CN1882691B - 对l-抗坏血酸进行微生物生产的方法 - Google Patents

对l-抗坏血酸进行微生物生产的方法 Download PDF

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Publication number
CN1882691B
CN1882691B CN200480023361.2A CN200480023361A CN1882691B CN 1882691 B CN1882691 B CN 1882691B CN 200480023361 A CN200480023361 A CN 200480023361A CN 1882691 B CN1882691 B CN 1882691B
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Chinese (zh)
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CN1882691A (zh
Inventor
阿兰·贝利
康妮·李
安妮·弗朗索瓦·迈耶
新城雅子
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DSM IP Assets BV
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN200480023361.2A 2003-08-14 2004-08-16 对l-抗坏血酸进行微生物生产的方法 Expired - Fee Related CN1882691B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03017677.0 2003-08-14
EP03017677 2003-08-14
PCT/CH2004/000511 WO2005017159A2 (en) 2003-08-14 2004-08-16 Microbial production of l-ascorbic acid

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410171433.3A Division CN104004776A (zh) 2003-08-14 2004-08-16 对l-抗坏血酸进行微生物生产的方法

Publications (2)

Publication Number Publication Date
CN1882691A CN1882691A (zh) 2006-12-20
CN1882691B true CN1882691B (zh) 2014-05-28

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CN200480023361.2A Expired - Fee Related CN1882691B (zh) 2003-08-14 2004-08-16 对l-抗坏血酸进行微生物生产的方法
CN201410171433.3A Pending CN104004776A (zh) 2003-08-14 2004-08-16 对l-抗坏血酸进行微生物生产的方法

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Country Status (9)

Country Link
US (3) US7700723B2 (enExample)
EP (2) EP2348113B1 (enExample)
JP (1) JP4896718B2 (enExample)
KR (1) KR101311562B1 (enExample)
CN (2) CN1882691B (enExample)
BR (1) BRPI0413542A (enExample)
EA (1) EA009287B1 (enExample)
ES (2) ES2593811T3 (enExample)
WO (2) WO2005017172A1 (enExample)

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WO2006084724A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene rcs 28
WO2006084737A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Gene rcs 23
CN101151365B (zh) * 2005-02-11 2012-05-23 帝斯曼知识产权资产管理有限公司 基因sms02
EP1846554A1 (en) * 2005-02-11 2007-10-24 DSMIP Assets B.V. Fermentive vitamin c production
WO2006084645A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene rcs 10
US20080305532A1 (en) * 2005-02-11 2008-12-11 Bastien Chevreux Gene For Coenzyme Pqq Synthesis Protein B From Gluconobacter Oxydans
US20080193972A1 (en) * 2005-02-11 2008-08-14 Bastian Chevreux Gene Rcs 25
WO2006084643A2 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene vcs 07
WO2006084733A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Gene rcs 21
CN101316929A (zh) 2005-09-08 2008-12-03 帝斯曼知识产权资产管理有限公司 新颖的基因sms 37
EP1934337A1 (en) 2005-09-09 2008-06-25 DSMIP Assets B.V. Nadp-dependent glucose dehydrogenase from gluconobacter oxydans
CN101341250B (zh) * 2005-09-09 2013-03-20 帝斯曼知识产权资产管理有限公司 使用具有被打断的葡糖脱氢酶基因(gms 01)的微生物来生产生物质的工艺
FR2906817B1 (fr) * 2006-10-04 2012-04-06 Gervais Danone Sa Procede de culture pour favoriser la production de vitamine k2 par les bacteries lactiques et ses applications a la preparation de produits alimentaires
EP1918382A1 (en) * 2006-11-02 2008-05-07 DSMIP Assets B.V. Semi-continuous cascade fermentation process for pantothenate production
EP1918383A1 (en) * 2006-11-02 2008-05-07 DSMIP Assets B.V. Semi-continuous fermentation process for pantothenate production
EP2229450A1 (en) * 2008-01-10 2010-09-22 DSM IP Assets B.V. Novel gene sms 44
CN103073601B (zh) * 2013-02-01 2015-08-19 东北制药集团股份有限公司 一种2-酮基-l-古龙酸溶液加晶种的可控浓缩结晶方法
NZ743055A (en) * 2013-03-08 2020-03-27 Xyleco Inc Equipment protecting enclosures
US9340817B2 (en) 2013-03-27 2016-05-17 Sample6 Technologies, Inc. Methods of making recombinant phage, compositions and articles of manufacture of same for bacterial detection
WO2014205221A2 (en) * 2013-06-19 2014-12-24 Sample6 Technologies, Inc. Phage-based bacterial detection assay
WO2015025062A1 (en) 2013-08-23 2015-02-26 Boehringer Ingelheim Rcv Gmbh & Co Kg Novel adsorbent composition and use thereof
AU2015236045B2 (en) * 2014-03-25 2021-09-23 Ginkgo Bioworks, Inc. Methods and genetic systems for cell engineering
CN116053017B (zh) * 2022-11-04 2023-08-22 医波(厦门)科技有限公司 一种复合磁性微球及其制备方法和应用

