AU2004312342A1 - 5-fluoro-, chloro- and cyano-pyridin-2-yl-tetrazoles as ligands of the metabotropic glutamate receptor-5 - Google Patents
5-fluoro-, chloro- and cyano-pyridin-2-yl-tetrazoles as ligands of the metabotropic glutamate receptor-5 Download PDFInfo
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- AU2004312342A1 AU2004312342A1 AU2004312342A AU2004312342A AU2004312342A1 AU 2004312342 A1 AU2004312342 A1 AU 2004312342A1 AU 2004312342 A AU2004312342 A AU 2004312342A AU 2004312342 A AU2004312342 A AU 2004312342A AU 2004312342 A1 AU2004312342 A1 AU 2004312342A1
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- Prior art keywords
- tetrazol
- fluoro
- cyano
- compounds
- benzonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 title claims description 28
- 102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 title description 23
- 239000003446 ligand Substances 0.000 title description 5
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- 150000001875 compounds Chemical class 0.000 claims description 116
- 238000011282 treatment Methods 0.000 claims description 40
- -1 chloro, bromo, iodo, methoxymethyl Chemical group 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 33
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 27
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- 239000000203 mixture Substances 0.000 claims description 22
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- 125000000217 alkyl group Chemical group 0.000 claims description 19
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- NHDIQVFFNDKAQU-UHFFFAOYSA-N tripropan-2-yl borate Chemical compound CC(C)OB(OC(C)C)OC(C)C NHDIQVFFNDKAQU-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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| Application Number | Priority Date | Filing Date | Title |
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| US53063303P | 2003-12-19 | 2003-12-19 | |
| US60/530,633 | 2003-12-19 | ||
| PCT/US2004/041401 WO2005066155A1 (en) | 2003-12-19 | 2004-12-13 | 5-fluoro-, chloro- and cyano-pyridin-2-yl-tetrazoles as ligands of the metabotropic glutamate receptor-5 |
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| EP1706392A2 (en) * | 2004-01-08 | 2006-10-04 | Syngenta Participations AG | Pesticidal heterocyclic dihaloallyl compounds |
| UY29796A1 (es) | 2005-09-29 | 2007-04-30 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| US20120095056A1 (en) * | 2009-03-19 | 2012-04-19 | Neurosearch A/S | 2,5-disubstituted tetrazole derivatives and their use as nicotinic acetylcholine receptor modulators |
| WO2011073297A1 (en) * | 2009-12-18 | 2011-06-23 | Neurosearch A/S | Tetrazole derivatives as nicotinic acetylcholine receptor moudlators |
| WO2011073298A1 (en) * | 2009-12-18 | 2011-06-23 | Neurosearch A/S | Tetrazole derivatives as nicotinic acetylcholine receptor modulators |
| CN102762572A (zh) | 2010-02-01 | 2012-10-31 | 诺瓦提斯公司 | 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物 |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| EP2531490B1 (en) | 2010-02-02 | 2014-10-15 | Novartis AG | Cyclohexyl amide derivatives as crf receptor antagonists |
| GB201312800D0 (en) | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
| WO2016001452A1 (en) | 2014-07-04 | 2016-01-07 | Universität Zürich | Compounds, in particular for use in the treatment of a disease or condition for which a bromodomain inhibitor is indicated |
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| US6660753B2 (en) * | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| PL369598A1 (en) * | 2001-02-21 | 2005-05-02 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| CA2462289C (en) * | 2001-10-04 | 2010-02-23 | Nicholas D. Cosford | Heteroaryl substituted tetrazole modulators of metabotropic glutamate receptor-5 |
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- 2004-12-13 KR KR1020067011449A patent/KR20060126993A/ko not_active Withdrawn
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- 2004-12-13 ES ES04813689T patent/ES2303969T3/es not_active Expired - Lifetime
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- 2004-12-13 BR BRPI0417308-2A patent/BRPI0417308A/pt not_active IP Right Cessation
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2006
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- 2006-06-07 ZA ZA200604681A patent/ZA200604681B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UY28685A1 (es) | 2005-06-30 |
| RU2006118021A (ru) | 2007-12-10 |
| HK1095598A1 (en) | 2007-05-11 |
| IL175909A0 (en) | 2008-02-09 |
| EP1713791A1 (en) | 2006-10-25 |
| WO2005066155A1 (en) | 2005-07-21 |
| DE602004013469T2 (de) | 2009-06-18 |
| AR046768A1 (es) | 2005-12-21 |
| ATE393767T1 (de) | 2008-05-15 |
| MXPA06006674A (es) | 2007-04-16 |
| US20070255061A1 (en) | 2007-11-01 |
| EP1713791B1 (en) | 2008-04-30 |
| ZA200604681B (en) | 2007-04-25 |
| CN1906187A (zh) | 2007-01-31 |
| TW200524602A (en) | 2005-08-01 |
| KR20060126993A (ko) | 2006-12-11 |
| JP2007514790A (ja) | 2007-06-07 |
| DE602004013469D1 (de) | 2008-06-12 |
| BRPI0417308A (pt) | 2007-09-11 |
| CA2548039A1 (en) | 2005-07-21 |
| ES2303969T3 (es) | 2008-09-01 |
| NO20062533L (no) | 2006-09-19 |
| DE602004013469T9 (de) | 2009-09-24 |
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