CN1903850A - 一种制备枸橼酸铋雷尼替丁的方法 - Google Patents
一种制备枸橼酸铋雷尼替丁的方法 Download PDFInfo
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- CN1903850A CN1903850A CN 200610103786 CN200610103786A CN1903850A CN 1903850 A CN1903850 A CN 1903850A CN 200610103786 CN200610103786 CN 200610103786 CN 200610103786 A CN200610103786 A CN 200610103786A CN 1903850 A CN1903850 A CN 1903850A
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- Prior art keywords
- bismuth citrate
- ranitidine
- reaction
- ammonia
- ammoniacal liquor
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Abstract
Description
制备方案 | 杂质含量 | 溶媒残留 |
A1 | 2.1% | 0.5% |
A2 | 4.0% | 0.7% |
A3 | 5.2% | 1.1% |
B1 | 0.5% | 0 |
B2 | 1.0% | 0 |
B3 | 0.75% | 0 |
Claims (9)
Priority Applications (1)
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CNB2006101037865A CN100402514C (zh) | 2006-08-01 | 2006-08-01 | 一种制备枸橼酸铋雷尼替丁的方法 |
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CNB2006101037865A CN100402514C (zh) | 2006-08-01 | 2006-08-01 | 一种制备枸橼酸铋雷尼替丁的方法 |
Publications (2)
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CN1903850A true CN1903850A (zh) | 2007-01-31 |
CN100402514C CN100402514C (zh) | 2008-07-16 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101862320A (zh) * | 2010-06-29 | 2010-10-20 | 郝志艳 | 一种盐酸雷尼替丁/枸橼酸铋钾药物组合物固体制剂 |
CN102304107A (zh) * | 2011-07-13 | 2012-01-04 | 王健祥 | 一种雷尼替丁羧酸铋的制备方法 |
CN103896888A (zh) * | 2014-03-28 | 2014-07-02 | 常州兰陵制药有限公司 | 枸橼酸铋雷尼替丁的制备方法 |
CN107382921A (zh) * | 2017-07-28 | 2017-11-24 | 常州兰陵制药有限公司 | 制备枸橼酸铋雷尼替丁的方法 |
CN107501216A (zh) * | 2017-08-03 | 2017-12-22 | 江苏汉斯通药业有限公司 | 高稳定性枸缘酸铋雷尼替丁的合成新方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH679582A5 (zh) * | 1988-07-18 | 1992-03-13 | Glaxo Group Ltd | |
CN1156143A (zh) * | 1995-10-20 | 1997-08-06 | 糜志远 | 枸橼酸铋雷尼替丁产品制备技术 |
CN1102585C (zh) * | 1999-04-28 | 2003-03-05 | 常州兰陵制药有限公司 | 雷尼替丁枸橼酸铋盐的制备方法 |
CN1256332C (zh) * | 2004-04-29 | 2006-05-17 | 王健祥 | 一种雷尼替丁枸橼酸铋或者雷尼替丁酒石酸铋复合物的制备方法 |
-
2006
- 2006-08-01 CN CNB2006101037865A patent/CN100402514C/zh active Active
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101862320A (zh) * | 2010-06-29 | 2010-10-20 | 郝志艳 | 一种盐酸雷尼替丁/枸橼酸铋钾药物组合物固体制剂 |
CN102304107A (zh) * | 2011-07-13 | 2012-01-04 | 王健祥 | 一种雷尼替丁羧酸铋的制备方法 |
CN103896888A (zh) * | 2014-03-28 | 2014-07-02 | 常州兰陵制药有限公司 | 枸橼酸铋雷尼替丁的制备方法 |
CN103896888B (zh) * | 2014-03-28 | 2015-11-18 | 常州兰陵制药有限公司 | 枸橼酸铋雷尼替丁的制备方法 |
CN107382921A (zh) * | 2017-07-28 | 2017-11-24 | 常州兰陵制药有限公司 | 制备枸橼酸铋雷尼替丁的方法 |
CN107501216A (zh) * | 2017-08-03 | 2017-12-22 | 江苏汉斯通药业有限公司 | 高稳定性枸缘酸铋雷尼替丁的合成新方法 |
CN107501216B (zh) * | 2017-08-03 | 2021-01-19 | 江苏汉斯通药业有限公司 | 高稳定性枸缘酸铋雷尼替丁的合成新方法 |
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Publication number | Publication date |
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CN100402514C (zh) | 2008-07-16 |
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Owner name: LIDA PHARMACEUTICAL CO., LTD., ZHUHAI FREE TRADE Z |
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Free format text: CORRECT: ADDRESS; FROM: 519020 GUIHUA NORTH ROAD, GONGBEI, ZHUHAI CITY, GUANGDONG PROVINCE TO: 519020 NO.132, GUIHUA NORTH ROAD, GONGBEI, ZHUHAI SPECIAL ECONOMIC ZONE, GUANGDONG PROVINCE |
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Effective date of registration: 20100826 Address after: 519020, Zhuhai Special Economic Zone, Guangdong, Gongbei Osmanthus Road No. 132 Co-patentee after: Zhuhai Free Trade Zone Lida Pharmaceutical Co., Ltd. Patentee after: Lizhu Medicine Group Co., Ltd. Address before: 519020 Guihua Road, Zhuhai, Guangdong, Gongbei Patentee before: Lizhu Medicine Group Co., Ltd. |
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EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd. Assignor: Zhuhai Free Trade Zone Lida Pharmaceutical Company Limited|Livzon Pharmaceutical Group Limited by Share Ltd Contract record no.: 2010990000799 Denomination of invention: Method of preparing bismuth citrate ranitidine Granted publication date: 20080716 License type: Exclusive License Open date: 20070131 Record date: 20100930 |