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US5082785A (en) 1987-01-30 1992-01-21 Hoffmann-La Roche Inc. Biosynthesis of 2 keto-l-gulonic acid
WO1989006688A2 (en) 1988-01-14 1989-07-27 F. Hoffmann-La Roche & Co. Aktiengesellschaft Novel enzyme
DE69133494T2 (de) * 1990-09-17 2006-07-13 Dsm Ip Assets B.V. Microbiologische Herstellung von L-Ascorbinsäure
US5376544A (en) 1992-09-08 1994-12-27 Rutgers The State University Of New Jersey Enzymes for the production of 2-keto-L-gulonic acid
AU6731896A (en) * 1995-07-17 1997-02-18 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Cyclitol
ES2215263T3 (es) * 1997-12-01 2004-10-01 Dsm Ip Assets B.V. Aldehido deshidrogenasa.
US20020012979A1 (en) * 1998-06-08 2002-01-31 Alan Berry Vitamin c production in microorganisms and plants
GB0119864D0 (en) * 2001-08-15 2001-10-10 Cerestar Holding Bv Process for the manufacture of 2-keto-L-gulonic acid
US20050153412A1 (en) * 2002-04-22 2005-07-14 Tatsuo Hoshino Aldehyde dehydrogenase II
WO2003104445A1 (en) * 2002-06-06 2003-12-18 Roche Vitamins Ag Aldehyde dehydrogenase
CN100558886C (zh) * 2002-09-27 2009-11-11 帝斯曼知识产权资产管理有限公司 醛脱氢酶基因
JP4471841B2 (ja) 2002-09-27 2010-06-02 ディーエスエム アイピー アセッツ ビー．ブイ． 微生物によるビタミンｃの製造
US7544494B2 (en) 2002-09-27 2009-06-09 Dsm Ip Assets B.V. Vitamin C from sorbosone
EP1716240B1 (en) 2004-01-30 2010-06-02 DSM IP Assets B.V. Microbial production of vitamin c
US20080226126A1 (en) * 2005-01-31 2008-09-18 Yoshinori Ohno Object-Tracking Apparatus, Microscope System, and Object-Tracking Program
EP1846554A1 (en) 2005-02-11 2007-10-24 DSMIP Assets B.V. Fermentive vitamin c production

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MICROBIAL PRODUCTION OF 2-KETO-L-GULONIC ACIDFROM L-SORBOSE AND D-SORBITOL BYGLUCONOBACTER MELANOGENUS;SUGISAWA T ET AL;AGRICULTURAL AND BIOLOGICAL CHEMISTRY54 5;199005;54(5);1201-1209，具体参见摘要、表III *

Also Published As

Publication number Publication date
WO2005017159A3 (en) 2005-11-03
WO2005017159A2 (en) 2005-02-24
ES2593811T3 (es) 2016-12-13
US7700723B2 (en) 2010-04-20
CN1882691A (zh) 2006-12-20
JP2007502102A (ja) 2007-02-08
EP1664303A2 (en) 2006-06-07
US20070184534A1 (en) 2007-08-09
EA200600408A1 (ru) 2006-08-25
EP2348113A2 (en) 2011-07-27
US8338144B2 (en) 2012-12-25
EP1664303B1 (en) 2013-04-24
KR101311562B1 (ko) 2013-09-26
BRPI0413542A (pt) 2006-10-17
US20100203598A1 (en) 2010-08-12
CN104004776A (zh) 2014-08-27
US20130217080A1 (en) 2013-08-22
EP2348113B1 (en) 2016-06-29
WO2005017172A1 (en) 2005-02-24
EP2348113A3 (en) 2012-11-14
EA009287B1 (ru) 2007-12-28
KR20060064629A (ko) 2006-06-13
ES2421294T3 (es) 2013-08-30
JP4896718B2 (ja) 2012-03-14

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