CN1898239A - 新的二氮杂螺烷及其在治疗ccr8介导的疾病中的用途 - Google Patents

新的二氮杂螺烷及其在治疗ccr8介导的疾病中的用途 Download PDF

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Publication number
CN1898239A
CN1898239A CNA200480038668XA CN200480038668A CN1898239A CN 1898239 A CN1898239 A CN 1898239A CN A200480038668X A CNA200480038668X A CN A200480038668XA CN 200480038668 A CN200480038668 A CN 200480038668A CN 1898239 A CN1898239 A CN 1898239A
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Prior art keywords
diazaspiro
isobutoxybenzyl
undecane
decane
benzyl
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Pending
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Chinese (zh)
Inventor
哈坎·布莱德
斯蒂芬·康诺利
黑兹尔·J·戴克
安妮亚·利西厄斯
斯蒂芬·普赖斯
艾戈尔·沙莫夫斯基
马科·范登霍伊维尔
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AstraZeneca AB
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AstraZeneca AB
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Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1898239A publication Critical patent/CN1898239A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
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  • Reproductive Health (AREA)
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  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
CNA200480038668XA 2003-10-23 2004-10-21 新的二氮杂螺烷及其在治疗ccr8介导的疾病中的用途 Pending CN1898239A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE03028115 2003-10-23
SE0302811A SE0302811D0 (sv) 2003-10-23 2003-10-23 Novel compounds

Publications (1)

Publication Number Publication Date
CN1898239A true CN1898239A (zh) 2007-01-17

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CNA200480038668XA Pending CN1898239A (zh) 2003-10-23 2004-10-21 新的二氮杂螺烷及其在治疗ccr8介导的疾病中的用途

Country Status (17)

Country Link
US (1) US20070249648A1 (cg-RX-API-DMAC7.html)
EP (1) EP1678178A1 (cg-RX-API-DMAC7.html)
JP (1) JP2007509141A (cg-RX-API-DMAC7.html)
KR (1) KR20060088557A (cg-RX-API-DMAC7.html)
CN (1) CN1898239A (cg-RX-API-DMAC7.html)
AR (1) AR046600A1 (cg-RX-API-DMAC7.html)
AU (1) AU2004284028B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0415613A (cg-RX-API-DMAC7.html)
CA (1) CA2542226A1 (cg-RX-API-DMAC7.html)
IL (1) IL174698A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA06004300A (cg-RX-API-DMAC7.html)
NO (1) NO20062335L (cg-RX-API-DMAC7.html)
SE (1) SE0302811D0 (cg-RX-API-DMAC7.html)
TW (1) TW200528451A (cg-RX-API-DMAC7.html)
UY (1) UY28572A1 (cg-RX-API-DMAC7.html)
WO (1) WO2005040167A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200603174B (cg-RX-API-DMAC7.html)

Cited By (4)

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CN102939290A (zh) * 2010-03-19 2013-02-20 辉瑞大药厂 2,3-二氢-1h-茚-1-基-2,7-二氮杂螺[3.6]壬烷衍生物及其作为生长激素释放肽受体的拮抗剂或反向激动剂的用途
CN104271581A (zh) * 2011-12-22 2015-01-07 会聚制药有限公司 用作电压门控钠通道调制剂的2-(吡啶-2基)-1,7-二氮杂螺[4.4]壬-6-酮化合物
CN104364239A (zh) * 2012-06-13 2015-02-18 霍夫曼-拉罗奇有限公司 新型二氮杂螺环烷烃和氮杂螺环烷烃
CN113207291A (zh) * 2018-10-24 2021-08-03 亚瑞克西斯制药公司 2-(2-丙烯酰基-2,6-二氮杂螺[3.4]辛-6-基)-6-(1h-吲唑-4-基)苄腈衍生物及相关化合物作为用于抑制肿瘤转移的g12c突变kras蛋白的抑制剂

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SE0202133D0 (sv) 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
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JP4845873B2 (ja) * 2004-03-03 2011-12-28 ケモセントリックス インコーポレーティッド 二環式および架橋した窒素複素環
WO2006107252A1 (en) * 2005-04-04 2006-10-12 Astrazeneca Ab Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases
CN101155812A (zh) * 2005-04-04 2008-04-02 阿斯利康(瑞典)有限公司 新二氮杂螺烷和它们治疗ccr8介导的疾病的用途
EP1869044A1 (en) * 2005-04-04 2007-12-26 AstraZeneca AB Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases
GB0514018D0 (en) * 2005-07-07 2005-08-17 Ionix Pharmaceuticals Ltd Chemical compounds
TW200800999A (en) * 2005-09-06 2008-01-01 Astrazeneca Ab Novel compounds
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US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
MX2008015696A (es) * 2006-06-09 2009-02-10 Icos Corp Acidos fenil aceticos sustituidos como antagonistas de dp-2.
KR20090030347A (ko) * 2006-07-19 2009-03-24 아스트라제네카 아베 신규 트리시클릭 스피로피페리딘 화합물, 이들의 합성 및 이들의 케모킨 수용체 활성의 조절제로서의 용도
EP2061791A1 (en) 2006-09-15 2009-05-27 Schering Corporation Spiro-condensed azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabilism
KR20090071589A (ko) 2006-09-15 2009-07-01 쉐링 코포레이션 통증 및 지질 대사 장애의 치료에 유용한 아제티딘 및 아제티돈 유도체
CN101534822A (zh) * 2006-09-15 2009-09-16 先灵公司 治疗疼痛、糖尿病和脂质代谢紊乱
WO2008099165A1 (en) * 2007-02-15 2008-08-21 Astrazeneca Ab Piperidine derivatives and their use for treatment of ccr8 mediated diseases
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WO2013066718A2 (en) * 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
AU2013272288B2 (en) * 2012-06-08 2018-01-18 The United States Government As Represented By The Department Of Veterans Affairs FBXO3 inhibitors
PL2900669T3 (pl) 2012-09-25 2020-01-31 F. Hoffmann-La Roche Ag Pochodne heksahydropirolo[3,4-C]pirolu i związki pokrewne jako inhibitory autotaksyny (ATX) oraz inhibitory produkcji kwasu lizofosfatydowego (LPA) do leczenia np. chorób nerek
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
US9776979B2 (en) * 2013-09-26 2017-10-03 Sanford-Burnham Medical Research Institute EBI2 modulators
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
UA118201C2 (uk) 2013-11-26 2018-12-10 Ф. Хоффманн-Ля Рош Аг НОВИЙ ОКТАГІДРОЦИКЛОБУТА[1,2-c;3,4-c']ДИПІРОЛ-2-ІЛ
US10562869B2 (en) 2014-03-17 2020-02-18 Remynd Nv Oxadiazole compounds
CR20160418A (es) 2014-03-26 2016-11-07 Hoffmann La Roche Nuevos compuestos biciclicos de 7 eslabones
SG11201607839UA (en) 2014-03-26 2016-10-28 Hoffmann La Roche Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
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