TW200524602A - Nitrogen-containing heterocycles affecting glutamatergic synaptic transmission - Google Patents

Nitrogen-containing heterocycles affecting glutamatergic synaptic transmission Download PDF

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Publication number
TW200524602A
TW200524602A TW093139143A TW93139143A TW200524602A TW 200524602 A TW200524602 A TW 200524602A TW 093139143 A TW093139143 A TW 093139143A TW 93139143 A TW93139143 A TW 93139143A TW 200524602 A TW200524602 A TW 200524602A
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TW
Taiwan
Prior art keywords
compound
scope
patent application
item
alkyl
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TW093139143A
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English (en)
Chinese (zh)
Inventor
David Wensbo
Louise Edwards
Methvin Isaac
Donald A Mcleod
Abdelmalik Slassi
Tao Xin
Thomas M Stormann
Annika Kers
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Astrazeneca Ab
Nps Pharma Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34748746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200524602(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Nps Pharma Inc filed Critical Astrazeneca Ab
Publication of TW200524602A publication Critical patent/TW200524602A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW093139143A 2003-12-19 2004-12-16 Nitrogen-containing heterocycles affecting glutamatergic synaptic transmission TW200524602A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53063303P 2003-12-19 2003-12-19

Publications (1)

Publication Number Publication Date
TW200524602A true TW200524602A (en) 2005-08-01

Family

ID=34748746

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093139143A TW200524602A (en) 2003-12-19 2004-12-16 Nitrogen-containing heterocycles affecting glutamatergic synaptic transmission

Country Status (20)

Country Link
US (1) US20070255061A1 (cg-RX-API-DMAC7.html)
EP (1) EP1713791B1 (cg-RX-API-DMAC7.html)
JP (1) JP2007514790A (cg-RX-API-DMAC7.html)
KR (1) KR20060126993A (cg-RX-API-DMAC7.html)
CN (1) CN1906187A (cg-RX-API-DMAC7.html)
AR (1) AR046768A1 (cg-RX-API-DMAC7.html)
AT (1) ATE393767T1 (cg-RX-API-DMAC7.html)
AU (1) AU2004312342A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0417308A (cg-RX-API-DMAC7.html)
CA (1) CA2548039A1 (cg-RX-API-DMAC7.html)
DE (1) DE602004013469T9 (cg-RX-API-DMAC7.html)
ES (1) ES2303969T3 (cg-RX-API-DMAC7.html)
IL (1) IL175909A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA06006674A (cg-RX-API-DMAC7.html)
NO (1) NO20062533L (cg-RX-API-DMAC7.html)
RU (1) RU2006118021A (cg-RX-API-DMAC7.html)
TW (1) TW200524602A (cg-RX-API-DMAC7.html)
UY (1) UY28685A1 (cg-RX-API-DMAC7.html)
WO (1) WO2005066155A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200604681B (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1706392A2 (en) * 2004-01-08 2006-10-04 Syngenta Participations AG Pesticidal heterocyclic dihaloallyl compounds
UY29796A1 (es) 2005-09-29 2007-04-30 Astrazeneca Ab Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US20120095056A1 (en) * 2009-03-19 2012-04-19 Neurosearch A/S 2,5-disubstituted tetrazole derivatives and their use as nicotinic acetylcholine receptor modulators
WO2011073297A1 (en) * 2009-12-18 2011-06-23 Neurosearch A/S Tetrazole derivatives as nicotinic acetylcholine receptor moudlators
WO2011073298A1 (en) * 2009-12-18 2011-06-23 Neurosearch A/S Tetrazole derivatives as nicotinic acetylcholine receptor modulators
CN102762572A (zh) 2010-02-01 2012-10-31 诺瓦提斯公司 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists
GB201312800D0 (en) 2013-07-17 2013-08-28 Heptares Therapeutics Ltd mGlu5 modulators
WO2016001452A1 (en) 2014-07-04 2016-01-07 Universität Zürich Compounds, in particular for use in the treatment of a disease or condition for which a bromodomain inhibitor is indicated

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
PL369598A1 (en) * 2001-02-21 2005-05-02 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
CA2462289C (en) * 2001-10-04 2010-02-23 Nicholas D. Cosford Heteroaryl substituted tetrazole modulators of metabotropic glutamate receptor-5

Also Published As

Publication number Publication date
UY28685A1 (es) 2005-06-30
RU2006118021A (ru) 2007-12-10
HK1095598A1 (en) 2007-05-11
IL175909A0 (en) 2008-02-09
EP1713791A1 (en) 2006-10-25
WO2005066155A1 (en) 2005-07-21
DE602004013469T2 (de) 2009-06-18
AR046768A1 (es) 2005-12-21
ATE393767T1 (de) 2008-05-15
MXPA06006674A (es) 2007-04-16
US20070255061A1 (en) 2007-11-01
AU2004312342A1 (en) 2005-07-21
EP1713791B1 (en) 2008-04-30
ZA200604681B (en) 2007-04-25
CN1906187A (zh) 2007-01-31
KR20060126993A (ko) 2006-12-11
JP2007514790A (ja) 2007-06-07
DE602004013469D1 (de) 2008-06-12
BRPI0417308A (pt) 2007-09-11
CA2548039A1 (en) 2005-07-21
ES2303969T3 (es) 2008-09-01
NO20062533L (no) 2006-09-19
DE602004013469T9 (de) 2009-09-24

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