CN1889951A - 取代的苯并唑及其用作raf激酶抑制剂的应用 - Google Patents

取代的苯并唑及其用作raf激酶抑制剂的应用 Download PDF

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Publication number
CN1889951A
CN1889951A CNA2004800361998A CN200480036199A CN1889951A CN 1889951 A CN1889951 A CN 1889951A CN A2004800361998 A CNA2004800361998 A CN A2004800361998A CN 200480036199 A CN200480036199 A CN 200480036199A CN 1889951 A CN1889951 A CN 1889951A
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phenyl
alkyl
group
chemical compound
alkyl group
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CNA2004800361998A
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Chinese (zh)
Inventor
S·拉姆西
S·萨布拉马尼安
J·费尔哈亨
D·J·珀恩
T·汉森
C·谢弗
C·麦克布莱德
B·H·莱文
A·科斯泰尔思
P·A·任豪
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Novartis Vaccines and Diagnostics Inc
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Chiron Corp
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Publication of CN1889951A publication Critical patent/CN1889951A/zh
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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  • Epidemiology (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Structural Engineering (AREA)
  • Materials Engineering (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNA2004800361998A 2003-10-16 2004-10-15 取代的苯并唑及其用作raf激酶抑制剂的应用 Pending CN1889951A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51196603P 2003-10-16 2003-10-16
US60/511,966 2003-10-16

Publications (1)

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CN1889951A true CN1889951A (zh) 2007-01-03

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US (3) US7423150B2 (enExample)
EP (1) EP1682126B1 (enExample)
JP (1) JP4755991B2 (enExample)
KR (1) KR20060118472A (enExample)
CN (1) CN1889951A (enExample)
AT (1) ATE435015T1 (enExample)
AU (1) AU2004281151A1 (enExample)
CA (1) CA2542653A1 (enExample)
DE (1) DE602004021838D1 (enExample)
ES (1) ES2327418T3 (enExample)
IL (1) IL174965A0 (enExample)
MX (1) MXPA06004236A (enExample)
PL (1) PL1682126T3 (enExample)
PT (1) PT1682126E (enExample)
TW (1) TW200526208A (enExample)
WO (1) WO2005037273A1 (enExample)

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CN103038364A (zh) * 2010-03-09 2013-04-10 达纳－法伯癌症研究所公司 诊断和治疗具有或发展对于第一种癌症治疗的抗性的患者中的癌症的方法
CN101754965B (zh) * 2007-05-21 2014-03-19 诺华股份有限公司 Csf-1r抑制剂、组合物及使用方法
CN105949178A (zh) * 2015-03-09 2016-09-21 张锐豪 一种苯并咪唑类化合物、其制备方法、中间体及应用

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PT1636585E (pt) 2003-05-20 2008-03-27 Bayer Pharmaceuticals Corp Diarilureias com actividade inibidora de cinase
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