CN1902186B - 作为flt-3激酶抑制剂的噻唑和吡唑衍生物 - Google Patents

作为flt-3激酶抑制剂的噻唑和吡唑衍生物 Download PDF

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Publication number
CN1902186B
CN1902186B CN2004800403740A CN200480040374A CN1902186B CN 1902186 B CN1902186 B CN 1902186B CN 2004800403740 A CN2004800403740 A CN 2004800403740A CN 200480040374 A CN200480040374 A CN 200480040374A CN 1902186 B CN1902186 B CN 1902186B
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phenyl
compound
formula
group
title compound
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Expired - Fee Related
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CN2004800403740A
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English (en)
Chinese (zh)
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CN1902186A (zh
Inventor
G·博尔德
A·弗劳尔斯海默
P·菲雷
V·瓜尼亚诺
升谷敬一
A·沃佩尔
J·舍普费尔
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CN2004800403740A 2003-11-14 2004-11-12 作为flt-3激酶抑制剂的噻唑和吡唑衍生物 Expired - Fee Related CN1902186B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0326601.2A GB0326601D0 (en) 2003-11-14 2003-11-14 Organic compounds
GB0326601.2 2003-11-14
PCT/EP2004/012892 WO2005047273A1 (fr) 2003-11-14 2004-11-12 Derives de thiazole et de pyrazole en tant qu'inhibiteurs de la kinase flt-3

Publications (2)

Publication Number Publication Date
CN1902186A CN1902186A (zh) 2007-01-24
CN1902186B true CN1902186B (zh) 2010-12-22

Family

ID=29726576

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2004800403740A Expired - Fee Related CN1902186B (zh) 2003-11-14 2004-11-12 作为flt-3激酶抑制剂的噻唑和吡唑衍生物

Country Status (13)

Country Link
US (1) US7795288B2 (fr)
EP (1) EP1687285B1 (fr)
JP (1) JP4869939B2 (fr)
KR (1) KR20060108673A (fr)
CN (1) CN1902186B (fr)
AU (2) AU2004289447A1 (fr)
BR (1) BRPI0416039A (fr)
CA (1) CA2545350A1 (fr)
ES (1) ES2469644T3 (fr)
GB (1) GB0326601D0 (fr)
MX (1) MXPA06005356A (fr)
RU (1) RU2006120490A (fr)
WO (1) WO2005047273A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005287170B2 (en) 2004-09-17 2012-03-29 Exelixis, Inc Pyrazole kinase modulators and methods of use
MX2007012392A (es) * 2005-04-04 2007-12-05 Ab Science Derivados de oxazol sustituidos y su uso como inhibidores de tirosina cinasa.
ZA200710105B (en) * 2005-05-24 2009-04-29 Serono Lab Thiazole derivatives and use thereof
US20060281788A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
US20060281769A1 (en) * 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators
US20060281700A1 (en) * 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using aminopyrimidines kinase modulators
US20070004660A1 (en) * 2005-06-10 2007-01-04 Baumann Christian A Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines
US20060281755A1 (en) * 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using aminopyrimidines kinase modulators
KR20080031997A (ko) * 2005-08-02 2008-04-11 아이알엠 엘엘씨 단백질 키나제 억제제로서의 5-치환 티아졸-2-일 아미노화합물 및 조성물
CN101610768B (zh) * 2006-04-20 2012-03-21 詹森药业有限公司 抑制c kit激酶的方法
US8859602B2 (en) 2006-04-20 2014-10-14 Janssen Pharmaceutica Nv Inhibitors of c-fms kinase
PL2021335T3 (pl) 2006-04-20 2011-10-31 Janssen Pharmaceutica Nv Związki heterocykliczne jako inhibitory kinazy C-FMS
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
JO3240B1 (ar) 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
US8993615B2 (en) 2008-08-08 2015-03-31 The Johns Hopkins University Compositions and methods for treatment of neurodegenerative disease
WO2011119777A2 (fr) 2010-03-23 2011-09-29 The Johns Hopkins University Compositions et méthodes de traitement d'une maladie neurodégénérative
US9255072B2 (en) 2011-03-04 2016-02-09 National Health Rsearch Institutes Pyrazole compounds and thiazole compounds as protein kinases inhibitors
JOP20180012A1 (ar) 2012-08-07 2019-01-30 Janssen Pharmaceutica Nv عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد
US9303046B2 (en) 2012-08-07 2016-04-05 Janssen Pharmaceutica Nv Process for the preparation of heterocyclic ester derivatives
GB201402277D0 (en) * 2014-02-10 2014-03-26 Sentinel Oncology Ltd Pharmaceutical compounds
CN104829536B (zh) * 2015-05-04 2017-12-29 陕西科技大学 一种具抗肿瘤活性的苯基吡唑羧酸类化合物及其合成方法
CN108690006B (zh) * 2017-04-12 2022-02-18 中国药科大学 一类化合物及其在抗aml药物中的用途
CN110732500B (zh) * 2018-07-19 2024-02-27 湖南农业大学 一种基于机器视觉的芒果分级装置
CN111718310B (zh) * 2019-08-19 2021-06-11 中国药科大学 苯基取代的五元杂环类化合物及其制备方法、用途和药物组合物

