN1906187A CN 1906187 A CN1906187 A CN 1906187A CN A2004800406448 A CNA2004800406448 A CN A2004800406448A CN 200480040644 A CN200480040644 A CN 200480040644A CN 1906187 A CN1906187 A CN 1906187A
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China
Prior art keywords
alkyl
compound
tetrazolium
treatment
pyridine
Prior art date
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Pending
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CNA2004800406448A
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English (en)
Chinese (zh)
Inventor
D·温斯博
L·爱德华兹
M·伊萨克
D·A·麦莱奥德
A·斯拉西
忻涛
T·M·斯托尔曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
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AstraZeneca AB
NPS Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34748746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1906187(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB, NPS Pharmaceuticals Inc filed Critical AstraZeneca AB
Publication of CN1906187A publication Critical patent/CN1906187A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2004800406448A 2003-12-19 2004-12-13 作为代谢型谷氨酸受体－5配体的5－氟－,氯－和氰基－吡啶－2－基－四唑类化合物 Pending CN1906187A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53063303P 2003-12-19 2003-12-19
US60/530,633 2003-12-19

Publications (1)

Publication Number Publication Date
CN1906187A true CN1906187A (zh) 2007-01-31

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ID=34748746

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CNA2004800406448A Pending CN1906187A (zh) 2003-12-19 2004-12-13 作为代谢型谷氨酸受体－5配体的5－氟－,氯－和氰基－吡啶－2－基－四唑类化合物

Country Status (20)

Country Link
US (1) US20070255061A1 (cg-RX-API-DMAC7.html)
EP (1) EP1713791B1 (cg-RX-API-DMAC7.html)
JP (1) JP2007514790A (cg-RX-API-DMAC7.html)
KR (1) KR20060126993A (cg-RX-API-DMAC7.html)
CN (1) CN1906187A (cg-RX-API-DMAC7.html)
AR (1) AR046768A1 (cg-RX-API-DMAC7.html)
AT (1) ATE393767T1 (cg-RX-API-DMAC7.html)
AU (1) AU2004312342A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0417308A (cg-RX-API-DMAC7.html)
CA (1) CA2548039A1 (cg-RX-API-DMAC7.html)
DE (1) DE602004013469T9 (cg-RX-API-DMAC7.html)
ES (1) ES2303969T3 (cg-RX-API-DMAC7.html)
IL (1) IL175909A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA06006674A (cg-RX-API-DMAC7.html)
NO (1) NO20062533L (cg-RX-API-DMAC7.html)
RU (1) RU2006118021A (cg-RX-API-DMAC7.html)
TW (1) TW200524602A (cg-RX-API-DMAC7.html)
UY (1) UY28685A1 (cg-RX-API-DMAC7.html)
WO (1) WO2005066155A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200604681B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105377832A (zh) * 2013-07-17 2016-03-02 赫普泰雅治疗有限公司 4-(3-氰基苯基)-6-吡啶基嘧啶mglu5调节剂

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1706392A2 (en) * 2004-01-08 2006-10-04 Syngenta Participations AG Pesticidal heterocyclic dihaloallyl compounds
UY29796A1 (es) 2005-09-29 2007-04-30 Astrazeneca Ab Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US20120095056A1 (en) * 2009-03-19 2012-04-19 Neurosearch A/S 2,5-disubstituted tetrazole derivatives and their use as nicotinic acetylcholine receptor modulators
WO2011073297A1 (en) * 2009-12-18 2011-06-23 Neurosearch A/S Tetrazole derivatives as nicotinic acetylcholine receptor moudlators
WO2011073298A1 (en) * 2009-12-18 2011-06-23 Neurosearch A/S Tetrazole derivatives as nicotinic acetylcholine receptor modulators
CN102762572A (zh) 2010-02-01 2012-10-31 诺瓦提斯公司 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists
WO2016001452A1 (en) 2014-07-04 2016-01-07 Universität Zürich Compounds, in particular for use in the treatment of a disease or condition for which a bromodomain inhibitor is indicated

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
PL369598A1 (en) * 2001-02-21 2005-05-02 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
CA2462289C (en) * 2001-10-04 2010-02-23 Nicholas D. Cosford Heteroaryl substituted tetrazole modulators of metabotropic glutamate receptor-5

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105377832A (zh) * 2013-07-17 2016-03-02 赫普泰雅治疗有限公司 4-(3-氰基苯基)-6-吡啶基嘧啶mglu5调节剂
CN105377832B (zh) * 2013-07-17 2018-05-04 赫普泰雅治疗有限公司 4-(3-氰基苯基)-6-吡啶基嘧啶mglu5调节剂
CN108434147A (zh) * 2013-07-17 2018-08-24 赫普泰雅治疗有限公司 4-(3-氰基苯基)-6-吡啶基嘧啶mglu5调节剂
AU2018241104B2 (en) * 2013-07-17 2019-07-11 Nxera Pharma Uk Limited 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
CN108434147B (zh) * 2013-07-17 2021-02-02 赫普泰雅治疗有限公司 4-(3-氰基苯基)-6-吡啶基嘧啶mglu5调节剂
US11584732B2 (en) 2013-07-17 2023-02-21 Heptares Therapeutics Limited Methods of treatment using 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
US11680053B2 (en) 2013-07-17 2023-06-20 Heptares Therapeutics Limited Methods of treatment using 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
US12415795B2 (en) 2013-07-17 2025-09-16 Nxera Pharma Uk Limited 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators

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Publication number Publication date
UY28685A1 (es) 2005-06-30
RU2006118021A (ru) 2007-12-10
HK1095598A1 (en) 2007-05-11
IL175909A0 (en) 2008-02-09
EP1713791A1 (en) 2006-10-25
WO2005066155A1 (en) 2005-07-21
DE602004013469T2 (de) 2009-06-18
AR046768A1 (es) 2005-12-21
ATE393767T1 (de) 2008-05-15
MXPA06006674A (es) 2007-04-16
US20070255061A1 (en) 2007-11-01
AU2004312342A1 (en) 2005-07-21
EP1713791B1 (en) 2008-04-30
ZA200604681B (en) 2007-04-25
TW200524602A (en) 2005-08-01
KR20060126993A (ko) 2006-12-11
JP2007514790A (ja) 2007-06-07
DE602004013469D1 (de) 2008-06-12
BRPI0417308A (pt) 2007-09-11
CA2548039A1 (en) 2005-07-21
ES2303969T3 (es) 2008-09-01
NO20062533L (no) 2006-09-19
DE602004013469T9 (de) 2009-09-24

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