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WO2003062215A1 (fr) * 2002-01-25 2003-07-31 Kylix Pharmaceuticals B.V. (thia-/oxa-/pyra) zoles substitues 4(hetero-) aryle pour inhibition de tie-2

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US4649146A (en) * 1983-01-31 1987-03-10 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives and pharmaceutical composition comprising the same
EP0149884B1 (fr) * 1983-09-09 1992-12-16 Takeda Chemical Industries, Ltd. Dérivés de 5-pyridyle-1,3-thiazole, leur préparation et utilisation
GB8611102D0 (en) * 1986-05-07 1986-06-11 Fisons Plc Heterocyclic compounds
EP0248523B1 (fr) * 1986-05-07 1991-10-16 FISONS plc Pyrazoles
JPH11193281A (ja) * 1997-10-27 1999-07-21 Takeda Chem Ind Ltd アデノシンａ３受容体拮抗剤およびチアゾール化合物
BR9915132A (pt) * 1998-11-06 2001-08-07 Basf Ag Método para inibir a atividade de quinase de proteìna, compostos da fórmula i e sais farmaceuticamente aceitáveis dos mesmos, uso do mesmo, e, composição farmacêutica.
UA71587C2 (uk) * 1998-11-10 2004-12-15 Шерінг Акцієнгезелльшафт Аміди антранілової кислоти та їхнє застосування як лікарських засобів
JP2002531503A (ja) * 1998-12-07 2002-09-24 スミスクライン・ビーチャム・コーポレイション Ｍｙｔ１キナーゼ阻害剤
HUP0300382A3 (en) * 2000-03-29 2006-11-28 Cyclacel Ltd 2-substituted 4-heteroaryl-pyrimidines and their use in the treatmetn of proliferative disorders and pharmaceutical compositions containing the compounds
BR0110302A (pt) * 2000-04-18 2003-01-14 Agouron Pharma Compostos de pirazol para inibição de proteìnas cinase, sal e pró-droga farmaceuticamente aceitável, metabólito farmaceuticamente ativo ou sal farmaceuticamente aceitável de metabólito, composição farmacêutica, método de tratamento de condição doentia em mamìferos mediada pela atividade de proteìna cinase, método de modulação ou inibição da atividade de um receptor de proteìna cinase
TW200401638A (en) * 2002-06-20 2004-02-01 Bristol Myers Squibb Co Heterocyclic inhibitors of kinases
BRPI0412820A (pt) * 2003-07-25 2006-09-26 Pfizer compostos de aminopirazol e utilização como inibidores de chk1

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Also Published As

Publication number Publication date
CN1902186A (zh) 2007-01-24
EP1687285A1 (fr) 2006-08-09
EP1687285B1 (fr) 2014-03-05
AU2004289447A1 (en) 2005-05-26
GB0326601D0 (en) 2003-12-17
JP2007511484A (ja) 2007-05-10
BRPI0416039A (pt) 2007-01-02
JP4869939B2 (ja) 2012-02-08
WO2005047273A1 (fr) 2005-05-26
RU2006120490A (ru) 2008-01-10
AU2009202639A8 (en) 2009-07-30
AU2009202639A1 (en) 2009-07-23
CA2545350A1 (fr) 2005-05-26
MXPA06005356A (es) 2006-07-10
KR20060108673A (ko) 2006-10-18
US7795288B2 (en) 2010-09-14
US20070167449A1 (en) 2007-07-19
ES2469644T3 (es) 2014-06-18

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Owner name: NOVARTIS CO., LTD.

Free format text: FORMER NAME: NOVARTIS AG

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Granted publication date: 20101222

Termination date: 20151112